Growth Factor Serum.

Serums

About this product

A growth factor serum designed to address fine lines, wrinkles, and loss of firmness through plant-derived actives and stem cell extracts.

Full ingredients

Aqua/Water/Eau, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Phospholipids, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Fragrance (Parfum), Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Vegetable Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol

Guru Score

87%

Yay

Early verdict · Few reviews so far

2Gurus

2Yay

0Mixed

0Nay

What they liked

Plumps fine lines and boosts firmness
Hydrating and supports skin barrier
Plant-based growth factor blend

What they flagged

Expensive
Contains silicone

What the gurus are saying

This serum earns consistent praise for plumping fine lines and wrinkles while firming skin and boosting hydration, with experts highlighting the bluebell stem cell extract and botanical actives like ginseng that support elasticity and barrier repair. The main trade-off is price, which experts describe as a genuine investment; one expert uses it nightly over retinoid with strong results but notes it is not a necessity for everyone. A small amount of silicone sits lower in the formula than the plant extracts, so it remains plant-forward overall.

Synthesized from 2 expert reviews · most recent take December 2025

Best for

Mature skin

Type

SerumsDrops & dropper

Key actives

Vitamin EPeptides

Formula notes

Contains fragranceNo drying alcohol

Where to buy

Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Darnell Cox | 50+ Healthy Aging Expert

55k subs

✓Yay

"I love this ZO Skin Health Growth Factor Serum. It's super expensive, super super expensive, but it's one that I really love. It tends to be the one that I use a lot."

Top Pick: eye cream

All 6 takes from Darnell Cox | 50+ Healthy Aging Expert

What's in my Travel Bag?

"This is by ZO Skin Health, it's a Growth Factor Serum. I've been having so much trouble with my eyes, but I love this. It has changed"

Over 30 and ready to master the ultimate skincare routine? 🎙️Join me for an IG Live Show where

"I love this ZO Skin Health Growth Factor Serum. It's super expensive, super super expensive, but it's one that I really love. It tends to be the one that I use a lot."

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"I use that product daily I love it, you guys. That's like Botox in a bottle, just saying. I love it. It's the ZO Skin Health Growth Factor Serum, and how I use that is I use it actually as a moisturizer over the top of my retinoid at night, so I'll put on a retinoid and then I'll put that over the top of it. Amazing. Expensive, you have to, but you guys have to make sure if you're investing in these kinds of treatments, which, you know, it's an investment, I would 100% make you guys go out and buy your sunscreen, buy your medical-grade creams, buy your stem cell serums, all that stuff you need to be helping on the outside."

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"I really like the ZO Skin Health Growth Factor Serum. It's super expensive so I don't necessarily recommend everybody needs to use that post microneedling."

Why is Skincare so Important for Healthy Aging?🤔 Find out on today’s IG LIVE SHOW! 🤩 Let’s start w

"The best overall eye cream in my opinion is the ZO Skin Health Growth Factor Eye and [...] it basically addresses everything so if you've got multiple concerns that's a good one but it's super expensive as well."

Over 30 and ready to master the ultimate skincare routine? 🎙️Join me for an IG Live Show where

"I want to splurge the ZO Skin Health Growth Factor Serum is quite amazing and a new one that I've been using that I really like."

Dr. Somji Skin

359k subs

✓Yay

"I love this product because I know that I'm going to send someone away and they're going to get the results. [...] It really helps to plump out fine lines wrinkles, firming, it's very anti-aging. It's fantastic for hydration and helps to restore the barrier function as well. [...] You've got these bluebell stem cell so it helps prevent future aging, you've got [...] polymorphia sinensis root extract which helps calm and soothe the skin as well as has ginseng extract which helps with elasticity and firmness. If you actually look at the ingredients, yes we've got some silicone in there which is a little bit disappointing, but those root extracts come up a lot more higher on the list so it's a very natural, plant-based growth factor stimulating serum."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Vitamin E

Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.

Source: NIH, National Library of Medicine

Frequently asked.

What is ZO Skin Health Growth Factor Serum?

A growth factor serum designed to address fine lines, wrinkles, and loss of firmness through plant-derived actives and stem cell extracts.

Is ZO Skin Health Growth Factor Serum worth it?

Yes. All 2 gurus who reviewed it give it their stamp of approval, for a Guru Score of 87%.

What is ZO Skin Health Growth Factor Serum's Guru Score?

ZO Skin Health Growth Factor Serum holds a Guru Score of 87%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.