Paula's Choice Cellular Youth Longevity Serum is an anti-aging serum designed to support skin firmness, smoothness, radiance, and a more youthful appearance.
Water (Aqua/Eau), Propanediol, Glycerin, Triheptanoin, Methyl Gluceth-20, Simmondsia Chinensis (Jojoba) Seed Oil, Tridecyl Trimellitate, Maltodextrin, 1,2-Hexanediol, Dimethicone, Taurine, Bacillus Ferment, Ganoderma Lucidum (Mushroom) Stem Extract, Helianthus Annuus (Sunflower) Sprout Extract, Lycium Barbarum Fruit Extract, Acetyl Tetrapeptide-2, Isomalt, Coco-Caprylate/Caprate, Hydroxyacetophenone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, C9-12 Alkane, Dilinoleic Acid/Butanediol Copolymer, Glyceryl Behenate, Polyglyceryl-6 Octastearate, Sodium Phytate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Potassium Chloride, Acacia Senegal Gum, Xanthan Gum, Polysorbate 60, Sorbitan Isostearate, Synthetic Fluorphlogopite, Caprylyl Glycol, Citric Acid, Castor Oil/IPDI Copolymer, Lecithin, Cyanocobalamin, Tin Oxide, Iron Oxides (Ci 77491), Titanium Dioxide (Ci 77891)
Guru Score
The Guru Score: every expert's verdict on a product, in one simple number.
Under the score you'll see how many experts weighed in, or "Early verdict" while only a few have. Paid takes count for half in the score.
Guru Certified means at least 6 experts, a score of 85% or more, and almost no Nays.
How we score →Mixed
Early verdict · Few reviews so farWhat the gurus are saying
This serum skips heavy actives like retinoids and high-dose vitamin C, instead using antioxidants and supportive ingredients to help boost natural collagen and ceramide production. People do see results: visibly smoother, more even skin with glow. However, reviewers split on value. Some found the ingredients too basic for the cost; others liked the results but thought $72 to $77 is steep for a supportive formula.
What they liked
What they flagged
Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.
Independent of what the gurus think, this is what the published research supports about the main active ingredients here.
Sun protection is the best evidenced way to slow visible ageing, and the filters are what does the work. Mineral and chemical filters both protect when a product is applied thickly enough and often enough, which is where most people fall short rather than on the choice of filter.
Source: DermNet
Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.
Paula's Choice Cellular Youth Longevity Serum is an anti-aging serum designed to support skin firmness, smoothness, radiance, and a more youthful appearance.
The gurus are split. 0 of the 3 gurus give it their stamp of approval while 2 would skip it, which lands it in the middle at a Guru Score of 61%.
Paula's Choice CellularYouth Age-Disrupting Longevity Serum for Firming, Lifting, and Smoothing holds a Guru Score of 61%. That is our read on how warmly the experts talk about it, based on the verdicts of 3 expert reviewers we have collected.
Paula's Choice CellularYouth Age-Disrupting Longevity Serum for Firming, Lifting, and Smoothing is generally suited to mature skin.
Lower-priced serums the gurus still rate highly, versus this mid-range pick.
See how they stack up →



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