Neocutis

Bio-Serum Firm.

Serums

About this product

A lightweight serum formulated with growth factors, peptides, and marine extracts designed to support skin firmness, elasticity, and texture in mature skin.

Full ingredients

Water (Aqua), Glycerin, Caprylic/Capric Triglyceride, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene/Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium EDTA, Sodium Hydroxide, Phenoxyethanol

Guru Score

74%

Mixed

3 experts · Moderate agreement

3Gurus

2Yay

1Mixed

0Nay

What they liked

Lightweight yet deeply hydrating
Strong clinical backing for firmness
Recommended for post-procedure skin

What they flagged

Vitamin C benefit unclear

What the gurus are saying

Growth factors combined with peptides in this serum earned clinical backing for reducing deep wrinkles and improving skin firmness and density over 12 weeks. The lightweight formula absorbs quickly, making it suitable for mature skin and post-procedure recovery. Gurus note it sits at the premium price point but trust it clinically for those working on loss of elasticity.

Synthesized from 3 expert reviews · most recent take June 2026

Best for

Mature skin

Type

SerumsDrops & dropper

Key actives

Vitamin C Hyaluronic acidVitamin EPeptides Squalane

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Dr. Mamina

281k subs

~Yay

"Neocutis Bio-Serum Firm has growth factors plus peptides and strong clinical data on firmness and density. It's recommended for post-procedure use and as an option for working on firming and loss of elasticity."

All 2 takes from Dr. Mamina

What Skincare Products Are Actually Worth Your Money | Where to Splurge vs Save

"As well as the Neoccutis Bio Serum Firm. These are definitely more on the high end."

Peptides in Skincare: What They Actually Do and How to Choose the Right One | Derm Explains

Dr. Aleksandra Brown

142k subs

~Yay

"This is also human-derived growth factor. It retails for about $290. The key benefits here are that it smooths the skin in as little as 7 days, that's pretty fast. It can target sagging skin, loss of volume, dullness. It's really lightweight yet deeply hydrating at the same time. The key ingredients are a proprietary peptide blend, growth factors, and hyaluronic acid."

Dr. Shereene Idriss

1.72M subs

~Mixed

"If you have a lot of money and you're willing to spend $275, Neocutis has a Bio-Serum Firm that contains this form of vitamin C in addition to glycerin and certain growth factors. Are you spending your money on the vitamin C? I do not know. Again I do not know enough to recommend this product, but let me know in the comment section if you've tried it and if you like it."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Vitamin E

Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.

Source: NIH, National Library of Medicine

Frequently asked.

What is Neocutis Bio-Serum Firm?

A lightweight serum formulated with growth factors, peptides, and marine extracts designed to support skin firmness, elasticity, and texture in mature skin.

Is Neocutis Bio-Serum Firm worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 74%.

What is Neocutis Bio-Serum Firm's Guru Score?

Neocutis Bio-Serum Firm holds a Guru Score of 74%. That is our read on how warmly the experts talk about it, based on the verdicts of 3 expert reviewers we have collected.