Peter Thomas Roth Peptide Skin Injection Amplified Wrinkle Fix Refillable Serum.

Q: Is Peter Thomas Roth Peptide Skin Injection Amplified Wrinkle Fix Refillable Serum worth it?

Yes. All 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 77%.

Serums

About this product

A peptide serum from Peter Thomas Roth, sold in a refillable format and designed to target the look of wrinkles and fine lines.

Guru Score

77%

Yay

5 experts · Moderate agreement

What they liked

Fragrance-free
Comes in a pump dispenser with refill system

What they flagged

Pricey for a serum
May feel suffocating on acne-prone skin

What the gurus are saying

Peptides aimed at muscle movement and fine lines are what these gurus keep returning to, and many like the light, silky feel that leaves no greasy finish. Some doubt the Botox comparison and the price, and a few find the base thick and very sealing, which may not suit acne-prone skin. Those with dry skin may find it a comfortable fit, and it can sit nicely under other products in the morning.

Synthesized from 5 expert reviews · most recent take February 2026

Best for

Mature skin

Type

SerumsDrops & dropper

Where to buy

Sephora → Ulta → Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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No BS Beauty

89k subs

✓Yay

"For dry skin, I've got [...] the Peter Thomas Roth Skin Injection Amplified Wrinkle Fix Refillable Peptide Serum. It's 65 bucks. [...] This one's great for dry skin because it's very emollient. It's got dimethicone and squalane in it, which are great for hydrating skin. So if your skin tends to be on the drier side, this one's nice. Or for your morning routine, this one's really nice and works well under and with other products."

All 7 takes from No BS Beauty

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"I'm not a big fan of peptides marketing themselves as Botox in a bottle. [...] Botox is injected, and no topical product can compare with something that's injected. It can help, but it's not going to be on the same power. I don't think it can prolong a topical product not needing it for another six months. That's way over the top promising for a product, especially peptides. [...] I think it does help with fine lines, wrinkles, hydration, all that stuff."

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"I enjoyed this little sample. [...] It was a nice little sample. [...] I liked it. It was nice. I would buy it."

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"It feels really silky and nice. [...] There's no scent to it. It feels really nice. It soaks in. It feels non-greasy and non-heavy. [...] For the stars of the show, we've got 2% Matrixel, 5% Argalene, and 2% Matrixel Synthesis, and 10% Argu, which I think is Argolene. So that's their patented or their trademarked one, said 10% Argu peptide solution twice daily for six months is prolong your need for injectable."

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"This is the last Peter Thomas Roth product I ever bought. Probably will be the last one I ever buy. The Peter Thomas Roth Peptide Skin Injection Amplified Serum is a really siliconey lotion serum with peptides such as argolene matrixle synthesis and luasil as well as sodium hyaluronate and sacroyces ferment. It's 1 oz for 65 bucks. It's very thick siliconey. I'm sure I'll finish this but obviously I'm not going to repurchase it."

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"It is on the thick side. [...] It is very occlusive. It's got some very occlusive ingredients in there. So it's great for sealing everything in. But I will say if you have acne prone skin be cautious because it contains several ingredients that are very acneogenic which you may not love. [...] For beneficial ingredients we've got squalane, damethone, argireline peptide, matrixyl synthesis peptide, the luasal peptide and vitamin E. Really wonderful product."

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"The Peter Thomas Roth Skin Injection is a newer one that I've been testing. [...] I will say if you have acne prone skin, I would not recommend this because it does contain a high amount of damethone which for some people can be kind of skin suffocating. For me with my super dry skin, I actually don't mind it. I actually really like it. But in addition to the damethone, it's got a lot of good peptides in here. Argolene, matrixyl, matrixyl synthesis, all this good stuff."

Dr. Shereene Idriss

1.73M subs

✓Yay

"Peter Thomas Roth has his Peptide Skin Injection Amplified Wrinkle Fix Refillable Serum. This is a combination of Matrixyl and Argireline. So it's going to help with collagen production, but it's also going to help to minimize the muscle movement and the look of fine lines in the now. So you're going to get smoothing and firming effects."

Dr. Aleksandra Brown

151k subs

✓Yay

"I really like this. It's super lightweight, but it's also packed with peptides to firm and plump the skin. It absorbs pretty quick. You don't need much. Comes in a really nice pump. It's a [...] really lightweight serum. No greasy residue whatsoever. Doesn't leave you shiny. It's designed to target and visibly reduce wrinkles and fine lines. This formula leverages a blend of peptides to signal collagen production. Also improves skin elasticity."

All 2 takes from Dr. Aleksandra Brown

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"The serum is designed to target and visibly reduce wrinkles and fine lines. The formula here leverages a blend of peptides to signal collagen production and improve skin elasticity, making it a powerful addition to an anti-aging routine. The key ingredient is a peptide complex which encourages collagen synthesis helping to restore firmness and elasticity. It also contains hyaluronic acid which will hydrate deeply keeping the skin plump and smooth, as well as neuropeptides."

AliceintheRabbitHole

59k subs

✓Yay

"I've been wanting to try this one for so long, the Peptide Skin Injection Amplified Wrinkle Fix Serum. This has 19% peptide complex of amplified matrixyl and argireline. I do like that this is a refill system, the lots of plastic refill system, it's better than not having a refill at all. I would say it is the kind of creamy texture of a serum, they've got the cosmetic elegance down, it feels lovely to apply."

All 2 takes from AliceintheRabbitHole

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"I tried the Peter Thomas Roth peptide skin injection as another alternative to something like the Snoxin. [...] It's fine, I just don't think that you necessarily have to spend a lot on these peptide products, especially given where we are in the research."

The Budget Dermatologist

724k subs

✓Yay

"Peter Thomas Roth Peptide Skin Injection is a little more pricey but this has that argireline in it and it has some other great ingredients in it as well."

All 3 takes from The Budget Dermatologist

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"Peter Thomas Roth skin injection also has argireline in it and some other great skincare ingredients so you will apply this to the skin it's as part of your skincare routine it's going to absorb into your skin and kind of soften your muscle muscular contraction and lessen how severely your wrinkles can be formed basically so you can use these morning or night in your routine depending on kind of your total routine I love to use peptides this one I will, I'd love to use this in the morning so I have my topical skincare product that is attacking the muscular movement."

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"Peter Thomas Roth Peptide Skin Injection is a little more pricey but this has that argireline in it and it has some other great ingredients in it as well."

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"For double the price of The Ordinary you can get this one by Peter Thomas Roth called Skin Injection. This also has Matrix 3000 in it, it has acetyl hexapeptide 8. I do not believe it has copper in it. It's quite pricey. I got this recently from Sephora. It's newer to my personal skincare stockpile but Peter Thomas Roth is such a great brand."

Peter Thomas Roth Peptide Skin Injection Amplified Wrinkle Fix Refillable Serum.

77%

What the gurus are saying.

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