Rejuran

Rejuran Healer Dual Effect Ampoule.

Mists & Essences

About this product

A lightweight ampoule essence containing PDRN (polydeoxyribonucleotide) derived from salmon, designed to hydrate and support skin barrier repair.

Full ingredients

Rubus Fruticosus (Blackberry) Leaf Extract, Glycyrrhiza Glabra (Licorice) Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Vaccinium Angustifolium (Blueberry) Fruit Extract, Morus Nigra Fruit Extract, Arbutin, Butylene Glycol, Glycerin, Polysorbate 20, Hydrolyzed Dna, Gerotine/Hydrolyzed Dna, Sodium Hyaluronate, Carbomer, Xanthan Gum, Adenosine, Tocopheryl Acetate, Niacinamide, Bisabolol, PEG-6, Water, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, 1,2-Hexanediol, Dipropylene Glycol, Sodium Chloride, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide NP, Oleic Acid

Guru Score

72%

Mixed

Early verdict · Few reviews so far

What they liked

May help reduce breakouts

What they flagged

Results unclear without other actives
Salmon byproduct sourcing concerns

What the gurus are saying

PDRN's real impact splits the room. One reviewer saw fewer breakouts on the side she used it, though she suspects her other serum did most of the work and hasn't been convinced the PDRN itself delivers anything special. Another swears by it as a holy grail staple. Not much consensus to go on yet, and the salmon-derived ingredient carries ethical concerns worth knowing about if that matters to you.

Synthesized from 2 expert reviews · most recent take September 2026

Best for

Dry skin Sensitive skin

Type

Mists & EssencesDrops & dropper

Key actives

Niacinamide Hyaluronic acidVitamin ECeramidesSqualane

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Sephora → Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

AliceintheRabbitHole

59k subs

~Nay

"While I [...] did feel like [...] I saw fewer breakouts on the Rejuran side and it looked better, everyone I asked said the other side looked better, and looking back, I realize that a lot of the clarity in my skin was probably from the Continuum serum I was using, not the PDRN. My results were ultimately fine, but I'm not convinced the PDRN itself is doing anything special, and I've quit using PDRN again for ethical reasons related to the salmon byproduct."

Mad About Skin

731k subs

~Yay

"It lifts and tightens. Not like a face lift kind of but just lifts and tightens. It's the sort of product that takes like two or three years off the skin without trying, and I think it's for 20 pounds, so I can get on board with that. It definitely gives you that glow. It lifts and it tightens instantly and it's got some long-term anti-aging benefits. Honestly, I was prepared to hate this because of the packaging. I love it and I've been using it ever since. So, yeah, absolute holy grail."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Urea

Urea both holds water in the skin and gently loosens dead surface cells. At higher strengths it has good evidence for very dry or thickened skin.

Source: DermNet

Ceramides

Ceramides are part of the skin's own barrier, and moisturisers built around them have evidence for holding water in and settling the tightness and flaking that come with a damaged barrier.

Source: DermNet

Frequently asked.

What is Rejuran Healer Dual Effect Ampoule?

A lightweight ampoule essence containing PDRN (polydeoxyribonucleotide) derived from salmon, designed to hydrate and support skin barrier repair.

Is Rejuran Healer Dual Effect Ampoule worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 72%.

What is Rejuran Healer Dual Effect Ampoule's Guru Score?

Rejuran Healer Dual Effect Ampoule holds a Guru Score of 72%. That is our read on how warmly the experts talk about it, based on the verdicts of 2 expert reviewers we have collected.