A dual-chamber serum combining human-derived growth factors, peptides, and botanical extracts designed to reduce wrinkles, improve skin texture, and support skin firmness and elasticity.
Human-derived growth factors paired with peptides visibly reduce fine lines and wrinkles within two weeks, with clinical studies tracking improvements over 24 weeks; gurus note it also helps with skin sagging and firmness, especially on the neck and jawline, though results build gradually and require consistent use. The price sits around $295, and one reviewer flagged ethical considerations around human-derived growth factors worth researching yourself. Applied twice daily to clean skin, it layers safely with other actives and works well for reactive skin types.
Synthesized from 10 expert reviews · most recent take July 2026
"I love this stuff. It's got their human fibroblast conditioned media, which they have a proprietary interest in and have been using in this serum for a very long time. It is amazing, for me it's worth it. I use it very sparingly, just around my eyes and around my mouth, so I can make a bottle last three or four months. At Dermstore sometimes there are good sales, so it might be worth checking out. Love it, good product."
"This is one of few products that really has helped me with my skin hugely. Between this, vitamin C, and a good sunscreen, it's really helped my skin a ton. Fine lines are less noticeable, skin just looks smoother. I'm impressed with this stuff."
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"If you're going to spend that much money, I would recommend the SkinMedica TNS Advanced+ Serum. That one offers more benefits and better ingredients. It doesn't have the fragrant essential oil in there either. The nice thing is it's friendly for acne-prone skin. I love the texture of it, feels nice, but at this price I expect a little more, maybe a little more peptides or maybe some growth factors or something. It's not bad, it's just I won't repurchase it."
"This expensive one, the SkinMedica TNS Advanced+ Serum -- so expensive. I did a lot of research because I kept thinking I need to buy a backup because this one's getting low; I've been using it a lot lately. I looked at like a million websites -- Dermstore, Derm Avenue, Editor's Pick, Lovely Skin, RX -- and I haven't decided yet. But I mentally can't pay over $200 for it at this point. It's about $300, but mentally I just can't allow myself to pay more than $200 because usually I get a coupon code, and then certain stores, if you subscribe to auto-replenishment like every four months, you get a discount. But Dermstore couldn't tell me what the price would be on the refill -- I see two prices for auto-refill: one says $236 and lower down there's another that says $183. I could spend $183; $236 I'm not going to do."
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"I really love the SkinMedica TNS serum but I really got tired of paying $300 and then feeling guilty when I used it or guilty when I bought it because that's a ridiculous amount of money. I didn't at first love this ingredient, growth factors, epidermal growth factors, because there's not like 20, 30 years of studies on the safety of it. I'm pretty sure they're safe for most people but do your own research on it, don't listen to me, don't listen to anybody else, do your own digging on it because it depends on your skin type and things like that."
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"The winner for favorite luxe skincare product of the year is -- you guys guessed it, I know you did because you watch a lot of my videos -- it's the SkinMedica TNS Advanced+ Serum, which is coming out with new packaging this year. Hopefully they don't raise the price. Fingers crossed, because I can't afford much more."
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"SkinMedica TNS Advanced+ Serum is one of the most clinically supported growth factor serums on the market. It's $295, though it does go on sale. It's one of the few products that really helped with a dull appearance and the appearance of fine lines and wrinkles within about a week, even a couple of days. This is one of a handful of products that have been total game changers for me. Their human fibroblast conditioned media is the real deal. It's fragrance free, lightweight, gel texture, and allows layering. The packaging is the major bummer. The product itself is great but the packaging sucks; they could use a revamp. The fake foil gets on you, it's a dual chamber, it's kind of a pain, and one chamber consistently pumps out a lot more than the other. If you get that issue, there are holes you can stick paper clips into, but for a $295 serum the packaging leaves a lot to be desired. Otherwise it's a really nice, silky texture, you can use it underneath sunscreen in the daytime, and it works well for all skin types, dry or oily."
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"This is an expensive one. If you can get on sale it's a deal, but I will never pay the market price for this. I will only buy it if it's a really good sale, lots of cash back, and a good gift with purchase because otherwise it's just so expensive. Revive serum has something that's very similar and it's one-third of the price."
"The SkinMedica TNS Advanced+ Serum is an amazing product. If you use it for a week, it's hard not to notice the results. I've tested a lot of products that have similar ingredients, but this one really stands out. The packaging is quite nice, the size is large at 1.69 ounces, and the texture is quite nice with a gel texture to it. I've been pretty impressed with it."
"It's got a creamy texture with all those nice growth factors and anti-aging ingredients in here, which there's only a handful of products that really make a difference that I could tell using them, and SkinMedica was one of them."
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"They're repackaging the TNS Advanced+ Serum. I initially thought they were going to get rid of the dual chamber system. It appears as though they're not going to get rid of the dual chamber system, but they are going to upgrade it so it's more functional. This is a big bulky container and I hate the fake metal because that starts to chip off. The dual chambers can be really annoying. I've read though if you store it upside down that helps it dispense better. There's little holes, and if you have an issue, you can use a paper clip and jam it in there."
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"SkinMedica TNS Advanced Serum, absolutely love this stuff. Once I add this into my routine it's one of the few handful of products that I could tell a difference in my skin within a week or less. This one uses their human fibroblast conditioned media they have a trademark on it, it also contains peptides and botanicals, great for anti-aging skin renewal. Certainly made a huge difference in my fine lines, noticeable difference. But it's $295 which is really expensive, so it's worth buying it on sale. If you subscribe to it you can get an extra discount, and you can cancel if you change your mind."
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"I love this. It's great for dry skin. I use it a lot at night, on my neck, and even on post-procedure skin because it has all the nice rejuvenating ingredients as well as the anti-aging ingredients. You can get some of that human fibroblast conditioned media at a more affordable price point with this one. The packaging changed and I'm not sure how I feel about it, though I didn't love the old packaging either. This one helps fight wrinkles, especially around the eye area. On the third or fourth day the very first time I used the SkinMedica TNS Advanced+ Serum, I looked at my eye area and it just looked so much better. It was really a game-changing product for me. I had never tried a product before that, within three or four days, just looked so much better, more youthful. It also helps firm and brighten skin. The star of the show is their human fibroblast conditioned media, which helps with fine lines, wrinkles, skin tone, and texture."
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"There's certain products that I will say I have used within a couple days I noticed positive results. It's probably three products. Uh Geek and Gorgeous Apad, Geek and Gorgeous Seaglow, and the SkinMedica TNS serum. That's it."
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"SkinMedica TNS Advanced Serum. The pumps are annoying because they don't dispense at the same time. So like the first five uses of it, you're just using one of the two serums and it's really annoying. It's wonderful."
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"This one turned 95 bucks if price were no issue I'd have this one on hand all the time. The SkinMedica TNS Advanced+ Serum is wonderful. It's one of a handful of products where I've used it and almost the next day I could tell my skin look better and smoother and things like that. This is definitely probably the number one pick I really enjoy it. It's fragrance free. The dual pump is kind of annoying sometimes, not quite even, but they've got two holes here so if one of them gets off track you just stick like a paper clip in there and you can even it out. This has to be my number one pick. It's really nice."
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"This stuff is wonderful. It contains their personally made human fibroblast conditioned media, it also contains the praline peptide and whey protein. The pump is a little annoying because you can see how it has two little holes there, one part has half of the ingredients in and the other one has the other half of the ingredients, so you really want both of them to dispense at the same time to get your bang for your buck. It is a game-changing product."
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"The SkinMedica TNS serum is amazing and it's super expensive. I still love it. There's a lot of good dupes for it but still really wonderful, but it's so expensive. If I could take one expensive product that would probably be it."
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"Lotion serum texture, fragrance free, works great daytime or nighttime. Human fibroblast conditioned media is the third ingredient, and then we've also got peptides, aloe, vitamin E, and a ferment grape flour extract. I love this product. I've repurchased it many times. It happens to be easily the most expensive one out of all of them. But I don't typically use it all over my entire face. I typically focus on certain areas where I get fine lines, around my mouth and around my eyes, a little bit on the forehead and right in the middle between my eyebrows. A bottle of this will last me three or four months with very conservative usage of it. So it doesn't seem as expensive."
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"I like to use this one because it's got some really good growth factors in there. It's really great for anti-aging, but it's too good to waste any of it."
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"The SkinMedica TNS serum is really good. It's got the human fibroblast condition media. It's more expensive, about three times the price of some alternatives, and it's almost half the size, but it's really good. I've repurchased it a couple times at least, and I most products I don't repurchase unless I really really like them and I'm committed to continuing to use them."
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"It's expensive but this one uses their brand's proprietary human fibroblast conditioned media, which is why it is so expensive. This is one in a handful of products where two, three days in, I did notice a difference for me, especially around my eyes."
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"I've been obsessed with the SkinMedica TNS serum which is upwards of $300 a bottle. I've loved the SkinMedica TNS serum, it's upwards of $300. I've repurchased a couple times, but I got really good deals. When I use that within a couple days it's like an amazing difference on my skin. I'm always on the hunt for the next best thing because of that same feeling."
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"My number one product out of all of these, the one I've noticed the most benefits from, is the SkinMedica TNS Advanced+ Serum. It's 1 oz for $295, which is probably too expensive for most people. This is one product where I applied it to my skin and within two or three days I noticed my skin looked softer and smoother, and lines looked less apparent. The star of the show is their human fibroblast conditioned media, which encourages skin cell renewal and supports collagen and elastin levels, revealing a smoother, more radiant, and youthful complexion. It also contains dimer tripeptide-43, grape flower seed extract, and whey proteins. It's at Dermstore, and they've repackaged it, so it now has two separate independent pumps, which is better because neither pump gets stuck the way they did with the old packaging, and I'm glad they got rid of the fake foil packaging because that foil would start to peel off. I don't use it in large amounts; I just apply it where my skin needs it. I don't smooth it on my cheeks because my cheeks don't have fine lines and wrinkles, but around my eyes and around my mouth is where I focus. This is really a hugely beneficial product."
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"I just purchased the TNS Advanced+ Serum and I've been using it twice a day for one week and I'm already shocked at the results. It's one of the few products I say has instant results, amazing like you could tell the difference. Not every product has that experience but some people do. It's ridiculously expensive, but I'd get it on sale or sign up for some of the cash back websites because sometimes you'll have like 20% off and then sometimes it'll be like a 10% cash back so it ends up being even more savings."
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"It's got the SkinMedica patented human growth factor complex, it's also got prolene peptide as well as a milk peptide complex for anti-aging and collagen production in skin. It also has apple extract and vitamin E for hydrating skin. It's really lovely. It's really expensive, but you can make this one last a long time. I probably been working on this specific bottle for four months with probably another month in it, so just using it sparingly where my wrinkles are. I don't use it everywhere, I just focus on the areas where there's wrinkles."
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"The closest I've gotten so far to an all-in-one product is the SkinMedica TNS Advanced+ Serum, which we all know is very freaking expensive, but for me, that's the closest I've gotten to it."
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"I've tested both of these. For the price, I've just found comparingly that the SkinMedica TNS Advanced+ Serum is more beneficial -- more efficient, more effective for me. Maybe for some people the alternatives will be better, but I found the SkinMedica to be one of the most efficient, effective anti-aging products out of all of them."
"It's got the SkinMedica patented human growth factor complex, it's also got prolene peptide as well as a milk peptide complex for anti-aging and collagen production in skin. It also has apple extract and vitamin E for hydrating skin. It's really lovely. It's really expensive, if it's too expensive I totally get it, but you can make this one last a long time. I make this bottle last a long time too. I probably been working on this specific bottle for four months, it's probably got another month in it, so just using it sparingly where my wrinkles are. I don't use it everywhere, I just focus on the areas where there's wrinkles."
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"The SkinMedica TNS Advanced+ Serum is another one of a handful of products -- maybe 10 in my life -- that have been near-instant game changers. It's $300, though."
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"Within two or three days of using the SkinMedica TNS serum, the difference I noticed in my skin was hard to deny that it was beneficial. Growth factors have undeniable results for me when using a growth factor serum."
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"This stuff is a handful of products that I start using and within days my skin just looks and feels so much better. I love it."
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"SkinMedica's got a reputation with their growth factors that go back several years and they've cultivated it in a certain manner and function. I love this product absolutely. If you can get it on sale, that's something to consider, because it is expensive, about two and a half times the price of comparable products, though it still has a lot in it."
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"My first one is the SkinMedica TNS Advanced+ Serum, which is really expensive, but it gives my skin amazing, nearly overnight results. It really helps with fine lines and wrinkles. If you're super young you probably don't need it, but once you start getting a little older and start to notice wrinkles, fine lines, a little bit of sagginess or droopiness, seriously, within a couple nights this stuff does make a huge difference, at least it has for me and a lot of other people. It gives skin a nice plumped appearance, firmer, and wrinkles look a little less noticeable. They use their patented fibroblast cocktail, which is really amazing. It is a gamechanger. I'm very judicious about how I use it. A couple things I dislike: I dislike the dual pump system, it's annoying and frustrating, it doesn't always come out all at once. I also really dislike the silver packaging because after you've been using it for a month or two it starts to flake off and you start to notice flakes on your skin. But it is worth every penny. It's amazing and has no fragrance."
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"It's really nice lightweight serum. This is one of a few holy grail products for me. Within a few days my skin really started to look better to me. The human fibroblast condition media stimulates elastin and collagen production deep down in skin which helps with fine lines, wrinkles, and saginess. Enhances wound healing especially after treatments like micro needling or lasers. Reduces redness and dryness as well as transepidermal water loss. Helps with rejuvenation, tone, and texture and helps reduce any inflammation. It's really nice."
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"I'm addicted to it. I love it. It's so expensive, but I do feel like I can tell a difference in my skin when I stop using it. And when I first started using it, I could tell the difference."
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"The SkinMedica TNS Advanced+ Serum is one of the few products I've used where I've noticed a dramatically different appearance of my wrinkles after using it. It just makes a huge difference in my skin. There's not a lot of products I can say made a noticeable difference like within a day or two, and this is one of them. They could charge even more and I'd probably still repurchase it."
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"The SkinMedica TNS Advanced+ Serum, this one's upwards of almost 300 bucks if you can get it on sale it might be worth it. Occasionally there's a good sale typically around the holidays and I'll be able to get it for like 100 to 150 bucks, but that's typically not often. Although right now it's on sale at Derm Store, I think it's like 70 bucks off, so if you're looking at it it might be a decent time to buy it, but still pricey."
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"The SkinMedica TNS Advanced Serum is $295. It's one of the few products where I can notice results quite quickly. If I stop using it for a while and I start using it again, I'll notice the results again really nicely. It has great growth factors in it, really nice in terms of antioxidant protection for fine lines and wrinkles."
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"It has a very nice moisture texture to it. If you use it at night time, it's really nice. If you've got dry skin or during the winter if your skin gets really dry, you can also use it in the daytime as well. It is on the thicker side. This one's pretty affordable, too. It's got a really nice gel texture. It smooths in really easily."
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"The SkinMedica TNS serum was huge for me. I love that stuff. It's so expensive, but I use it super sparingly. I use it on my forehead, a little bit around my eyes, and around my mouth. I don't really use it anywhere else. Using it on dry skin or right after a mist helps it absorb quicker. A bottle of it will last me six or seven months just using it very, very, very sparingly on those couple areas."
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"This is probably a little bit better than their previous packaging, but still not much of an upgrade in my opinion. But I love the product. It's amazing. It's one of the sole products that really makes a noticeable difference in fine lines and wrinkles, and it's a game changer."
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"I love the SkinMedica TNS Advanced+ Serum. This is a tough one. It's very expensive. It's likely to get more expensive. But I love this stuff. This is something that I don't want to have to compromise on. I don't see myself taking these out for my routine anytime soon because it's really a work horse. It really helps with fine lines and wrinkles, and I can notice it when I stop using it for a week or two, to when I start using again. I can notice a difference. So, it's amazing. There's not a lot of skincare products that are like within a couple days you notice a difference. It's amazing the difference it makes."
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"I was at a standstill, things weren't necessarily getting better, and I added in the SkinMedica TNS Advanced serum and within a couple weeks it made an absolutely amazing difference that I could notice. Even my dad noticed, which was amazing because he doesn't notice much. I added it in without really having to sacrifice anything, change anything else, or have to deal with irritation. The SkinMedica one is very expensive, it's about $300, but it is an absolutely amazing ingredient that when you add it to your routine, I think if you have some signs of aging you will notice a radical difference very quickly."
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"They use human fibroblast conditioned media and this is one of a handful of products where I used it and within a few days I noticed my skin look better. There's not a lot of products that I can say that about. Most products, especially like actives and things like that, take months or weeks or a long time before you start to notice the benefits, but with this one product I could tell within I think two or three days that my skin just looked better, it felt better, the fine lines were less noticeable. It's expensive, but it's amazing. It comes out of two nozzles which can be kind of frustrating, but if you have a problem with it coming out of two nozzles, if you stick paper clips in these two holes you push it down and it'll dispense better. Really nice, no scent in it, really nice serum."
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"I love this stuff. It's expensive, but if you're going to be into this one you've got to learn to watch for sales because when you can get on sale it saves a lot of money really fast. The thing is that around the metal of this it starts to flake off and starts to get on your face, which is not a good look, but I need to repurchase it."
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"I love peptides. I love growth factors. They're great for helping deep down in your skin, renew it, soothe it, help with collagen production. The SkinMedica TNS Advanced Serum is one of my favorites. This stuff's really nice."
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"The SkinMedica TNS Advanced+ Serum, I just love this stuff. It sucks because it's so expensive, but it really is a game changer. This contains their proprietary formula of human fibroblast conditioned media cells which helps with collagen production and increase in plumpness in skin, and it is noticeable within a few nights to a week or two. It's amazing. I hate that it's amazing because it's so expensive, but most products that are really expensive typically aren't worth the money, but that is one of a handful of them."
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"The SkinMedica TNS Advanced+ Serum is one of the two products I've noticed work the fastest with the fastest results. Almost nothing can deliver that fast, but even this product is a couple weeks or a week or two before I noticed a difference. It's got no denaturating drying types of alcohol, which is nice for sensitive skin. There's no fragrance ingredients and no noticeable scent, which is also very nice for sensitive skin. The manufacturing location is the US. It has a lotiony texture."
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"I'm going to start with the SkinMedica TNS Advanced+ Serum. I just finished this one with the new packaging last month, and I picked up a backup because with this price I'm not going to throw it away. I love this serum, it's so wonderful. The star of the show for this one is human fibroblast conditioned media, a proprietary ingredient made by SkinMedica that works as a cell signaling molecule to stimulate cell growth, proliferation, and healing. There's a handful of products where I've used them and within a day or two I have noticed benefits, and there's not a lot of them, because most products require you to be on top of it, require consistency, require patience. With this one, I didn't need any of that. Even the next day of using it, my skin just looked so much better. The first time I used this was probably about 9 years ago, and I'm very stingy with it."
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"I love this stuff. It's got their human fibroblast conditioned media, which they have a proprietary interest in and have been using in this serum for a very long time. It is amazing, for me it's worth it. I use it very sparingly, just around my eyes and around my mouth, so I can make a bottle last three or four months. At Dermstore sometimes there are good sales, so it might be worth checking out. Love it, good product."
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"My favorite growth factor product is the SkinMedica TNS Advanced Serum. It's got SkinMedica's proprietary human fibroblast conditioned media. It's one of the products I've noticed to be most beneficial for my skin care. This one's just a really great serum, I use it very sparingly."
"SkinMedica TNS Advanced Plus Serum is the OG growth factor serum with the longest track record, having been around since the late 90s with meaningful clinical data. It's recommended post-procedure for laser, peel, or microneedling treatments."
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"Growth factors help support skin repair, regeneration, and overall skin resilience. Now, they don't replace retinoids, but they do work alongside them to improve skin quality, especially as skin ages. Some options I trust clinically include the SkinMedica TNS Advanced+ Serum as well as the Neoccutis Bio Serum Firm. These are definitely more on the high end."
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"Some of my favorite growth factors are the SkinMedica TNS Advanced+ Serum. Growth factors are signaling molecules that can help increase collagen production like retinoids can but they aren't as irritating to the skin like retinoids might be. You'll want to apply your growth factor serum as the first step after you wash your face in both the morning and the evening."
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"My favorite supportive products for the jawline and neck include SkinMedica TNS Advanced+ Serum, along with other products that contain peptides and/or growth factors that support skin health and firmness. It's not miracles, but meaningful improvements. And I think you'll see faster changes with these products than with retinoids."
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"SkinMedica TNS Advanced Plus Serum is the OG growth factor serum with the longest track record, having been around since the late 90s with meaningful clinical data. It's recommended post-procedure for laser, peel, or microneedling treatments."
"It has hyaluronic acid and hydrayed lime seed extract which stimulates epidermal thickening. So the combination of these two chambers in this one product is really like two products in one. Although it retails for $295, you might almost want to think of it as two separate products for $150 each. It doesn't make it cheaper, but this is one that patients come into my practice requesting and that is why I have it because the reviews from the patients have been stellar and people love this."
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"It has hyaluronic acid and hydrayed lime seed extract which stimulates epidermal thickening. So the combination of these two chambers in this one product is really like two products in one. Although it retails for $295, you might almost want to think of it as two separate products for $150 each. It doesn't make it cheaper, but this is one that patients come into my practice requesting and that is why I have it because the reviews from the patients have been stellar and people love this."
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"I'm talking about SkinMedica's TNS Advanced+ Serum. These can help to stimulate fibroblast to produce more collagen and elastin and to help reduce crepiness and laxity overall. You can use it longer term for your neck and your chest. It will take longer for you to see full results, but you can absolutely use it. If you combine it with in office procedures, you will see results more effectively."
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"SkinMedica TNS serum has growth factors, cytokines, and Matrix proteins that people swear by. This is a particular product I recommend for patients who cannot tolerate retinols on their neck even though they try to buff it with a moisturizer. I tell them just go for this for your neck or those hard to reach areas. It's a great adjunct to have."
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"This is a tried and true and yes it is expensive but this has EGF, TGF beta and FGF, okay? And they're all human derived. It doesn't mean they're coming from human skins. It means human skins was put in a culture medium and that culture medium was then taken, filtered, sterilized and stabilized and you're getting that and that's what you're applying on the surface of your skin. This works best for deep wrinkles elasticity. I love it post-procedurally after micro needling, any type of radio frequency with micro needling, any type of frail. It really does help to renew your skin and works best for deep aging concerns and it comes at a pricey heft of nearly $295. But this is something that I don't necessarily use every single night because of the price. I can tolerate retinol. So I'll use a retinol on my face. But I may use this on my neck and chest if I do not tolerate the retinols, especially after I exfoliate. I love her. She's great."
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"SkinMedica has their TNS Advanced serum. You can use this from here to here, you will not get irritated on your neck, unlike if you use a retinol on your neck and chest where most of you will get irritated. You can even find hexapeptide-2, which helps with fine lines in the active seal. So there's vitamin C, peptides, and moisturizer, also ceramides in this. This is purely growth factors and peptides in here. I can use this one from here to here and I do use this at night underneath my moisturizer, which gives me an extra boost."
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"SkinMedica TNS Advanced Serum is a blend of growth factors, cytokines, and matrix proteins that can stimulate fibroblasts, which are the cells responsible for producing collagen, to increase collagen synthesis. It's pricey, but if you've tried all the rest and feel like you need more, venture into this. If you want something for your neck and chest and you've never been able to tolerate a retinol but you want something more than coenzyme Q10, try this, it definitely helps."
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"It comes in a dual chamber pump and you get two types of serums that get pumped out of it that you mix together when you apply it. There is a very light scent to it, just beware because it does pill over other products that have actives. I personally use this at night on my face, neck and chest. I actually use this exclusively on my neck and chest on most nights because my neck and chest cannot always tolerate a retinol and sometimes it gets irritated. Their growth factor cocktail is made up of medium long amino acid sequences, which are basically small proteins that help your cells to signal one another to stimulate growth, proliferation and differentiation, which is what you want your face and your skin to have in order to stay youthful."
"The SkinMedica TNS Advanced+ Serum kickstarted things with growth factors and is the one that people often hold up to be the pinnacle in terms of performance. This is the one that uses actually human-derived growth factors, which comes with some ethical considerations that people will have to make their own judgment on. And the price point is upwards of $300. This isn't for me; it's not in my budget, and I don't want to be investing in this product at the expense of other steps in my routine. It just doesn't align with my individual budget. That doesn't mean it's not great; it is. Because these are actually human-derived growth factors, you're probably going to see some very quick results, and some next-level results when it comes to anti-aging. For me, I just think there are some ethical considerations at least to think about here. I'm not making that call for you; people should do their own research and make their own decision. And the price just isn't within my bracket."
"The Skin Medica TNS Advanced Plus Serum is one of the human derived ones and it's clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. It has a dual growth factor system which can stimulate collagen and elastin production. It's super lightweight, fast absorbing formula designed for really that mature aging skin. The key ingredients here are the TNSMR which is the blend of growth factors and peptides, and Renaissance complex which contains the botanicals and marine extracts."
All 3 takes from Dr. Aleksandra Brown
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"The Skin Medica TNS Advanced Plus Serum is one of the human derived ones and it's clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. It has a dual growth factor system which can stimulate collagen and elastin production. It's super lightweight, fast absorbing formula designed for really that mature aging skin. The key ingredients here are the TNSMR which is the blend of growth factors and peptides, and Renaissance complex which contains the botanicals and marine extracts."
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"SkinMedica TNS Advanced+ Serum is clinically proven to reduce deep wrinkles and improve skin texture in 12 weeks. The dual growth factor system stimulates the collagen and elastin production. It's really lightweight, super fast absorbing formula designed for that really mature aging skin. The key ingredient here is the TNSMR, the blend of growth factors and peptides. It also has the Renaissance complex which is the botanicals and marine extracts."
Best Anti-Aging Ingredients Ranked by a Dermatologist
"Another one that's really popular is the Skin Medica TNS Advanced Plus Serum. This is human derived, the clinical standard, but it's significant splurge."
"The price point is about $300 and it has the studies to back up its clinical use and the benefits you'll see. It's extremely popular amongst physicians and definitely has a cult following with a plethora of clinical data around it to support its efficacy. This one is derived from humans, specifically the foreskin. If you're looking for growth factors derived from humans that have been around for the longest, this would be the option to go with. If you're a growth factor purist, this would be the one for you. It really is kind of like that idealistic type of product that has been the gold standard for some time now. When using this in your routine, it's simply cleanse, treat, protect. You can cleanse at night, use the serum, moisturize, and in the morning cleanse, use the serum, use sunscreen. You can layer it with other actives and it is going to be stable with other actives as well."
"It's from SkinMedica. Their TNS Advanced+ Serum certainly is not cheap. It retails for $295, but the formulation as well as just the level of evidence and clinical studies, really no other product can beat that. This supports skin rejuvenation with a dual chamber system that's really unique where it combines growth factors along with peptides and antioxidants, helps to visibly reduce and smooth appearance of fine lines and wrinkles and even helps with skin sagging and also a little bit of skin tone and hyperpigmentation. You can start to see visible results in just two weeks, up to 24 weeks of use is when they stopped the studies, looking at the data. So it's definitely something that you can use immediately post procedure as well as continue to use even after procedure for continuing those benefits. The chamber system is really interesting. You have chamber one, the TNS MR, which is the advanced formula with basically next generation of growth factors that really supports healthy skin function and innovative peptide complex that helps to nourish your skin. And then chamber two is what they call the RSC system, which is basically actives of botanical extracts and marine extracts."
"This is a peptide and growth factor serum. You just need one pump for your entire face and neck. It's definitely a more expensive skincare product, and I always say if you're going to invest a hundred or more dollars in a skincare product, it should generally have some type of clinical trials showing its efficacy. This has good clinical data showing it helps with fine lines, wrinkles, and even skin sagging. There's not a lot in skincare that helps with sagging. It's not going to lift your jowls up, but for people who apply it to their neck or around their eyes, they do notice noticeable improvements. This is just a product I really enjoy using. As someone with rosacea and more reactive skin, I also find it quite calming and not irritating. I'm a big fan. They recommend using it morning and night, generally on clean skin."
All 2 takes from Dr. Sam Ellis
Dermatologists' NO FAIL Anti-Aging Skincare Routine | Dr. Sam Ellis
"This is a peptide and growth factor serum. You just need one pump for your entire face and neck. It's definitely a more expensive skincare product, and I always say if you're going to invest a hundred or more dollars in a skincare product, it should generally have some type of clinical trials showing its efficacy. This has good clinical data showing it helps with fine lines, wrinkles, and even skin sagging. There's not a lot in skincare that helps with sagging. It's not going to lift your jowls up, but for people who apply it to their neck or around their eyes, they do notice noticeable improvements. This is just a product I really enjoy using. As someone with rosacea and more reactive skin, I also find it quite calming and not irritating. I'm a big fan. They recommend using it morning and night, generally on clean skin."
Anti-Aging Skincare Products Worth EVERY SINGLE PENNY | Dr. Sam Ellis
"The SkinMedica TNS Advanced+ Serum is a combination growth factor peptide serum that is a Holy Grail for so many people who take their anti-aging game very seriously. You would apply it to your bare clean skin ideally twice a day, and it's been shown to help with fine lines and wrinkles, but it's also been shown to help with sagging. Sometimes people are just starting to notice their skin is getting a little bit saggy, a little less firm, and tons of people swear by this in terms of seeing really truly visible results when it comes to tightening things up. There's not a lot of stuff in skincare that can really do that. This is another one of those products that has clinical testing behind it, so it's not just like cross your fingers and hope. They did a really nice 24-week study, so that is longer than a lot of skin studies most end at like 12 weeks. It showed progressive improvement of the skin starting at 2 weeks and getting better all the way through 24 weeks. I have a handful of patients within my cosmetic practice that I would consider super agers, these are women in their 60s and 70s who just look incredible, and I think every single one of them uses this product."
"SkinMedica TNS Advanced+ Serum is really expensive. That said, you will find SkinMedica TNS serum users out there who will cut your throat if you take that stuff away from them, so clearly it does something for some people. Is it going to do anything for you? I don't know, and the reason I don't know is not because I'm an idiot, it's because we don't have good data to predict who's going to respond to these things and who's not. You've got to stay consistent with something like this in order to begin to turn a corner and see meaningful change. People who claim they saw results after a week: pull over to the rest stop and keep going with it, then talk to me, because stuff doesn't really happen that quickly. I'm not so sure about the anti-sag claims either. You're telling me not only is it going to boost collagen to improve wrinkles, but it's also going to reposition stuff and rebuild the underlying bone and supportive framework that has been lost as a result of the aging process? I am skeptical. My experience using this product is that it is very uneventful, it is a thin, clear, colorless liquid, doesn't really have an odor to it or a tingle."
"The TNS Advanced Plus Serum is a stem cell serum with growth factors that help to brighten skin, tighten, help with elasticity, and promote collagen."
Common questions
Frequently asked.
What is SkinMedica TNS Advanced+ Serum?
A dual-chamber serum combining human-derived growth factors, peptides, and botanical extracts designed to reduce wrinkles, improve skin texture, and support skin firmness and elasticity.
Is SkinMedica TNS Advanced+ Serum worth it?
Mostly yes. 9 of the 10 gurus who reviewed it give it their stamp of approval, for a Guru Score of 82%.
What is SkinMedica TNS Advanced+ Serum's Guru Score?
SkinMedica TNS Advanced+ Serum holds a Guru Score of 82%. That is our read on how warmly the experts talk about it, based on the verdicts of 10 independent expert reviewers we have collected.
Who is SkinMedica TNS Advanced+ Serum best for?
SkinMedica TNS Advanced+ Serum is generally suited to mature skin.
Spend less, score well
Cheaper alternatives the gurus rate.
Lower-priced serums the gurus still rate highly, versus this luxury pick.
