Index / DRMTLGY / Peptide Night Cream
DRMTLGY

Peptide Night Cream.

DRMTLGY Peptide Night Cream
Serums

About this product

A peptide-enriched night cream formulated with ceramides, shea butter, and vitamin E to hydrate and support the skin's moisture barrier.

Type

SerumsCream

Key actives

Vitamin ECeramidesPeptides

Formula notes

Fragrance-freeNo drying alcohol

Full ingredients

Guru Score

Not verified

Score withheld

!
Not independently verified

2 of the 3 takes here are sponsored by the brand. That leaves a single independent take, which is not enough to verify a score, so we are holding it back rather than publishing a number built on paid reviews. The takes are below, each labeled.

3Gurus
3Approved
0Mixed
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What the gurus are saying

A fluffy, medium-weight cream that soaks in without greasiness and works across most skin types, earning consistent praise as a budget-friendly staple. Gurus highlight its richness and peptide blend as particularly strong for dry or tight skin in cooler months, though those with very oily skin may want to reserve it for nighttime. It pairs well with other actives like retinol.
Synthesized from 3 expert reviews · most recent take March 2026
Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved takes Critical takes Mixed takes Hide sponsored
Approved
"Next up is the DRMTLGY Peptide Night Cream, which is about 46 bucks. It's a peptide-enriched cream. It's fragrance-free, great for sensitive skin. It's great for barrier repair as well. It's really nice. DRMTLGY has a lot of nice stuff."
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"Dermatology Peptide Night Cream, very nice product, love it. I already have a backup of this one as well."
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"Last but not least, the DRMTLGY Peptide Night Cream. It's really full of good ingredients. We've got shea butter, we've got peptides, we've got ceramides, we've got vitamin E, we've got allantoin, we've got cholesterol. It's really nice. It comes with the little plastic thing, so I just kind of do that thinking it protects it, but I'm sure it probably doesn't make that much of a difference. Pretty thick product and wonderful."
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"Next up is the DRMTLGY Peptide Night Cream, which is about 46 bucks. It's a peptide-enriched cream. It's fragrance-free, great for sensitive skin. It's great for barrier repair as well. It's really nice. DRMTLGY has a lot of nice stuff."
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"Next up is the DRMTLGY Peptide Night Cream, which is 34 bucks. This one also has ceramides, shea butter, vitamin E, and allantoin. This is one of my favorites and favorite coordinating products, and it's one of the ones I'd pick out because it contains a nice variety of good peptides."
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"The DRMTLGY Peptide Night Cream is 34 bucks. It also contains going camid, shea butter, vitamin E, and allantoin."
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"Last but not least, the DRMTLGY Peptide Night Cream, 2.1 ounces for 46 bucks, although they have sales and discounts on their website all the time. Fragrance-free, alcohol-free, cruelty-free, vegan. Its main components: glycerin, shea butter. It's also got ceramides, it's got the Matrixyl 3000 peptide duo, it's got the Syn-Ake peptide, which can help skin produce sodium hyaluronate according to research, and then a lantern."
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"The DRMTLGY Peptide Night Cream is 2 oz for 32 bucks and it contains the Matrixyl 3000 peptide, it contains the Syn-Coll peptide, and then it contains the Syn-Ake peptide. It also contains shea butter, ceramides, and vitamin E. It's really nice, and you don't have to just use it during your evening routine, you can use it morning or whenever."
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"The DRMTLGY Peptide Night Cream has got the good peptides in there. Really nice, moisturizing cream, not terribly expensive, it's really nice."
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"It's called Dermatology Peptide Night Cream, 2.1 ounces, forty four dollars. I don't know why they named it a night cream because it really works well daytime or evening, I'm not sure why they did that, but it contains five peptides. It also contains several ceramides, which make it really nice for skin. It's fragrance free, cruelty free, and vegan. I'll link to it. Dermatology, they have some really nice stuff, if you haven't tried anything from them check them out, because they have a lot of products that are dupes for a lot more expensive products, so I think they're well worth checking out for that reason alone."
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"Next up the DRMTLGY Peptide Night Cream, which is really nice. It's got peptides in it, what else, it's got some silicones, it's got ceramide, it's got the urea in there, it's got allantoin, it's got vitamin E. I would almost say this is thicker than the last one. Very nice, it's great for anti-aging. They do say it's a night cream, but honestly I use this one in my daytime if I'm not using an ascorbic acid serum, I will use this under my peptide serum or something like that. But if I'm using my ascorbic acid, then I don't like the peptides mixing around with the ascorbic acid because I feel like the ascorbic acid can break it down, so I don't go crazy with it, but if I'm using something else it's great with that."
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"The DRMTLGY Peptide Night Cream is a little bit more expensive than the last one, however I want to remind everyone this one is just over 2 oz, so it's like 15% more, it's a little bit more pricey. It's 46 bucks. So in here we've got shea butter, we've got several different ceramides, we've got five different peptides, and we've got vitamin E. Well worth checking out."
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"It contains five different peptides and three different ceramides. It's a really nice fragrance-free skincare cream and you can certainly fit it into your evening routine or your morning routine. At $32 for 2.1 ounces, it's a little bit larger than the average moisturizer. I'm getting low on this one so I'll definitely be stocking up on this one during the sale."
Approved
"The Peptide Night Cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."
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"The Peptide Night Cream. Love this. It is a beautiful fluffy mediumweight moisturizer that is perfect for every skin type. One of my absolute favorite moisturizers. It sits by my bed. It is worth every penny."
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"This was the first product I ever tried from dermatology, the Peptide Night Cream. It is a beautiful mediumweight moisturizer. Perfect for normal to dry skin."
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"You can use this day or night. In the winter and fall months I need something this hydrating for my daytime routine. It's kind of a fluffy, sort of creamy formula, soaks right into the skin, doesn't leave a greasy residue. I think it's great for maybe not very oily skin but anywhere from dry skin to slightly oily or normal skin you're going to really enjoy DRMTLGY Peptide Night Cream."
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"My budget pick for moisturizer is the DRMTLGY Peptide Night Cream. Great budget pick, gets the job done, super nourishing. You can use it as a day moisturizer or a night moisturizer."
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"Of course my Holy Grail Peptide Night Cream, the DRMTLGY Peptide Night Cream now comes in a huge tub. I certainly hope they do something with the lettering, mine always smears off. You guys asked and apparently they decided to deliver on a jumbo tub of the Peptide Night Cream, so it will save you a little bit and you won't have to keep repurchasing and wasting plastic. I think that is an awesome move on their part."
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"I love their Peptide Night Cream. I've loved it for years and years and it's one of moisturizer that I have used for years and years. I love the texture of the Peptide Night Cream, and it's nice to have it in a jumbo size for a little bit of savings."
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"The Peptide Night Cream is amazing. I love this. It now comes in a jumbo. I use it summer, I use it winter, I use it morning, I use it evening. If you have dry skin, you have mature skin, you're going to love this. It's just a nice fluffy formula, one of my absolute all-time favorite moisturizers."
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"The Peptide night cream I have purchased this countless number of times I love it I've used it for over 3 years I recommend it all the time. I even recommend it for normal to oily skin types using a thin layer in the evening it can be your night cream. You can also use it to buffer your retinoid products or sandwich your retinoid products with this it can help protect so that you don't get that irritating red and flakiness. This is one of the best moisturizers I think that is out there on the market one of my all-time faves. Never stings never burns even when my skin is super irritated it's soothing and calming and can be used in so many ways. It's chalked full of ceramides and peptides it just gives that skin that moisture that it needs throughout the day if you're using it in your daytime routine or overnight if you're layering it with your retinoids or just using it as an overnight moisturizer. Highly highly recommend."
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"This is a little bit thicker in consistency, but a really nice moisturizer that I have used up and enjoyed."
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"Another great find is the DRMTLGY Peptide Night Cream. Honestly, it's a midweight moisturizer that can be used for morning and night."
Approved
"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine. You could use this in your morning even though they market this as a night cream, you could still use this in your morning if you really want, just know it's going to be a little bit richer. This one has a little bit more to it. It has more peptides. There's also ceramides in here as well. Very moisturizing and repairing, but a great cream to firm the skin and help to stimulate collagen and of course to help soften fine lines and wrinkles."
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"I do prefer to use this at night time paired up with my TR retinol, a copper peptide. You can pair this moisturizer up with a lot of different things so if you love your peptides and you want something in a cream form you have to try this. I'm going to give this a 9 out of 10."
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"My next favorite is also by DRMTLGY, and this is the Peptide Night Cream. I have talked about this quite a bit on and off over the last several years, and this is one of my favorites for fall but even transitioning into the winter months as well. I don't necessarily use this during the summer because I just feel like it's a little bit too much for my combination skin. It is very moisturizing, but at the same time it's very lightweight and it doesn't feel heavy on the skin, and it has that nice spreadability, it's not super thick, which is why I feel like this is a great cream to transition from summer to fall. It really is great. Now did you know that there is a larger size now? They always had their 2 oz size, and now they came out with a 4 oz size, which is what this is. So if you plan on using this all fall and winter, I would say go with the 4 oz, you just get more product. You can use this in the morning even though this is marketed as a night cream, it just depends if this is going to work well with the types of makeup and sunscreen that you are pairing with it. I have used this a handful of times in my morning routine and it's nice, it does give a glow to your skin, just keep that in mind, but I mainly keep this for my nighttime routine paired with retinol, copper peptides, chemical exfoliants. It just has that nice richness without feeling heavy."
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"This is one of my favorite creams to use during the winter months, especially in my nighttime routine because it's very rich and very moisturizing on the skin. So, if you live in a colder climate like I do, this is going to be great. Even if you live in a warmer climate all year round, it's still going to be a lovely one. Just use it for your nighttime routine. You could use this in your morning even though they market this as a night cream, you could still use this in your morning if you really want, just know it's going to be a little bit richer. This one has a little bit more to it. It has more peptides. There's also ceramides in here as well. Very moisturizing and repairing, but a great cream to firm the skin and help to stimulate collagen and of course to help soften fine lines and wrinkles."
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"This is one of my go-to creams during the winter because it is pretty rich and moisturizing but more lightweight on the skin compared to other options. Even though this is a night cream, you can still use this in your morning routine, just make sure that you put a sunscreen on top of this. It's a great anti-aging cream that contains five types of peptides to firm the skin and to address fine lines and wrinkles. There's three types of ceramides in here as well, there is shea butter and vitamin E. This is wonderful if you have dry, tight skin, especially in your nighttime routine."
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"If you wish to use a cream based product that contains peptides, I really love the DRMTLGY Peptide Night Cream. I like this one specifically for the fall winter months because it's very rich and very moisturizing, but you're also getting the benefits of those peptide ingredients. This is a night cream, so it's thicker and richer. You could use this in your morning routine, but you may or may not feel like this is suited based on the types of sunscreens you use or the makeup, it is a little bit heavier for daytime, but now that we're coming into fall this actually might be a great option for you. You'll have to play around, but I like to keep this strictly for my nighttime routine, and when I'm not using vitamin C in my morning skincare routine then I'm incorporating a peptide of some kind."
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"This really is a lovely one. It gives your skin this nice glow, your skin is just so moisturized, but then of course we're treating those fine lines and we're trying to develop more firm skin."
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