Cream.

"Tretinoin is the most well-studied topical retinoid in use in dermatology for treating hyperpigmentation. It can significantly improve hyperpigmentation in as little as 4 weeks and those benefits continue to increase out to 40 weeks of ongoing use. Tretinoin was actually one of the first topical retinoids to not only be studied for hyperpigmentation but to be studied for hyperpigmentation in deeper skin tones. Here's the trade-off though. About half of people experience side effects like dryness, peeling, and skin irritation. And this irritation can actually end up leading to post-inflammatory hyperpigmentation if not properly managed by the overseeing dermatologist."

"You've heard about tretinoin, honestly tretinoin can be used on the back to treat back acne just like the face, but success with that is kind of variable."

"It's FDA approved for the treatment of acne on the trunk, back, and chest. All topical retinoids can improve the visible signs of sun damage and wrinkles. Since it's a retinoid and they all kind of work the same way, even though they have different receptor specificities, at the end of the day, they all end up doing more or less the same thing."

"Tretinoin, also known as all-trans retinoic acid and sold under a variety of brands including Retin-A, is a prescription-only topical form of vitamin A that can visibly improve mild to moderate photodamage including fine and coarse wrinkles, freckles, other pigmentation, and improve overall skin texture after months of daily use. One of the advantages of using a topical retinoid is that it can improve the appearance of wrinkles because it gets down to the deeper layers of the skin to not only improve collagen production to smooth out wrinkles but also to help actively protect the collagen that you have. Skin biopsies taken before and after 10 to 12 months of tretinoin versus placebo found that while skin collagen formation dropped 14% in the control group, it rose 80% in the tretinoin group."

"Prescription retinoids like tretinoin, if you have acne that can scar over time, this can help soften and smooth the surface of the scar. Topical retinoids can also improve collagen production in the deeper layers of the skin, so if you have a depressed scar that can help subtly soften it a bit and plump the skin. It will not get rid of those scars, but it can over time with consistent use improve the appearance. Plus, if your scarring is due to acne, this will help control and prevent future breakouts. So long as the acne goes untreated, addressing the scarring is futile because you have that process going on that is driving the scarring. Tretinoin is also going to be helpful for hyperpigmentation, it helps slow down the pigment producing process and helps lift up the hyperpigmentation out of the skin, plus it's anti-inflammatory."

"Tretinoin is used not only for acne but also for anti-aging effects and for hyperpigmentation. Tretinoin is actually used to treat a ton of stuff in dermatology. It is assumed as a generally conservative measure that tretinoin is probably not the best thing to be using during pregnancy. Starting with animal studies, it actually can cause birth defects in animals when given orally, but with tretinoin we're not giving it to patients by mouth, we're just putting it on the skin. In animal models like mice, when given orally it can cause birth defects similar to what would occur with taking isotretinoin or Accutane. Animal studies actually do show fetal malformations when tretinoin is applied at very very very high doses to the skin, which again is not in keeping with how it is typically prescribed to people. The absorption of tretinoin from the skin is actually pretty low, generally speaking about one to two percent of tretinoin is absorbed. A lot of things can influence absorption of tretinoin into the skin. If you have an underlying skin condition, absorption might be a lot greater. You also have to factor in the body location."

"Tretinoin used prior to surgery can not only help cut down on the severity of scarring, but it also can help with healing. It's been examined with tretinoin specifically. In fact, a lot of cosmetic procedures benefit from pre-procedure use for a few weeks of topical tretinoin. Also, if you're inclined towards hyperpigmentation, priming the skin with several weeks of using topical tretinoin can also cut down on the risk of hyperpigmentation as well. Unfortunately, inner thigh skin does not tend to tolerate topical tretinoin particularly well, but if you tolerate it, it's worth considering."

"If you've ever used tretinoin, it's often irritating in the beginning. Well, we can use that to our advantage when treating molluscum. Your dermatologist might prescribe you or your child some tretinoin, tell you to put it on the molluscum with a toothpick to cause an irritant reaction. Plus tretinoin also can have some immunomodulatory properties that may be beneficial in clearing molluscum and make the bumps go away a lot faster."

"I use Tretinoin Cream and I really like it because I find that the cream is pretty moisturizing."

"Tretinoin can improve collagen, but it is not going to change nasolabial folds sagging or prominent deep, deep wrinkles."

"If you are already using a topical retinoid like tretinoin, adapalene, you might give it a try. No promises, no guarantees it's going to work, but topical retinoids can be effective. They can be helpful for softening them and helping to flatten them out."

"Prescription topical tretinoin is available in strengths ranging anywhere from 0.01 all the way up to 0.1%. It's FDA approved for the treatment of acne, and also FDA approved for facial wrinkles and is used to treat hyperpigmentation. Multiple clinical studies have shown that topical tretinoin improves the visible signs of skin aging including fine lines, uneven pigmentation, and rough skin texture. One particularly important study followed patients for 2 years who were using 0.05% tretinoin once a day. That study showed that long-term use of topical 0.05% tretinoin daily was not only safe, but was effective for improving the visible signs of moderate to severe sun damage. The research doesn't suggest that a higher percentage strength is any better than a lower percentage strength. Higher percentages of topical tretinoin can work faster, but they also can be significantly more irritating and that irritation can actually cause hyperpigmentation for some people. For other people it makes it intolerable, they bail on the topical. They get too much dryness, too much peeling, too much flaking."

"So in a world of kind of overpromised skincare ingredients, tininoan deserves its good reputation."

"My personal Holy Grail anti-aging topical retinoid is prescription tretinoin and that is relatively affordable considering how potent it is. Occasionally it's actually covered by your insurance so you might pay as little as $5 to $10 for it, and even if it's not covered by your insurance you can go out of pocket and get the generic version and that's usually around $50. Topical tretinoin can be a bit irritating, but it's very effective for anti-aging benefits."

"Finally I've been able to incorporate tretinoin successfully into my skincare routine and have done so over the past 6 months. I've had a bit of a cycle on my skincare journey for the past four, maybe five years of following all the guidelines and the advice and still my skin couldn't get past that redness, peeling, and irritation, so I would stop. But that stops today."

"Tretinoin is often referred to as the gold standard in anti-aging skincare and it's been around for decades, but around 3 years ago it really went viral and it seemed that just about everyone wanted to incorporate it as an ingredient in their skincare routine. Well, 3 years is a long time in skincare and as we close out 2024 there seems to be an emerging tretinoin backlash. Lots of content creators that were previous huge advocates for the use of the ingredient are now saying they no longer use tretinoin and documenting the reasons why. There often seems to be an emerging narrative in some of the skincare blogs about how tretinoin might not be as amazing as we first thought and could be causing a lot of problems in our skin. I'm someone that uses tretinoin a couple of times a week and that's personally what works well for me."

"Tretinoin is a high potency, super popular retinoid which is used for anti-aging, minimizing fine lines and wrinkles, maximizing collagen and elastin production. Lots of people say it's the gold standard when it comes to anti-aging skincare."

"Tretinoin has often been termed the gold standard in anti-aging. Has been the bestselling prescription strength retinoid for the longest time ever. However, in 2026, it's reported that tretinoin prescription volumes are actually down by 24%."

"Tretinoin also increases cellular turnover leading to a smoother look to our skin, and it's proven to have some significant benefits when it comes to fading and tackling hyperpigmentation. It really is one of those ingredients that does an awful lot, but a lot of people report significant side effects and irritation. Most of the side effects and irritation will be at the early stages of incorporating it into your skincare routine, but there are often people who will experience just random bouts of sensitivity and irritation, even if they've been established retinoid and tretinoin users for many years. So that irritation is something you always have to be aware of and kind of have in the back of your mind. It will come and it will go, but it's definitely one of the most irritating ingredients that we will apply to our skin as part of our skincare routine."

"Often referred to as the gold standard in anti-aging. It's fantastic when it comes to minimizing fine lines and wrinkles, boosting collagen and elastin production. It's a favorite with skincare nerds, dermatologists, and the wider community."

"Does tretinoin work? It absolutely does. Whilst there were very limited studies at the time when the brand was making all these bold claims, since there have been a lot more studies, data points which show just how effective tretinoin is in terms of anti-aging, smoothing out fine lines and wrinkles, and resurfacing the skin. Definitely a gold standard when it comes to anti-aging, but one that comes with quite a controversial past."

"This is tretinoin, which is a prescription super high strength retinoid. Lots of people will go for this as their go-to anti-aging choice and it works really well, but you get a lot of side effects. You get a lot of irritation, the peeling, the redness, the dryness, all of that."

"Tretinoin is a great prescription retinoid that really helps to get rid of any type of skin damage. It really is like that hero ingredient. It will make your skin freak out when you first use it, you might get some purging, breakout, sensitivity, and that's primarily because it is just such a powerful ingredient. I would use this as proof for why you should use tretinoin, particularly if you're around 30 years old or older. You will love it."

"Tretinoin is known to be like the gold standard best ingredient ever for fighting darkness and hyperpigmentation in the skin, but it is really, really powerful and has the potential to really sensitize and irritate your skin. Every time I've tried to use tretinoin on my under eye area, even though I have like the lowest dose of tretinoin you can get, I still notice irritation and sensitivity. Even though the rest of my face doesn't react, my under eye area does, which is really frustrating because I know it works, but at the same time, whether it be redness, bumps, or eczema, my under eye area really, really doesn't like tretinoin. For my face, tretinoin has been absolutely incredible and I love using it. But for the under eye area, it's only something that I can use like maybe once every few weeks, if that, because dealing with the sensitivity and irritation afterwards is just not worth it."

"Tretinoin is a prescription retinoid that is pretty much the most effective ingredient at helping to get rid of deep set damage like premature aging. Tretinoin is the gold standard and pretty much the most concentrated and powerful skincare ingredient you can get to fight against deep set damage. It is incredible and I have absolutely loved introducing it into my routine. I will admit I am not at the point where I'm using it every single day. I can only tolerate it at the lowest percentage around like two to maybe three times per week. Getting tretinoin into your routine is the best way of fighting against the deep set damage that premature aging can introduce to your skin. But a word of caution, if you are someone who really struggles with sensitive or irritated skin, I would definitely not recommend tretinoin unless your dermatologist says so."

"Tretinoin is a prescription grade skin care ingredient that is one of the most well researched and most powerful ways of getting rid of deep set damage in your skin. It's amazing for treating all different types of concerns whether it be premature aging, acne, acne scarring, dark spots, dark circles. This year I've been using it almost every other day and it really is incredible. It would honestly be a sin for me to not recommend tretinoin as a really effective way of getting rid of acne scarring because it is like pharmaceutical grade treatment, you can't really get better than that. However, if you're someone who has very sensitive skin or very reactive skin, I will say that tretinoin is probably not the best thing for you because even at an extremely low percentage, I will sometimes experience irritation from tretinoin use. If I go a week without using tretinoin and then I reintroduce it into my routine, here comes the flaky skin, here comes the stinging sensations, the redness. It's definitely not for the faint of heart or faint of skin."

"Tretinoin, which is my prescription tretinoin that I use, and this stuff is wonderful. I tried prescription tretinoin a long long time ago, it was a different version and it was very drying. However, if you have dry or sensitive skin, the tretinoin version of it I've had great luck with it, so I think that one is worth checking out as well."

"Tretinoin, which is a prescribed retinoid, is worth checking out. Retinoids are going to be our biggest friend the older we get if your skin tolerates it, go for it."

"I tried one like 10 years ago and I'm like that I'm never touching another retinoid again. The next day my skin was just on fire. It was a bad experience. It was terrible. But I've found formulas that are more hydrating and more beneficial for dry skin as opposed to the formula I tried which is just the original generic one with a lot of alcohol in it."

"I decided that my neck tolerated well too so that I can still treat the skin on my neck while I was treating my face with tretinoin and then as the years went on I started to slowly migrate that tretinoin down to my neck and now I'm at 3 to four nights per week using this directly onto the neck area and like I said I am very pleased with that. On my chest I would like to do the same, but if I can just be consistent with three to four nights per week on my chest this year then I am happy because sometimes my chest can be a little bit sensitive to this as well. I also would like to use it more on the backs of my hands before going to bed. I do like to put a little bit into my hand cream, obviously apply that all over the hands and then go to bed. You don't want to use your tretinoin during the day because tretinoin is actually light sensitive, it's very sensitive to daylight so it actually degrades in sunlight, so to achieve best results it's best to use this at night time."

"Tretinoin is the one product that I've been the most consistent with out of everything that I have shared in this video. I have been using Tretinoin for 6 years and I have loved my experience. I don't necessarily love the flakiness and the irritation that came with this product, which by the way is very common, most people experience dryness and irritation, but if you can be patient and get through that process you really won't experience that anymore. Once your skin becomes accustomed to retinol, your skin will just be glowy and looking its best. Tretinoin really is a product that does it all. It softens fine lines, it helps to improve texture and tone, it really does fade discoloration and post acne marks, and it can also help with cell turnover, stimulates new collagen, great for acne prone skin. It literally does it all. It's the gold standard product that is proven to work and it is considered a medication in most countries. Here in Canada my dermatologist prescribes this to me."

"I've been on prescription tretinoin for almost four years and it has been the best four years of my skincare journey because this product has really improved my skin like you wouldn't believe. Tretinoin is wonderful for so many skin concerns so if you are acne prone, you have texture, you have dark spots and post acne marks, you have fine lines and wrinkles, this ingredient can really dramatically improve your skin. Consistency is key, you need to have patience. Tretinoin is a journey, retinol is a journey as well. You want to be patient and consistent because this product doesn't work overnight and the longer you use it the more improvements you see with your skin. Prior to using tretinoin I had a lot of dark spots, post acne marks, I had texture as well, and I was acne prone. Since being on tretinoin now for almost four years, my skin has dramatically improved. The texture and tone is a lot nicer and I don't break out as much. Of course I still break out once in a while but not to the extent that I was experiencing prior to. It really is a wonderful ingredient to go on if your skin can tolerate it."

"I've been on prescription tretinoin for almost four years and it has been the best four years of my skincare journey because this product has really improved my skin like you wouldn't believe. Tretinoin is wonderful for so many skin concerns, if you are acne prone, you have texture, you have dark spots and post-acne marks, you have fine lines and wrinkles, this ingredient can really dramatically improve your skin. Consistency is key, you need to have patience. Tretinoin is a journey. You want to be patient and consistent because this product doesn't work overnight and the longer you use it the more improvements you see with your skin. Prior to using tretinoin I had a lot of dark spots, post-acne marks, texture, and I was acne prone. Since being on tretinoin for almost four years my skin has dramatically improved, the texture and tone is a lot nicer and I don't break out as much. Of course I still break out once in a while but not to the extent that I was experiencing prior. It really is a wonderful ingredient to go on if your skin can tolerate it."

"Tretinoin can be harsh and irritating for a lot of skin types, especially when you're first starting out. It is stronger than a retinol and stronger than a retinaldehyde. I love this product so much, it has really changed my skin. I have been on this for over four years and it is the number one gold standard on the market that is proven to work because there's a lot of studies and science behind it. Tretinoin is great if you have early signs of aging, you're developing fine lines and wrinkles, this can help soften fine lines and wrinkles over time. It can really help improve texture, uneven skin tone, dark spots, post-acne marks, and that dull-looking complexion. If you have acne-prone skin and a lot of acne, dermatologists will usually prescribe tretinoin to treat acne. I am acne prone and I can definitely say that tretinoin really helps to prevent acne, especially when you are consistent with the product. This is a big part of my nighttime routine."

"Tretinoin has to be used very gradually, especially if you are new to it, because if you use too much too quickly you're going to certainly get what's called retinoid dermatitis and you can get skin peeling, flaking, drying. Not in everyone, but definitely can happen in many people if you use too much of it. So if you're new to retinoids I definitely tell people to start low and slow, so start with a lower strength and just use a little bit."

"Tretinoin has to be used very gradually, especially if you are new to it, because if you use too much too quickly you're going to certainly get what's called retinoid dermatitis and you can get skin peeling, flaking, drying. Not in everyone, but definitely can happen in many people. If you're new to retinoids, I definitely tell people to start low and slow. Start with a lower strength and just use a little bit very slowly. I tell people like a chocolate chip or a green pea size for the whole face. You can dab it in five places and then rub it in. So let's say you use it two nights a week for two weeks without any issues, then try to go every other night, and if after a month you are good, you could potentially go every night. If you're using it for two weeks, two nights a week, and you're still having issues, what you can do is a retinoid sandwich where you put a layer of moisturizer on first, then the tretinoin, and then you can do another moisturizer on top of that. Some people might think that could affect the effectiveness of the tretinoin, but actually there was a study done to show that doing a moisturizer before tretinoin did not have different effects compared to putting moisturizer only after tretinoin. So doing that moisturizer sandwich is definitely a really helpful technique."

"Retinoid creams like Tretinoin can help with some collagen remodeling. It doesn't get rid of stretch marks completely, but there is some data to support that it can help decrease the appearance."

"One of the biggest skincare adjustments for me was to stop using tretinoin for wrinkle prevention, this is my #1, ride-or-die skincare prescription cream, so you can imagine how hard it was to give up. Unfortunately, this ingredient can have adverse effects during pregnancy, so I had to remove it from my skincare routine."

"I'm four and a half years strong on tretinoin and it's the single best thing I have ever done for my skin. I consider this to be the goat of skincare ingredients, it is the greatest of all time. But it's not without nuance."

"Tretinoin is part of that family of retinoids. There is a prescription form of retinol that's called tretinoin. I consider this to be the goat of skincare ingredients, the greatest of all time. It does everything. It does dark spots, it does collagen, it does texture, it actually can help minimize UV damage associated like pre-cancerous lesions to some extent, it protects your skin, it increases the thickness of your skin, it helps organize the collagen, it helps with the elastin, and it does all of it extremely well, especially relative to other ingredients. It's foundationally been studied like it's perhaps one of the best studied ingredients in all skincare. It has incredible staying power. Tretinoin has been around for 60 years and still kicking, so this is an ingredient you can really rely on."

"It's really good for anti-aging, it's able to treat wrinkles, but is it going to eliminate really deep etched in wrinkles if you've never done anything for 60 years? No. Those are going to need procedures that are going to be done by your dermatologist. Here comes the downside of tretinoin. It cannot be used during pregnancy. Some of this is a theoretical risk, but it's based off of the idea that you cannot take oral retinoids during pregnancy because they're teratogenic, and if you use them topically you're going to absorb some, so that could be problematic. It's also irritating. In part, it's by virtue of what it does. It increases skin cell turnover and increases inflammation directly, but it also activates certain receptors that increases irritation, and so because of that it makes it intolerable for certain people. If you have rosacea, if you have flushing, if you feel like your face is super dry and chapped just after a simple wash, if you have a history of atopic dermatitis, you're probably going to fall more into that sensitive skin category and you'll need to approach this delicately. Regardless of whether you have sensitive skin or you don't have sensitive skin, you should ease into the use of tretinoin. Start slow and then go high, which means starting with lower doses, starting with 0.025 percent."

"Tretinoin has a few things against it. One of which it cannot be used during pregnancy, some of this is a theoretical risk but it's based off of the idea that you cannot take oral retinoids during pregnancy because they're teratogenic, and if you use them topically you're going to absorb some, and so that could be problematic. It's also irritating. It increases skin cell turnover. Tretinoin works on multiple different retinoid receptors, some of those activate irritation. It actually increases inflammation directly and activates certain receptors that increase irritation, and because of that that makes it intolerable for certain people. If you have sensitive skin, if you have rosacea, if you have flushing, if you feel like your face is super dry and chapped just after a simple wash, if you have a history of atopic dermatitis, you're probably going to fall more into that sensitive skin category and you'll need to approach this delicately. Regardless of whether you have sensitive skin or you don't have sensitive skin, you should ease into the use of tretinoin. Start slow and then go high, which means starting with lower doses. Starting with that 0.025 percent and then increasing to 0.1 percent can be really good if you're easing into it. Starting with once every three days then going to once every two days and then once every night, just easing into it, that's going to make a big difference."

"The retinoid family consists of retinol, retinal, tretinoin, adapalene and so many more. Tretinoin is a first generation retinoid. Across the board you're going to see some of the best, some of the most impactful, most meaningful, most clearcut transitional, transformative skincare results you're going to see with any ingredient, and that's been the case for decades. Once you get to the active form of tretinoin, it works on specific receptors either RAR receptors or RXR receptors. Tretinoin is a little bit more balanced in the receptors that it binds to."

"For acne, both are top tier very effective. Most of the studies show that high strength tretinoin is more effective than low strength tretinoin. There's a study comparing high strength tretinoin to tretinoin, and it found that tretinoin was significantly more effective than tretinoin in treating acne when you compare them head to head. It also found that they had equal or equivalent tolerability. When you compare these head to head they're both good for acne, and generally when you come to see me in my clinic I'm going to prescribe you tretinoin first. I'm going to see how your skin responds to it. I might start you on the lower dose, especially if you have sensitive skin."

"I would still give the nod to Tretinoin in this category because of the breadth of data that we know is available for Tretinoin and going over decades just countless, countless studies delivering really consistent results, very generalizable results that anyone should expect to see when you use this. There are some studies with 0.05% showing similar benefits, and I would say that time will tell where other retinoids land, but I just don't think we're quite there yet to make that claim. In general, most dermatologists are going to start you on Tretinoin first."

"Photo protection sun protection is paramount when using Tretinoin, although it's always important, this one certainly will make you more likely to get a burn. In the mechanism of Tretinoin there's a few things that happen that make it effective in treating psoriasis and that's a downregulation or an inhibition of ornithine decarboxylase, which is something that leads to kind of growth of your skin cells and that's why it's helpful in treating psoriasis. It also downregulates something called epidermal growth factor receptor, and so epidermal growth factor receptor is a receptor once it's triggered it leads to epidermal growth. Tretinoin will actually thicken your epidermis layer of the skin but it does it in a way that normalizes it so you don't get these abnormal cells like you do in psoriasis, so it's exactly what you want when you're treating acne or you're treating anti-aging."

"If you want to step it up, Tretinoin of course is your go-to. It's a prescription type of retinoid and it has the most data. It's what all the other retinols are built off of, so if you're looking for the one that the goat of all retinols, then Tretinoin is going to be the way to go. It is what it is. You can't say okay get a retinol and not mention Tretinoin."

"You have prescription ingredients like tretinoin that you could use on your body as well. No rule saying you can't. In fact, it would be helpful."

"Tretinoin, no, and shout out, seriously, like miracle product. Something that I've been struggling with for years has been figuring out how often and how much to be using of each of these products. I was healing my acne, I was getting rid of the painful stuff that was deep down, the top acne like tiny little bumps and stuff which I'm very prone to. I was seeing such incredible results with the firmness of my skin."

"Tretinoin has been a life changer for me. When I first started using it, it was a combination of like an acne treatment and just like anti-aging. I was using it kind of on and off through my Curology prescription for like a year but at a much lower dose. I'm currently on 0.05, and when I started using tretinoin at a higher dosage, within a few months people were asking me if I got Botox. It just tightened up my skin, it's amazing, it's like a miracle product. And it's also the main thing that prevents me from breaking out. Essentially tretinoin is doing all the work."

"Tretinoin is a prescription retinoid that I prescribe, a dermatologist would prescribe, usually at 0.025 to 0.5%, they can go up to 0.1%. But tretinoin is the goat of retinoids, it's the king of retinoids, it's the most studied retinoid out of the retinols, retinals, retinaldehyde that you see over the counter. Tretinoin is retinoic acid and it's active right off the bat, so it's quite potent. It's also unstable with light, whether it's fluorescent light or UV light. When my patients come in and they're saying that they're not getting enough benefits from the retinoid in terms of acne or hyperpigmentation, I'm always going to ask when are you using it. You want to use your retinoid at bedtime because even fluorescent light can break down your tretinoin, and they've shown that in studies that it is unstable with light. I always say just a pea-size amount to your entire face at bedtime, follow up with a moisturizer."

"Tretinoin, we have tons of data that supports tretinoin's use for fine lines, wrinkles, and hyperpigmentation. If you wanted a more of a collagen boosting punch, adapalene might have some benefits with collagen but we only have limited studies on that. With tretinoin we have tons of data that supports its use for fine lines, wrinkles, and hyperpigmentation."

"Tretinoin, the retinoid I prescribe, has been shown to be deactivated by sunlight and artificial light, so we always say apply that at bedtime."

"I've used tretinoin on and off for years and then the last time most recently I just started getting some of the peeling stuff out of nowhere and I don't want to wait that out. I have decided that I'd rather have happy skin than wait that out and stick to something that's irritating my skin. So I just stopped. I'm not willing to put myself through it even though I know tretinoin can be doing good long-term things. If my skin's irritated I just stop what I'm doing. It's just not worth it. I'd rather have wrinkly skin and just have happy hydrated skin. That's what I'm going for. I have looked at a ton of studies that compare retinol, retinaldehyde and tretinoin and while yes tretinoin is the quickest acting, the other ones you get similar results just not as quickly but you still get the results of epidermal thickening which translates to lines and wrinkles and all of those things. It just takes longer and it might not be as intense but if you can't handle tretinoin, if it causes inflammation, then again, it's just not the right fit for me."

"This is the gold standard for topical products when it comes to regenerative and reparative products. This is a medicine, you need to have a prescription for it, it is not cosmetic. It is clinically proven to reduce fine lines and wrinkles, to help with hyperpigmentation. This is the one. It can also be extremely irritating, and that's why I use this much later in my routine. I don't do it first up anymore, which I did for years, but now I do it later after my skin has had a couple of hours to absorb the other stuff."

"If you're using prescription based retinoids, even third generation retinoids like tretinoin, then probably you want to stay clear. The role of topical retinoids in these cases is still very controversial. There are prospective studies that have examined the use during the first trimester of pregnancy with 96 and 100, 106 women that did not find an increase of major malformations or evidence of retinoid embryopathy, but just looking at 96 and 106 women in two separate studies is not high enough in terms of case reports. You need larger cohorts to really be encouraged that topical retinoids are safe."

"If you're using retinols for anti-aging benefit then prescription grade things like tretinoin are fantastic."

"Tretinoin is a prescription-grade product, so you have to go to a dermatologist and get a prescription for this product. But this product is only 176 dirhams, so it is super affordable. If you've never used any retinol in your life, you can't just go and buy this product. You have to start with a gentle retinol cream or retinol serum, 0.1, 0.2. When you can use it constantly three to four times a week, then you can go to a higher concentration like 0.3, 0.6, and after that, when your skin is ready, you can move to Tretinoin. Tretinoin is a product that you can apply on your face 100 percent, and I also apply it on my body, on my neck. But unlike a lot of videos you might have seen on social media where people literally squeeze out an entire jar of Tretinoin into a container with serum or any other type of moisturizer, mix it up, and then store it, that is something I do not recommend, because when you mix and store products like that on your own, you're basically tampering with its efficacy, with its preservative structure, which is not recommended."

"Tretinoin is one of the best exfoliators I refer. It is fabulous for anti-aging. Tretinoin is a prescription-grade product, so you have to go to a dermatologist and get a prescription for this product, but this product is only 176 rupees, so it is super affordable. The only thing you need to be aware of with tretinoin is that if you have never used any retinol in your life, you can't just go and buy this product. You should always start with a gentle retinol cream."

"Retinoids are just a really good all-rounder class of ingredients they tackle so many skin concerns"

"In your skin retinol can be converted to tretinoin, which is an approved drug. There's a lot of evidence that tretinoin works and we also know a lot about how it works, its pharmacological mechanism of action. We do have evidence that applying normal amounts of retinol to skin will change the level of substances inside the skin, these are the same ones that change with tretinoin and they're expected to be an important part of how tretinoin actually works."

"Tretinoin is the oldest, it was approved in the 1960s, so it has been studied the most. Most of the evidence we have on retinoids are based on tretinoin, so we know that it works for all the standard retinoid things like acne, pigment, and wrinkles, but there are also studies on more unusual things like skin cancer, stretch marks, and cellulite. It's the drug retinoid that has the biggest variety of formulas. You can get concentrations between 0.025 and 0.1% and it's compounded a lot so you can control the percent there too. Some studies sort of suggest that if you have a low concentration it'll end up working as well as a higher concentration, it might just take a bit longer but they will be less irritating. You can get tretinoin in gels and creams, and there are some studies that indicate that cream bases might be less irritating."

"The Olay Retinol 24 Night Cream is very silky, one of the silkiest moisturizers I've ever tried, and it's really gentle."

"I've been using tretinoin since my 30s and it has helped to maintain that nice glowy texture and smoothness to my skin and it also helps prevent some of the premature signs of aging. I've been with agency for about 2 to 3 years now. I started at 0.035% and right now I've graduated to 0.14% tretinoin in my custom prescription formula."

"Tretinoin is the gold standard. Retinoids help to accelerate the cell turnover process but they also help to smooth skin's texture and tone and they also help to stop the overproduction of melanin, AKA hyperpigmentation. You do need a prescription to get tretinoin, but you can sit right where you're set and have that prescription."

"There's nothing else that is proven like tretinoin to work in your skin to produce more collagen to reduce wrinkles to brighten your skin by thinning the outer dead layer of skin while thickening the deeper layers of skin. Everyone's asking for skin tightening and skin firming and the main ingredient that's proven beyond a shadow of a doubt to do that safely is tretinoin. I can definitely say that the differences I'm seeing in my skin now with the combined ingredients are significant."

"Tretinoin, it is the gold standard, it's the heavy hitter. It's the thing that has 40 years of study into it saying that it really does work. Start with that, but it is prescription."

"All the research agrees that it's the one thing that helps your skin to produce more collagen. It helps your skin to look plumper and firmer. It reduces wrinkles, it reduces discolorations, and it does it all in one little bottle. You just put on a pea-size amount of this every night once you work up to it and you can watch the years melt away on your skin over time. It is really the gold standard of anti-aging. You talk to any dermatologist and they'll tell you Tretinoin is the way to go, and the longer you're on it the better off you'll be. I've been on it for 11 years now and I wish I had started earlier. The people who I see who have the best skin now are people who got on Tretinoin and have used it for years and they don't go for Botox, they don't go for fillers, they don't go for laser treatments. It really is a testament to what it can do for your skin."