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OneSkin

OS-01 Eye Topical Supplement.

OneSkin OS-01 Eye Topical Supplement
Eye Care

About this product

A rich eye cream topical supplement formulated with a high concentration of the proprietary OS-01 peptide, designed to target signs of aging around the delicate eye area.

Full ingredients

Guru Score

78%

Yay

7 experts · Moderate agreement
7Gurus
6Yay
1Mixed
0Nay
#15 in Eye CareSee the ranking →

What they liked

  • Works well under makeup
  • Lasts several weeks per bottle

What they flagged

  • Pump dispenses too much product at once
  • Product hardens inside the pump opening
  • Expensive for unproven results

What the gurus are saying

The high concentration of OS-01 peptide in this eye formula earns consistent praise for visibly reducing fine lines and crinkles, with several gurus noting they repurchased after the first use. The cream is notably rich and thick yet absorbs quickly and works well under makeup, making it practical for daily morning application. Experts emphasize that the thinner, more delicate eye skin benefits from this specialized, more potent formulation compared to the brand's facial serum.
Synthesized from 7 expert reviews · most recent take May 2026

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
Mixed
"The eye cream I'm using right now is the OneSkin OS-01 Eye Topical Supplement. You might wonder why because I said in my review that I wouldn't spend that much money on it and I still stand by that. But it has a lovely texture. I really enjoy how it feels on the skin. So, no need to toss it despite still standing to the fact that I wouldn't repurchase it."
All 2 takes from Doctor Anne
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"The eye cream I'm using right now is the OneSkin OS-01 Eye Topical Supplement. You might wonder why because I said in my review that I wouldn't spend that much money on it and I still stand by that. But it has a lovely texture. I really enjoy how it feels on the skin. So, no need to toss it despite still standing to the fact that I wouldn't repurchase it."
OneSkin OS 01 EYE Topical Supplement Review: Are Zombie Cells Making You look Older? | Doctor Anne
"OneSkin OS-01 Eye Topical Supplement contains the highest concentration of their OS-01 Senescence Blocking Peptide, also known as Decapeptide-52, plus two additional peptides, SH-Polypeptide-121 and Acetyl-Hexapeptide-8 (Argireline), along with Shea Butter, Squalane and oils, Glycerin, Hyaluronic Acid, Panthenol, Niacinamide, Coffee Extract, and Coenzyme Q10. The studies behind it have a very small sample size, a few other flaws, and results that weren't that impressive, and the whole marketing and narrative around it don't sit right with me, so I'd firmly put it into the experimental ingredient category, definitely not a routine staple. The cream itself is off-white, has no noticeable scent, and a beautiful, silky smooth texture that sinks in within seconds. I didn't get along too well with the pump packaging: one pump gave way too much product so you had to be careful not to waste it, and even using it every night I still had a plug forming inside the opening where the product would harden [...] within 24 hours. Complaints aside, the product itself is absolutely beautiful, a dream to apply, feels surprisingly rich but still sinks in within seconds, no tackiness, no pilling, and could be used morning and night as it worked under makeup as well. It [...] has a lovely texture and a really nice ingredient list, but for me doesn't warrant the hefty price tag of 124 € a bottle. The story behind it is nice, but in my opinion not convincing enough to pay that much, and after using it consistently for two months every night, my eyes don't look any less aged than they did before. If you have the money to spare and want a rich, non-greasy, hydrating eye cream, go for it, but if it is results you are after, a retinol containing eye cream will probably give you more bang for your buck."
Yay
"OneSkin also makes an eye cream which I like but my favorite of all time and it's expensive but man it's good."
All 4 takes from Darnell Cox | 50+ Healthy Aging Expert
Over 30 and ready to master the ultimate EVENING skincare routine? 🎙️Join me for an IG Live Show
"OneSkin also makes an eye cream which I like but my favorite of all time and it's expensive but man it's good."
All of your pressing questions answered in today’s Instagram live show!
"This one by OneSkin uses a peptide OS-01. It helps with all the zombie and senescent cells. It's amazing. But this alone is not an active ingredient; peptides alone are not enough for your skin. I'm obsessed with this brand OneSkin because of the way that it's working. I swear it's repaired my skin."
All of your pressing questions answered in today’s Instagram live show!
"This one by OneSkin uses a peptide OS01, it helps with all the zombie and senescent cells, it's amazing. But this alone is not an active ingredient. Peptides alone are not enough for your skin. I'm obsessed with this brand, OneSkin, because they're really the way that it's..."
Over 30 and ready to master the ultimate skincare routine? 🎙️Join me for an IG Live Show where
"OneSkin just came up with one for the eyes."
Yay
"I used it repeatedly for over a year and then I started using the eye cream and the face cream because I'm a huge eye cream person anyway and the very first time I used it I got on that day and I ordered another one. It's got that consistency that I like, the thickness. It's everything that I wanted in a cream. So I'm kind of hooked on it."
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"Their eye cream has the proprietary peptide just like the facial supplement does. It's a little bit thicker but it has a more potent amount because this area of our skin is a little bit different than the rest of our face. They also decided to increase the amount of OS1 peptide and the potency of the eye cream because this is the area that really crinkles and wrinkles more than any other area. The OS1 peptide helps with our senescent cells. When our skin gets damaged it goes into either repair or it dies off, but it also can go into senescence where it no longer replicates because it has damage. It also starts the inflammation cascade. The senescent cells send out these signals so that our immune system can come in and sweep everything away."
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"I put away my Dermatology eye cream that I love and I'm using this one. [...] These have been lasting, I'm in it 5 weeks and they feel like maybe they're 2/3 done. [...] This is a little bit more concentrated than the facial topical serum."
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"I've been using the OneSkin eye cream twice a day along with their moisturizer. Both formulas have their OS-01 peptide that's supposed to help combat senescent cells or our aging dying cells. I really like the formulas, they're super hydrating."
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"I used it repeatedly for over a year and then I started using the eye cream and the face cream because I'm a huge eye cream person anyway and the very first time I used it I got on that day and I ordered another one. It's got that consistency that I like, the thickness. It's everything that I wanted in a cream. So I'm kind of hooked on it."
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"I like this, but I actually saw more difference in their topical face supplement and body supplement than I did. So I'm kind of on the fence whether I'll repurchase this because it's definitely a bougie buy."
Yay
"I'm kind of locked in with OneSkin's OS-01 Eye Topical Supplement. I started using this last year and I've been loving it and I am sticking to it. The OS-01 is one of the latest and most advanced peptides that really help your skin become more resilient to the aging process. It's creamy, which I really like because it's very moisturizing without being heavy. It does absorb beautifully, but at the same time it does plump out the fine lines. It just feels good. It's powerful, love it."
All 4 takes from Gothamista
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"I'm kind of locked in with OneSkin's OS-01 Eye Topical Supplement. I started using this last year and I've been loving it and I am sticking to it. The OS-01 is one of the latest and most advanced peptides that really help your skin become more resilient to the aging process. It's creamy, which I really like because it's very moisturizing without being heavy. It does absorb beautifully, but at the same time it does plump out the fine lines. It just feels good. It's powerful, love it."
2024 Skincare Faves!
"I've been using from OneSkin their OS-01. This was also my winter favorites although I kind of started in the summertime. I only put it there because the texture is more creamy and it's more dense, although I'm at a point now where I kind of want that all year round. Right now I kind of need it for me. This has been the perfect day night combination for well aging, slow aging eyes and repair. The OS-01 peptide is one of the latest, newest and most advanced in peptide technology and so that excites me."
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"The eye cream that I'm using right now and have been through this season is from OneSkin, their OS-01 Eye Topical Supplement. I love that it is a nice rich dense and moisturizing eye cream. This does however absorb really well and dries down really fast, so it is not like this heavy greasy thing at all. It works well under makeup. I think as my skin around here is just feeling like it's getting thinner more brittle, I kind of appreciate the more moisturizing eye creams. [...] There's my love for peptides and they have one of the most advanced interesting and proven peptides in their formulas. They developed the OS-01 peptide that has been in the making for seven years and it's the only proven C-blocking peptide. Senescent cells are associated with aging, so this peptide helps switch them off so that the skin can start behaving like its younger self again. The formula helps with so many other aspects of aging skin especially around the eye area. I use this all around my under eyes as well as my brow bone. I feel so far this has been great and I notice subtle changes already. [...] I usually apply it especially around the center of my neck and there's definitely a lot less crinkling around here and also on my thin eyelids."
My Ultimate At-Home Facial
"For eyes I usually use my Tretinoin formula but this is a trade-off day so instead I'm going to use from OneSkin their OS-01 Eye Topical Supplement. This is a rich creamy peptide formula with a high concentration of a new peptide OS-01 which claims to be the first scientifically proven to reverse skin's biological age."
Yay
"I do like eye products that have caffeine or a higher concentration of peptide. For example, OneSkin OS-01 Eye Topical Supplement has a higher concentration of peptides in their eye products because this is very thin delicate skin. It's the thinnest skin of our body, the eyelid skin, so we have to take care of that and you do need specialized products for that area."
Yay
"Eye products are really difficult for me because the skin is so dehydrated and crepey now. I notice immediately when something isn't doing enough. I have very high standards here. And this one does. It's creamy, it's hydrating, and over time, I think it's genuinely helped the overall quality of the skin there. So yes, I already have an open one that I'm using every day. There was never a question that I would."
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"Eye products are really difficult for me because the skin is so dehydrated and crepey now. I notice immediately when something isn't doing enough. I have very high standards here. And this one does. It's creamy, it's hydrating, and over time, I think it's genuinely helped the overall quality of the skin there. So yes, I already have an open one that I'm using every day. There was never a question that I would."
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"It's the OneSkin OS-01 Eye Topical Supplement. I talked a lot about OneSkin this year and their OS-01 peptide. That peptide neutralizes senescent cells, which destroys healthy cells around it. [...] This particular product has the highest concentration of the OS-01 peptide to combat the signs of aging around the eyes. This product is really nice and rich and just absolutely beautiful. The first time I tried it because they sent it to me in PR, I got online and bought another one the very next day. [...] I use this every morning."
My Winter MORNING Skincare Routine for Mature Skin
"So this one is the OneSkin OS-01 Eye Topical Supplement. And this one I consistently come back to because it's doing more than just moisturizing. It contains their OS1 peptide designed to target senescent cells, which are those zombie cells that contribute to visible aging. I love it because it's rich but not heavy. It's firm without drying. And I never get milia from it, which can sometimes happen around the eyes. Like I have gone through so many of these things I couldn't even tell you."
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"I talk a lot about One Skin because I love that their products go after senescent cells, also called zombie cells that degrade our healthy skin cells as we age. I've probably gone through two or three of the OS1 eye supplements. It's creamy, it's hydrating, and I just love it."
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"I use this every day. I use this every morning and I have for months and months. It contains the highest level of their OS1 peptide which reduces senescent cells, those pesky zombie cells that terrorize all the healthy skin cells around it."
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"I apply my OneSkin OS-01 Eye Topical Supplement which contains the OS-01 peptide which kills senescent cells. That is like the double espresso shot for my eyes. But they are feeling plumper and more alive."
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"This is also by OneSkin. It is their OS-01 eye supplement. For the record, no one needs an eye cream, except I need an eye cream, and that's all I'm saying on the matter. I'm pretty committed, but this is not your typical eye cream. It uses the same OS-01 peptide as the face version, but it has a higher concentration. Plus, it has extras like Arjgerolene, CoQ10, and caffeine, which deals with puffiness and fine lines. It's firming around that eye area, but it is never greasy, and there is no millia. This has been my go-to for ages."
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"This is also by OneSkin. It is their OS-01 eye supplement. Now, for the record, no one needs an eye cream, except I need an eye cream, and that's all I'm saying on the matter. I'm pretty committed, but this is not your typical eye cream. It uses the same OS-01 peptide as the face version, but it has a higher concentration. Plus, it has extras like Arjgerolene, CoQ10, and caffeine, which deals with puffiness and fine lines. It's firming around that eye area, but it is never greasy, and there is no millia. This has been my go-to for ages."
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"This one is also a new addition. It is by OneSkin, it is the OS-01 Eye Topical Supplement, and this was love at first use. I mean I tried it and immediately I got online and bought another one like that day. In fact I also got another one during the Black Friday sale that's waiting for me in California. This is what keeps my eye area hydrated and plump. So whereas the serum is all about the texture and smoothing everything else, this is really about plumping it up. And I have super high hopes for that OS-01 peptide in relation to longer term plumping and reducing of fine lines."
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"I love my OneSkin and when I stop my OneSkin I totally know a difference. I'm on their subscription, I get the body, the eye, and this every about three months is what how long this lasts me. This gets rid of senescent cells, and senescent cells are what linger around, those cells that are like those aging cells, dead cells, and we do have a process that gets rid of those, but of course as we age everything is not working efficiently, so this helps with that. And I totally see a difference in just overall good skin health and plumpness of the face."
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"Number four on the list is glycolic acid. This is my go-to exfoliant. It's one of those ingredients that just earns its place in my grown-up skincare routine. [...] Glycolic is that little tiny janitor that sweeps away all the dead cells on the surface so that new fresh ones can shine through. It smooths texture, brightens tone, and even helps other ingredients like peptides and antioxidants work even better because they can actually get where they need to go. I would recommend you start slow. Once a week is plenty until your skin builds up tolerance. [...] Glycolic isn't just exfoliating. It also tells your skin to make more collagen and hyaluronic acid. So over time, you get firmer, plumper, and more hydrated skin. For me, it's one of those quiet heroes."
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"I use each of these products every single day. I mean, this makes me so happy to get this in PR."
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"I'm on my second bottle of both the face and the eye supplement and I have two more bottles of each standing by. I did stock up during the Black Friday sale. I use these in my morning routine and I'm really really anxious to see the long-term results."
⭐️ Title
"I got their bundle which has the face supplement which I use as a serum, the eye cream as well as the body lotion. Now I haven't really been using these long enough to truly give my feedback."
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"This was designed to thicken the under eye skin area to boost hydration and reduce dark circles as well as those fine lines. But for me, it's all about the texture. Texture is everything. So, I want it to have the right thickness and I want it coupled with hydration and plumpness. That's what I'm looking for. And the very first time I applied this, I immediately got online and I bought another one. And I have used it every day since."
Yay
"I also was sent the OneSkin OS-01 Eye Topical Supplement and this has been an eye cream that I've been incorporating quite a bit in my routine as well. This was not a product that I thought I would be obsessed with but I do feel like my skin looks so nice since using these and I literally use these every day."
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"I also was sent the OneSkin OS-01 Eye Topical Supplement and this has been an eye cream that I've been incorporating quite a bit in my routine as well. This was not a product that I thought I would be obsessed with but I do feel like my skin looks so nice since using these and I literally use these every day."
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"I also really enjoyed the OneSkin OS-01 Eye Topical Supplement this year. I noticed a big difference when I was using this consistently, but I will say I have used this eye cream more."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is OneSkin OS-01 Eye Topical Supplement?

A rich eye cream topical supplement formulated with a high concentration of the proprietary OS-01 peptide, designed to target signs of aging around the delicate eye area.

Is OneSkin OS-01 Eye Topical Supplement worth it?

Mostly yes. 6 of the 7 gurus who reviewed it give it their stamp of approval, for a Guru Score of 78%.

What is OneSkin OS-01 Eye Topical Supplement's Guru Score?

OneSkin OS-01 Eye Topical Supplement holds a Guru Score of 78%. That is our read on how warmly the experts talk about it, based on the verdicts of 7 expert reviewers we have collected.

Who is OneSkin OS-01 Eye Topical Supplement best for?

OneSkin OS-01 Eye Topical Supplement is generally suited to mature skin.

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