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DRMTLGY

Peptide Night Cream.

DRMTLGY Peptide Night Cream
Moisturizers

About this product

A peptide-enriched night cream formulated with ceramides, shea butter, and vitamin E to hydrate and support the skin's moisture barrier.

Full ingredients

Guru Score

77%

Yay

5 experts · Moderate agreement
5Gurus
4Yay
1Mixed
0Nay

What they liked

  • Rich moisturization without a heavy feel
  • Works as both day and night cream
  • Fragrance-free and supports barrier repair

What they flagged

  • Texture didn't stand out to some
  • Too heavy for oily or combination skin in summer

What the gurus are saying

A fluffy, medium-weight cream that soaks in without greasiness and works across most skin types, earning consistent praise as a budget-friendly staple. Gurus highlight its richness and peptide blend as particularly strong for dry or tight skin in cooler months, though those with very oily skin may want to reserve it for nighttime. It pairs well with other actives like retinol.
Synthesized from 5 expert reviews · most recent take July 2026

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
Mixed
"I finally finished the Dermatology Peptide Night Cream. I know a lot of people really love this brand, and they were kind enough to send me products, but I didn't feel as wowed by this as I thought I would. Don't get me wrong, I like it, I finished it, but there wasn't a lot that stood out to me. The ingredients look great, but the experience of use just didn't stand out the way a product like the Experiment did."
Yay
"Next up is the DRMTLGY Peptide Night Cream, which is about 46 bucks. It's a peptide enriched cream. It's fragrance free, great for sensitive skin. It's great for barrier repair as well. It's really nice. DRMTLGY has a lot of nice stuff."
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"Dermatology Peptide Night Cream, very nice product, love it. I already have a backup of this one as well."
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"Last but not least, the DRMTLGY Peptide Night Cream. It's really full of good ingredients. We've got shea butter, we've got peptides, we've got ceramides, we've got vitamin E, we've got allantoin, we've got cholesterol. It's really nice. It comes with the little plastic thing, so I just kind of do that thinking it protects it, but I'm sure it probably doesn't make that much of a difference. Pretty thick product and wonderful."
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"Next up is the DRMTLGY Peptide Night Cream, which is about 46 bucks. It's a peptide enriched cream. It's fragrance free, great for sensitive skin. It's great for barrier repair as well. It's really nice. DRMTLGY has a lot of nice stuff."
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"Next up is the DRMTLGY Peptide Night Cream, which is 34 bucks. This one also has ceramides, shea butter, vitamin E, and allantoin."
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"The DRMTLGY Peptide Night Cream is 34 bucks. It also contains [...] going camid, shea butter, vitamin E, and allantoin."
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"Last but not least, the DRMTLGY Peptide Night Cream, 2.1 ounces for 46 bucks, although they have sales and discounts on their website all the time. Fragrance-free, alcohol-free, cruelty-free, vegan. Its main components: glycerin, shea butter. It's also got ceramides, it's got the Matrixyl 3000 peptide duo, it's got the Syn-Ake peptide, which can help skin produce sodium hyaluronate according to research, and then a lantern."
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"The DRMTLGY Peptide Night Cream is 2 oz for 32 bucks and it contains the Matrixyl 3000 peptide, it contains the Syn-Coll peptide, and then it contains the Syn-Ake peptide. It also contains shea butter, ceramides, and vitamin E. It's really nice, and you don't have to just use it during your evening routine, you can use it morning or whenever."
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"It's really wonderful fragrance free you don't just have to use it in your evening routine I use this in my daytime routine as well"
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"The DRMTLGY Peptide Night Cream has got the good peptides in there. Really nice, moisturizing cream, not terribly expensive, it's really nice."
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"It's called Dermatology Peptide Night Cream, 2.1 ounces, forty four dollars. I don't know why they named it a night cream because it really works well daytime or evening, I'm not sure why they did that, but it contains five peptides. It also contains several ceramides, which make it really nice for skin. It's fragrance free, cruelty free, and vegan. I'll link to it. Dermatology, they have some really nice stuff, if you haven't tried anything from them check them out, because they have a lot of products that are dupes for a lot more expensive products, so I think they're well worth checking out for that reason alone."
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"Next up the DRMTLGY Peptide Night Cream, which is really nice. It's got peptides in it. What else, it's got some silicones, it's got ceramide, it's got the urea in there, it's got allantoin, it's got vitamin E. I would almost say this is thicker than the last one, man, it's hard to kind of rationalize all the thicknesses of them. But very nice, it's great for anti-aging. They do say it's a night cream, but honestly I use this one in my daytime if I'm not using an ascorbic acid serum. I will use this under my vitamin C serum or something like that, but if I'm using my ascorbic acid then I don't like the peptides mixing around with it because I feel like the ascorbic acid can break it down, so I don't go crazy with it. But if I'm using something else, it's great with that."
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"The DRMTLGY Peptide Night Cream is a little bit more expensive than the last one, however I want to remind everyone this one is just over 2 oz, so it's like 15% more, it's a little bit more pricey. [...] It's 46 bucks. So in here we've got shea butter, we've got several different ceramides, we've got five different peptides, and we've got vitamin E. Well worth checking out."
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"It's their Peptide Night Cream. It's really nice, sometimes they use it during the daytime as well. It contains five different peptides, it also contains three different ceramides. It's a really nice fragrance-free skincare cream and you can certainly fit it into your evening routine or your morning routine. It's really nice, and it's 32 bucks, and it's 2.1 ounces, so it's a little bit larger than the average moisturizer. I'm getting low on this one, so I'll definitely be stocking up on this one during the sale."
Yay
"This is a mid-weight cream that glides on the skin so smoothly and rubs in so easily. I actually really like to use it as a moisturizer during the day because I feel like it layers so well under sunscreen on a day that I'm feeling particularly dry, and then I save even thicker richer products for nighttime. But if you have more normal to combination to oily skin and you're looking for a nighttime moisturizer that isn't too occlusive or heavy and delivers some nice peptides to the skin so it has some anti-aging properties to it as well, I think this is a great option. So many different types of skin could also find a use for this in their routine, and as a dermatologist that makes a product a favorite is if I feel like it has really universal appeal."
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"The moisturizer I have been loving lately is the Dermatology Peptide Night Cream. This is sort of a thick whipped sort of like a marshmallowy texture that rubs in really well and it just feels delicious on the skin. It is very rich but still doesn't feel super thick or heavy, and that's the thing I've loved about it the most. You get the moisturization that you want out of a thick night cream without that thick night cream feel. I loved this moisturizer a lot and I even feel like on days when I feel dry in the morning I also put it on in the morning under my sunscreen and it works great for that as well, even though it says night cream."
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"This is a mid-weight cream that glides on the skin so smoothly and rubs in so easily. I actually really like to use it as a moisturizer during the day because I feel like it layers so well under sunscreen on a day that I'm feeling particularly dry, and then I save even thicker richer products for nighttime. But if you have more normal to combination to oily skin and you're looking for a nighttime moisturizer that isn't too occlusive or heavy and delivers some nice peptides to the skin so it has some anti-aging properties to it as well, I think this is a great option. So many different types of skin could also find a use for this in their routine, and as a dermatologist that makes a product a favorite is if I feel like it has really universal appeal."
Yay
"The Peptide Night Cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."
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"The Peptide Night Cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."
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"This was the first product I ever tried from dermatology, the Peptide Night Cream. It is a beautiful mediumweight moisturizer. Perfect for normal to dry skin."
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"You can use this day or night. In the winter and fall months I need something this hydrating for my daytime routine. It's kind of a fluffy, sort of creamy formula, soaks right into the skin, doesn't leave a greasy residue. I think it's great for maybe not very oily skin but anywhere from dry skin to slightly oily or normal skin you're going to really enjoy DRMTLGY Peptide Night Cream."
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"My budget pick for moisturizer is the DRMTLGY Peptide Night Cream. Great budget pick, gets the job done, super nourishing. You can use it as a day moisturizer or a night moisturizer."
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"Of course my Holy Grail Peptide Night Cream, the DRMTLGY Peptide Night Cream now comes in a huge tub. I certainly hope they do something with the lettering, mine always smears off. You guys asked and apparently they decided to deliver on a jumbo tub of the Peptide Night Cream, so it will save you a little bit and you won't have to keep repurchasing and wasting plastic. I think that is an awesome move on their part."
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"I love their Peptide Night Cream. I've [...] loved it for years and years [...] and it's one of moisturizer that I have used for years and years. I love the texture of the Peptide Night Cream, and it's nice to have it in a jumbo size for a little bit of savings."
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"The Peptide Night Cream is amazing. I love this. It now comes in a jumbo. I use it summer, I use it winter, I use it morning, I use it evening. If you have dry skin, you have mature skin, you're going to love this. It's just a nice fluffy formula, one of my absolute all-time favorite moisturizers."
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"I have purchased this countless number of times I love it I've used it for over 3 years"
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"This is a little bit [...] thicker in consistency, but a really nice moisturizer that I have used up and enjoyed."
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"Another great find is the DRMTLGY Peptide Night Cream. Honestly, it's a midweight moisturizer that can be used for morning and night."
Yay
"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine. You could use this in your morning even though they market this as a night cream, you could still use this in your morning if you really want, just know it's going to be a little bit richer. [...] This one has a little bit more to it. It has more peptides. There's also ceramides in here as well. Very moisturizing and repairing, but a great cream to firm the skin and help to stimulate collagen and of course to help soften fine lines and wrinkles."
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"My next favorite is also by DRMTLGY, and this is the Peptide Night Cream. I have talked about this quite a bit on and off over the last several years, and this is one of my favorites for fall but even transitioning into the winter months as well. I don't necessarily use this during the summer because I just feel like it's a little bit too much for my combination skin. It is very moisturizing, but at the same time it's very lightweight and it doesn't feel heavy on the skin, and it has that nice spreadability, it's not super thick, which is why I feel like this is a great cream to transition from summer to fall. It really is great. Now did you know that there is a larger size now? They always had their 2 oz size, and now they came out with a 4 oz size, which is what this is. So if you plan on using this all fall and winter, I would say go with the 4 oz, you just get more product. You can use this in the morning even though this is marketed as a night cream, it just depends if this is going to work well with the types of makeup and sunscreen that you are pairing with it. I have used this a handful of times in my morning routine and it's nice, it does give a glow to your skin, just keep that in mind, but I mainly keep this for my nighttime routine paired with retinol, copper peptides, chemical exfoliants. It just has that nice richness without feeling heavy."
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"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine. You could use this in your morning even though they market this as a night cream, you could still use this in your morning if you really want, just know it's going to be a little bit richer. [...] This one has a little bit more to it. It has more peptides. There's also ceramides in here as well. Very moisturizing and repairing, but a great cream to firm the skin and help to stimulate collagen and of course to help soften fine lines and wrinkles."
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"This is one of my go-to creams during the winter as well because it is pretty rich it's moisturizing"
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"If you wish to use a cream based product that contains peptides, I really love the DRMTLGY Peptide Night Cream. I [...] like this one specifically for the fall winter months because it's very rich and very moisturizing, but you're also getting the benefits of those peptide ingredients. [...] This is a night cream, so it's thicker and richer. You could use this in your morning routine, but you may or may not feel like this is suited based on the types of sunscreens you use or the makeup, it is a little bit heavier for daytime, but now that we're coming into fall this actually might be a great option for you. You'll have to play around, but I like to keep this strictly for my nighttime routine, and when I'm not using vitamin C in my morning skincare routine then I'm incorporating a peptide of some kind."
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"This really is a lovely one. It gives your skin this nice glow, your skin is just so moisturized, but then of course we're treating those fine lines and we're trying to develop more firm skin."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Urea

Urea both holds water in the skin and gently loosens dead surface cells. At higher strengths it has good evidence for very dry or thickened skin.

Source: DermNet

Ceramides

Ceramides are part of the skin's own barrier, and moisturisers built around them have evidence for holding water in and settling the tightness and flaking that come with a damaged barrier.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Frequently asked.

What is DRMTLGY Peptide Night Cream?

A peptide-enriched night cream formulated with ceramides, shea butter, and vitamin E to hydrate and support the skin's moisture barrier.

Is DRMTLGY Peptide Night Cream worth it?

Mostly yes. 4 of the 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 77%.

What is DRMTLGY Peptide Night Cream's Guru Score?

DRMTLGY Peptide Night Cream holds a Guru Score of 77%. That is our read on how warmly the experts talk about it, based on the verdicts of 5 expert reviewers we have collected.

Who is DRMTLGY Peptide Night Cream best for?

DRMTLGY Peptide Night Cream is generally suited to dry skin and sensitive skin.

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