Rejuran

Rejuran Turnover Ampoule.

Mists & Essences

About this product

A topical ampoule formulated with 0.5% salmon-derived PDRN, designed to hydrate and calm the skin.

Full ingredients

Water, Aloe Barbadensis Leaf Juice, Butylene Glycol, PEG-6, Rubus Fruticosus (Blackberry) Leaf Extract, Glycerin, Niacinamide, Glycyrrhiza Glabra (Licorice) Root Extract, Calendula Officinalis Flower Extract, Vaccinium Angustifolium (Blueberry) Fruit Extract, Morus Nigra Fruit Extract, Sodium Hyaluronate, Hydrolyzed Dna, Tocopheryl Acetate, Xanthan Gum, Carbomer, Caprylyl Glycol, Polysorbate 20, Hexylene Glycol, Phenoxyethanol, Benzyl Alcohol, (-)-Alpha-Bisabolol, Adenosine, Arbutin, Ethylhexylglycerin

Guru Score

74%

Mixed

4 experts · Moderate agreement

What they liked

Hydrating, a little goes a long way
Suitable for sensitive and reactive skin

What they flagged

Limited clinical data on PDRN ingredient

What the gurus are saying

Overnight hydration and a noticeably calmer complexion keep reviewers reaching for this PDRN ampoule, even though the key ingredient has no real clinical data; the brand's reputation from its in-office injectables reassures them. At 0.5% PDRN from salmon, it contains calming and hydrating ingredients like niacinamide and adenosine, and a little goes a long way when used primarily at night.

Synthesized from 4 expert reviews · most recent take September 2026

Best for

Sensitive skin

Type

Mists & EssencesDrops & dropper

Key actives

Niacinamide Hyaluronic acidVitamin E

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Sephora → Amazon → Google →

Opens a store search. We may earn from these links.

Scan it in the shopFree iPhone app. Scores in the aisle.

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Dr. Sam Ellis

897k subs

~Nay

"But people are extrapolating that data and saying if we apply PDRN topically, then we can have anti-aging benefits, and to me that is such a big leap. [...] Could this serum hydrate your skin and make it look more glowy? Absolutely. But that also could be coming from the rest of the formulation and it is not proving that you're getting any type of enhanced skin longevity or regeneration from the PDRN that's in there. [...] My verdict is skip, at least for now."

Hyram

4.34M subs

~Yay

"I've used it more at night than during the day because it's very hydrating, a little goes a long way, and every time I use it overnight my skin looks glowier and healthier in the morning. For the price point, given the company's history, the ingredient list, and the type of PDRN they use, this is definitely one of the best, if not the best."

Top Pick: research-backed pdrn formula

AliceintheRabbitHole

59k subs

~Mixed

"There's still not real data behind PDRN, this ingredient just will not go away and we still don't have the data, but they're not only claiming it's an anti-aging ingredient, they say it can also help with irritation, and that's something I do need, so that's ultimately why I grabbed this. I don't love the packaging though, it's the same dropper style on the mini as the full size, and it almost looks like it's meant to resemble a needle."

Dr. Jenny Liu

323k subs

~Yay

"The Rejuran Turnover Ampoule is derived from the same brand that made the Rejuran healer injectables, which are skin boosters used in office. It contains topical high purity PDRN for collagen rejuvenation and repair, and is really great for calming the skin, helping post-procedure, supporting your skin barrier, maintaining post-procedure results, improving hydration. [...] It's even suitable for sensitive skin and reactive skin types."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Vitamin E

Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.

Source: NIH, National Library of Medicine

Frequently asked.

What is Rejuran Turnover Ampoule?

A topical ampoule formulated with 0.5% salmon-derived PDRN, designed to hydrate and calm the skin.

Is Rejuran Turnover Ampoule worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 74%.

What is Rejuran Turnover Ampoule's Guru Score?

Rejuran Turnover Ampoule holds a Guru Score of 74%. That is our read on how warmly the experts talk about it, based on the verdicts of 4 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.