SkinMedica

TNS Essential Serum.

Serums

About this product

A lightweight serum with growth factors and peptides designed to support skin firmness, brightness, and texture over time.

Best for

Mature skin

Type

SerumsDrops & dropper

Key actives

Vitamin C Hyaluronic acidVitamin EPeptides

Formula notes

Fragrance-freeNo drying alcohol

Full ingredients

Human Fibroblast Conditioned Media, Water/Aqua/Eau, Cetyl Ethylhexanoate, Olea Europaea (Olive) Fruit Unsaponifiables, Alpha-Arbutin, Isoceteth-20, Arachidyl Alcohol, Glycerin, Ethoxydiglycol, Butyrospermum Parkii (Shea) Butter, Palmitoyl Tripeptide-5, Ergothioneine, Dipalmitoyl Hydroxyproline, Hydrolyzed Sericin, Phospholipids, Ubiquinone, Rubus Fruticosus (Blackberry) Leaf Extract, Saccharomyces Ferment Lysate Filtrate, Tetrahexyldecyl Ascorbate, Aminobutyric Acid, Phytosterols, Tocopherol, Tocotrienols, Squalene, Oryza Sativa (Rice) Bran Wax (Oryza Sativa Cera), Sodium Hyaluronate, Tocopheryl Acetate, Camellia Oleifera Leaf Extract, Dimethicone, Ethylhexyl Palmitate, Silica Dimethyl Silylate, Polyacrylate-13, Polyisobutene, Polysorbate 20, Behenyl Alcohol, Arachidyl Glucoside, Cetearyl Alcohol, Steareth-10, Steareth-20, Butylene Glycol, Maltodextrin

Guru Score

63%

Mixed

Early verdict · Few reviews so far

2Gurus

1Approved

0Mixed

1Skip

What the gurus are saying

The smell is divisive and the packaging wastes product at this price point, which gurus found frustrating on a $300 serum. Those who stuck with it past the first few weeks noticed it helps with fine lines, brightness, texture, and redness, though results take a couple of weeks to show and work best when used sparingly in targeted areas like the forehead and around the eyes. One tester saw no visible change after two months, so outcomes vary widely.

Synthesized from 2 expert reviews · most recent take September 2025

Where to buy

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How it works Independent by design. Every take comes from a creator we have no relationship with. We do not ask anyone to review, and affiliate links never move a score.

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved takes Critical takes Mixed takes Hide sponsored

HotandFlashy

1.23M subs

~Skip

"I did try SkinMedica TNS years ago in 2017. I did a two-month trial on it and I used it once a day for 2 months. I took before and after pictures and there was no difference in my skin from the before to the after after 2 months. I wasn't willing to plunk down another $295 for another bottle of it. Plus, can I tell you the stuff stinks? It smells like death and putting that on my face every day I was like no thank you. Plus it didn't do anything for the price that they're asking for."

No BS Beauty

89k subs

~Approved

"I really enjoy that stuff. I've probably repurchased it, probably bought it four times. This is one of the closest similar products I've found. It takes a little bit more time to notice the benefits like with SkinMedica TNS within a week, but this takes a little bit longer, a couple weeks, but with the money saved and the extra product in here it's well worth it. With a little time you notice it helps with fine lines, brightness, texture, puffiness, redness. It's friendly with other products, which is why with retinols and things like that and vitamin C I love using it. I'm very impressed with this stuff, especially given what they've been able to do with the price and the other good ingredients."

All 3 takes from No BS Beauty

Evening Skincare Routine - Dermaplaning, Layering Actives & Anti-Aging Products

"I love it. It's really wonderful. I try and use this early in my routine, so it gets the most benefits. But the packaging on a $300 product is terrible. I can't believe they haven't fixed this yet. I try and use it as sparingly as I possibly can because I don't want to spend more money on it. So, I really just try and use a very small amount on the specific areas that need the most help, which is my forehead, around my eyes, and around my mouth."

Black Friday Skincare and Beauty Deals to Check Out!

"I purchased SkinMedica's TNS Essential Serum probably about a year ago or so. The one I got from them was legit."

TNS Dupe?!?! RevivSerums Ultimate Serum Review, Comparison to SkinMedica TNS

Common questions

Frequently asked.

What is SkinMedica TNS Essential Serum?

A lightweight serum with growth factors and peptides designed to support skin firmness, brightness, and texture over time.

Is SkinMedica TNS Essential Serum worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 63%.

What is SkinMedica TNS Essential Serum's Guru Score?

SkinMedica TNS Essential Serum holds a Guru Score of 63%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 independent expert reviewers we have collected.