SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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✓Yay

"SkinCeuticals PTOX combines acetyl hexapeptide 8 with a peptide targeting forehead lines and crow's feet through two different mechanisms, giving it more range than single mechanism options. It's definitely one of my go-tos for neuropeptide serums."

Darnell Cox | 50+ Healthy Aging Expert

55k subs

✓Mixed

"SkinCeuticals makes a PTOX which is like 180 bucks. I personally don't spend a ton of money on skincare, it doesn't cost a fortune. A lot of these really super high priced products are not any better than the cheaper versions of them. Sometimes they are, most of the time they're not."

Allie Glines

829k subs

✓Yay

"The SkinCeuticals P-Tiox Anti-Wrinkle Peptide Serum was a slam dunk for me this year. It's pricey, but since I've been pregnant or breastfeeding for over three years and can't use retinol, [...] it was really nice to use a peptide serum that has actually visibly plumped up my few fine lines. [...] I noticed a visible difference and love it so much."

All 2 takes from Allie Glines

My NEW Favorite Things (NO Makeup?! 🤯)

"I'm going to give this a fair shot and use this very regularly, and boy oh boy I really do see a difference. My deepest lines are in my smile lines and I do feel like they've lightened up a little bit and they've kind of plumped up. I also have some lines here and I feel like that's also getting better. The cool thing about this too is you can use it kind of around the eye area. They kind of call this like Botox in a bottle, even though it doesn't actually freeze anything like Botox would."

THE BEST HAIR, SKIN, NAILS & MORE OF 2025!

"The SkinCeuticals P-Tiox Anti-Wrinkle Peptide Serum was a slam dunk for me this year. It's pricey, but since I've been pregnant or breastfeeding for over three years and can't use retinol, [...] it was really nice to use a peptide serum that has actually visibly plumped up my few fine lines. [...] I noticed a visible difference and love it so much."

Nipun Kapur

411k subs

✓Yay

"This is the only product which has broken my loyalty from the ordinary R line. The ordinary R line matrical is my signature combo back since 2022."

Translated from the guru's original language.

All 3 takes from Nipun Kapur

My routine made Affordable! Dupes & Swaps for my favorite skincare products

"This is the only product which has broken my loyalty from the ordinary R line. The ordinary R line matrical is my signature combo back since 2022."

Translated from the guru's original language.

My Anti-Aging Night Skincare Routine | How to Use Exosomes & Layer Growth Factors | Nipun Kapur

"PTOxs is like my love. I can't even tell you how many bottles of this I have finished since last year and this I know it's a really price product but I am telling you it is worth every single dime."

Translated from the guru's original language.

Top 5 Anti-Aging Essentials for 36-Year-Olds | Must-Have Tips to Look Younger | Nipun Kapur

"Ive been testing out the skin ceuticals pti oxe and i know its expensive its like 500 rums and that product is giving me some great results"

Translated from the guru's original language.

Dr. Aleksandra Brown

148k subs

✓Yay

"This is a cutting edge peptide based serum designed to target expression lines like your crow's feet, maybe some movement forehead wrinkles. It almost has like a Botox-like effect. It also helps improve skin texture and radiance while strengthening the skin barrier. It can be used alone or to enhance the effects of neurotoxin treatments. [...] The key ingredients here are advanced peptide complex, the 2% hexapeptide and 2% dipeptide, which helps smooth out the expression lines."

Dr. Daniel Sugai

722k subs

✓Yay

"My favorite product of 2024 my wife and I love this new peptide Serum by skin cuticals the ptoo serum and I have patients on it I use it my wife uses it it's a great way to not only increase collagen production but it makes my fine lines and wrinkles on my forehead and around the eyes they seem less apparent"

Top Pick: peptide serum

Dr Dray

2.69M subs

✓Mixed

"It's $148, and I think this serum is too little too late in a saturated market of peptide serums. It's a good product, but there are so many other similar formulations with these particular peptides for much less, like the QRxLabs peptide booster serum, which I find just as good and honestly more hydrating than this. It's the price point that keeps me from recommending it, it's just way too expensive, so I would never buy this myself."

Gothamista

683k subs

✓Yay

"I love how it makes the skin look, it gives that beautiful glassy, hydrated sheen. Most noticeably, I feel like it actually does make my pores appear smaller, and my pores have been gaping as of late so I've been quite self-conscious about them. It's [...] a concentrated treatment with 10% of their exclusive Myrixin complex, a group of six plant extracts high in antioxidants that also help improve the appearance of lines and pores."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Frequently asked.

What is SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream?

A peptide-based serum containing acetyl hexapeptide-8 and dipeptide complex designed to reduce the appearance of expression lines, particularly around the eyes and forehead.

Is SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream worth it?

Mostly yes. 6 of the 9 gurus who reviewed it give it their stamp of approval, for a Guru Score of 81%.

What is SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream's Guru Score?

SkinCeuticals P-TIOX Wrinkle Modulating Peptide Cream holds a Guru Score of 81%. That is our read on how warmly the experts talk about it, based on the verdicts of 9 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.