What is OneSkin OS-01 Face Topical Supplement?

OS-01 Face is a peptide-based facial moisturizer from OneSkin, designed to hydrate the skin and support a smoother, firmer-looking, healthier-aging complexion.

Is OneSkin OS-01 Face Topical Supplement worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 74%.

What is OneSkin OS-01 Face Topical Supplement's Guru Score?

OneSkin OS-01 Face Topical Supplement holds a Guru Score of 74%. That is our read on how warmly the experts talk about it, based on the verdicts of 12 expert reviewers we have collected.

Who is OneSkin OS-01 Face Topical Supplement best for?

OneSkin OS-01 Face Topical Supplement is generally suited to dry skin and mature skin.

What is OneSkin OS-01 Face Topical Supplement good for, according to the experts?

In their reviews, experts say OneSkin OS-01 Face Topical Supplement is good for skin barrier support (3 experts), fine lines and wrinkles (1 expert), loss of firmness (1 expert), crepey skin (1 expert) and calming retinoid irritation (1 expert).

Is OneSkin OS-01 Face Topical Supplement good for skin barrier support?

3 experts who reviewed OneSkin OS-01 Face Topical Supplement say it is. Darnell Cox | 50+ Healthy Aging Expert put it this way: “It has changed my skin barrier.”

OneSkin OS-01 Face Topical Supplement: a Guru Score of 74%

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Dr. Daniel Sugai

723k subs

~Yay

"Peptide moisturizers like OneSkin, that's a pricier brand, [...] but the OS-1 peptide behind it clears out dull senescent cells [...] and makes room for new cells to help boost collagen production. That's a great brand, so that I would splurge on."

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"OneSkin has done a good job with their science-backed OS-01 peptide."

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"It's actually causing more inflammation and damaging our collagen. So if we clear those cells out, we can have collagen production at a more efficient rate. I like this one a lot for my mature users. It does come out as a thicker texture. It's nice to seal in your vitamin C serum or your retinoid and it will help boost your collagen. So it is a higher price point, but very nice, very nourishing. I like the texture."

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"I saw the paper, is evidence this company is founded by PhDs. This peptide they found has helped clear out old senescent cells that are no longer regenerating and thus make way for youthful cells to help regenerate and increase collagen production and tell your dermis to wake up and thicken itself up with more collagen. So the OneSkin face is a nice ingredient to apply after your actives like retinoids or if you wanted to apply that after your vitamin C serum or after your ptox, go right ahead."

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"OneSkin has a proprietary OS-01 peptide that helps clear out the old cells that don't regenerate and it helps reverse biological age. OneSkin has been founded by PhDs and they do have papers that support their peptide that pretty much tell your skin cells to make more collagen, which is great. It's a little bit pricey but I like that there's evidence behind this."

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"One skin being a nice one with the OS-01 peptide that has been shown to clear out the old non-regenerating cells out and helps stimulate collagen production. [...] Those peptides will be a cell signal to tell your skin to make more collagen which is excellent. [...] I would recommend those products."

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"One Skin, which is a higher price point, but a lot of studies backing up their OS one peptide."

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"So their face supplement, they have a sunscreen, but they also have just a face moisturizer and a body moisturizer. So that's something you can consider to actually reverse the biological age of your skin, but you're paying for it. But I love that the PhDs that founded the company have sent me studies. I was able to look through the studies and I like the products and so I use their sunscreen and their moisturizers quite a bit."

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"Here's the OS-01 peptide by OneSkin. This is a face supplement just to seal it all in and get a little bit of a collagen boost. Remove those old senescent cells. We talked about zombie cells where you have cells that are just party poopers that came to the party and aren't really having fun. They're just taking up space. They're not dividing. They're not increasing collagen or fibroblast activity."

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"OneSkin with their proprietary OS1 peptide, their face supplement moisturizer has been really nice and I like that brand a lot. They're great products, great sunscreen and great moisturizers that will help boost collagen production and clear out the cells that are just not regenerating anymore."

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"The brand that I discovered in 2024 that has impressed me is OneSkin. So their face supplement, very nice, and it has their proprietary OS-01 peptide. It has studies backing it that will help with your biological age and clear out senescent non-regenerating cells. I've been impressed by this brand."

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"OneSkin has great peptides that they were able to show me data, the evidence behind it that they work really well in the skin."

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"I'm really liking peptides in my skin care so we can simplify our routine. OneSkin has a science-backed OS-01 peptide in their eye cream, their body and facial moisturizers, their sunscreens. [...] I love that they have transparent studies behind that peptide and cell signaling clearing out old non-regenerating cells and making way for regenerating cells so you can actually improve your biological age of the skin. That's really cool but you're paying for it."

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"If you look at senescent therapies, these senescent cells, and you want to clear them out, the one I've talked about the most would be the OneSkin OS-01 peptide. This brand has been founded by PhDs. I got to see the data and it's very impressive."

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"I like peptide moisturizers for those in their late thirties and up. [...] Some that come to mind would be One Skin, their OS1 peptide face supplement."

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Beyond50Skin

32k subs

~Yay

"A new moisturizer by OneSkin with their OS1 peptide and this is a much richer formula than their facial moisturizer. [...] I am definitely a fan of one skin and that OS1 peptide for combating senescent cells. Just absolutely lovely and I can tell the texture of this is just gorgeous. Excited to try this."

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"I'm at the very end so I've opened it up and I'm going to use a little bit of this now. Early on when I was starting this routine I would use the anti-pigmentation formula first, [...] but they really want you to use the OS-01 peptide directly on clean skin, so I've kind of switched that up. They say if you're using like a watery serum you can put the OS-01 peptide after and then move on with the rest of your skincare routine."

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"OneSkin has their OS-01 peptide, which is supposed to help with senescent cells and the cells that are dying, and the ones that are adjacent to it, it's supposed to protect them. There's some really amazing science around it. It takes me about three pumps and I've been trying it for I think this is my fifth week, maybe heading into my sixth week. [...] The thing that you have to know about this: number one, it's frightfully expensive."

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"I'm using the OneSkin moisturizer if I'm doing an evening where I'm doing my exfoliation treatment by dermal I also put this moisturizer on over it but I let it dry down a bit. This is the same formula that I'm using in the morning and the way they recommend using it is twice a day so I can see if there's an actual difference in a couple months using the formula as recommended."

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"I've been using that twice a day and their moisturizer, both formulas have their OS-01 peptide that's supposed to help combat senescent cells or our aging dying cells. So I really like the formulas, they're super hydrating."

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"It's a topical supplement by OneSkin. This is the only product I know that calls itself a supplement and it's not a serum, it's not a moisturizer, it's kind of an in between. The idea is this peptide goes deep into the skin, actually helps reduce senescent cells, those skin cells that are dying off. It reduces sort of the cascade of inflammation that happens when cells die, sort of tamps that down so that you have more youthful skin, skin that can repair itself from the inside out."

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"I started using the eye cream and I started using the face cream um because I'm a huge eye eye cream person anyway and the very first time I used it I got on that day and I ordered another one. It's got that just that consistency that I like the thickness. It's just it's it's everything that I wanted in in a cream."

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"The OS1 topical supplement with their proprietary peptide blend seems to do something that no other topical skincare product does. [...] I will keep it in my skincare wardrobe. It will be on repeat purchase, but it is a bougie product, so I'm going to introduce it on occasion just when I feel like my skin needs a boost. This is a beautiful topical serum and supplement if you want to get your skin to behave and look younger and firmer."

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"I got through a travel size and I also got through a full size of the One Skin moisturizer with their proprietary peptide that helps with senescent cells."

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Darnell Cox | 50+ Healthy Aging Expert

55k subs

~Yay

"Um, I love the new I I love the one skin oso1 peptide. That is something that I use throughout."

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"I'm a big fan of that OneSkin. Huge fan. That's the skin care that uses that OS-01 peptide that helps to rid the body of senescent cells. It clears the way for those skin cells that you want to receive all of those good peptides and all of that good skin care, like, okay, let's prioritize who we're getting it to, we'll clear out all the ones that are dying. I do micro needle the back of the thighs too, and [...] I will absolutely micro needle the butt, the back of the thighs."

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"This is where [...] I don't go anywhere without this, hands down in my opinion the best moisturizer on the planet. Why? Because it has an active ingredient in it as well. It has that peptide, the OS1 peptide that helps to decrease those senescent cells, those zombie cells, those cells that are like dying. They're in the process of dying and we want to speed them up so we get the good stuff, the rest of the skin care where it wants to go. This is the body version of this."

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"I'm putting on One Skin. This is an OS-01 peptide. I am obsessed with this. And the reason is because, well, number one, it changed my skin. It really did. I put little dots everywhere, rub this around a little bit, and then press it into the skin."

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"I love OneSkin. It has changed my skin barrier. I use it on my neck and face after everything else."

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"This is OneSkin, which is an OS-01 peptide. I did a whole show on peptides and how they're kind of like the text messengers of our body. They tell us what to do. This OS-01 peptide really kind of helps to eliminate senescent cells, which are those zombie cells that create oxidative stress. So it helps to, it's not like it exfoliates, but it helps to rid [...] your skin of those damaged cells, which then continues to damage the skin cells around it."

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"I'm obsessed with this brand, OneSkin, because the way that it's working, I swear it's repaired my skin barrier on my neck. It's a moisturizer and yes it's a peptide and so it does some sort of heavy lifting in terms of senescent cells and zombie cells without the irritation of exfoliation from retinoids. But it's not an active ingredient that is, you're done, that's all you need right."

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"I'm now also loving OneSkin which I'm using on my neck and I feel like it's building back my skin barrier because my neck is overly sensitive from a lot of retinoids and stuff that I've done over the years. [...] This is a peptide, it's OS-01 that works with senescent cells, those zombie cells [...] that have oxidative stress and are just sitting there causing damage. This helps alleviate that."

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"I use the body lotion and that OneSkin OS-01 peptide. Great to clear the way for those other peptides to come in."

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"It could be a one skin with an OS-01 peptide, a PDRN peptide, and a calming balm over the top of it. [...] I have done that before, but it's not something that I would coach, especially if you haven't done it."

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"I stick with the basics, which is simple wash, retinoids at night, followed by a peptide that I'm loving called OneSkin OS-01. It's on my ultimate skincare protocol."

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"I'm obsessed with this brand, OneSkin, because the way that it's working, I swear it's repaired my skin barrier on my neck. It's a moisturizer and yes it's a peptide, and so it does some sort of heavy lifting in terms of senescent cells and zombie cells without the irritation of exfoliation from retinoids. But it's not an active ingredient that is, you're done, that's all you need, right."

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"I'm loving loving OneSkin as a moisturizer for my hands and the reason is because it works with those zombie cells, those senescent cells that really affect every other thing that they bump into with oxidative stress."

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"What I do is I cleanse my face and then instead of doing the watery stuff, I do a one skin, which has an OS1 peptide."

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"I'm loving this as a moisturizer. And I don't use this as a moisturizer without an active ingredient on first. This is the OneSkin OS-01 peptide. How this works, think about it like fasting for your skin. It helps with those senescent cells, those zombie cells. So when your skin is dying, you've got these dying cells and sometimes just like zombie cells within your body, they get pissed off and cause oxidative stress and bump into everything else and then everything just goes downhill."

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"It's literally [...] helped to rebuild the skin barrier on my neck. Because our neck skin is very different than our body skin or our face skin, right? It doesn't secrete oil. It secretes water. Our face secretes oil. So I have over the years, when I was perimenopausal, kept doing my same skincare routine, and without the [...] moisture that happens with the estrogen drop, all of a sudden you eat up your skin barrier. This type of moisturizer has really helped."

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"I'm loving this as a moisturizer. And I don't use this as a moisturizer without an active ingredient on first. This is the one skin OS-01 peptide. How this works, think about it like fasting for your skin. It helps with those senescent cells, those zombie cells. So when your skin is dying, you've got these dying cells and sometimes just like zombie cells within your body, they get pissed off and cause oxidative stress and bump into everything else and then everything just goes downhill."

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"One Skin is an OS1 peptide, the longevity peptide, that diminishes and gets rid of senescent, or zombie, cells. Those cells with oxidative stress cause irritation and inflammation to everything around them, so it's important to clear them out before adding other products, otherwise you're feeding a dying cell instead of getting product to the cells that need it."

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"This is by OneSkin, a peptide called OS-01. I put this on first on the neck to get rid of the senescent cells, the zombie cells that are about to die. I do this at night, then follow with a retinoid, then a barrier cream, sandwiching the retinoid in between so it does not dry out or irritate the neck."

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"Um, I love the new I I love the one skin oso1 peptide. That is something that I use throughout."

Dr Dray

2.69M subs

~Mixed

"I think OneSkin Face Lotion is a hundred dollar niacinamide containing lotion for the face. What is there about that that is any different from any of the thousands of niacinamide containing moisturizers on the market that you can get for twenty bucks, fifteen bucks, five bucks, at any drugstore or Target? I just think it's all marketing essentially. I would not go for that."

Dr. Mamina

283k subs

~Yay

"One skin, their line has an amazing peptide that also addresses senescent cells. Lines like these are focusing on improving how skin cells behave, not just how skin looks. This is very aligned with longevity science."

Sincerely Miss Ash

196k subs

~Yay

"I really haven't used anything like this before in terms of the technology that this contains. This really is next level in skincare technology. This is scientifically proven to get to the root cause of skin aging. This has a senescence blocking peptide that helps to get to that root cause of aging. So it's going to help stimulate collagen. It's going to help with elasticity, softening, and preventing fine lines and wrinkles and just giving more of that rejuvenated look and feel to the skin."

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"This is the topical supplement for the face. Now, this is very different, very unique, next level in skin care technology. Honestly, this is very advanced and it's actually scientifically proven to get to the root cause of skin aging where this is going to help give more of that youthful healthy complexion."

AliceintheRabbitHole

59k subs

~Mixed

"Looking at their funded studies, the research was well designed, but I ended up feeling like it might just show that good moisturizing ingredients work well rather than that their OS01 peptide specifically is amazing. My bottom line is I don't think these are bad products, I actually think they're well made, I appreciate that they're fragrance free, and I like peptides, but I don't think I'm the target audience, so these are out for me."

Dr. Sam Ellis

902k subs

~Yay

"This is a moisturizer I've been enjoying a lot lately. And if you're not familiar with OneSkin, they're kind of like a biotech skin care company hybrid that's based here in the Bay Area. They have a proprietary peptide that helps with cellular aging and basically helps stop the aging signaling that happens between your cells. So, a very unique peptide that is not offered in other skincare, which is why I wanted to give you an option to incorporate it into your anti-aging routine."

Dr. Jenny Liu

324k subs

~Yay

"I've been using it for 6 months now and definitely have noticed a better quality to my skin barrier. What is in this product is the OS-01 peptide which is a very unique peptide that basically cleans out the old senescent cells. As we age in all of our organs we have cells that basically don't work as well, they get older and also cells that get damaged and kind of build up and that buildup of older damaged cells contributes to aging."

Doctor Anne

56k subs

~Mixed

"I am skeptical when it comes to high price skincare, and I think your best bet to age healthier or preserve the health of your skin while aging is to wear sunscreen, moisturize regularly, and make healthy lifestyle choices. But I am willing to give it a go, because I've lost quite a bit of weight over the last year and a half, so if anything could make the skin on my body reverse age, that would be much appreciated."

Skin Obsessed Mary

33k subs

~Yay

"I switched from a super expensive Augustinus Bader moisturizer to a One Skin moisturizer that's about half the price. It's still pricey, but I'm enjoying it even more. [...] One Skin has now taken Bader's spot, and [...] in my opinion it is worth every single penny."