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Modulating Glucosides.

NIOD Modulating Glucosides

About this product

A lightweight milky serum formulated with modulating glucosides, plant-based ceramides, amino acids, and botanical extracts designed to calm irritation, strengthen the skin barrier, and provide hydration.

Best for

Key actives

Formula notes

Fragrance-freeNo drying alcohol

Full ingredients

Guru Score

89%

Approved

4 experts · Moderate agreement
4Gurus
4Approved
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What the gurus are saying

This serum works almost immediately to relieve burning, itching, and redness, with reviewers reporting visible calm within minutes to an hour of application. The milky texture feels deeply comforting and pairs well with actives like tretinoin and retinoids, making it especially valuable for anyone managing irritation from stronger treatments or experiencing eczema or rosacea flare-ups. One reviewer noted results can be slightly hit-or-miss depending on the person, though the consensus strongly favors using it either daily as a barrier-support step or on standby for when skin is genuinely distressed.
Synthesized from 4 expert reviews · most recent take April 2026

Where to buy

How it works Independent by design. Every take comes from a creator we have no relationship with. We do not ask anyone to review, and affiliate links never move a score.
Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved takes Critical takes Mixed takes Hide sponsored
Mad About Skin
Mad About Skin
723k subs
✓Approved
"The Modulating Glucosides is the best bar none the best of the calming, soothing, and barrier supporting serums. You'll find it. It's just stunning. Modulating Glucosides are fantastic at restoring barrier health, but the other ingredients they've used in here, I think, have really just turbocharged the results you see. After just two applications, your skin will be restored to its equilibrium. It won't be angry, red, irritated. It's a quick fix and you can either use this as a daily step in your skincare routine to kind of futureproof against irritation or you can use it like I do when your skin is irritated. Use it as a treatment. It's really up to you. But this is amazing after you've shaved as well. Apply this after you've shaved. You won't get the razor bumps. You won't get that irritation, the redness, the dryness. It's just a fantastic fantastic product. And you can use it on the face, the neck, the body, wherever you have irritation, sensitivity, and dry skin."
Top Pick: calming, soothing, and restorative serum
All 7 takes from Mad About Skin
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"The Neod Modulating Glucosides is a total underappreciated hero product. This is phenomenal. I genuinely believe that everybody should have the Modulating Glucosides on hand for those times where our skin needs it. This has a beautiful blend of different ingredients to calm and soothe the skin. The ingredients that you get in the Modulating Glucosides you can't find in any other serum. It's the blend of different calming ingredients that really make this special and I think it's something truly unique in the skincare world. It's also not super expensive. Neod aren't the cheapest brand, but this is one of their more affordable products. If your skin is stressed out and screaming, apply this before you go to bed and you will wake up with your skin returned to equilibrium, this is phenomenal. You can either use it as a treatment when your skin is going through it, which is what I personally do, or if you're somebody that has very reactive and sensitive skin, use this as a daily step in your evening skincare routine to prevent inflammation and sensitivity."
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"This is one of the best on the market. You really have to read the full ingredients, which they break apart by each ingredient on their website, to truly appreciate how effective this serum is. I know people that say they've got super sensitive skin from going in with harsh exfoliants or higher actives. They've used this and within like 30 minutes the skin is restored, it's balanced. It just works like a miracle. If you've got super sensitive skin and you've struggled for years to get on top of that, try this. Incorporate it twice a day in your skincare routine and you'll see results after the first couple of days. It's amazing. Yes, it has a slightly higher price point, but for me I think that's worth it if it's what your skin actually needs. If you need advanced support and your skin craves that, this is a product that I definitely think is worth the investment."
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"Personally, it works really well for me. I prefer it to niacinamide, which I find quite irritating. And it does do great for oil control. So yes, I am a big fan of it. I would just always say it's a little hit and miss sometimes in terms of the results that you get."
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"This is a beautiful product and the formulation and technology in here is so amazing, it's like next level glucoside action which will really help protect the barrier function of the skin. If you're someone that gets a lot of redness, peeling, sensitivity, irritation, this is an absolute must. It's quite a lightweight serum but you put that on the skin morning and evening and it will honestly mean that you can use some higher strength actives in the rest of your routine without it damaging your skin barrier or causing too much sensitivity. This is the product that I will use if I'm using a higher potency retinoid, I'll use it alongside this just to make sure that I'm minimizing the risk of any side effects and it works every single time. If you have very sensitivity prone skin, use this twice a day year round. For others, I'd say buy it and have it on hand for those times where your skin goes through it, maybe you've overdone it with an active and you want to restore your barrier function, or the weather's changing and you've got some seasonal dryness and irritation, reach for the Modulating Glucosides. It's just an amazing product."
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"The Modulating Glucosides fixes it like that. Hands down the best calming, soothing, and restorative serum you will ever ever use. If you're someone that has very irritation prone skin year round, you might want to stock up because honestly, this will be the savior your skin is looking for. There are lots of really expensive and bougie calming and soothing serums out there. I don't think you need to splurge on them. I think, get this, your skin will love you. And it definitely just restores that equilibrium. Helps repair the skin barrier function and it's just an absolute holy grail for me in winter for some people year round."
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"It prevents those side effects and minimizes them. I use it when I need it. So I have it on standby. It's always on my vanity in my bathroom. When I get like maybe the shaving rash, the shaving bumps, maybe I get some irritation from an exfoliant or something, I'll slap this on afterwards. Gone. Literally gone. It is the best calming and soothing serum you will ever ever try. If you're in the market for the ultimate calming and soothing skincare experience, get the NIOD Modulating Glucosides. Second to none. It's just a miracle worker."
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"The Modulating Glucosides is the best bar none the best of the calming, soothing, and barrier supporting serums. You'll find it. It's just stunning. Modulating Glucosides are fantastic at restoring barrier health, but the other ingredients they've used in here, I think, have really just turbocharged the results you see. After just two applications, your skin will be restored to its equilibrium. It won't be angry, red, irritated. It's a quick fix and you can either use this as a daily step in your skincare routine to kind of futureproof against irritation or you can use it like I do when your skin is irritated. Use it as a treatment. It's really up to you. But this is amazing after you've shaved as well. Apply this after you've shaved. You won't get the razor bumps. You won't get that irritation, the redness, the dryness. It's just a fantastic fantastic product. And you can use it on the face, the neck, the body, wherever you have irritation, sensitivity, and dry skin."
Sincerely Miss Ash
Sincerely Miss Ash
195k subs
✓Approved
"This is a great serum to have on hand for when you need it. But if you want to be consistent and use it every day, twice a day, then of course you can. This is actually great for those that have sensitive skin, dryness, flakiness, your skin is inflamed, it's red, it's really irritated. This will bring your skin back to life. It will bring it back to that normal state. It's very repairing. It keeps that skin nice and strong and healthy. It's also very hydrating as well. And if you have a lot of redness, it will subside on that rosiness as well. If you're starting tretinoin for the first time or retinol, glycolic acid, something like that that tends to dry out and irritate the skin, start using this alongside those actives to keep the skin as nourished as possible, keeping it hydrated and strong. This will help to prevent further dryness and irritation when you're using those actives. It has like this really nice comforting thick milky consistency that spreads across the skin so nicely. You can use this on your neck and your chest if you need to. And it always sits great with other skincare products and even your makeup. I feel like everybody should have this serum in their collection for when they need it."
All 5 takes from Sincerely Miss Ash
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"It has that nice milkiness to it where it provides a lot of moisture. It makes that skin barrier nice and strong and repaired and it just gives instant relief within a minute or so. Your skin feels a lot better and you just have that comfort again. So you can use this every day as a preventative or you can just use this when your skin needs it. I use this mostly in the winter months because that's when my skin is more compromised, it's more dry and it's feeling tight because of the drier, colder weather. That's when I start to incorporate this in my nighttime or in my morning routine. This always does the trick so this always has to be in my collection. I do feel like the Modulating Glucosides works quicker in terms of relieving that discomfort."
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"NIOD Modulating Glucosides is a lifesaver, it's a gamechanging product that works almost immediately. If you're someone that's dealing with a lot of irritation, sensitivities, that burning itchy feel to your skin, it's really red and inflamed and dry and irritated, I'm telling you try this. This has that milky consistency that just feels so comforting when you put it on your skin, and I would say within 10 or 15 minutes or so your skin already feels better, that itch and that burning sensation has subsided. It really helps to limit down on some of that rosiness that we can experience as well. This has a lot of repairing ingredients but also it is extremely hydrating as well. I have used this in my morning routine many times so it does work great with sunscreen and makeup, but I do like to use this more so at night time."
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"This is a great serum to have on hand for when you need it. But if you want to be consistent and use it every day, twice a day, then of course you can. This is actually great for those that have sensitive skin, dryness, flakiness, your skin is inflamed, it's red, it's really irritated. This will bring your skin back to life. It will bring it back to that normal state. It's very repairing. It keeps that skin nice and strong and healthy. It's also very hydrating as well. And if you have a lot of redness, it will subside on that rosiness as well. If you're starting tretinoin for the first time or retinol, glycolic acid, something like that that tends to dry out and irritate the skin, start using this alongside those actives to keep the skin as nourished as possible, keeping it hydrated and strong. This will help to prevent further dryness and irritation when you're using those actives. It has like this really nice comforting thick milky consistency that spreads across the skin so nicely. You can use this on your neck and your chest if you need to. And it always sits great with other skincare products and even your makeup. I feel like everybody should have this serum in their collection for when they need it."
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"The NIOD Modulating Glucosides is a great serum for hydration and to repair the skin barrier. If you have sensitive skin or you're using active ingredients that are causing your skin to have dryness, flakiness, redness, tightness, you have that burning sensation to your skin and your skin is just angry, this serum will bring your skin back to life. It will hydrate it and it will really help to repair that damaged, compromised skin barrier. This has a milky consistency that instantly relieves my skin every time I use it. This is honestly the only serum that I have ever used that gives me instant relief when my skin is at its angriest. This really is a quick-acting serum that works when your skin is in discomfort. It also helps to reduce redness as well. You can use this every day twice a day or you can just use it when you need it. This is also great to pair up with your active ingredients like tretinoin or retinol or glycolic acid. Use this with those actives to really help keep your skin comfortable and hydrated and repaired."
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"I picked up two because I am definitely going to be using this a lot more come the winter months as this is great for dry flaky irritated skin. If your skin is rosy and it's just angry, this is honestly one of the best serums on the market to instantly relieve your discomfort. This really does work and I love it. It always has to be a part of my skincare collection."
Kelly Driscoll
Kelly Driscoll
90k subs
✓Approved
"I also like NIOD Modulating Glucosides. This texture splits the difference between the denseness and richness of other options. This is an interesting one because it uses plant-based ceramides as well as some other lipids which will help your skin barrier. But this one is particularly one of my favorites when my skin is feeling incredibly irritated, which is another symptom that your skin barrier needs some strengthening."
All 2 takes from Kelly Driscoll
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"If your skin is very irritated, it is singing, it is burning, it is itching, maybe you are having a flare-up of rosacea or of eczema, I would really suggest if your skin is in an extreme state of ailing go for Modulating Glucosides. Not only do they have more ingredients in here that are really made to address stinging, burning, itching and really relieve that on contact or very very fast. I have used this serum in the past for skin that is really ailing and it always works, it never fails me. When I get an eczema flare-up I will use this, even if I don't want to put it all over my face but I just have that flare-up. I get a lip eczema a lot, I will just put this on my lips just to relieve the itching and burning. The word for this is relief. It is a serum that really relieves the skin. Yes, with long-term use it strengthens your skin, it hydrates your skin, it fights dehydration, has some great antioxidants to it. It's a well-rounded serum that can be used in many instances, but if your skin is really ailing I would say just go for Modulating Glucosides."
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"I also like NIOD Modulating Glucosides. This texture splits the difference between the denseness and richness of other options. This is an interesting one because it uses plant-based ceramides as well as some other lipids which will help your skin barrier. But this one is particularly one of my favorites when my skin is feeling incredibly irritated, which is another symptom that your skin barrier needs some strengthening."
No BS Beauty
No BS Beauty
89k subs
✓Approved
"The NIOD Modulating Glucosides serum, which is $22 right now with the NIOD sale through the end of November. It's got EGCG in it, several amino acids, and ginger extract."
Common questions

Frequently asked.

What is NIOD Modulating Glucosides?

A lightweight milky serum formulated with modulating glucosides, plant-based ceramides, amino acids, and botanical extracts designed to calm irritation, strengthen the skin barrier, and provide hydration.

Is NIOD Modulating Glucosides worth it?

Yes. All 4 gurus who reviewed it give it their stamp of approval, for a Guru Score of 89%.

What is NIOD Modulating Glucosides's Guru Score?

NIOD Modulating Glucosides holds a Guru Score of 89%. That is our read on how warmly the experts talk about it, based on the verdicts of 4 independent expert reviewers we have collected. At least one expert has named it a Top Pick in its category.

Who is NIOD Modulating Glucosides best for?

NIOD Modulating Glucosides is generally suited to sensitive skin.

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