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ONESkin

OS-01 Face Supplement.

ONESkin OS-01 Face Supplement
Supplements

About this product

A topical face treatment from OneSkin built around its OS-01 peptide, marketed to target signs of skin aging and support skin health, especially for mature skin.

Best for

Mature skin
Supplements

The Guru Index verdict

82%

Approved

✓Approved · 82%
4Reviewers
4Approved
0Mixed
0Skip

What the gurus are saying

Gurus consistently praise OneSkin's peptide for visible anti-aging results and collagen-boosting effects, with particular enthusiasm from experts recommending it for mature skin. The thick, nourishing texture is noted as an effective sealer for serums. Results appear subtle for some users, and the higher price point is acknowledged as a trade-off for efficacy. Community consensus is positive, though one reviewer found benefits noticeable mainly upon discontinuation.
Synthesized from 4 expert reviews

Where to buy

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Darnell Cox | 50+ Healthy Aging Expert
Darnell Cox | 50+ Healthy Aging Expert
54k subs · 616 devotees
✓Approved
"I am obsessed with this. And the reason is because, well, number one, it changed my skin. It really did. I put little dots everywhere, rub this around a little bit, and then press it into the skin."
Dr. Mamina
Dr. Mamina
277k subs · 626 devotees
✓Approved
"One skin, their line has an amazing peptide that also addresses scinesscent cells. Lines like these are focusing on improving how skin cells behave, not just how skin looks. This is very aligned with longevity science."
Dr. Daniel Sugai
Dr. Daniel Sugai
716k subs · 23k devotees
✓Approved
"OneSkin's face supplement has the OS-01 peptide. This company has been founded by PhDs. It has studies backing up their peptide that will clear senescent cells that are no longer dividing, not adding much to your anti-aging game. It's actually causing more inflammation and damaging our collagen. So, if we clear those cells out, we can have collagen production at a more efficient rate. And so, I like this one a lot for my mature users. It does come out as a thicker texture. It's nice to seal in your vitamin C serum or your retinoid and it will help boost your collagen. So, it is a higher price point, but very nice, very nourishing. I like the texture."
All 3 takes from Dr. Daniel Sugai
Best Facial Moisturizers of 2025
"OneSkin's face supplement has the OS-01 peptide. This company has been founded by PhDs. It has studies backing up their peptide that will clear senescent cells that are no longer dividing, not adding much to your anti-aging game. It's actually causing more inflammation and damaging our collagen. So, if we clear those cells out, we can have collagen production at a more efficient rate. And so, I like this one a lot for my mature users. It does come out as a thicker texture. It's nice to seal in your vitamin C serum or your retinoid and it will help boost your collagen. So, it is a higher price point, but very nice, very nourishing. I like the texture."
Dermatologist Explains: Anti-Aging Skincare Routine By Age
"One skin. So their face supplement, they have a sunscreen, but they also have just a face moisturizer and a body moisturizer. So that's something you can consider to actually reverse the biological age of your skin"
Discover How You're Aging Your Skin & Ways To Turn Back The Clock
"The brand that I discovered in 2024 that has impressed me is ones skin so their face supplement very nice and it has their proprietary os1 peptide has studies backing it that will help with your biological age"
Skin Obsessed Mary
Skin Obsessed Mary
33k subs · 3k devotees
✓Approved
"I use each of these products every single day. I mean, this makes me so happy to get this in PR."
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All 5 takes from Skin Obsessed Mary
I Didn’t Repurchase Most of These
"The results here were a little bit more subtle. I deliberately stopped using it to see if I noticed the absence of this in my routine. Well, I did. My skin looked slightly duller, like less resilient somehow. Nothing dramatic, but enough that I noticed. So this quietly worked its way back into my constant rotation. Now, I don't use this as a moisturizer, which is what I think it was intended for. For me, it works much better layered as like a peptide serum underneath richer products. That's actually been the sweet spot. So this one has now survived the testing phase, and that actually says a lot."
Over 50: I Don’t Rebuy Everything I Love
"The one skin face supplement sits in this space right now. So, it's build as a moisturizer, but for me, it's not moisturizing enough that I can use it that way."
🛍️ From PR to Impulse Buys — ALL the Goodies!
"I use each of these products every single day. I mean, this makes me so happy to get this in PR."
✨ OneSkin Review | OS-01 Peptide That Changed My Routine ✨
"There is one skincare brand I'm actually afraid to stop using because the results were that good. I'm talking about One Skin and especially their OS-01 peptide. Very occasionally there are some products that truly stand out. One Skin is one of them. It started with their body lotion, and I just didn't expect much. But three months later, this horrible, crepey, wrinkly skin was disappearing. I mean, completely disappearing."
✨ OneSkin Review | OS-01 Peptide That Changed My Routine ✨
"For me personally, this isn't hydrating enough to use as my only moisturizer, which is its intention. I tend to just add a separate moisturizer on top."
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