Daily Power Defense.

About this product

A lightweight serum from ZO Skin Health formulated with peptides, antioxidants, and a small amount of retinol to support skin renewal and protection.

Full ingredients

Aqua/Water/Eau, Dicaprylyl Carbonate, Cetearyl Isononanoate, Glycerin, Pentylene Glycol, Cetearyl Alcohol, Steareth-20, Safflower Oil/Palm Oil Aminopropanediol Esters, Laminaria Digitata Extract, Opuntia Ficus-Indica Stem Extract, Arabidopsis Thaliana Extract, Marrubium Vulgare Meristem Cell Culture, Leontopodium Alpinum Meristem Cell Culture, Retinyl Palmitate, Tocopheryl Acetate, Tocopherol, Micrococcus Lysate, Caprylyl Glycol, Hexylene Glycol, Lactose, Galactoarabinan, Lecithin, Schizophyllan, Beta-Glucan, 1,2-Hexanediol, Carbomer, Cellulose, Maltodextrin, C14-22 Alcohols, Cetearyl Glucoside, C12-20 Alkyl Glucoside, Hydroxypropyl Methylcellulose, Disodium EDTA, Sodium Hydroxide, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Fragrance/Parfum, Ultramarines (Ci77007), Limonene

Guru Score

85%

Yay

Early verdict · Few reviews so far

2Gurus

2Yay

0Mixed

0Nay

What they liked

Stable formula patients use long-term
Works morning and night

What they flagged

Retinol and copper peptides together may over-exfoliate

What the gurus are saying

This serum earns strong praise for its stable formulation and peptide-rich blend, with dermatologists noting many patients use it long-term without trouble and respect it as one of ZO's bestsellers. The one thing to watch: it contains both retinol and copper peptides, which both speed cell turnover, so those already using other exfoliating actives may want to ease off to a few times a week to avoid dryness or barrier damage. Applied before sunscreen as an antioxidant step, it works well for most skin types.

Synthesized from 2 expert reviews · most recent take February 2026

Best for

Mature skin

Type

Drops & dropper

Key actives

RetinoidVitamin E

Formula notes

Contains fragranceNo drying alcohol

Where to buy

Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Darnell Cox | 50+ Healthy Aging Expert

55k subs

✓Yay

"This is the Daily Power Defense. So again you're treating your skin in an antioxidant type of way prior to sunscreen. If you want a luxury brand, ZO Skin Health, I love them honestly. It's the best skincare on the market today."

Top Pick: skincare

All 4 takes from Darnell Cox | 50+ Healthy Aging Expert

What's in my Travel Bag?

"So this is the ZO Skin Health Daily Power Defense. That's what I used this morning, followed by the same eye cream and then sunscreen."

What are my TOP 10 Healthy Aging Hacks?🤔 (PART 1) 🎙️Tune into my IG LIVE SHOW as I dive DEEP into

"This is by ZO Skin Health, I love it, it's daily Power Defense. So for those of you who've got money to burn but you also want effective skin care, this is [...] a great, great product. [...] It's not a vitamin C but it kind of works the same."

Curious about peptides? 👀✨ Are they actually worth it… or just another skincare trend? 🎙️ Watch

"This is by Zo Skin Health. It is Daily Power Defense and it already has a ton of peptides in it. It has the Matrixyl 3000. It's got [...] DNA repair. There's a lot of stuff going on with it. [...] This has a tiny bit of retinol in it. [...] So you have to be very careful when you're adding two things that exfoliate, right? The copper peptide is cell turnover and anything that has even a touch of retinoid is cell turnover. You want to make sure you're not doing too much of that, because it could make your skin dry and flaky and irritated and could damage the skin care barrier a little bit."

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Dr. Somji Skin

359k subs

✓Yay

"Really nice formulation and not too much going wrong with it, and that's the reason why I see a lot of patients using that long-term without any problems. It's one of the biggest sellers. You can use it morning and night. It's a nice stable serum, probably your favorite all around serum in the range. I really like this product."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Retinoids

Retinoids are among the best studied ingredients in dermatology, with solid evidence for acne and for the fine lines and rough texture that come from sun exposure. Dryness and flaking in the first few weeks are common and usually settle.

Source: DermNet

Vitamin E

Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.

Source: NIH, National Library of Medicine

Frequently asked.

What is ZO Skin Health Daily Power Defense?

A lightweight serum from ZO Skin Health formulated with peptides, antioxidants, and a small amount of retinol to support skin renewal and protection.

Is ZO Skin Health Daily Power Defense worth it?

Yes. All 2 gurus who reviewed it give it their stamp of approval, for a Guru Score of 85%.

What is ZO Skin Health Daily Power Defense's Guru Score?

ZO Skin Health Daily Power Defense holds a Guru Score of 85%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.