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Modulating Glucosides.

NIOD Modulating Glucosides

About this product

A lightweight serum formulated with modulating glucosides designed to calm irritation, support skin barrier function, and provide hydration.

Best for

Sensitive skin

The Guru Index verdict

89%

Approved

Approved · 89%
3Reviewers
3Approved
0Mixed
0Skip

What the gurus are saying

Gurus consistently praise this as a fast-acting, essential serum for irritated, sensitive, or compromised skin. The recurring strengths are quick relief (within minutes), visible barrier repair, reduced redness, and the ability to buffer against active ingredients like retinoids and acids. The milky texture and versatility across face, neck, and body are frequently highlighted. Reviewers use it both as daily prevention for sensitive skin and as a targeted treatment during flare-ups or seasonal dryness, with no noted drawbacks mentioned.
Synthesized from 3 expert reviews

Key actives & flags

PeptidesSqualaneFragrance-freeAlcohol-free

Full ingredients

Aqua (Water), Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic/​Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-T-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl Tripeptide-8, Superoxide Dismutase, Sodium Pca, Pca, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Fruit/​Leaf Extract, Zingiber Officinale (Ginger) Root Extract

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored
Approved
"The modulating glucosides is the best bar none the best of the calming, soothing, and barrier supporting serums. You'll find it. It's just stunning. Modulating glucosides are fantastic at restoring barrier health, but the other ingredients they've used in here, I think, have really just turbocharged the results you see. After just two applications, your skin will be restored to its equilibrium. It won't be angry, red, irritated. It's a quick fix and you can either use this as a daily step in your skincare routine to kind of futureproof against irritation or you can use it like I do when your skin is irritated. Use it as a treatment. It's really up to you. But this is amazing after you've shaved as well. Apply this after you've shaved. You won't get the razor bumps. You won't get that irritation, the redness, the dryness. It's just a fantastic fantastic product. And you can use it on the face, the neck, the body, wherever you have irritation, sensitivity, and dry skin."
Top Pick: calming, soothing, and restorative serum
All 3 takes from Mad About Skin
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"This is a beautiful product and the formulation and technology in here is so amazing, it's like next level glucoside action which will really help protect the barrier function of the skin. If you're someone that gets a lot of redness, peeling, sensitivity, irritation, this is an absolute must. It's quite a lightweight serum but you put that on the skin morning and evening and it will honestly mean that you can use some higher strength actives in the rest of your routine without it damaging your skin barrier or causing too much sensitivity. This is the product that I will use if I'm using a higher potency retinoid, I'll use it alongside this just to make sure that I'm minimizing the risk of any side effects and it works every single time. If you have very sensitivity prone skin, use this twice a day year round. For others, I'd say buy it and have it on hand for those times where your skin goes through it, maybe you've overdone it with an active and you want to restore your barrier function, or the weather's changing and you've got some seasonal dryness and irritation, reach for the Modulating Glucosides. It's just an amazing product."
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"The modulating glucosides fixes it like that. Hands down the best calming, soothing, and restorative serum you will ever ever use. If you're someone that has very irritation prone skin year round, you might want to stock up because honestly, this will be the savior your skin is looking for. There are lots of really expensive and bougie calming and soothing serums out there. I don't think you need to splurge on them. I think, get this, your skin will love you. And it definitely just restores that equilibrium. Helps repair the skin barrier function and it's just an absolute holy grail for me in winter for some people year round."
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"The modulating glucosides is the best bar none the best of the calming, soothing, and barrier supporting serums. You'll find it. It's just stunning. Modulating glucosides are fantastic at restoring barrier health, but the other ingredients they've used in here, I think, have really just turbocharged the results you see. After just two applications, your skin will be restored to its equilibrium. It won't be angry, red, irritated. It's a quick fix and you can either use this as a daily step in your skincare routine to kind of futureproof against irritation or you can use it like I do when your skin is irritated. Use it as a treatment. It's really up to you. But this is amazing after you've shaved as well. Apply this after you've shaved. You won't get the razor bumps. You won't get that irritation, the redness, the dryness. It's just a fantastic fantastic product. And you can use it on the face, the neck, the body, wherever you have irritation, sensitivity, and dry skin."
Approved
"This is a great serum to have on hand for when you need it. But if you want to be consistent and use it every day, twice a day, then of course you can. This is actually great for those that have sensitive skin, dryness, flakiness, your skin is inflamed, it's red, it's really irritated. This will bring your skin back to life. It will bring it back to that normal state. It's very repairing. It keeps that skin nice and strong and healthy. It's also very hydrating as well. And if you have a lot of redness, it will subside on that rosiness as well. If you're starting tretinoin for the first time or retinol, glycolic acid, something like that that tends to dry out and irritate the skin, start using this alongside those actives to keep the skin as nourished as possible, keeping it hydrated and strong. This will help to prevent further dryness and irritation when you're using those actives. It has like this really nice comforting thick milky consistency that spreads across the skin so nicely. You can use this on your neck and your chest if you need to. And it always sits great with other skincare products and even your makeup. I feel like everybody should have this serum in their collection for when they need it."
All 4 takes from Sincerely Miss Ash
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"It has that nice milkiness to it where it provides a lot of moisture. It makes that skin barrier nice and strong and repaired and it just gives instant relief within a minute or so. Your skin feels a lot better and you just have that comfort again. So you can use this every day as a preventative or you can just use this when your skin needs it. I use this mostly in the winter months because that's when my skin is more compromised, it's more dry and it's feeling tight because of the drier, colder weather. That's when I start to incorporate this in my nighttime or in my morning routine. This always does the trick so this always has to be in my collection. I do feel like the Modulating Glucosides works quicker in terms of relieving that discomfort."
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"This is a great serum to have on hand for when you need it. But if you want to be consistent and use it every day, twice a day, then of course you can. This is actually great for those that have sensitive skin, dryness, flakiness, your skin is inflamed, it's red, it's really irritated. This will bring your skin back to life. It will bring it back to that normal state. It's very repairing. It keeps that skin nice and strong and healthy. It's also very hydrating as well. And if you have a lot of redness, it will subside on that rosiness as well. If you're starting tretinoin for the first time or retinol, glycolic acid, something like that that tends to dry out and irritate the skin, start using this alongside those actives to keep the skin as nourished as possible, keeping it hydrated and strong. This will help to prevent further dryness and irritation when you're using those actives. It has like this really nice comforting thick milky consistency that spreads across the skin so nicely. You can use this on your neck and your chest if you need to. And it always sits great with other skincare products and even your makeup. I feel like everybody should have this serum in their collection for when they need it."
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"The NIOD Modulating Glucosides is a great serum for hydration and to repair the skin barrier. If you have sensitive skin or you're using active ingredients that are causing your skin to have dryness, flakiness, redness, tightness, you have that burning sensation to your skin and your skin is just angry, this serum will bring your skin back to life. It will hydrate it and it will really help to repair that damaged, compromised skin barrier. This has a milky consistency that instantly relieves my skin every time I use it. This is honestly the only serum that I have ever used that gives me instant relief when my skin is at its angriest. This really is a quick-acting serum that works when your skin is in discomfort. It also helps to reduce redness as well. You can use this every day twice a day or you can just use it when you need it. This is also great to pair up with your active ingredients like tretinoin or retinol or glycolic acid. Use this with those actives to really help keep your skin comfortable and hydrated and repaired."
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"I picked up two because I am definitely going to be using this a lot more come the winter months as this is great for dry flaky irritated skin. If your skin is rosy and it's just angry, this is honestly one of the best serums on the market to instantly relieve your discomfort. This really does work and I love it. It always has to be a part of my skincare collection."
Approved
"If your skin is very irritated, it is singing, it is burning, it is itching, maybe you are having a flare-up of rosacea or of eczema, I would really suggest if your skin is in an extreme state of ailing go for Modulating Glucosides. Not only do they have more ingredients in here that are really made to address stinging, burning, itching and really relieve that on contact or very very fast. I have used this serum in the past for skin that is really ailing and it always works, it never fails me. When I get an eczema flare-up I will use this, even if I don't want to put it all over my face but I just have that flare-up. I get a lip eczema a lot, I will just put this on my lips just to relieve the itching and burning. The word for this is relief. It is a serum that really relieves the skin. Yes, with long-term use it strengthens your skin, it hydrates your skin, it fights dehydration, has some great antioxidants to it. It's a well-rounded serum that can be used in many instances, but if your skin is really ailing I would say just go for Modulating Glucosides."
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