An anti-aging serum with growth factors, peptides, and botanicals in a dual-chamber pump system designed to reduce fine lines and support skin renewal.
Best for
Mature skin
Serums
The Guru Index verdict
84%
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✓Approved · 84%
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What the gurus are saying
Gurus consistently report visible results within days to a week of use, particularly for fine lines and skin smoothness, and most have repurchased it multiple times. The sticking point is the $295-300 price tag, which reviewers acknowledge as steep but often justify through potency and conservative usage stretching bottles three to four months. A recurring complaint is the dual-chamber pump system that doesn't always dispense evenly, though users note a paper clip fix works. The serum is praised as fragrance-free and acne-friendly, though a few reviewers wish for higher peptide concentrations at the price.
"SkinMedica TNS Advanced Plus Serum is the OG growth factor serum with the longest track record, having been around since the late 90s with meaningful clinical data. It's recommended post-procedure for laser, peel, or microneedling treatments."
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"Growth factors help support skin repair, regeneration, and overall skin resilience. Now, they don't replace retinoids, but they do work alongside them to improve skin quality, especially as skin ages. Some options I trust clinically include the SkinMedica TNS Advanced+ Serum as well as the Neoccutis Bio Serum Firm. These are definitely more on the high end."
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"Some of my favorite growth factors are the skin Meda TNS Advanced Plus serum"
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"My favorite supportive products for the jawline and neck include Skin Medica, the TNS Advanced Plus Serum"
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"SkinMedica TNS Advanced Plus Serum is the OG growth factor serum with the longest track record, having been around since the late 90s with meaningful clinical data. It's recommended post-procedure for laser, peel, or microneedling treatments."
"This is one of few products that really has helped me with my skin hugely. Between this, vitamin C, and a good sunscreen, it's really helped my skin a ton. Fine lines are less noticeable, skin just looks smoother. I'm impressed with this stuff."
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"If you're going to spend that much money, I would recommend the SkinMedica TNS Advanced+ Serum. That one offers more benefits and better ingredients. It doesn't have the fragrant essential oil in there either. The nice thing is it's friendly for acne-prone skin. I love the texture of it, feels nice, but at this price I expect a little more, maybe a little more peptides or maybe some growth factors or something. It's not bad, it's just I won't repurchase it."
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"If you can afford this and this price isn't a big deal, spend instead on the SkinMedica TNS Advanced+ Serum because in my opinion that one offers more benefits and better ingredients. It doesn't have the fragrant essential oil in there either. The one nice thing is it's friendly for acne prone skin."
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"I really love the SkinMedica TNS serum but I really got tired of paying $300 and then feeling guilty when I used it or guilty when I bought it because that's a ridiculous amount of money. I didn't at first love this ingredient, growth factors, epidermal growth factors, because there's not like 20, 30 years of studies on the safety of it. I'm pretty sure they're safe for most people but do your own research on it, don't listen to me, don't listen to anybody else, do your own digging on it because it depends on your skin type and things like that."
"The SkinMedica TNS Advanced+ Serum is an amazing product. If you use it for a week, it's hard not to notice the results. I've tested a lot of products that have similar ingredients, but this one really stands out. The packaging is quite nice, the size is large at 1.69 ounces, and the texture is quite nice with a gel texture to it. I've been pretty impressed with it."
"It's got a creamy texture with all those nice growth factors and anti-aging ingredients in here, which there's only a handful of products that really make a difference that I could tell using them, and SkinMedica was one of them."
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"They're repackaging the TNS Advanced+ Serum. I initially thought they were going to get rid of the dual chamber system. It appears as though they're not going to get rid of the dual chamber system, but they are going to upgrade it so it's more functional. This is a big bulky container and I hate the fake metal because that starts to chip off. The dual chambers can be really annoying. I've read though if you store it upside down that helps it dispense better. There's little holes, and if you have an issue, you can use a paper clip and jam it in there."
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"SkinMedica TNS Advanced Serum, absolutely love this stuff. Once I add this into my routine it's one of the few handful of products that I could tell a difference in my skin within a week or less. This one uses their human fibroblast conditioned media they have a trademark on it, it also contains peptides and botanicals, great for anti-aging skin renewal. Certainly made a huge difference in my fine lines, noticeable difference. But it's $295 which is really expensive, so it's worth buying it on sale. If you subscribe to it you can get an extra discount, and you can cancel if you change your mind."
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"SkinMedica TNS Advanced Serum. The pumps are annoying because they don't dispense at the same time. So like the first five uses of it, you're just using one of the two serums and it's really annoying. It's wonderful."
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"This one turned 95 bucks if price were no issue I'd have this one on hand all the time. The SkinMedica TNS Advanced+ Serum is wonderful. It's one of a handful of products where I've used it and almost the next day I could tell my skin look better and smoother and things like that. This is definitely probably the number one pick I really enjoy it. It's fragrance free. The dual pump is kind of annoying sometimes, not quite even, but they've got two holes here so if one of them gets off track you just stick like a paper clip in there and you can even it out. This has to be my number one pick. It's really nice."
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"This stuff is wonderful. It contains their personally made human fibroblast conditioned media, it also contains the praline peptide and whey protein. The pump is a little annoying because you can see how it has two little holes there, one part has half of the ingredients in and the other one has the other half of the ingredients, so you really want both of them to dispense at the same time to get your bang for your buck. It is a game-changing product."
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"The SkinMedica TNS serum is amazing and it's super expensive. I still love it. There's a lot of good dupes for it but still really wonderful, but it's so expensive. If I could take one expensive product that would probably be it."
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"Lotion serum texture, fragrance free, works great daytime or nighttime. Human fibroblast conditioned media is the third ingredient, and then we've also got peptides, aloe, vitamin E, and a ferment grape flour extract. I love this product. I've repurchased it many times. It happens to be easily the most expensive one out of all of them. But I don't typically use it all over my entire face. I typically focus on certain areas where I get fine lines, around my mouth and around my eyes, a little bit on the forehead and right in the middle between my eyebrows. A bottle of this will last me three or four months with very conservative usage of it. So it doesn't seem as expensive."
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"The SkinMedica TNS serum is really good. It's got the human fibroblast condition media. It's more expensive, about three times the price of some alternatives, and it's almost half the size, but it's really good. I've repurchased it a couple times at least, and I most products I don't repurchase unless I really really like them and I'm committed to continuing to use them."
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"It's expensive but this one uses their brand's proprietary human fibroblast conditioned media, which is why it is so expensive. This is one in a handful of products where two, three days in, I did notice a difference for me, especially around my eyes."
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"I've been obsessed with the SkinMedica TNS serum which is upwards of $300 a bottle. I've loved the SkinMedica TNS serum, it's upwards of $300. I've repurchased a couple times, but I got really good deals. When I use that within a couple days it's like an amazing difference on my skin. I'm always on the hunt for the next best thing because of that same feeling."
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"I just purchased the TNS Advanced+ Serum and I've been using it twice a day for one week and I'm already shocked at the results. It's one of the few products I say has instant results, amazing like you could tell the difference. Not every product has that experience but some people do. It's ridiculously expensive, but I'd get it on sale or sign up for some of the cash back websites because sometimes you'll have like 20% off and then sometimes it'll be like a 10% cash back so it ends up being even more savings."
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"It's got the SkinMedica patented human growth factor complex, it's also got prolene peptide as well as a milk peptide complex for anti-aging and collagen production in skin. It also has apple extract and vitamin E for hydrating skin. It's really lovely. It's really expensive, but you can make this one last a long time. I probably been working on this specific bottle for four months with probably another month in it, so just using it sparingly where my wrinkles are. I don't use it everywhere, I just focus on the areas where there's wrinkles."
"It's got the SkinMedica patented human growth factor complex, it's also got prolene peptide as well as a milk peptide complex for anti-aging and collagen production in skin. It also has apple extract and vitamin E for hydrating skin. It's really lovely. It's really expensive, if it's too expensive I totally get it, but you can make this one last a long time. I make this bottle last a long time too. I probably been working on this specific bottle for four months, it's probably got another month in it, so just using it sparingly where my wrinkles are. I don't use it everywhere, I just focus on the areas where there's wrinkles."
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"Within two or three days of using the SkinMedica TNS serum, the difference I noticed in my skin was hard to deny that it was beneficial. Growth factors have undeniable results for me when using a growth factor serum."
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"This stuff is a handful of products that I start using and within days my skin just looks and feels so much better. I love it."
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"It's really nice lightweight serum. This is one of a few holy grail products for me. Within a few days my skin really started to look better to me. The human fibroblast condition media stimulates elastin and collagen production deep down in skin which helps with fine lines, wrinkles, and saginess. Enhances wound healing especially after treatments like micro needling or lasers. Reduces redness and dryness as well as transepidermal water loss. Helps with rejuvenation, tone, and texture and helps reduce any inflammation. It's really nice."
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"I'm addicted to it. I love it. It's so expensive, but I do feel like I can tell a difference in my skin when I stop using it. And when I first started using it, I could tell the difference."
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"The SkinMedica TNS Advanced+ Serum, this one's upwards of almost 300 bucks if you can get it on sale it might be worth it. Occasionally there's a good sale typically around the holidays and I'll be able to get it for like 100 to 150 bucks, but that's typically not often. Although right now it's on sale at Derm Store, I think it's like 70 bucks off, so if you're looking at it it might be a decent time to buy it, but still pricey."
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"The SkinMedica TNS Advanced Serum is $295. It's one of the few products where I can notice results quite quickly. If I stop using it for a while and I start using it again, I'll notice the results again really nicely. It has great growth factors in it, really nice in terms of antioxidant protection for fine lines and wrinkles."
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"It has a very nice moisture texture to it. If you use it at night time, it's really nice. If you've got dry skin or during the winter if your skin gets really dry, you can also use it in the daytime as well. It is on the thicker side. This one's pretty affordable, too. It's got a really nice gel texture. It smooths in really easily."
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"I love the SkinMedica TNS Advanced+ Serum. This is a tough one. It's very expensive. It's likely to get more expensive. But I love this stuff. This is something that I don't want to have to compromise on. I don't see myself taking these out for my routine anytime soon because it's really a work horse. It really helps with fine lines and wrinkles, and I can notice it when I stop using it for a week or two, to when I start using again. I can notice a difference. So, it's amazing. There's not a lot of skincare products that are like within a couple days you notice a difference. It's amazing the difference it makes."
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"I was at a standstill, things weren't necessarily getting better, and I added in the SkinMedica TNS Advanced serum and within a couple weeks it made an absolutely amazing difference that I could notice. Even my dad noticed, which was amazing because he doesn't notice much. I added it in without really having to sacrifice anything, change anything else, or have to deal with irritation. The SkinMedica one is very expensive, it's about $300, but it is an absolutely amazing ingredient that when you add it to your routine, I think if you have some signs of aging you will notice a radical difference very quickly."
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"They use human fibroblast conditioned media and this is one of a handful of products where I used it and within a few days I noticed my skin look better. There's not a lot of products that I can say that about. Most products, especially like actives and things like that, take months or weeks or a long time before you start to notice the benefits, but with this one product I could tell within I think two or three days that my skin just looked better, it felt better, the fine lines were less noticeable. It's expensive, but it's amazing. It comes out of two nozzles which can be kind of frustrating, but if you have a problem with it coming out of two nozzles, if you stick paper clips in these two holes you push it down and it'll dispense better. Really nice, no scent in it, really nice serum."
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"I love this stuff. It's expensive, but if you're going to be into this one you've got to learn to watch for sales because when you can get on sale it saves a lot of money really fast. The thing is that around the metal of this it starts to flake off and starts to get on your face, which is not a good look, but I need to repurchase it."
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"I love peptides. I love growth factors. They're great for helping deep down in your skin, renew it, soothe it, help with collagen production. The SkinMedica TNS Advanced Serum is one of my favorites. This stuff's really nice."
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"The SkinMedica TNS Advanced+ Serum, I just love this stuff. It sucks because it's so expensive, but it really is a game changer. This contains their proprietary formula of human fibroblast conditioned media cells which helps with collagen production and increase in plumpness in skin, and it is noticeable within a few nights to a week or two. It's amazing. I hate that it's amazing because it's so expensive, but most products that are really expensive typically aren't worth the money, but that is one of a handful of them."
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"The SkinMedica TNS Advanced+ Serum is one of the two products I've noticed work the fastest with the fastest results. Almost nothing can deliver that fast, but even this product is a couple weeks or a week or two before I noticed a difference. It's got no denaturating drying types of alcohol, which is nice for sensitive skin. There's no fragrance ingredients and no noticeable scent, which is also very nice for sensitive skin. The manufacturing location is the US. It has a lotiony texture."
"It has hyaluronic acid and hydrayed lime seed extract which stimulates epidermal thickening. So the combination of these two chambers in this one product is really like two products in one. Although it retails for $295, you might almost want to think of it as two separate products for $150 each. It doesn't make it cheaper, but this is one that patients come into my practice requesting and that is why I have it because the reviews from the patients have been stellar and people love this."
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"It has hyaluronic acid and hydrayed lime seed extract which stimulates epidermal thickening. So the combination of these two chambers in this one product is really like two products in one. Although it retails for $295, you might almost want to think of it as two separate products for $150 each. It doesn't make it cheaper, but this is one that patients come into my practice requesting and that is why I have it because the reviews from the patients have been stellar and people love this."
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"SkinMedica TNS serum has growth factors, cytokines, and Matrix proteins that people swear by. This is a particular product I recommend for patients who cannot tolerate retinols on their neck even though they try to buff it with a moisturizer. I tell them just go for this for your neck or those hard to reach areas. It's a great adjunct to have."
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"My number one product for epidermal growth factors is going to be the TNS Advanced+ Serum by SkinMedica. This is tried and true and yes it is expensive, but this has EGF, TGF beta, and FGF, okay? And they're all human derived. It means human skin was put in a culture medium and that culture medium was then taken, filtered, sterilized and stabilized and you're getting that and that's what you're applying on the surface of your skin. This works best for deep wrinkles, elasticity. I love it post-procedurally after micro needling, any type of radio frequency with micro needling, any type of frail. It really does help to renew your skin and works best for deep aging concerns and it comes at a pricey heft of nearly $295. But this is something that I don't necessarily use every single night because of the price."
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"This is a tried and true and yes it is expensive but this has EGF, TGF beta and FGF, okay? And they're all human derived. It doesn't mean they're coming from human skins. It means human skins was put in a culture medium and that culture medium was then taken, filtered, sterilized and stabilized and you're getting that and that's what you're applying on the surface of your skin. This works best for deep wrinkles elasticity. I love it post-procedurally after micro needling, any type of radio frequency with micro needling, any type of frail. It really does help to renew your skin and works best for deep aging concerns and it comes at a pricey heft of nearly $295. But this is something that I don't necessarily use every single night because of the price. I can tolerate retinol. So I'll use a retinol on my face. But I may use this on my neck and chest if I do not tolerate the retinols, especially after I exfoliate. I love her. She's great."
"The Skin Medica TNS Advanced Plus Serum is one of the human derived ones and it's clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. It has a dual growth factor system which can stimulate collagen and elastin production. It's super lightweight, fast absorbing formula designed for really that mature aging skin. The key ingredients here are the TNSMR which is the blend of growth factors and peptides, and Renaissance complex which contains the botanicals and marine extracts."
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"The Skin Medica TNS Advanced Plus Serum is one of the human derived ones and it's clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. It has a dual growth factor system which can stimulate collagen and elastin production. It's super lightweight, fast absorbing formula designed for really that mature aging skin. The key ingredients here are the TNSMR which is the blend of growth factors and peptides, and Renaissance complex which contains the botanicals and marine extracts."
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"SkinMedica TNS Advanced+ Serum is clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. The dual growth factor system stimulates the collagen and elastin production. It's really lightweight, super fast absorbing formula designed for that really mature aging skin. The key ingredient here is the TNSMR, the blend of growth factors and peptides. It also has the Renaissance complex which is the botanicals and marine extracts."
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"Another one that's really popular is the Skin Medica TNS Advanced Plus Serum. This is human derived, the clinical standard, but it's significant splurge."
"It's from SkinMedica. Their TNS Advanced+ Serum certainly is not cheap. It retails for $295, but the formulation as well as just the level of evidence and clinical studies, really no other product can beat that. This supports skin rejuvenation with a dual chamber system that's really unique where it combines growth factors along with peptides and antioxidants, helps to visibly reduce and smooth appearance of fine lines and wrinkles and even helps with skin sagging and also a little bit of skin tone and hyperpigmentation. You can start to see visible results in just two weeks, up to 24 weeks of use is when they stopped the studies, looking at the data. So it's definitely something that you can use immediately post procedure as well as continue to use even after procedure for continuing those benefits. The chamber system is really interesting. You have chamber one, the TNS MR, which is the advanced formula with basically next generation of growth factors that really supports healthy skin function and innovative peptide complex that helps to nourish your skin. And then chamber two is what they call the RSC system, which is basically actives of botanical extracts and marine extracts."
"The SkinMedica TNS Advanced+ Serum is a combination growth factor peptide serum that is a Holy Grail for so many people who take their anti-aging game very seriously. You would apply it to your bare clean skin ideally twice a day, and it's been shown to help with fine lines and wrinkles, but it's also been shown to help with sagging. Sometimes people are just starting to notice their skin is getting a little bit saggy, a little less firm, and tons of people swear by this in terms of seeing really truly visible results when it comes to tightening things up. There's not a lot of stuff in skincare that can really do that. This is another one of those products that has clinical testing behind it, so it's not just like cross your fingers and hope. They did a really nice 24-week study, so that is longer than a lot of skin studies most end at like 12 weeks. It showed progressive improvement of the skin starting at 2 weeks and getting better all the way through 24 weeks. I have a handful of patients within my cosmetic practice that I would consider super agers, these are women in their 60s and 70s who just look incredible, and I think every single one of them uses this product."
"The TNS Advanced Plus Serum is a stem cell serum with growth factors that help to brighten skin, tighten, help with elasticity, and promote collagen."
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