Peptide 21 Wrinkle Resist Moisturizer.

Moisturizers

About this product

A peptide-rich moisturizing cream formulated with 21 types of peptides designed to hydrate skin and support firmness.

Full ingredients

Water/Aqua/Eau, Isononyl Isononanoate, Glycerin, Butylene Glycol, Caprylic/Capric Triglyceride, Pentylene Glycol, Cetearyl Alcohol, Sorbitan Stearate, Cyclopentasiloxane, Dimethicone, Butyrospermum Parkii (Shea) Butter, Glyceryl Stearate, PEG-100 Stearate, Palmitoyl Tripeptide-5, Tripeptide-10 Citrulline, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-1, Acetyl Hexapeptide-8, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Palmitoyl Hexapeptide-19, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Acetyl Octapeptide-3, Tripeptide-1, Palmitoyl Tripeptide-1, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Leuconostoc/Radish Root Ferment Filtrate, Hydrolyzed Soy Protein, Natto Gum, Glycine Soja (Soybean) Protein, Superoxide Dismutase, Potassium Sorbate, Pseudoalteromonas Ferment Extract, Citric Acid, Cistus Incanus Flower/Leaf/Stem Extract, Gynostemma Pentaphyllum Leaf/Stem Extract

Guru Score

82%

Yay

Early verdict · Few reviews so far

2Gurus

2Yay

0Mixed

0Nay

What they liked

Rich, creamy texture
Highly hydrating

What they flagged

Nothing. None of the experts who reviewed it raised a problem.

What the gurus are saying

The cream draws praise for its hydrating, creamy texture that leaves skin feeling nourished. Gurus also highlight the peptide blend as a standout ingredient mix, with one noting that certain peptides in the formula have been studied for their ability to extend the effects of cosmetic procedures. The price is higher than many alternatives, but the peptide concentration is what earns it a place on recommendation lists.

Synthesized from 2 expert reviews · most recent take January 2026

Best for

Dry skin Mature skin

Type

MoisturizersCream

Key actives

Peptides

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Doctorly

3.58M subs

✓Yay

"Peptides are a breakout group of ingredients over the last couple of years that has now become a cornerstone in skincare because the way they're made, they're all very deliberately purposely created. Each one actually has a specific function in your skin. The skin injection peptide cream from Peter Thomas Roth is outstanding. They have a serum and then they have a cream and the cream and the serum both have 21 different types of peptides in it including ingredients like argerene and arjgerox. Now arjgerox I believe that particular combination of peptides has been shown to increase the longevity of your botox. So if you get botox done it usually lasts only 3 months. This can increase longevity at up to 6 months. So it is just a really interesting combination of ingredients and it's power packed with different types of peptides. And because of that, even though it's a little bit more pricey, it definitely makes our list of the year definitely."

Nipun Kapur

409k subs

✓Yay

"I'm going in with the same Peptide 21 cream by Peter Thomas Roth because this is really very very hydrating and super creamy. I've used it and I'm honestly loving the results and I'm going to continue using it until this bottle finishes, and then I will potentially repurchase it."

All 3 takes from Nipun Kapur

I Duped The World's Most Expensive Creams From $1,000 To $14

"My dupe is the Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer for $100 versus so differ $100. Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer fabulous you get 16 plus peptides actually 21 peptides but not all of them are pure peptides and lots and lots of moisturizing agents."

How To Layer Retinol Products For Maximum Results - Full Demo

"That is the Peter Thomas Roth Peptide 21 that I'm using"

My skincare routine for the full week! Skincare Vlog | Nipun Kapur

Frequently asked.

What is Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer?

A peptide-rich moisturizing cream formulated with 21 types of peptides designed to hydrate skin and support firmness.

Is Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer worth it?

Yes. All 2 gurus who reviewed it give it their stamp of approval, for a Guru Score of 82%.

What is Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer's Guru Score?

Peter Thomas Roth Peptide 21 Wrinkle Resist Moisturizer holds a Guru Score of 82%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected.