Advanced Antioxidant Serum.

Serums

About this product

A serum formulated with vitamin C, vitamin A, and multiple antioxidants including ferulic acid, glutathione, and superoxide dismutase to protect and brighten skin.

Full ingredients

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide NP, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophylls, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva-Ursi Leaf Extract, Lupinus Albus Seed Oil, Curcuma Longa Root Extract, Elaeis Guineensis Oil, Phenoxyethanol

Guru Score

78%

Yay

Early verdict · Few reviews so far

2Gurus

2Yay

0Mixed

0Nay

What they liked

Airless pump packaging preserves antioxidant potency

What they flagged

Vitamin C forms are weak and largely ineffective

What the gurus are saying

The weak forms of vitamin C in this serum matter less than you might think, because the rest of the antioxidant lineup (glutathione, superoxide dismutase, ferulic acid) is strong enough to carry the load. Experts praise the vitamin A and C pairing, but here's the catch: since antioxidants break down in oxygen, the serum comes in a pipette bottle, which means you cannot be certain how potent it still is when you use it. For maximum effect, gurus suggest only buying antioxidant serums in airless pump bottles.

Synthesized from 2 expert reviews · most recent take June 2025

Type

SerumsDrops & dropper

Key actives

Vitamin CVitamin ECeramidesPeptides

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Doctorly

3.58M subs

✓Yay

"Paul's Choice has an interesting one, it's a good one. It has a lot of those supporting antioxidants in there. I think it has glutathione, it has superoxide dismutase, it has ferulic acid. Interestingly the forms of vitamin C in it are very low for me. It has THDC tetrahexadecyl ascorbate and then magnesium ascorbyl phosphate, which is absolute trash when it comes to vitamin C's, but if those vitamin C's do nothing, I actually think the rest of the supporting antioxidants in that formulation are good enough to compensate. So I actually like this product as another alternative for your antioxidants."

Dr. Vanita Rattan

1.23M subs

✓Yay

"Paula's Choice I really like the antioxidant serum"

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Vitamin C

Topical vitamin C is an antioxidant with reasonable evidence for dullness and uneven tone. It breaks down in light and air, so how a product is formulated and packaged matters as much as the percentage on the front.

Source: DermNet

Ceramides

Ceramides are part of the skin's own barrier, and moisturisers built around them have evidence for holding water in and settling the tightness and flaking that come with a damaged barrier.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is Paula's Choice Advanced Antioxidant Serum?

A serum formulated with vitamin C, vitamin A, and multiple antioxidants including ferulic acid, glutathione, and superoxide dismutase to protect and brighten skin.

Is Paula's Choice Advanced Antioxidant Serum worth it?

Yes. All 2 gurus who reviewed it give it their stamp of approval, for a Guru Score of 78%.

What is Paula's Choice Advanced Antioxidant Serum's Guru Score?

Paula's Choice Advanced Antioxidant Serum holds a Guru Score of 78%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected.