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DRMTLGY

Peptide Night Cream.

DRMTLGY Peptide Night Cream
Serums

About this product

A fragrance-free peptide and ceramide moisturizer designed for evening use, formulated with five peptides and three ceramides to hydrate and support skin barrier health.

Best for

Dry skinSensitive skin
Serums

The Guru Index verdict

83%

Approved

Approved · 83%
3Reviewers
3Approved
0Mixed
0Skip

What the gurus are saying

Gurus are consistently enthusiastic about this cream, praising its fluffy, mediumweight texture that absorbs without greasiness and works across skin types from dry to normal to slightly oily. The recurring strength is its versatility: reviewers use it at night, day, under retinoids as a buffer, or layered with other actives, and report it's soothing even on irritated skin. The consensus is that it's an effective, long-term staple for hydration and fine-line support, though a few note it skews rich for warmer months or very oily skin.
Synthesized from 3 expert reviews

Key actives & flags

Vitamin ECeramidesPeptidesFragrance-freeAlcohol-free

Full ingredients

Water/​Aqua/​Eau, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii (Shea) Butter, Caprylic/​Capric Triglyceride, Cetyl Alcohol, Dimethicone, PEG-100 Stearate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Trifluoroacetyl Tripeptide-2, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol, Tridecane, Allantoin, Tocopherol (Vitamin E), Glycol Distearate, Potassium Cetyl Phosphate, Butylene Glycol, Ethylhexylglycerin, Acrylates/​C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Polysorbate 20, Dextran, Magnesium Chloride, Phenoxyethanol, Disodium EDTA, Sodium Hydroxide

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored
Approved
"It contains five different peptides and three different ceramides. It's a really nice fragrance-free skincare cream and you can certainly fit it into your evening routine or your morning routine. At $32 for 2.1 ounces, it's a little bit larger than the average moisturizer. I'm getting low on this one so I'll definitely be stocking up on this one during the sale."
Approved
"The peptide night cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."
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All 6 takes from Beyond50Skin
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"The peptide night cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."
DRMTLGY Skincare: Best Anti-Aging Skincare for Mature Skin Over 50 (Black Friday Deals!)
"This was the first product I ever tried from dermatology, the Peptide Night Cream. It is a beautiful mediumweight moisturizer. Perfect for normal to dry skin."
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"You can use this day or night. In the winter and fall months I need something this hydrating for my daytime routine. It's kind of a fluffy, sort of creamy formula, soaks right into the skin, doesn't leave a greasy residue. I think it's great for maybe not very oily skin but anywhere from dry skin to slightly oily or normal skin you're going to really enjoy DRMTLGY Peptide Night Cream."
Skincare HACKS FOR MATURE SKIN! (DRMTLGY Fails, Faves and Tips!)
"I love their peptide night cream. I've loved it for years and years and it's one of moisturizer that I have used for years and years. I love the texture of the peptide night cream, and it's nice to have it in a jumbo size for a little bit of savings."
SKINCARE Fails & Faves for Mature Over 50 Skin (DRMTLGY 30% BlackFriday/Cyber Monday Sale)
"The peptide night cream is amazing. I love this. It now comes in a jumbo. I use it summer, I use it winter, I use it morning, I use it evening. If you have dry skin, you have mature skin, you're going to love this. It's just a nice fluffy formula, one of my absolute all-time favorite moisturizers."
Best Anti-Aging Skincare for Over 50 | Ranking DRMTLGY's Top 10 Best Sellers
"The peptide night cream I have purchased this countless number of times I love it I've used it for over 3 years I recommend it all the time. I even recommend it for normal to oily skin types using a thin layer in the evening it can be your night cream. You can also use it to buffer your retinoid products or sandwich your retinoid products with this it can help protect so that you don't get that irritating red and flakiness. This is one of the best moisturizers I think that is out there on the market one of my all-time faves. Never stings never burns even when my skin is super irritated it's soothing and calming and can be used in so many ways. It's chalked full of ceramides and peptides it just gives that skin that moisture that it needs throughout the day if you're using it in your daytime routine or overnight if you're layering it with your retinoids or just using it as an overnight moisturizer. Highly highly recommend."
Approved
"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine. You could use this in your morning even though they market this as a night cream, you could still use this in your morning if you really want, just know it's going to be a little bit richer. This one has a little bit more to it. It has more peptides. There's also ceramides in here as well. Very moisturizing and repairing, but a great cream to firm the skin and help to stimulate collagen and of course to help soften fine lines and wrinkles."
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All 4 takes from Sincerely Miss Ash
12 DRMTLGY BEST SELLERS || I HAVE TRIED EVERY ONE.. ARE THEY WORTH THE HYPE? SINCERELY MISS ASH
"I do prefer to use this at night time paired up with my TR retinol, a copper peptide. You can pair this moisturizer up with a lot of different things so if you love your peptides and you want something in a cream form you have to try this. I'm going to give this a 9 out of 10."
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"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine. You could use this in your morning even though they market this as a night cream, you could still use this in your morning if you really want, just know it's going to be a little bit richer. This one has a little bit more to it. It has more peptides. There's also ceramides in here as well. Very moisturizing and repairing, but a great cream to firm the skin and help to stimulate collagen and of course to help soften fine lines and wrinkles."
DRMTLGY BLACK FRIDAY SALE 2024 | MUST HAVE ANTI-AGING PRODUCTS THAT ACTUALLY DELIVER RESULTS!
"This is one of my go-to creams during the winter because it is pretty rich and moisturizing but more lightweight on the skin compared to other options. Even though this is a night cream, you can still use this in your morning routine, just make sure that you put a sunscreen on top of this. It's a great anti-aging cream that contains five types of peptides to firm the skin and to address fine lines and wrinkles. There's three types of ceramides in here as well, there is shea butter and vitamin E. This is wonderful if you have dry, tight skin, especially in your nighttime routine."
6 ANTI-AGING PRODUCTS FROM DRMTLGY THAT I CAN'T STOP USING | THESE REALLY DO WORK FOR SIGNS OF AGING
"This really is a lovely one. It gives your skin this nice glow, your skin is just so moisturized, but then of course we're treating those fine lines and we're trying to develop more firm skin."
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