What is Plated Skin Science Exosome Serum?

A gel-textured serum with human-derived exosomes and platelet extract formulated to improve fine lines, wrinkles, and redness while supporting faster post-treatment skin recovery.

Is Plated Skin Science Exosome Serum worth it?

The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 74%.

What is Plated Skin Science Exosome Serum's Guru Score?

Plated Skin Science Exosome Serum holds a Guru Score of 74%. That is our read on how warmly the experts talk about it, based on the verdicts of 6 expert reviewers we have collected.

Who is Plated Skin Science Exosome Serum best for?

Plated Skin Science Exosome Serum is generally suited to mature skin.

Plated Skin Science Exosome Serum: a Guru Score of 74%

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved takes Critical takes Mixed takes Hide sponsored

Hyram

4.35M subs

~Approved

"It's a simple serum. It's basically just some hydrating ingredients, hyaluronic acid and stem cells. I would definitely feel comfortable using this if it was gifted to me. Would I go out and purchase it myself? Probably not."

Doctor Youn

5.56M subs

~Approved

"I would give exosome serums right now an eight out of 10. Exosomes really are the future of skincare. These are essentially little messenger packets that will cause your skin to act in a certain way. Right now we're kind of in the infancy of exosome serums, in that they can help reduce redness, possibly improve fine lines, but I think we've got a lot in the future that exosomes can do. I would give it a nine. A lot of patients post treatment that use it say they feel like their skin heals a lot quicker, but that also is maybe attributing to the anti-inflammatory, getting rid of redness. I [...] would say a nine, but I would knock one or two off because they're damn expensive. But it's replacing some other stuff if you look at it like that. So we carry the Plated Skin Science Exosome Serum in the office and you've seen some patients who've used that."

No BS Beauty

89k subs

~Approved

"It works really nicely right under sunscreen or makeup. I think it's got a silicone in it so it kind of gives it that nice sheen that looks like a good primer. In addition to the exosomes it's got arginine and cilantro oil, which is a great antioxidant. Really nice product."

All 8 takes from No BS Beauty

Plated Skin Science Daily Anti-Aging Exosome Serum Review, How to Use, Dupes & Alternatives

"This ingredient reduces inflammation and has soothing benefits for the skin. The skin that benefits the most [...] is aging, thinning skin, skin that's irritated or post laser or post microneedling, and those looking for long term collagen preservation. Results are gradual, cumulative, and signaling based, so the more you use it the better off [...] you are. [...] I apply this everywhere else on my face, because when you spend that much I want the product to last as long as possible, I want to get every little inch out of it and make it work. [...] The platelets are great, [...] this one has like 17 million platelets or something like that, so it's more concentrated and more expensive. But the exosomes are great for your skin."

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"This one has a nice gel texture, and I've been applying it wherever I'm the most dry and where I get the most wrinkles, which is typically around my eyes and around my mouth. [...] I'm glad they added some soothing ingredients to it, it's nice to have options. [...] I've been using it since Friday and it seems like this is going to last longer than I thought, I really thought I was going to have the bottle finished by the weekend and it's still going strong. I've been using it a couple times a day, so a little goes a long way with this, which is nice. [...] I got this through a beauty box giveaway, they do a Friday daily giveaway where you just pay shipping and they send it to you, and this was [...] normally like a $150 product and I got it for 12 bucks. It does expire soon, at the end of August, but it's a big bottle. I've been using it a little thicker in my neck area, it's definitely thick, it contains methone 4%, and the processed skin proteins are kind of their deal, so keeping the skin moisturized is the point."

What's Plated's Renewosome™ Technology & Exosome's Benefits? Plated Skin Science Intense Serum

"For what this product promises, it promises to reduce the look of fine lines and wrinkles, even the appearance of dark spots and redness, and enhance luminosity and glow. I'd agree this does all those, with the exception that I didn't apply it where I get dark spots, because I'm not wealthy, but if I were rich, I'd probably slather it all over and then I could tell you more. But for wrinkles and fine lines, it definitely has helped, especially around my eyes. I notice that the most. It helps with the fine lines and instantly plumps the skin, near instantly upon application. [...] I do believe this probably would help with melasma too, quite nice. But again, I just didn't want to slather it all over, because this little bottle, I'm going to make it last forever. [...] It's a really new field for anti-aging. A lot of anti-aging is proven, retinoids are great, peptides are still pretty new but great, ascorbic acid is great. This is just kind of a whole new phase, and you can use it with those other ingredients as a way to fully work on anti-aging."

What Are the Newest & Best Anti-Aging Ingredients for Mature & Aging Skin? My Youthful Skin Faves

"The Plated Skin Science Exosome Serum is Plated's strongest Exosome Serum, which contains over one trillion units of human platelet extract. It's geared for advanced signs of aging but can be used on a daily basis. It's pricey, but [...] I've noticed the one from the calm line really helped calm my skin down and helped with plumping, so I'm hoping I'll get the same benefit from this one."

I Ranked My Most Expensive Skincare… Here’s What’s Actually Worth It & How to Save on Luxe Products

"They use blood that's just expiring to remove their exosomes from it. So instead of using plant-based PDRN type exosomes, they use actual human donor exosomes, which, in my experience using it, I find makes it a little bit more effective fighting fine lines and wrinkles. It also contains argan and celantriol, which is an antioxidant. So it's a very simple formula. It is expensive."

Predictions on Skincare & Beauty Trends 2026 - Anti-Aging Ingredients & New Technology for Wrinkles

"The Plated Exosome Serum, this is around 255 to 265 dollars for half an ounce, so it's very expensive. I will say the people who have used Plated absolutely love it. I've got a couple friends who use it and find it totally game changing and amazing. I've used it. I've finished their calm serum and I'm about halfway through this one. I just use it only where I have wrinkles so I don't waste it anywhere else. I use it around my mouth, around my eyes, and in between my eyebrows, that's it, because I feel like it's so expensive it's wasted otherwise."

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"Plated helps with collagen production deep down in the skin, and if you use it in conjunction with microneedling or laser, it's even better. Very nice product, no scent, very short ingredient list. [...] The Plated really does work well in conjunction with microneedling, so you can't get it wrong with that, or something with collagen peptides and things like that."

Best Exosome Skincare Products for Anti-Aging, Fine Lines, and Wrinkles

Dr. Sam Ellis

868k subs

~Mixed

"I did try the Plated Skin Science Exosome Serum just out of personal curiosity. I knew some derms who carried it in their office and I was like, that feels pretty legit. So I used it every day for 3 months, and I do feel like it helped with the redness of my rosacea and maybe my skin looked a little bit less textured, but it wasn't enough of an impact for me to feel confident recommending this or selling this to my patients. So for me right now, it's kind of TBD when it comes to exosomes."

Mixed Makeup

1.47M subs

~Approved

"This has human platelets in it, so think PRP, they're using human platelets in this with the exosomes. It's a little bit more of a straightforward serum, they say to use it once a day. It comes in a much smaller bottle, only 15 ml, whereas the other one is 30 ml, so you're getting a lot more product with the other one. But the Plated Skin Science Exosome Serum is a much better experience, even though you're not getting those additional antioxidants and copper peptides you get in the other product. I do find that it does not have a disgusting smell to it, it has some kind of smell but it's not disgusting, and it dries down nicer, and you can use it morning or night. Instead of just touting wound healing, [...] they're also promoting that it helps with wrinkles and with any kind of dark spots or redness, so it seemed like they were promoting [...] it as helping with any kind of skin issue you're dealing with, whether it's redness, dark spots, aging, or wound healing. It's definitely an interesting one. I think it's a much better experience, but you're getting half the product for about the same price."

All 2 takes from Mixed Makeup

Exosomes in Skincare: The Future of Anti-Aging?

Nighttime Skincare Routine for Perioral Dermatitis & Melasma

"This is a little tiny travel size of the Plated Skin Science Exosome Serum. I got this from my esthetician. [...] I've been using it because last time I went through an entire bottle of this and I wasn't sure if I saw any results. [...] The claim is that you see results from these exosomes, and it's a little pricey, but you're supposed to see results from the exosomes when you use it right after some kind of treatment. So I did the Cosmelan a week ago, my skin is red, and it's supposed to help calm the redness and help heal your skin a little bit faster, so you get more results. I actually want to put it on my neck too."

Dr. Jenny Liu

319k subs

~Mixed

"There are a few brands currently on the market that have exosomes formulated in their products, and they're definitely not cheap. Plated Skin Science Exosome Serum is $267. It's hard to tell from their website where the exosomes are derived from, so there's a potential concern about their novelty and, ethically, where they're derived from. I think more research needs to be done on their efficacy in skincare formulation and how we can more safely and ethically harvest exosomes, but it's an exciting ingredient."