Peter Thomas Roth

Peptide 21 Cream.

Serums

About this product

A peptide-rich moisturizing cream formulated with 21 types of peptides designed to hydrate skin and support firmness.

Best for

Dry skin Mature skin

Type

SerumsCream

Key actives

Peptides

Formula notes

Fragrance-freeNo drying alcohol

Full ingredients

Water/Aqua/Eau, Isononyl Isononanoate, Glycerin, Butylene Glycol, Caprylic/Capric Triglyceride, Pentylene Glycol, Cetearyl Alcohol, Sorbitan Stearate, Cyclopentasiloxane, Dimethicone, Butyrospermum Parkii (Shea) Butter, Glyceryl Stearate, PEG-100 Stearate, Palmitoyl Tripeptide-5, Tripeptide-10 Citrulline, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-1, Acetyl Hexapeptide-8, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Palmitoyl Hexapeptide-19, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Acetyl Octapeptide-3, Tripeptide-1, Palmitoyl Tripeptide-1, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Leuconostoc/Radish Root Ferment Filtrate, Hydrolyzed Soy Protein, Natto Gum, Glycine Soja (Soybean) Protein, Superoxide Dismutase, Potassium Sorbate, Pseudoalteromonas Ferment Extract, Citric Acid, Cistus Incanus Flower/Leaf/Stem Extract, Gynostemma Pentaphyllum Leaf/Stem Extract

Guru Score

80%

Approved

Early verdict · Few reviews so far

2Gurus

2Approved

0Mixed

0Skip

What the gurus are saying

The cream draws praise for its hydrating, creamy texture that leaves skin feeling nourished. Gurus also highlight the peptide blend as a standout ingredient mix, with one noting that certain peptides in the formula have been studied for their ability to extend the effects of cosmetic procedures. The price is higher than many alternatives, but the peptide concentration is what earns it a place on recommendation lists.

Synthesized from 2 expert reviews · most recent take January 2026

Where to buy

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How it works Independent by design. Every take comes from a creator we have no relationship with. We do not ask anyone to review, and affiliate links never move a score.

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Doctorly

3.57M subs

✓Approved

"The cream and the serum both have 21 different types of peptides in it including ingredients like argerene and arjgerox. Now arjgerox I believe that particular combination of peptides has been shown to increase the longevity of your botox. So if you get botox done it usually lasts only 3 months. This can increase longevity at up to 6 months. So it is just a really interesting combination of ingredients and it's power packed with different types of peptides. And because of that, even though it's a little bit more pricey, it definitely makes our list of the year definitely."

Nipun Kapur

401k subs

✓Approved

"I'm going in with the Peptide 21 Cream by Peter Thomas Roth because this is really very very hydrating and super creamy. I've used it and I'm honestly loving the results and I'm going to continue using it until this bottle finishes."

Common questions

Frequently asked.

What is Peter Thomas Roth Peptide 21 Cream?

A peptide-rich moisturizing cream formulated with 21 types of peptides designed to hydrate skin and support firmness.

Is Peter Thomas Roth Peptide 21 Cream worth it?

Yes. All 2 gurus who reviewed it give it their stamp of approval, for a Guru Score of 80%.

What is Peter Thomas Roth Peptide 21 Cream's Guru Score?

Peter Thomas Roth Peptide 21 Cream holds a Guru Score of 80%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 independent expert reviewers we have collected.