Medicube PDRN Pink Peptide Serum: a Guru Score of 67%

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

~Yay

"Let me give you an example, the Medicube PDRN serum. This is soothing and non-irritating, so it's one of the peptide products you can use right after micro needling without it stinging."

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"This is by Medicube. It's called PDRN Pink Peptide Serum that has changed my skin. I'm not kidding."

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"This is salmon sperm. This is a multi-peptide by Medicube. It's [...] PDRN Pink Peptide Serum. So it's got multiple peptides in it, but it also has nucleotides derived from salmon sperm. [...] The nucleotides in salmon sperm very closely match the nucleotides found in our skin. When we have genetic gaps, we're missing something, that's a sign of aging. [...] When your genes aren't replicating exactly how they're supposed to, that's a sign of aging. [...] What this does is it fills in those genetic gaps. So it helps a lot with DNA repair. [...] There's lots of different versions, but right now, this is my favorite."

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"I love a PDRN, this pink peptide by Medicube, the salmon sperm peptide. It works because the nucleotides of salmon sperm mimic the nucleotides in our skin, filling in genetic gaps to make skin more resilient and function better."

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"I like this PDRN by Medicube. This is part of the evening routine that I'm doing right now."

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"Let me give you an example, the Medicube PDRN serum. This is soothing and non-irritating, so it's one of the peptide products you can use right after micro needling without it stinging."

Mad About Skin

727k subs

~Yay

"Medicate do one of my favorites."

Nipun Kapur

408k subs

~Mixed

"Medicube is something that can give you a lot of nourishment. It can give hydrate and moisturize your skin well. But if you're looking at the true magic of PDRN, and you will not know the magic of PDRN unless you have used a high quality product, Medicube is really a 5 on 10. From an anti-aging perspective, it is really a 5 on 10."

No BS Beauty

89k subs

~Nay

"This stuff smelled so strong, just floral perfumey. It was just too much. [...] The ingredients looked fine except for fragrance right in the middle and the fragrance was strong and it was overwhelming and it gave me the beginning of a migraine. So I didn't apply it on my face."

All 2 takes from No BS Beauty

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"The scent is so strong. It doesn't really dissipate well. I rinsed it off before I actually washed it off. I really scrubbed it off because it was very strong. [...] This one has a small amount of sodium DNA, which is the PDRN that they mentioned. Sodium DNA is based from typically salmon. It contains DNA fragments, long chains of nucleotides that help support and repair and regenerate the skin. It also contains turmeric, ubiquinone, and five peptides, which are at the very end of the ingredient list. Aside from the fragrance, if it didn't have the fragrance in here, I'd probably be using it. [...] The strong scent is way way too much for my migraines. So, sadly, I'm not going to be able to use it."

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"This stuff smelled so strong, just floral perfumey. It was just too much. [...] The ingredients looked fine except for fragrance right in the middle and the fragrance was strong and it was overwhelming and it gave me the beginning of a migraine. So I didn't apply it on my face."

Dr. Jenny Liu

321k subs

~Yay

"It's their PDRN Pink Peptide Serum. The color got me at first. I've never seen a serum so pink and vibrant. [...] The ingredients are really interesting and very fascinating, definitely catching on that salmon PDRN trend that is really popular in Korea and has made its way over here in the western side of the world. It actually does contain salmon PDRN with a peptide complex and niacinamide to overall improve skin texture, tone, and help with skin rejuvenation. It's really aimed at improving the quality of your skin, the appearance of fine lines, wrinkles, dullness, hydrating your skin, improving overall even tone. It is hypoallergenic and suitable for sensitive skin."

Top Pick: peptide serum

All 2 takes from Dr. Jenny Liu

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"It's their PDRN Pink Peptide Serum. The color got me at first. I've never seen a serum so pink and vibrant. [...] The ingredients are really interesting and very fascinating, definitely catching on that salmon PDRN trend that is really popular in Korea and has made its way over here in the western side of the world. It actually does contain salmon PDRN with a peptide complex and niacinamide to overall improve skin texture, tone, and help with skin rejuvenation. It's really aimed at improving the quality of your skin, the appearance of fine lines, wrinkles, dullness, hydrating your skin, improving overall even tone. It is hypoallergenic and suitable for sensitive skin."

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"It contains salmon sperm DNA peptide complex that works complimentary to the salmon sperm to enhance skin firmness and resilience. And niacinamide has so many great benefits with skin barrier support, improving texture as well as brightening the skin. So this one of all the ones that I've used is really one of my personal favorites."

Dr. Aleksandra Brown

142k subs

~Yay

"This is like if you're going to get into this salmon sperm and PDRN and this is the one I would go for because it has highest content of actual active ingredient. It has 10,000 parts per million or 1% salmon PDRN and that's the highest concentration you can get over the counter. It's super lightweight hydrating serum. Helps improve even tone and boost elasticity for like that firmer, more radiant complexion. It absorbs pretty fast. I like to use it on top of my toner. It leaves you feeling really hydrated, plump. I do like moisturizer on top of it because I feel like it might be a little sticky otherwise, but I find a lot of serums sticky. This one's great if you have dry skin, want hydration. You could use it twice a day or if you're somebody like me who uses actives, it goes really good underneath your retinol or your tretinoin. The key ingredients here are the 10,000 parts per million of the salmon PDRN, the five peptide complex, and the holy basil leaf extract."

All 2 takes from Dr. Aleksandra Brown

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"It's really lightweight. It's hydrating. It helps improve that uneven tone and boost elasticity for that firmer, more radiant complexion. It absorbs really fast. It leaves skin plump and luminous. It targets visible signs of aging like fine lines and loss of resilience. The key ingredients is the salmon PDRN at 10,000 parts per million, five peptide complex, and holy basil leaf extract. I find it to be just a little bit more hydrating. As a matter of fact, I have found it to be a little bit too hydrating to do videos like YouTube because I end up being too glowy. So, if you're somebody who's extra dry and you want like the best over-the-counter and you want to try PDRN, I would probably try the Medicube."

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"This is like if you're going to get into this salmon sperm and PDRN and this is the one I would go for because it has highest content of actual active ingredient. It has 10,000 parts per million or 1% salmon PDRN and that's the highest concentration you can get over the counter. It's super lightweight hydrating serum. Helps improve even tone and boost elasticity for like that firmer, more radiant complexion. It absorbs pretty fast. I like to use it on top of my toner. It leaves you feeling really hydrated, plump. I do like moisturizer on top of it because I feel like it might be a little sticky otherwise, but I find a lot of serums sticky. This one's great if you have dry skin, want hydration. You could use it twice a day or if you're somebody like me who uses actives, it goes really good underneath your retinol or your tretinoin. The key ingredients here are the 10,000 parts per million of the salmon PDRN, the five peptide complex, and the holy basil leaf extract."

C

CYoung

94k subs

~Yay

"I tried the new disposable Medicube PDRN serum, it has a little scent but not too crazy, and a thick texture that kind of films on the skin. If you have oily combo skin it can feel kind of heavy, but if you use the massage device with it, it slides in really well and goes inside nicely. The PDRN amount is a lot higher compared to Anua, and it feels bouncy, which makes it great to use as a makeup primer."

All 3 takes from CYoung

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"I tried the new disposable Medicube PDRN serum, it has a little scent but not too crazy, and a thick texture that kind of films on the skin. If you have oily combo skin it can feel kind of heavy, but if you use the massage device with it, it slides in really well and goes inside nicely. The PDRN amount is a lot higher compared to Anua, and it feels bouncy, which makes it great to use as a makeup primer."

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"Everybody recognized this one because of its pretty pink color, it was a surprise hit, two testers picked it as their top choice. One loved the pretty pink color and how smoothly it glides, perfect for her beauty devices, no problem for oily skin either, it felt clean not sticky. Yuna, with sensitive skin, said it felt lightweight but super hydrating and the scent was just right. For me, this brand feels like a marketing company more than a cosmetic company, they make so many products and it's appealing on TikTok but maybe not in real life. But I'll admit this serum they made is okay, it has a lot more PDRN in it compared to the Anua PDRN serum, and even on my dry mature skin it felt pretty hydrating, they also do buy one get one promotions a lot at Olive Young. If you're curious about PDRN and want to try it, I'd say this isn't a bad choice, and it's cute too."

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"This is so Instagrammable, the color is pretty pink, and since salmon extract smells a little fishy they added fragrance, not too strong, bearable. It contains PDRN at 10,000 PPM, which is 1 percent, a pretty high percentage, and also niacinamide, peptides, and coenzyme Q10, so it's really good as an antioxidant. It absorbs pretty quickly, but the texture isn't super light, and I like that. If you're dry, mature skin over 40, starting to get aging and your skin is getting thinner, you'll like it even more."

A

AliceintheRabbitHole

59k subs

~Nay

"This just did not work for my skin type. I felt like I was getting an increase in redness when I used this product, though it's possible that came from the fragrance or the vitamin B12 ingredient rather than the PDRN itself, since this is a higher concentration than I'd knowingly tried up until this point. So for me this is a no, I'm sure it will work for some amount of people, but it was sadly a no-go for me."

Kelly Driscoll

90k subs

~Mixed

"There is some evidence to suggest that it may help with skin elasticity and may help to reduce irritation within the skin. The DNA polymer itself should help with collagen stimulation and the fibroblast boosting. I'm still a bit on the fence about this. I do really talk mostly about fragrance-free skincare on my channel, and so I do want to be very clear here: not only is this being sourced from rose extract, but they have also added in some artificial fragrance as well. So this is a fragrance product. If you're sensitive to artificial fragrance, you may not want to use this. If you're sensitive to essential oils, you want to be careful here, because the rose extract itself, although it's not the volatile essential oil, it is going to carry some of that in the extract, it's just going to be very diluted. And if you have sensitivities to fragrant plant extracts, rose is considered one of them. So again, some reservations here. They're also rounding out the PDRN with a selection of peptides that help with aging. We've got acetyl hexapeptide 8, that's a Botox-like peptide. We have copper tripeptide 1, may help to stimulate collagen. We have matrixyl 3000, which helps with collagen."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Peptides

Peptides are short protein fragments meant to signal repair. The evidence for them is thinner than for retinoids or vitamin C, and it varies a lot by the specific peptide, so the category is more promising than proven.

Source: NIH, National Library of Medicine

Frequently asked.

What is Medicube PDRN Pink Peptide Serum?

A pink serum containing salmon-derived PDRN (polydeoxyribonucleotide), peptide complex, and niacinamide, designed to improve skin texture, tone, and address signs of aging.

Is Medicube PDRN Pink Peptide Serum worth it?

The gurus are split. 5 of the 9 gurus give it their stamp of approval while 2 would skip it, which lands it in the middle at a Guru Score of 67%.

What is Medicube PDRN Pink Peptide Serum's Guru Score?

Medicube PDRN Pink Peptide Serum holds a Guru Score of 67%. That is our read on how warmly the experts talk about it, based on the verdicts of 9 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.