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NIOD Copper Amino Isolate Serum 3:1.

NIOD Copper Amino Isolate Serum 3:1
Serums
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About this product

A high-concentration copper peptide serum designed to support skin firmness, elasticity, and collagen production through a 1% copper peptide complex in a lightweight, water-like texture.

Full ingredients

Guru Score

83%

Yay

11 experts · Strong agreement
11Gurus
9Yay
1Mixed
1Nay
#23 in SerumsSee the ranking →

What they liked

  • Water-thin texture that spreads easily
  • High concentration of copper peptides
  • Works well with most other skincare products

What they flagged

  • Very expensive, $60 to $93 per bottle
  • Runny consistency hard to control
  • Incompatible with ascorbic acid vitamin C

What the gurus are saying

This serum firms skin and refines texture through its robust copper peptide formula, with gurus consistently noting visible improvements in elasticity and pore appearance within weeks of regular use. The water-thin texture spreads easily and absorbs without stickiness, though the $90+ price point gives some pause, one reviewer found similar results in cheaper peptide alternatives, and another found the runny consistency nearly unusable. Most who lean into peptides say the results justify the splurge, especially during sales.
Synthesized from 11 expert reviews · most recent take August 2026

Best for

Type

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Opens a search for this product. Some links are affiliate links and we may earn a small commission at no extra cost to you. It never sways a score or a verdict.

More from NIOD 16 products · Guru Score 88% → How it works Independent by design. Every take comes from a creator we have no relationship with. We do not ask anyone to review, and affiliate links never move a score.

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
✓Yay
"If you wanted to completely splurge and step it all the way up, the NIOD Copper Amino Isolate Serum is the cult favorite in this category. It retails for $93 for a 1 oz bottle, they do have a 15 ml one, but proportionally to the volume you get it's significantly more expensive. It delivers a really high concentration of copper peptides for people who want to lean in all the way."
✓Yay
"This one is the thinnest of the copper peptide serums I use, truly like water, and I really like this serum for that reason, especially for the summer months because of how lightweight it is on the skin. It never causes peeling, it's never sticky or tacky, it truly dries down like your skin. I do find the Ordinary and the Allies of Skin [...] to be more hydrating on the skin over the NIOD, so it depends on your skin type and what you're looking for."
All 11 takes from Sincerely Miss Ash
THE ORDINARY & NIOD APRIL SALE 2026 | TOP 18 ANTI-AGING PRODUCTS + THE PRODUCTS THAT ALWAYS SELL OUT
"And I do feel like this provides quicker results, at least from my experience with this product. This one does give better results. This is quite pricey, so whenever there is a sale, I do like to stock up on these. It is phenomenal and it has a different texture. This is very thin like water and it's also dark blue. Once you open this up, you have about six months to finish it. This one has a really nice texture that spreads across the skin. It's hydrating. It's not sticky or tacky either."
LUXURY SKINCARE THAT'S ACTUALLY WORTH THE MONEY - MY MOST USED HIGH-END PRODUCTS WITH REAL RESULTS
"This is truly a holy grail. Copper peptides is one of my favorite ingredients to incorporate on an everyday basis or several times through the week. I love copper peptides because peptides are great, but copper peptides truly take your skin to the next level. It firms the skin a little bit quicker. It also helps to stimulate collagen. It has wound healing properties to it, so it helps to speed up that healing process of the skin, just keeping your skin really healthy and radiant looking."
6 BEST COPPER PEPTIDE SERUMS || STIMULATE COLLAGEN & ACHIEVE FIRMER SKIN - SINCERELY MISS ASH
"I really like the way that this applies to the skin also so these are the six copper peptide products that I absolutely love and recommend"
DECIEM SALE 2024 | MUST HAVE PRODUCTS YOU NEED FROM THE ORDINARY, NIOD & LOOPHA - SINCERELY MISS ASH
"You would not believe the results that I have seen with this serum alone and I have been very consistent with this for over 2 years now, and I am just absolutely in love and obsessed with this. Copper peptides have wound healing properties, it can help to stimulate new collagen, address fine lines and wrinkles, help to firm the skin. I have noticed that with this serum in particular it does help to firm the skin and it does give a glow to the skin as well."
AGING BACKWARDS OVER 30 | BEST ANTI-AGING SKINCARE PRODUCTS OF 2023 | THESE ACTUALLY WORK!
"This one spreads even better across the skin and your skin also absorbs this really nicely as well. [...] The Ordinary one is a little bit more moisturizing on the skin because it has that thicker texture but this one is still quite nice and it really helps to hydrate the skin at the same time."
DECIEM SALE 2023 | MUST HAVE PRODUCTS YOU NEED! THE ORDINARY & NIOD SALE
"This is a serum that I talk about a lot here on my channel. I use this one almost every day. [...] I do feel like this one is a little bit more effective. I do feel like this one works a little quicker. This one has more of that watery texture. [...] I really really love this. It's [...] great for fine lines, great for signs of aging. [...] For 50% off, just pick up one and you'll know what I mean."
BEAUTY EMPTIES 2025 || SKINCARE, MAKEUP AND HAIRCARE PRODUCT'S I'VE USED UP - PROJECT PAN
"The ingredients in here are more advanced. I do find that this works a lot quicker but it's very comparable and similar to the ordinary. This one is more expensive. This one has more of that gel type of serum, it kind of mimics hyaluronic acid in the way of texture. So it just depends on maybe what consistency you like better, what your budget is, but this one is exceptional if you're looking for a copper peptide."
THE ORDINARY & NIOD SALE 2023 | I SPLURGED ONCE AGAIN AND THIS IS WHAT I PURCHASED!
"I'm really curious to see how this is going to work because it's been a while since I've used this and I can't remember how I liked it I can't remember if it pilled how it layered out with my skin care"
WHY YOUR ANTI-AGING SKINCARE ISN'T WORKING (The Truth About Skin Barrier Health + My Top Picks)
"I also really love the NIOD copper amino isolate serum. I tend to go back and forth between this and the Ordinary one. I just started using this one last year and I really like it because I feel like it has other ingredients that the Ordinary one does not have, and I find it to be a little bit more advanced than that one."
7 BEST LIGHTWEIGHT SKINCARE FOR SUMMER ☀️ | Non-Greasy Products That Layer Perfectly Under Makeup
"This first one, the NIOD Copper Amino Isolate Serum, is extremely lightweight and breathable. I [...] refuse to remove copper peptides from my weekly routine, I may not use it every day but I use it multiple times a week because I love the way this ingredient has transformed my skin over the last three years of being consistent with it. I have a lot of favorites when it comes to copper peptides and I love this one, though I also really love a couple of others."
5 AMAZING GROWTH FACTOR PAIRINGS THAT WILL LEVEL UP YOUR ANTI-AGING SKINCARE ROUTINES
"This one is the thinnest of the copper peptide serums I use, truly like water, and I really like this serum for that reason, especially for the summer months because of how lightweight it is on the skin. It never causes peeling, it's never sticky or tacky, it truly dries down like your skin. I do find the Ordinary and the Allies of Skin [...] to be more hydrating on the skin over the NIOD, so it depends on your skin type and what you're looking for."
✓Yay
"This is the Niod Copper Amino Isolate Serum, which is 93 bucks. The main difference between this and the Ordinary copper peptide serum is the texture. This one's got a very water-like texture, so it's pretty easy to fit into most routines, whereas the Ordinary has kind of a gel serumy texture. It's got 1% copper peptides, tripeptide 29, which they say helps with collagen production, vitamin E, and retinol peptide 189, which is claimed to function similar to retinol."
Top Pick: luxury copper peptide serum
All 3 takes from No BS Beauty
NIOD 2024 Sale Picks - I've Tried Everything at NIOD & Here's Their Best Products
"The copper Amino Isolate Serum is 47 bucks, this is a copper peptide serum great for nighttime use to help with anti-aging."
Favorite LUX Anti Aging Products - Day 7
"This is the Niod Copper Amino Isolate Serum, which is 93 bucks. The main difference between this and the Ordinary copper peptide serum is the texture. This one's got a very water-like texture, so it's pretty easy to fit into most routines, whereas the Ordinary has kind of a gel serumy texture. It's got 1% copper peptides, tripeptide 29, which they say helps with collagen production, vitamin E, and retinol peptide 189, which is claimed to function similar to retinol."
Favorite Copper Peptide Serums 😍 There's One For Everyone 🙌 Anti-Aging Week
"Really nice watery based serum, easy to fit in with any routine, but definitely on the more expensive price point."
✓Yay
"Copper peptides specifically have some of the most robust research behind them. One of the most respected products in this space is NIOD Copper Amino Isolate Serum 3:1. It's around $65 and is formulated with a 1% copper peptide complex that can help improve skin elasticity and structural anti-aging. It's a great product."
✓Yay
"This has been a staple in my routine for years. [...] I think this was one of the first peptide serums I ever used and I've absolutely loved it. It's not the cheapest product out there, but it's definitely an advanced formula that makes sure those peptides get to where they need to be in the skin in order to deliver maximum benefit. Such a great product, such a great formula, and definitely for people that have used peptides for some time and want to kick it up a notch."
All 8 takes from Mad About Skin
Top 5 ULTIMATE SKIN FIRMING SERUMS - Best Anti Aging Routine Yet
"It's also got a great blend of peptides in here which are really going to double down on that collagen production. This is amazing. And again, because it's part of that Ordinary family, they currently have a 23% off sale on this product, which will bring that price point down a little bit. Full price, it is actually a little bit out of the reach of a lot of people, but with that sale on, it will make it slightly more accessible."
Next Generation Botox In A Bottle - BEST PEPTIDE SERUMS 2026
"This has been a staple in my routine for years. [...] I think this was one of the first peptide serums I ever used and I've absolutely loved it. It's not the cheapest product out there, but it's definitely an advanced formula that makes sure those peptides get to where they need to be in the skin in order to deliver maximum benefit. Such a great product, such a great formula, and definitely for people that have used peptides for some time and want to kick it up a notch."
Peptides Are Not Over! BEST PEPTIDE SERUMS 2024
"When it comes to what I call the best Advanced peptide, if you want a product that does it all, super quick time, gives you like the maximum results, then I would recommend going for the NIOD Copper Amino Isolate Serum. [...] The reason this is so Advanced is not only does it have a great blend of peptides and copper peptides within it, it also uses a bespoke and patented delivery technology which means that it directs those peptides to where they need to be to get maximum results."
2024 ULTIMATE SKINCARE ROUTINE - How To Use Copper Peptides For Anti-Aging
"The standout performer of today is the NIOD Copper Amino Isolate Serum. This is the copper peptide that I'm using today. There are others on the market, but hands down the best copper peptide in skincare, planet Earth. The technology far outstrips anything else on the market. I do love this, but I will only buy it when it's on sale. I'm too cheap to be buying it full price."
NIOD SALE ANNOUNCED - Up To 50% Off 😱 (My NIOD Favourites)
"If you prefer something that isn't in a lipid base but is more traditional serum then the Copper Amino Isolate Serum is a great option. Very similar in terms of outcomes but this is a little bit more lightweight and has slightly lower price point. [...] If you're on a slightly lower budget, don't feel you have to compromise. This is a really great anti-aging option."
2 X FIRMER SKIN - The Best Copper Peptides #skincare
"It has the same great copper peptide blend as the lipid but it's in a more watery serum base. This is really going to come down to preference in terms of what you like in terms of texture. [...] If you want something that sinks in super quick then the serum might be more for you. I tend to mix and match between the two depending on what my skin needs. In summer I will go for the serum which is more lightweight, in winter I'll go for the more heavy duty lipid."
TOP 10 SKINCARE 2023 - Skincare Awards Part 2
"The best of the best in copper peptides is the NIOD Copper Amino Isolate Serum 3:1. It's got technology in here that makes sure those copper peptides get to where they need to be in order to deliver maximum results. It's also beautifully hydrating. However, it comes with a higher price point, so whilst this is absolutely worth every penny, for those of you that are on a budget or maybe don't want to stretch this price point, I understand."
Next Level SKIN FIRMING SERUMS - Reduce Sagging Jowls and Tighten Skin
"I find it's a nice middle ground, it's not the cheapest product out there but it's also not super expensive so it's a good mid price point and one that I definitely definitely love. The copper peptides in here are the ones that stand out and whilst it doesn't have quite the same advanced blend of different firming peptides as the first two, it uses that technology to really get maximum results for the skin and so it's a really really nice option."
✓Yay
"If you want the high-end version, the NIOD Copper Amino Isolate Serum 3:1, that'll cost you about 90 bucks, but it is great overall for skin health."
✓Nay
"This is NIOD's copper amino isolate serum, and I didn't feel like it did that much for me. [...] I really like peptide ingredients and copper peptide is supposed to be an incredible one, but when I looked into the data there isn't much research on copper peptides. My biggest issue though is how runny it is, it's incredibly unpleasant to use, [...] nearly unusable, and it's still not inexpensive. So that's a no for me."
✓Yay
"The NIOD Copper Amino Isolate Serum 3 1.1 used to be my favorite copper peptide serum, which I used faithfully for years. It was recently replaced by the Medik8 liquid peptides. It's incredibly expensive, [...] but either of them are fine."
Top Pick: copper peptide serum
All 6 takes from Doctor Anne
I Used Up ALL of These in 2025 - Skincare, Hair & Makeup Empties | Doctor Anne
"The NIOD Copper Amino Isolate Serum 3 1.1 used to be my favorite copper peptide serum, which I used faithfully for years. It was recently replaced by the Medik8 liquid peptides. It's incredibly expensive, [...] but either of them are fine."
My most loved skincare 2024 - Holy grail routine | Doctor Anne
"The last in the serum category is again repeated from the years before: NIOD Copper Amino Isolate Serum 3, hands down the copper peptide serum with the best texture I have tried."
So many skincare empties - Everything I used up in 2024 | Doctor Anne
"The NIOD Copper Amino Isolate Serum 3 is one I have repurchased numerous times. Yes, it is very expensive, but I want copper peptides in my routine and the texture in this one is the most beautiful I have found, which is why I keep reaching for it."
How I Treat Hyperpigmentation & Acne: Doctor Anne’s Fall Nighttime Skincare Routine
"The NIOD Copper Peptide Amino Isolate Serum 3 is a staple, I've been using it for a long time. There are more affordable ones, but this one has the best texture, and I always buy it when it's on sale during their Slowvember, which is when it is more affordable."
My most loved skincare 2023 - Holy grail routine | Doctor Anne
"It's my peptide fix."
So many skincare empties - Everything I used up in 2023 | Doctor Anne
"Already repurchased was the NIOD Copper Amino Isolate Serum 3, even more expensive than the Estee Lauder one, but by far the best Copper Peptides Serum I have tried in terms of texture. The first one was PR, the two others I have used since I have purchased myself, that is how much I love it."
✓Yay
"I really like the combination here, there's some other peptides in the mix. This is a very expensive serum that is up in the like the $90 range. It's very expensive, it works. This is one of the very few expensive products where I would say if it fits your budget go for it. I don't think that you will regret it. It will show you results. It made my skin feel so firm so fast, amazing."
All 2 takes from Kelly Driscoll
Hyped Skincare Ingredients, Are They Worth It?
"I really like the combination here, there's some other peptides in the mix. This is a very expensive serum that is up in the like the $90 range. It's very expensive, it works. This is one of the very few expensive products where I would say if it fits your budget go for it. I don't think that you will regret it. It will show you results. It made my skin feel so firm so fast, amazing."
Skincare That Actually Firms Skin!
"This firms the skin. It makes the skin feel [...] thicker, but in a good way. It feels thicker and firmer and more lifted. [...] After a couple of weeks of consistent use, it absolutely firms the skin and it does have this really interesting refining quality to the skin. If you have enlarged pores, it really helps to smooth those and make them look more refined and slightly tighter. It makes your skin just look really smooth, really lifted."
✓Yay
"As far as copper tripeptides go, there hasn't been a single formula that can beat this for me. [...] This is all about skin optimization, just helping your skin function more effectively and efficiently, but also this promotes good collagen for firmness and elasticity. It's always been hard for me to describe, but it's an overall noticeable improvement, not just in the texture or the way my skin feels, but also just in the way it looks."
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✓Mixed
"I find that the NIOD serum is fine, it works well, [...] but I don't enjoy using it as much. I find it a bit more unwieldy texturally speaking. The Ordinary serum has a little bit more substance to it and feels like you're putting more on than just a very thin liquid that slips through your fingers. That's really just a personal preference; it doesn't necessarily speak to efficacy per se."
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All 2 takes from Dr Dray
Are Copper Peptides Worth It? NIOD Copper Amino Isolate Review
"At this point I'm not convinced that it's worth that price point because I've tried a lot of peptide products over the years and I find that I often get very similar results and many of these products are significantly less expensive than this. [...] This is a good product, it's not bad. I think if you want a copper peptide serum to have in your routine for the possibility of improving elasticity, skin firmness, the look of wrinkles, this would be a great option."
*BEST* Copper Peptide Serum? The Ordinary Vs NIOD
"I find that the NIOD serum is fine, it works well, [...] but I don't enjoy using it as much. I find it a bit more unwieldy texturally speaking. The Ordinary serum has a little bit more substance to it and feels like you're putting more on than just a very thin liquid that slips through your fingers. That's really just a personal preference; it doesn't necessarily speak to efficacy per se."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is NIOD Copper Amino Isolate Serum 3:1?

A high-concentration copper peptide serum designed to support skin firmness, elasticity, and collagen production through a 1% copper peptide complex in a lightweight, water-like texture.

Is NIOD Copper Amino Isolate Serum 3:1 worth it?

Mostly yes. 9 of the 11 gurus who reviewed it give it their stamp of approval, for a Guru Score of 83%.

What is NIOD Copper Amino Isolate Serum 3:1's Guru Score?

NIOD Copper Amino Isolate Serum 3:1 holds a Guru Score of 83%. That is our read on how warmly the experts talk about it, based on the verdicts of 11 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.

Who is NIOD Copper Amino Isolate Serum 3:1 best for?

NIOD Copper Amino Isolate Serum 3:1 is generally suited to mature skin.

Cheaper alternatives the gurus rate.

Lower-priced serums the gurus still rate highly, versus this mid-range pick.

See how they stack up →

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