Name: OneSkin OS-01 Face Topical Supplement
Brand: OneSkin
Rating: 84.0 (8 reviews)

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored

Darnell Cox | 50+ Healthy Aging Expert

54k subs · 559 devotees

✓Approved

"I'm putting on One Skin. This is an OS-01 peptide. I am obsessed with this. And the reason is because, well, number one, it changed my skin. It really did. I put little dots everywhere, rub this around a little bit, and then press it into the skin."

All 7 takes from Darnell Cox | 50+ Healthy Aging Expert

Over 30 and ready to master the ultimate MORNING skincare routine? 🎙️Join me for an IG Live Show

What's in my Travel Bag?

"I love OneSkin. It has changed my skin barrier. I use it on my neck and face after everything else."

At-Home Body Treatments

"This is OneSkin, which is an OS-01 peptide. I did a whole show on peptides and how they're kind of like the text messengers of our body. They tell us what to do. This OS-01 peptide really kind of helps to eliminate senescent cells, which are those zombie cells that create oxidative stress. So it helps to, it's not like it exfoliates, but it helps to rid your skin of those damaged cells, which then continues to damage the skin cells around it. So it's great in protecting that skin barrier, and it's great on top of an already active ingredient. Would I argue that this is an active ingredient? I would, but it's not enough. You can do both. It's a great way to spread out that product of a retinoid."

All of your pressing questions answered in today’s Instagram live show!

"I'm obsessed with this brand, OneSkin, because the way that it's working, I swear it's repaired my skin barrier on my neck. It's a moisturizer and yes it's a peptide and so it does some sort of heavy lifting in terms of senescent cells and zombie cells without the irritation of exfoliation from retinoids. But it's not an active ingredient that is, you're done, that's all you need right."

Top 10 Skincare Mistakes

"I stick with the basics, which is simple wash, retinoids at night, followed by a peptide that I'm loving called OneSkin OS-01. It's on my ultimate skincare protocol."

All of your pressing questions answered in today’s Instagram live show!

"I'm obsessed with this brand, OneSkin, because the way that it's working, I swear it's repaired my skin barrier on my neck. It's a moisturizer and yes it's a peptide, and so it does some sort of heavy lifting in terms of senescent cells and zombie cells without the irritation of exfoliation from retinoids. But it's not an active ingredient that is, you're done, that's all you need, right."

Want younger-looking hands?🙌🏻 🎙️Tune into my IG Live Show where I’ll be Microneedling while

"I'm loving loving OneSkin as a moisturizer for my hands and the reason is because it works with those zombie cells, those senescent cells that really affect every other thing that they bump into with oxidative stress."

Dr. Daniel Sugai

716k subs · 23k devotees

✓Approved

"OneSkin has done a good job with their science-backed OS-01 peptide."

All 9 takes from Dr. Daniel Sugai

Things I Actually Do for Anti-Aging (Dermatologist Routine)

"OneSkin has done a good job with their science-backed OS-01 peptide."

Best Facial Moisturizers of 2025

"OneSkin OS-01 Face Topical Supplement has the OS1 peptide. This company has been founded by PhDs and has studies backing up their peptide that will clear senescent cells that are no longer dividing, not adding much to your anti-aging game. It's actually causing more inflammation and damaging our collagen. So if we clear those cells out, we can have collagen production at a more efficient rate. I like this one a lot for my mature users. It does come out as a thicker texture. It's nice to seal in your vitamin C serum or your retinoid and it will help boost your collagen. So it is a higher price point, but very nice, very nourishing. I like the texture."

Dermatologist Explains: How to Treat Neck Wrinkles and Tech Lines

"OneSkin has a proprietary OS-01 peptide that helps clear out the old cells that don't regenerate and it helps reverse biological age. OneSkin has been founded by PhDs and they do have papers that support their peptide that pretty much tell your skin cells to make more collagen, which is great. It's a little bit pricey but I like that there's evidence behind this."

Skincare Secrets to Manage Crepey Skin from a Dermatologist

"One skin being a nice one with the OS-01 peptide that has been shown to clear out the old non-regenerating cells out and helps stimulate collagen production. Those peptides will be a cell signal to tell your skin to make more collagen which is excellent. I would recommend those products. The One Skin you want to look for body, I have eye and face right here but I also have body somewhere, but you can use that over say your hyaluronic acid and that will help, and your peptide moisturizers will hopefully give you long-term benefits."

Dermatologist Explains: Anti-Aging Skincare Routine By Age

"The one that has great science, I was able to look through the papers is OneSkin. So their face supplement, they have a sunscreen, but they also have just a face moisturizer and a body moisturizer. So that's something you can consider to actually reverse the biological age of your skin, but you're paying for it. But I love that the PhDs that founded the company have sent me studies. I was able to look through the studies and I like the products and so I use their sunscreen and their moisturizers quite a bit."

Retinoid Irritation Explained by a Dermatologist | Skin Barrier Adaptation Science

"Here's the OS-01 peptide by OneSkin. This is a face supplement just to seal it all in and get a little bit of a collagen boost. Remove those old senescent cells. We talked about zombie cells where you have cells that are just party poopers that came to the party and aren't really having fun. They're just taking up space. They're not dividing. They're not increasing collagen or fibroblast activity. They might even be spewing negativity at the party being party poopers and a bunch of Eeyores by releasing inflammatory cytokines and damaging our collagen. So what the OS-01 peptide does, it helps clear those out."

Discover How You're Aging Your Skin & Ways To Turn Back The Clock

"The brand that I discovered in 2024 that has impressed me is OneSkin. So their face supplement, very nice, and it has their proprietary OS-01 peptide. It has studies backing it that will help with your biological age and clear out senescent non-regenerating cells. I've been impressed by this brand."

Overhyped Skincare Ingredients for Collagen Boosting- Dermatologist Reviews

"OneSkin has great peptides that they were able to show me data, the evidence behind it that they work really well in the skin."

Skincare Mistakes and Trends of the Year

"I'm really liking peptides in my skin care so we can simplify our routine. OneSkin has a science-backed OS-01 peptide in their eye cream, their body and facial moisturizers, their sunscreens. I love that they have transparent studies behind that peptide and cell signaling clearing out old non-regenerating cells and making way for regenerating cells so you can actually improve your biological age of the skin. That's really cool but you're paying for it."

Dr. Mamina

277k subs · 566 devotees

✓Approved

"One skin, their line has an amazing peptide that also addresses senescent cells. Lines like these are focusing on improving how skin cells behave, not just how skin looks. This is very aligned with longevity science."

Sincerely Miss Ash

194k subs · 4k devotees

✓Approved

"I really haven't used anything like this before in terms of the technology that this contains. This really is next level in skincare technology. This is scientifically proven to get to the root cause of skin aging. This has a senescence blocking peptide that helps to get to that root cause of aging. So it's going to help stimulate collagen. It's going to help with elasticity, softening, and preventing fine lines and wrinkles and just giving more of that rejuvenated look and feel to the skin. When you're consistent with this, like within a week to two weeks, you really notice that your skin does look more rejuvenated. It looks brighter. It just looks really healthy. This is very nourishing. It just feels so comforting on the skin and it does help to repair your skin. Whether your skin barrier is compromised or not, this is great to use on an everyday basis to keep your skin nice and healthy and repaired. It has hyaluronic acid, niacinamide, and allantoin. The anti-aging technology that this contains is something that I've never tried before. It's going to be great for fine lines and all of that good stuff. A great preventative product to use."

Dr. Jenny Liu

316k subs · 5k devotees

✓Approved

"What first caught my attention on this brand is the publication on this peptide in reputable scientific journals and I found it really fascinating and I started using it and then I just fell in love with the texture. I've been using it for 6 months now and definitely have noticed a better quality to my skin barrier. What is in this product is the OS-01 peptide which is a very unique peptide that basically cleans out the old senescent cells. As we age in all of our organs we have cells that basically don't work as well, they get older and also cells that get damaged and kind of build up and that buildup of older damaged cells contributes to aging. In the skin it's the same concept where you have damaged collagen and elastin that build up and that contributes to the loss of elasticity, the creepy skin, fine lines and wrinkles. So this peptide essentially goes in and kind of cleans out the old senescent cells, improves skin turnover and then indirectly promotes collagen and elastin production at the same time improving the integrity of our skin barrier and skin barrier health so our overall skin quality is better and the appearance of our skin looks better as well. In addition it also contains plant-derived oils that have antioxidant nourishing benefits along with niacinamide as well as azelaic acid and hyaluronic acid. I really love the creamy texture of the serum."

Beyond50Skin

31k subs · 1k devotees

✓Approved

"I've been using that twice a day and their moisturizer, both formulas have their OS-01 peptide that's supposed to help combat senescent cells or our aging dying cells. So I really like the formulas, they're super hydrating."

All 2 takes from Beyond50Skin

Get RID OF SUN SPOTS (New Fall Anti-Aging OVER 50 Skincare Routine)

"I'm using the OneSkin moisturizer if I'm doing an evening where I'm doing my exfoliation treatment by dermal I also put this moisturizer on over it but I let it dry down a bit. This is the same formula that I'm using in the morning and the way they recommend using it is twice a day so I can see if there's an actual difference in a couple months using the formula as recommended."

Thin Deflated LIPS OVER 50? Do This Now!

Allie Glines

830k subs · 36k devotees

✓Approved

"It has peptides, it has ceramides, it's supposed to give you visibly firmer, lifted, and smoother skin, and I swear my skin's loving whatever is happening here. This is like the first step and this is like the last step unless I'm using a face oil at night. Obsessed, love these so much."

Skin Obsessed Mary

33k subs · 4k devotees

~Mixed

"Unlike the body, the results here were a little bit more subtle. At one point, I deliberately stopped using it to see if I noticed the absence of this in my routine. Well, I did. My skin looked slightly duller, like less resilient somehow. Nothing dramatic, but enough that I noticed. So this quietly worked its way back into my constant rotation. Now, I don't use this as a moisturizer, which is what I think it was intended for. For me, it works much better layered as like a peptide serum underneath richer products. So for me, that's actually been the sweet spot. This one has now survived the testing phase, and that actually says a lot."

OS-01 Face Topical Supplement.

84%

What the gurus are saying.

Similar products worth a look.

This product, in the news.

This week's top beauty news, in your inbox.