Naturium Multi-Peptide Advanced Serum: a Guru Score of 71%

What the experts use it for.

The concerns the experts tie this product to, in their own words. Paid and founder takes don't count.

Irritated or reactive skin1 expert

“That encapsulation also is beneficial because it'll reduce the risk of any irritation.”

Loss of firmness1 expert

“Naturium Multi-Peptide Advanced Serum is a really great multi-purpose product for anyone really wanting to simplify their routine, looking for one product, one-stop shop that does the anti-aging concerns, skin firming benefits, but also at the same time protecting your skin from environmental damage.”

Dr. Jenny Liu, watch at 10:04

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Dr. Jenny Liu

324k subs

~Yay

"Naturium has great peptide combinations that support collagen."

All 2 takes from Dr. Jenny Liu

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"Naturium Multi-Peptide Advanced Serum is a really great multi-purpose product for anyone really wanting to simplify their routine, looking for one product, one-stop shop that does the anti-aging concerns, skin firming benefits, but also at the same time protecting your skin from environmental damage."

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"Naturium has great peptide combinations that support collagen."

Mad About Skin

734k subs

~Yay

"I love the Naturium multi-peptide serum, copper peptides encapsulated alongside other great peptides in a full blend. It's super inexpensive, and the encapsulation makes it really easy to incorporate and layer both in a morning and on an evening."

All 5 takes from Mad About Skin

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"I use the ones by Naturium, they have a great multipeptide option."

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"Just take the stress, take the stress out of your peptides, and go with encapsulation. This has been a little game changer for me in 2026. I moved to encapsulated peptides and honestly I've never looked back because I don't have enough time to be stressing about my skincare routine and layering and pairing. I want to enjoy it, slap the products on knowing that the brands have done the work for us with that encapsulation so I don't have to overthink it."

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"This is a great option if you're still not fully sold on the fact you can use peptides alongside other actives. [...] The peptides in here are actually encapsulated and that encapsulation will protect them against your vitamin C's, your exfoliating acids. [...] That encapsulation also is beneficial because it'll reduce the risk of any irritation. Peptides are calming and soothing on the skin, but [...] there is that small risk of irritation with certain people."

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"This is a product that kind of led the way with that encapsulation, one of the first products to really harness it, and will always have a place in my heart for that. It's beautiful, again you've got that copper peptides alongside your other peptides in encapsulated form. Another great product that you could absolutely use morning and evening, or just on an evening and then use another peptide for your morning, it's really up to you."

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"I love the Naturium multi-peptide serum, copper peptides encapsulated alongside other great peptides in a full blend. It's super inexpensive, and the encapsulation makes it really easy to incorporate and layer both in a morning and on an evening."

Skin Obsessed Mary

33k subs

~Yay

"On the affordable side is an incredible product regardless of the price, and the price is shocking. This is the Naturium Multi-Peptide Advanced Serum. It has copper peptides, guys, but what I really love the most is the texture, it's milky and bouncy, I mean it's just so good. And get this, I think I picked this up for $25. I mean, how are they doing it, seriously? It might not be for everyone, you may not need this, but it's definitely for me."

All 2 takes from Skin Obsessed Mary

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"On the affordable side is an incredible product regardless of the price, and the price is shocking. This is the Naturium Multi-Peptide Advanced Serum. It has copper peptides, guys, but what I really love the most is the texture, it's milky and bouncy, I mean it's just so good. And get this, I think I picked this up for $25. I mean, how are they doing it, seriously? It might not be for everyone, you may not need this, but it's definitely for me."

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"The Naturium Multi-Peptide Advanced Serum has a super impressive ingredient list including copper peptides. [...] It is so nice on the skin. It has this milky texture so it also delivers hydration which I just love. I mean it's just perfect for this middle-age skin and again it is so affordable. I just don't know how these guys keep doing it. [...] If you're looking for an affordable peptide serum I'd be marching right out to Target to get this."

Abbey Yung

887k subs

~Nay

"I don't think there is. Those are my initial thoughts. I obviously can't tell you guys how this performs versus The Ordinary in terms of results on my skin, because I did not use this for a long period of time to see results, and that would be tough since I have already been using The Ordinary for so long. So, [...] a little bit of a flop for me from Naturium, not terrible, just not enough for me."

HotandFlashy

1.23M subs

~Mixed

"It's an encapsulated copper peptide so it is also supposed to be stable and is also clear and has no use restrictions. It's [...] clear there are no use restrictions and you can use it anywhere if you wanted to try a copper peptide but you don't want to deal with the blue color or the potential for interactions with other things, I would say that something like the [...] Naturium would be a good way to go."

Mixed Makeup

1.46M subs

~Yay

"I love the Naturium Multi-Peptide Advanced Serum. It's one of my all-time favorite products I've ever made. If you have dry skin and want to hydrate a little bit, it's anything that's going to give you that hydration before you put on your moisturizer."

SponsoredFounder's own brand

All 5 takes from Mixed Makeup

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"I love the Naturium Multi-Peptide Advanced Serum. It's one of my all-time favorite products I've ever made. If you have dry skin and want to hydrate a little bit, it's anything that's going to give you that hydration before you put on your moisturizer."

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"The first one is from my brand, Naturium: it's our Multi-Peptide Advanced Serum. We have some really great peptides in them, including encapsulated copper peptides that yes, can be used with your vitamin C. We have our jeraline amplified in there, it helps to just make your skin look more lifted, and it helps it look smoother and brighter and just really nice and plump and juicy."

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"It has encapsulated copper peptides in here, there's argireline amplified in here, there's nice nourishing ingredients in here. It's a milky texture that hydrates your skin and just feels so nice. I can't live without this, I love having it on my skin, I have it on my skin right now. Morning, night, can be used with everything. I love it."

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"I love a peptide serum. [...] I'm always using peptide serums. I mean, the Naturium Multi-Peptide Advanced Serum, obsessed. [...] Peptides can hydrate your skin, but they do so many different things, every single different peptide. Some of them really are just for hydration and to plump up your skin, but then there are some that can really help with fine lines and wrinkles and anti-aging. [...] It makes you glow."

Fight Fine Lines & Wrinkles with NATURIUM Multi-Peptide Advanced Serum! | Susan Yara

"This might be my favorite Naturium launch of all time. [...] If you're not familiar with peptides, they're a string of amino acids that make up the proteins that make up basically all of our cells including our skin cells. [...] It has quickly become a Holy Grail in my skincare routine. I feel like I can't live without it anymore. [...] We have four really amazing superstar ingredients in here, two of them are obviously peptide ingredients. [...] First up there are copper peptides."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Alpha hydroxy acids

Alpha hydroxy acids loosen the bonds holding dead cells at the surface. The evidence supports smoother texture and more even tone over time, and they can leave skin more sensitive to sun.

Source: NIH, National Library of Medicine

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is Naturium Multi-Peptide Advanced Serum?

A milky peptide serum from Naturium that combines encapsulated copper peptides with other peptides, designed to hydrate and support firmer, smoother-looking skin.

Is Naturium Multi-Peptide Advanced Serum worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 71%.

What is Naturium Multi-Peptide Advanced Serum's Guru Score?

Naturium Multi-Peptide Advanced Serum holds a Guru Score of 71%. That is our read on how warmly the experts talk about it, based on the verdicts of 6 expert reviewers we have collected.

Who is Naturium Multi-Peptide Advanced Serum best for?

Naturium Multi-Peptide Advanced Serum is generally suited to mature skin.

What is Naturium Multi-Peptide Advanced Serum good for, according to the experts?

In their reviews, experts say Naturium Multi-Peptide Advanced Serum is good for irritated or reactive skin (1 expert) and loss of firmness (1 expert).