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OneSkin

OS-01 Eye Topical Supplement.

OneSkin OS-01 Eye Topical Supplement
Supplements

About this product

A rich eye cream topical supplement formulated with a high concentration of the proprietary OS-01 peptide, designed to target signs of aging around the delicate eye area.

Best for

Type

SupplementsCream

Formula notes

Fragrance-freeContains drying alcohol

Full ingredients

Guru Score

79%

Approved

7 experts · Strong agreement
7Gurus
5Approved
2Mixed
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What the gurus are saying

The high concentration of OS-01 peptide in this eye formula earns consistent praise for visibly reducing fine lines and crinkles, with several gurus noting they repurchased after the first use. The cream is notably rich and thick yet absorbs quickly and works well under makeup, making it practical for daily morning application. Experts emphasize that the thinner, more delicate eye skin benefits from this specialized, more potent formulation compared to the brand's facial serum.
Synthesized from 7 expert reviews · most recent take April 2026
Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved takes Critical takes Mixed takes Hide sponsored
Approved
"OneSkin also makes an eye cream which I like but my favorite of all time and it's expensive but man it's good."
Approved
"It's the OneSkin OS-01 Eye Topical Supplement. I talked a lot about OneSkin this year and their OS-01 peptide. That peptide neutralizes senescent cells, which destroys healthy cells around it. This particular product has the highest concentration of the OS-01 peptide to combat the signs of aging around the eyes. This product is really nice and rich and just absolutely beautiful. The first time I tried it because they sent it to me in PR, I got online and bought another one the very next day. I use this every morning."
All 3 takes from Skin Obsessed Mary
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"It's the OneSkin OS-01 Eye Topical Supplement. I talked a lot about OneSkin this year and their OS-01 peptide. That peptide neutralizes senescent cells, which destroys healthy cells around it. This particular product has the highest concentration of the OS-01 peptide to combat the signs of aging around the eyes. This product is really nice and rich and just absolutely beautiful. The first time I tried it because they sent it to me in PR, I got online and bought another one the very next day. I use this every morning."
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"Number four on the list is glycolic acid. This is my go-to exfoliant. It's one of those ingredients that just earns its place in my grown-up skincare routine. Glycolic is that little tiny janitor that sweeps away all the dead cells on the surface so that new fresh ones can shine through. It smooths texture, brightens tone, and even helps other ingredients like peptides and antioxidants work even better because they can actually get where they need to go. I would recommend you start slow. Once a week is plenty until your skin builds up tolerance. Glycolic isn't just exfoliating. It also tells your skin to make more collagen and hyaluronic acid. So over time, you get firmer, plumper, and more hydrated skin. For me, it's one of those quiet heroes."
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"I remember the eye cream because I'm a huge eye cream person anyway. And the very first time I used it, I got on that day and I ordered another one. It's got that just that consistency that I like, the thickness. It's just it's everything that I wanted in a cream."
Approved
"I used it repeatedly for over a year and then I started using the eye cream and the face cream because I'm a huge eye cream person anyway and the very first time I used it I got on that day and I ordered another one. It's got that consistency that I like, the thickness. It's everything that I wanted in a cream. So I'm kind of hooked on it."
All 4 takes from Beyond50Skin
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"Their eye cream has the proprietary peptide just like the facial supplement does. It's a little bit thicker but it has a more potent amount because this area of our skin is a little bit different than the rest of our face. They also decided to increase the amount of OS1 peptide and the potency of the eye cream because this is the area that really crinkles and wrinkles more than any other area. The OS1 peptide helps with our senescent cells. When our skin gets damaged it goes into either repair or it dies off, but it also can go into senescence where it no longer replicates because it has damage. It also starts the inflammation cascade. The senescent cells send out these signals so that our immune system can come in and sweep everything away."
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"I put away my Dermatology eye cream that I love and I'm using this one. These have been lasting, I'm in it 5 weeks and they feel like maybe they're 2/3 done. This is a little bit more concentrated than the facial topical serum."
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"I've been using the OneSkin eye cream twice a day along with their moisturizer. Both formulas have their OS-01 peptide that's supposed to help combat senescent cells or our aging dying cells. I really like the formulas, they're super hydrating."
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"I used it repeatedly for over a year and then I started using the eye cream and the face cream because I'm a huge eye cream person anyway and the very first time I used it I got on that day and I ordered another one. It's got that consistency that I like, the thickness. It's everything that I wanted in a cream. So I'm kind of hooked on it."
Mixed
"OneSkin OS-01 Eye Topical Supplement contains the highest concentration of their OS-01 Senescence Blocking Peptide, also known as Decapeptide-52, plus two additional peptides, SH-Polypeptide-121 and Acetyl-Hexapeptide-8 (Argireline), along with Shea Butter, Squalane and oils, Glycerin, Hyaluronic Acid, Panthenol, Niacinamide, Coffee Extract, and Coenzyme Q10. The studies behind it have a very small sample size, a few other flaws, and results that weren't that impressive, and the whole marketing and narrative around it don't sit right with me, so I'd firmly put it into the experimental ingredient category, definitely not a routine staple. The cream itself is off-white, has no noticeable scent, and a beautiful, silky smooth texture that sinks in within seconds. I didn't get along too well with the pump packaging: one pump gave way too much product so you had to be careful not to waste it, and even using it every night I still had a plug forming inside the opening where the product would harden within 24 hours. Complaints aside, the product itself is absolutely beautiful, a dream to apply, feels surprisingly rich but still sinks in within seconds, no tackiness, no pilling, and could be used morning and night as it worked under makeup as well. It has a lovely texture and a really nice ingredient list, but for me doesn't warrant the hefty price tag of 124 € a bottle. The story behind it is nice, but in my opinion not convincing enough to pay that much, and after using it consistently for two months every night, my eyes don't look any less aged than they did before. If you have the money to spare and want a rich, non-greasy, hydrating eye cream, go for it, but if it is results you are after, a retinol containing eye cream will probably give you more bang for your buck."
Approved
"The eye cream that I'm using right now and have been through this season is from OneSkin, their OS-01 Eye Topical Supplement. I love that it is a nice rich dense and moisturizing eye cream. This does however absorb really well and dries down really fast, so it is not like this heavy greasy thing at all. It works well under makeup. I think as my skin around here is just feeling like it's getting thinner more brittle, I kind of appreciate the more moisturizing eye creams. There's my love for peptides and they have one of the most advanced interesting and proven peptides in their formulas. They developed the OS-01 peptide that has been in the making for seven years and it's the only proven C-blocking peptide. Senescent cells are associated with aging, so this peptide helps switch them off so that the skin can start behaving like its younger self again. The formula helps with so many other aspects of aging skin especially around the eye area. I use this all around my under eyes as well as my brow bone. I feel so far this has been great and I notice subtle changes already. I usually apply it especially around the center of my neck and there's definitely a lot less crinkling around here and also on my thin eyelids."
All 2 takes from Gothamista
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"The eye cream that I'm using right now and have been through this season is from OneSkin, their OS-01 Eye Topical Supplement. I love that it is a nice rich dense and moisturizing eye cream. This does however absorb really well and dries down really fast, so it is not like this heavy greasy thing at all. It works well under makeup. I think as my skin around here is just feeling like it's getting thinner more brittle, I kind of appreciate the more moisturizing eye creams. There's my love for peptides and they have one of the most advanced interesting and proven peptides in their formulas. They developed the OS-01 peptide that has been in the making for seven years and it's the only proven C-blocking peptide. Senescent cells are associated with aging, so this peptide helps switch them off so that the skin can start behaving like its younger self again. The formula helps with so many other aspects of aging skin especially around the eye area. I use this all around my under eyes as well as my brow bone. I feel so far this has been great and I notice subtle changes already. I usually apply it especially around the center of my neck and there's definitely a lot less crinkling around here and also on my thin eyelids."
My Ultimate At-Home Facial
"For eyes I usually use my Tretinoin formula but this is a trade-off day so instead I'm going to use from OneSkin their OS-01 Eye Topical Supplement. This is a rich creamy peptide formula with a high concentration of a new peptide OS-01 which claims to be the first scientifically proven to reverse skin's biological age."
Approved
"I do like eye products that have caffeine or a higher concentration of peptide. For example, OneSkin OS-01 Eye Topical Supplement has a higher concentration of peptides in their eye products because this is very thin delicate skin. It's the thinnest skin of our body, the eyelid skin, so we have to take care of that and you do need specialized products for that area."
Mixed
"Speaking of OneSkin, I also really enjoyed their eye topical supplement this year. I noticed a big difference when I was using this consistently as well."
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Common questions

Frequently asked.

What is OneSkin OS-01 Eye Topical Supplement?

A rich eye cream topical supplement formulated with a high concentration of the proprietary OS-01 peptide, designed to target signs of aging around the delicate eye area.

Is OneSkin OS-01 Eye Topical Supplement worth it?

Mostly yes. 5 of the 7 gurus who reviewed it give it their stamp of approval, for a Guru Score of 79%.

What is OneSkin OS-01 Eye Topical Supplement's Guru Score?

OneSkin OS-01 Eye Topical Supplement holds a Guru Score of 79%. That is our read on how warmly the experts talk about it, based on the verdicts of 7 independent expert reviewers we have collected.

Who is OneSkin OS-01 Eye Topical Supplement best for?

OneSkin OS-01 Eye Topical Supplement is generally suited to mature skin.

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