Index / Dr. Dennis Gross / DermInfusions Fill + Repair Serum
Dr. Dennis Gross

DermInfusions Fill + Repair Serum.

Dr. Dennis Gross DermInfusions Fill + Repair Serum
Serums

About this product

A serum with peptides and exfoliating acids designed to target texture, fine lines, and hydration while supporting skin barrier repair.

Full ingredients

Guru Score

68%

Mixed

Early verdict · Few reviews so far
2Gurus
1Yay
0Mixed
1Nay

What they liked

  • Improves texture and tone quickly
  • Firms and brightens skin
  • Works as a simplified routine staple

What they flagged

  • Better for younger skin than mature skin

What the gurus are saying

Texture smooths visibly within days, credited to its peptide and exfoliating-acid blend. Opinion splits sharply on anti-aging impact: most gurus praise the formula for softening fine lines and boosting skin firmness, while skepticism emerges about whether it substantively addresses wrinkles despite the peptide content. All flag a mild floral fragrance that lingers slightly. Works for sensitive skin; patch-test before combining with tretinoin to check your tolerance.
Synthesized from 2 expert reviews · most recent take October 2025

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
~Yay
"This is one of the best serums I've ever used. It is one that will target multiple skin concerns. And if you truly wanted to limit down in your skincare routine and get rid of some of your serums, this could replace them because of the amount of key ingredients in here. So there's hyaluronic acid, there's peptides to help firm and stimulate collagen, there's niacinamide, there's some AHAs in here, there's beta glucan, centella asiatica. Honestly, the list truly goes on. And this is going to help with texture, tone, fine lines and wrinkles. It's going to hydrate your skin. It's going to repair and keep your skin barrier nice and strong and healthy. It literally does it all. And I love it so much. And you can use this in your morning and evening. And sometimes I will use this prior to prescription tretinoin. I don't always, but sometimes I do. And this is wonderful. If you can't use vitamin C in your morning routine, use this instead because there's a lot of antioxidants in here that can help to protect our skin from everyday pollution. It really does it all. There is a little bit of a floral scent to this. So, if you can't do fragrance, just keep that in mind. But this is a great time to pick this up. It's not cheap, but it works really well."
All 22 takes from Sincerely Miss Ash
5 NEXT LEVEL ANTI-AGING SERUMS THAT ACTUALLY FIRM SKIN AND MINIMIZE SIGNS OF AGING
"This is truly one of the best anti-aging serums I have ever used. I talk about this a lot on my channel because it actually performs and delivers real results. I will always recommend this because it's a serum that truly targets all skin concerns: dullness, texture, fine lines and wrinkles, crepiness, lacking moisture. The ingredient list with this product is quite lengthy, but if you look at that ingredient list and really go through it, you're going to see that they are good ingredients that actually have benefits to the skin. They are not filler ingredients. They are not unnecessary ingredients. These are ingredients that actually perform on the skin. There's peptides in here, niacinamide, ectoin, hyaluronic acid, ceramides, like the list goes on. There are so many great ingredients in here. A couple years ago when I first started using this, within the second to third day of using this, it completely wiped out the texture that I had on my chin."
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"This is the Derm Infusions Fill + Repair Serum. I've been using this on and off for a couple of years, and I will just use this sometimes with my moisturizer and sunscreen, and this performs so well, and it really is a serum that will target everything. It eliminates texture, giving the skin more of that softer, smoother feel. It brightens, softens fine lines. It helps to prevent, it hydrates, it repairs the skin. It brightens the skin. It does it all. If you really wanted to eliminate your vitamin C, your peptides, your hyaluronic acid serums, your retinol, your retinoid, you could, because the ingredient list here is quite extensive. There's four weights of hyaluronic acids. There are peptides, niacinamide, ectoin, there's squalane, colloidal oatmeal, ceramides, glycolic acid, mandelic acid, green tea, white tea, ashwagandha, and the list goes on. This really does work for texture and brightening and just giving that really nice youthful, healthy complexion. This does contain fragrance. It has a floral scent. It's very mild, but there is a fragrance. You are getting 30 mls of product. Two pumps is all I need. And it spreads really nicely. No peeling, no stickiness, no nothing. It sits great underneath sunscreen and makeup and it's wonderful."
8 HOLY GRAIL ANTI-AGING SKINCARE PRODUCTS I'D PAY DOUBLE FOR | THEY REALLY ARE THAT GOOD!
"This is a serum that truly targets all skin concerns. It firms, it brightens, it improves texture and tone. It honestly helps to hydrate, repair the skin, soften fine lines and wrinkles. It's a great preventative serum as well. And it just gives this smoother, softer look and feel to your skin. It really rejuvenates the skin. You can use this twice a day or you can just use this once a day. I sometimes use this in the morning in replacement of vitamin C. And at night time I will either use this on its own or I will pair this up with tretinoin or retinol for that matter. I never experience irritation when I do that. There are peptides, hyaluronic acid, niacinamide, there's white tea, centella asiatica, ceramides, and there are a few AHAs in here as well that really helps to get rid of that texture. Even if this doubled in price, I would still purchase it because this is a game changer for me personally. There is fragrance, a floral scent. It's very mild, but I just wanted to make sure that I mention that. This is honestly a lovely, lovely serum."
5 SKINCARE MUST-HAVES THAT ACTUALLY FIRM SKIN AND MINIMIZES SIGNS OF AGING
"I think this does a better job than using an exfoliating acid. When I use a lactic acid or something, sometimes it takes a while for me to see a difference in terms of texture, but with this one within 2 days that texture was completely wiped out. It does firm like a dream. It is expensive, but in my opinion it really is worth the money. I just really love this product and this is honestly one of the best from Dr. Dennis Gross hands down."
13 BEST ANTI-AGING SKINCARE PRODUCTS 2024 | AGING BACKWARDS OVER 30 - THESE ACTUALLY WORK!
"I've talked about this quite a bit in the past and it's still one of my absolute favorite serums. If you wanted to simplify your skincare routine right down, let's say you want to use less products but you want to have one product that basically targets everything, then I would say look into this. All you would need is a cleanser, this product, a moisturizer, and sunscreen. That's truly all you would need as this is going to target texture, tone, it will help to improve fine lines and wrinkles, it hydrates, it repairs your skin barrier, and it does give a brighter complexion as well. It does it all. This is a product that you can use every day twice a day or just once a day, it just depends on what you want to do. I have paired this up a handful of times with tretinoin, so I would use this first and then I would go in with tretinoin after that and then my moisturizer. And then sometimes if I want to take a break from vitamin C and peptides, I will use this in my morning skincare routine and this never ever disappoints."
TOP 5 LUXE ANTI-AGING SERUMS THAT ACTUALLY DELIVER AMAZING RESULTS - SINCERELY MISS ASH
"This has to be one of my favorite products from Dr. Dennis Gross and I just love this brand. The brand works really well on my combination skin. This especially is amazing. If you wanted to simplify your skincare routine completely and just have a cleanser, a serum, a moisturizer, and a sunscreen you could easily do that with this because this is going to target texture, discoloration, fine lines, and wrinkles. It's going to help hydrate the skin, calm the skin barrier. It does it all, it truly does it all. When I first started using this within 2 to 3 days this wiped out the texture that I had on my chin. This completely wiped it out and this gives that nice soft smooth feel and look to your skin. Your skin just looks so improved when you use this. With continuous use this is going to be exceptional. It's expensive, yes, but I promise you this works really well."
MY MORNING ANTI-AGING SKINCARE ROUTINE | A.M. SUMMER SKINCARE ROUTINE | OVER 30
"I've been loving the Dr. Dennis Gross DermInfusions Fill + Repair Serum. This has peptides but it also has niacinamide, there's some AHAs in here. This is perfect if you have texture. This really helps to give your skin more of that smoother, brighter canvas, and I really really love this. I've been using this product in my morning routine, but I don't pair it up with vitamin C. I just use one or the other."
6 ANTI-AGING SKINCARE PRODUCTS I'M LOVING FOR 2023 | THESE WORK AND I AM SO IMPRESSED!
"This really is one of the best anti-aging serums that I have used so far in 2023. This serum literally does it all, it helps to exfoliate, it helps to brighten the skin, it helps to give that smooth soft canvas. It really helps to treat fine lines and wrinkles, to firm the skin, to hydrate, but also to help repair the skin barrier at the same time. If you're someone that can't use a vitamin C serum or a retinol or tretinoin, then perhaps you may want to try this. This one has four different types of peptides and peptides are great to firm and to treat fine lines and wrinkles. There are four weights of hyaluronic acids to plump and hydrate the skin. There's niacinamide in here, so great for acne prone skin, great if you have dark spots, oily skin, or even if you have dry skin, niacinamide is a fabulous antioxidant. There's green tea in here which is another type of antioxidant. There is mandelic and glycolic acid in here, so this is going to smooth out any texture. It really helps to give that brighter look to the skin and it really helps to gently exfoliate at the same time, so if you have any texture at all this really helps to diminish it."
IF I COULD ONLY PICK 1 PRODUCT FROM MY FAVORITE SKINCARE BRANDS | FYI...THIS WAS REALLY HARD!
"I am absolutely obsessed with this, the Dr. Dennis Gross DermInfusions Fill + Repair Serum. This has four types of peptides but it has niacinamide as well, there are ceramides in here, there are AHAs, mandelic and glycolic acid, there's green tea, and the list goes on. There are so many amazing ingredients in here that will target a lot of skin concerns. This is great for anti-aging, great to repair and strengthen your skin barrier, it hydrates, it plumps, it exfoliates, it does it all. The first few days that I started using this serum I noticed that the texture on my skin was completely diminished, it was wiped out. This really does a good job to give your skin that smooth soft canvas, and so when you have skin that is soft without any texture, of course your makeup goes on better, your tinted sunscreens are going to look nicer on your skin, everything is going to be more improved, and your skincare products in general are going to absorb better into your skin as well. I absolutely love this, I'm obsessed, I've been using this a lot lately."
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"This is one of the best serums I've ever used. It is one that will target multiple skin concerns. And if you truly wanted to limit down in your skincare routine and get rid of some of your serums, this could replace them because of the amount of key ingredients in here. So there's hyaluronic acid, there's peptides to help firm and stimulate collagen, there's niacinamide, there's some AHAs in here, there's beta glucan, centella asiatica. Honestly, the list truly goes on. And this is going to help with texture, tone, fine lines and wrinkles. It's going to hydrate your skin. It's going to repair and keep your skin barrier nice and strong and healthy. It literally does it all. And I love it so much. And you can use this in your morning and evening. And sometimes I will use this prior to prescription tretinoin. I don't always, but sometimes I do. And this is wonderful. If you can't use vitamin C in your morning routine, use this instead because there's a lot of antioxidants in here that can help to protect our skin from everyday pollution. It really does it all. There is a little bit of a floral scent to this. So, if you can't do fragrance, just keep that in mind. But this is a great time to pick this up. It's not cheap, but it works really well."
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"This really has improved my skin, the texture and tone of my skin especially. I told you guys that I had texture on my chin when I first started using this and within a couple of days that texture was completely wiped out and it just keeps my skin super soft and it also has that brighter complexion as well. But with time and with continuous use this can really help with dark spots and fine lines as well. If you like Dr. Dennis Gross you're looking for a serum that does it all where you can eliminate some other products in your skincare routine then I would say go with this. I use this in my morning routine when I'm not using vitamin C or copper peptides and I will occasionally use this at night time especially when I'm not using tretinoin."
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"It hydrates. It repairs your skin barrier. And it's great for all skin types. It does have fragrance as well. It has a floral scent, just so you know. But it really does improve texture and it really makes your skin super soft, super smooth. It just gives this clarity to it as you get using it. And I just love the results that I see that I just always need to have this in my collection. I may not use this every time I finish up a new bottle. Like I might take a break from it and then maybe in a few months time I'll go back to it. Currently this is a part of my nighttime routine. It was for winter and spring. I am going to be switching things up a little bit now that I'm finished it, but I will consider using this again in the near future 100%."
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"This is really effective and it is worth the price tag. I know this is very expensive but the formulation is very impressive and there isn't anything like this on the market. I have not found a dupe to this yet. If you have a look at that ingredient list you're going to know what I mean. There are so many great ingredients in here to target fine lines and wrinkles, texture, tone, hydration, and to plump the skin while keeping everything nice and comfortable. This is a very gentle product in my opinion. There's baobab in here, caffeine, glutamine, there's panthenol, niacinamide, four types of hyaluronic acid, there's four types of peptides. It is exceptional. If you're someone that can't use vitamin C or a retinoid or tretinoin, some type of active because maybe your skin is just too sensitive, then I would say try this because you're getting a little bit of everything in here that is going to target multiple concerns. This could be your main treatment in both your morning and nighttime routine."
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"There is fragrance though, and I like the scent of it. It has a floral scent, and it's very mild, but just know that there is fragrance. But I really love this and the first thing that I noticed is softer, smoother skin. And then after that, my skin became brighter and then the clarity of my skin just looked more improved. So it can firm the skin as well. It plumps. It does it all. And this is exceptional. Generally, I will do two pumps of this. It spreads great. I've never experienced peeling with this. This doesn't leave your skin tacky or sticky, but you will have a little bit of a glow to your skin once it's all dried down. And this is one of the last serums that I use in my skincare routine because it does have a little bit of that milkiness to it. So, I might use a really nice hydrating serum beforehand and then this afterwards. And sometimes I will use retinoin on top of this. I will sometimes pair this up with peptides and other things. So depending on your skin sensitivity, you may or may not be able to use this with retinoin and other actives. But my skin loves this with retinoin. And the more consistent I am with this with retinoin, I see even a bigger difference with my skin in terms of brightness and clarity."
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"This is the Dr. Dennis Gross DermInfusions Fill + Repair Serum. You have heard me talk about this many times in the past. This is actually a serum that I am currently using in my nighttime skincare routine. This is a product that truly targets all skin concerns. If you're someone that is looking to minimize your skincare routines and you just want to use maybe a couple of products in your routine like a cleanser a serum a moisturizer and a sunscreen, then I would say pick up this serum because this is going to do it all. It's going to improve texture tone, it's going to soften fine lines. It's a great preventative serum. It's also very moisturizing and it helps to repair the skin as there are several ceramides in here. There are four types of peptides to help firm the skin. There are four types of hyaluronic acids to hydrate and plump the skin. There is superoxide dismutase which is an antioxidant. That ingredient is in here alongside other wonderful ingredients to improve texture and tone. Now the only thing with this is that there is fragrance and it's very mild."
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"This serum truly does it all. It helps with texture, tone, fine lines, and wrinkles. It's hydrating, it's repairing. So if you were looking for a good anti-aging serum that targets multiple skin concerns, then I would go and check out that product."
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"This product has been mentioned on my channel many times and I am obsessed with this. I use this a lot in my morning skincare routine so if I'm not using copper peptides or my vitamin C serum then I am using this. This is a serum that truly does it all. It helps to treat early signs of aging, it also helps to exfoliate to improve texture and tone. It really helps to hydrate and repair the skin at the same time. It really is one of a kind and the ingredient list is really impressive. There are four types of hyaluronic acids, so this is a plumping and hydrating serum which is why I like to use this in my morning routine. There are four types of peptides for signs of aging. There is glycolic and mandelic acid to help exfoliate and to really improve the texture and tone of the skin. There are several antioxidants in here as well and a lot of ingredients to moisturize the skin at the same time. A little bit goes a long way. I would say you would only need approximately two to three, possibly four pumps of this to apply all over your face and down your neck. I don't get irritation with this one, actually. I've never experienced pilling either."
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"The Dr. Dennis Gross DermInfusions Fill + Repair Serum is another one that I am obsessed with. I have talked about this a few times on my channel and I feel like I could go through a bottle of this every month, that's how much I love it, that's how much I use it when it's opened. I will use this in the morning if I'm not using vitamin C and sometimes I will even use this at night time when I am not using my retinol. This is exceptional for so many skin concerns. It really helps to get rid of texture, it really helps to give that smooth brighter look to your skin. There are AHAs in here and there's also peptides and it's just a wonderful formulation for signs of aging. When I first started using this within 3 days of use, the texture that I had on my skin, especially on my chin, was completely diminished."
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"The Dr. Dennis Gross DermInfusions Fill + Repair Serum, I am just absolutely obsessed with this. It has peptides and ceramides to strengthen and repair your skin barrier, and it has mandelic and glycolic acid in here to really help keep the skin nice and smooth. If you have any texture, this serum can really help to diminish your texture. The first few times that I used this, the texture on my chin was completely diminished, so this really performs well in terms of texture and just keeping everything so smooth and baby soft. But this also helps to brighten up your skin as well with niacinamide in here and other ingredients that are just so moisturizing on the skin. This is my go-to peptide right now. I use this in the morning and then the days that I don't use tretinoin, I use this at night time. Although I have a lot of favorites with peptides, I do like to alternate, but this is the one that I've been most consistent with just because I really love the results that I've seen. This does contain fragrance, so please keep that in mind if you are sensitive to fragrance. It has a floral scent."
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"I'm also going to pick up the Dr. Dennis Gross DermInfusions Fill + Repair Serum with hyaluronic acid. This is one of my go-to peptide serums, and there's a lot of other fabulous ingredients in here as well like niacinamide and there are some AHAs. This is one of those serums that will target multiple skin concerns like fine lines and wrinkles, dark spots, texture. It really helps to brighten up the skin. It really is a fabulous anti-aging product, and I love using this on a weekly basis, sometimes on an everyday basis as well. This one also has a fragrance to it. When I pair this up with the Dr. Dennis Gross Daily Moisturizer, this is exceptional to create that super soft feel to the skin. It just gets rid of any texture that is on my face."
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"I love the Dr. Dennis Gross DermInfusions Fill + Repair Serum. That serum launched a few months ago and I am in love with it. It has really improved my skin. Within three days of use I noticed a big difference with my skin. I had a little bit of texture on my chin that was completely wiped out. Since being consistent with it, the tone of my skin, the texture, it just looks so much more improved. It contains a lot of amazing anti-aging ingredients. It also hydrates, it exfoliates, and it's wonderful."
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"This is a serum that honestly targets multiple skin concerns so if you are looking to limit down on your skincare routine whether it's your morning or your nighttime or both and you're looking for a serum that targets many skin concerns like fine lines and wrinkles that uneven skin tone that dull complexion but also if you have texture then this serum will target all of those skin concerns. This is exceptionally great if you do have texture and I told you guys a little while ago within my first couple of uses of using this I did have some texture on my chin this wiped it out completely within a couple of days and that was really impressive. This gives my skin that super soft smooth look it gives my complexion that brighter look as well but with consistency this can help to soften fine lines and wrinkles to firm the skin and it really is exceptional. There is fragrance please keep that in mind there is a little bit of a floral scent to it it's very very mild but there is something there."
~Nay
"This has a little bit of a floral fragrance to it. If you can get something else, not because it's a bad product, it's a good product, but if you've got slightly mature skin, this is not the product that I recommend for you. If your skin is normal, normal to combination, or oily, this is not a product that I recommend for you. If you use it consistently and after two weeks of consistent use, the only difference I felt on my skin was the skin felt smooth and hydrated. Fine lines and wrinkles with this one, and that is because the ingredient story is just going to give you hydration with a little bit of peptides, but it doesn't work on your fine lines and wrinkles."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Ceramides

Ceramides are part of the skin's own barrier, and moisturisers built around them have evidence for holding water in and settling the tightness and flaking that come with a damaged barrier.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Frequently asked.

What is Dr. Dennis Gross DermInfusions Fill + Repair Serum?

A serum with peptides and exfoliating acids designed to target texture, fine lines, and hydration while supporting skin barrier repair.

Is Dr. Dennis Gross DermInfusions Fill + Repair Serum worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 68%.

What is Dr. Dennis Gross DermInfusions Fill + Repair Serum's Guru Score?

Dr. Dennis Gross DermInfusions Fill + Repair Serum holds a Guru Score of 68%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected.

Who is Dr. Dennis Gross DermInfusions Fill + Repair Serum best for?

Dr. Dennis Gross DermInfusions Fill + Repair Serum is generally suited to dry skin and mature skin.

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