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Skin Medica

TNS Advanced Serum.

Skin Medica TNS Advanced Serum
Serums

About this product

A serum containing growth factors, peptides, and cytokines designed to stimulate collagen production and improve skin firmness, fine lines, and texture.

Best for

Mature skin
Serums

The Guru Index verdict

84%

Approved

Approved · 84%
3Reviewers
3Approved
0Mixed
0Skip

What the gurus are saying

Gurus consistently praise this serum for delivering visible anti-aging results within days to weeks, particularly for crepiness and laxity on the face, neck, and chest. It's valued for tolerability on sensitive areas where retinols irritate and for its clinical backing among physicians. The universal complaint is the steep price; reviewers recommend buying only during sales and using extremely sparingly to extend bottle life. Some note it can pill over actives. The consensus is that it works, but whether the results justify the cost depends on access to discounts.
Synthesized from 3 expert reviews

Key actives & flags

Vitamin EPeptidesFragrance-freeAlcohol-free

Full ingredients

Aqua/​Water/​Eau, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Butter Ethyl Esters, Glycerin, Ethoxydiglycol, Lactococcus Ferment Lysate, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Dimer Tripeptide-43, Vitis Vinifera (Grape) Flower Cell Extract, Pyrus Malus (Apple) Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, PEG-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored
Approved
"There's certain products that I will say I have used within a couple days I noticed positive results. But that's typically far and few between for me. The handful of products that have given me results within a few days of benefit. It's probably three products. Geek and Gorgeous A.Pad, Geek and Gorgeous Seaglow, and the SkinMedica TNS Advanced Serum. That's it."
Top Pick: serum
All 4 takes from No BS Beauty
October Skincare & Beauty Product Empties - What I've Finished This Month!
"The Skin Medica TNS Advanced Serum is an expensive one. If you can get it on sale, it's a deal, but I will never pay the market price for this. I will only buy it if it's a really good sale, lots of cash back, and a good gift with purchase, because otherwise it's just so expensive. Revive serum has something that's very similar and it's one-third of the price."
Volufiline - The Ordinary New Volufiline Serum - Is It A Skin Plumping Miracle Worker & Worth Trying
"There's certain products that I will say I have used within a couple days I noticed positive results. But that's typically far and few between for me. The handful of products that have given me results within a few days of benefit. It's probably three products. Geek and Gorgeous A.Pad, Geek and Gorgeous Seaglow, and the SkinMedica TNS Advanced Serum. That's it."
Anti-Aging Full Routine - How I Treat Wrinkles & Fine Lines Plus Microneedling Device How to Use
"This is the big boy, the expensive one. And I like to use this one because it's got some really good growth factors in there. It's really great for anti-aging, but it's too good to waste any of it."
All About Wrinkles, How to Treat Them & Peptide Basics - LIVESTREAM 1-24-25
"The Skin Medica TNS Advanced Serum was huge for me. I love that stuff. It's so expensive, but anytime it was on sale during Black Friday I bought two bottles of it. I use it super sparingly. I use it on my forehead, I use a little bit around my eyes and then around my mouth. I don't really use it anywhere else. A bottle of it will last me six or seven months just using it very very sparingly. Using it on dry skin or right after a mist helps it kind of absorb quicker."
Approved
"Skin Medica's TNS Advanced Serum can help to stimulate fibroblast to produce more collagen and elastin and to help reduce crepiness and laxity overall. You can use it longer term for your neck and your chest. It will take longer for you to see full results, but you can absolutely use it. If you combine it with in office procedures, you will see results more effectively."
All 4 takes from Dr. Shereene Idriss
Everything No One Told You About The Skin On Your Neck & Chest | Dr. Shereene Idriss
"Skin Medica's TNS Advanced Serum can help to stimulate fibroblast to produce more collagen and elastin and to help reduce crepiness and laxity overall. You can use it longer term for your neck and your chest. It will take longer for you to see full results, but you can absolutely use it. If you combine it with in office procedures, you will see results more effectively."
Skincare for Your 30s: Anti-Aging, Adult Acne, Oily Skin | Dr. Shereene Idriss
"Skin Medica TNS Advanced Serum, you can use from here to here, you will not get irritated on your neck unlike if you use a retinol on your neck and chest. Most of you will get irritated and you will hate me, so you can go wild with this. You can even find hexapeptide 2 which helps with fine lines in the active seal, so there's vitamin C, peptides, and the moisturizer is also ceramides in this. This is purely growth factors and peptides in here. I use this at night underneath my moisturizer, which gives me an extra boost."
How to Prevent Skin Thinning & Boost Your Collagen! From a Dermatologist | Dr. Shereene Idriss
"Growth factors like this, Skin Medica TNS Advanced Serum, this is the one from my practice, this can stimulate fibroblasts which are the cells responsible for producing collagen to increase collagen synthesis. It's a blend of growth factors, cytokines, and Matrix proteins. It is pricey, so I will tell you if you've tried all the rest but you feel like you need more, then venture into this. If you want something for your neck and chest and you've never been able to tolerate a retinol but you want something more than coenzyme Q10, try this. It definitely helps."
Dermstore Black Friday Sale 2023: Top Picks for All Skin Concerns | Dr. Shereene Idriss
"It comes in a dual chamber pump and you get two types of serums that get pumped out of it that you mix together when you apply it. There is a very light scent to it, just beware because it does pill over other products that have actives. I personally use this at night on my face, neck, and chest. I actually use this exclusively on my neck and chest on most nights because my neck and chest cannot always tolerate a retinol and sometimes it gets irritated. Their growth factor cocktail is made up of medium and long amino acid sequences, which are basically small proteins that help your cells signal one another to stimulate growth, proliferation, and differentiation, which is what you want your skin to have in order to stay youthful."
Approved
"This is kind of a flagship product with a price point of about $300 and it has the studies to back up its clinical use and the benefits you'll see. It's extremely popular amongst physicians and definitely has a cult following with a plethora of clinical data around it to support its efficacy. This one is derived from humans, specifically the foreskin. If you're looking for growth factors derived from humans that have been around for the longest, this would be the option to go with, again at a much higher price point. If you're a growth factor purist, this would be the one for you. It really is kind of like that idealistic type of product that has been the gold standard for some time now."
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