OneSkin OS-01 Hair Peptide Scalp Serum: a Guru Score of 84%

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Dr. Sam Ellis

883k subs

✓Yay

"Once I started incorporating this, I tolerated my minoxidil so much better."

All 2 takes from Dr. Sam Ellis

My Most Purchased Haircare Products as a Hair Loss Expert | Dr. Sam Ellis

"Once I started incorporating this, I tolerated my minoxidil so much better."

Proven Treatments for Hair Thinning & Loss Besides Minoxidil | Dr. Sam Ellis

"The last hair serum I will go into today is one that I've been using for gosh almost a year now. My husband uses it as well and it's by the brand OneSkin. I find this brand very intriguing. They're almost like a biotech company. They're based here in the Bay Area and they have a proprietary OS1 peptide that's meant to work on something called senescent cells which are essentially cells that are sort of dying off and it helps clear those from the body. And the reason that's important is because senescent cells can kind of pollute the cells around them and make them less healthy and less well functioning. So I have female pattern hair loss. My husband has hair shedding. But this is the serum that he finds the most effective. When he was using it, he felt like his hair shedding really decreased. And when we ran out and after about a month, he felt like his hair shedding picked back up again. So this has been repurchased many times in our household."

Darnell Cox | 50+ Healthy Aging Expert

55k subs

✓Yay

"One Skin OS-01 hair, this has been a game changer. There's a lot of research on hair loss. It's getting rid of those damaged, senescent cells, zombie cells, and it's making way for the good. I do a droplet of this, and then this is an OS-01 peptide it's in the same thing as the best body lotion in the world. You can take a micro needling tool and roll it in, or you can stamp it. I tend to like to stamp because my hair is so fragile, I don't want to roll things over the top of it because what if it cuts my hair off. So that's how protective I am of my hair."

All 2 takes from Darnell Cox | 50+ Healthy Aging Expert

Over 50 and struggling with hairloss?😰 I know first-hand how that feels

"One Skin OS-01 hair, this has been a game changer. There's a lot of research on hair loss. It's getting rid of those damaged, senescent cells, zombie cells, and it's making way for the good. I do a droplet of this, and then this is an OS-01 peptide it's in the same thing as the best body lotion in the world. You can take a micro needling tool and roll it in, or you can stamp it. I tend to like to stamp because my hair is so fragile, I don't want to roll things over the top of it because what if it cuts my hair off. So that's how protective I am of my hair."

Over 50 and struggling with hairloss?😰 I know first-hand how that feels

"One Skin, this has been a game changer. If we think about when we take stuff orally, spermidine, that's what is in here, promotes autophagy. This is getting rid of those damaged, like senescent cells, zombie cells, and it's making way for the good. There's a lot of research on hair loss. So you do a droplet of this, and then this is an OS1 peptide, it's in the same thing as the best body lotion in the world. You take a micro needling tool and stamp it. I tend to like to stamp because my hair is so fragile, I don't want to roll things over the top of it because what if it cuts my hair off."

Beyond50Skin

32k subs

✓Yay

"The one thing that I did add over the last six months to this routine is the OS-01 peptide scalp serum. They came out with this at the end of the summer. And this is one of my absolute favorite adjuncts to the Rogaine. So this is a scalp serum with the OS-01 peptide that also helps with senescent cells. Skin cells are dying all over, accumulating, causing inflammation. So this helps with inflammation, also with healthy scalp. And I got through two of them, and I already have a backup."

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All 6 takes from Beyond50Skin

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"I've been using the OneSkin scalp serum. I love it. I always have a scalp serum in rotation. This is the one that I'm using right now. And I love it because it has that proprietary peptide that helps with senescent cells. Those cells are just hanging around causing trouble and inflammation."

OVER 50 SKINCARE EMPTIES: My Biggest DISAPPOINTMENTS & Instant Repurchases

"The one thing that I did add over the last six months to this routine is the OS-01 peptide scalp serum. They came out with this at the end of the summer. And this is one of my absolute favorite adjuncts to the Rogaine. So this is a scalp serum with the OS-01 peptide that also helps with senescent cells. Skin cells are dying all over, accumulating, causing inflammation. So this helps with inflammation, also with healthy scalp. And I got through two of them, and I already have a backup."

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"The One Skin scalp serum, number one scalp serum for 2025."

LIVE Chat: Catchup and Fall Makeup Over 50!

"I'm reviewing the One Skin Peptide Scalp Serum"

Struggling with Thinning, Dry, Grey Hair Over 50? Shampoos, Styling & Peptide Serum I’m Loving

"Once Skin has come out with their OS-01 peptide hair serum and I'm very excited to share this with you because I'm always up for new technologies in hair. I was using a growth factor serum in the past with micro needling, and I think the peptide serum is a really interesting option. The serum itself doesn't require the derma roller, you can just use the serum and get the benefit of the peptides for hair health. But you do have the option to use it with their micro needling roller if you want to help with penetration of the serum."

Empties, Fails & Faves LIVE! Over 50 + AMAZON Beauty Prime Day Chat

"One Skin, the new hair serum that I've been trying for you guys. I love this. I'm using the Klesium. I just finished up my sixth week, seventh week because there's so much in that little bottle. I can get seven weeks out of it. I do my callesium, then I put on my one skin on the days that I'm not using the callesium, and then I'm still using my minoxidil and lowle laser light therapy. This is the newest product in that hair routine. I had no shedding. My seasonal shed was slowed down. All my hair stayed in the antigen phase so much longer. I can attest that. I had not used my I just now started back on my Clesium. So it wasn't that I only used this to give it a really good solid try so that I could report back my honest feedback on the serum. Highly recommend this. And if you need a new hair serum and keep your scalp healthy, keep that hair growing and not falling off your head, highly recommend this."

Allie Glines

829k subs

✓Yay

"Especially postpartum, I've been loving the OneSkin Hair Peptide Scalp Serum, using it every day for over a month. I'm starting to lose hair postpartum but so far it's not as bad [...] and I feel like it's really working. [...] It's not heavy, has no minty tingle, doesn't leave residue and doesn't weigh my hair down. It's a fabulous formula."

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All 3 takes from Allie Glines

My Absolute Faves From November 2025 😍

"I have been loving this hair serum. I'm trying to get ahead of my hair loss this time around. I have been dousing my hair in this serum and I am really excited to see the regrowth. I'm more banking on the regrowth happening. The formula is great and it's something that's just easy to apply. It doesn't make my hair feel heavy or greasy because some scalp serums can be a little bit too much. It also doesn't have a tingly sensation. It's a really great serum and it has really great reviews. If you just look at all of their clinical studies and actual before and afters, you'll see how effective these are. I'll keep you posted on this in a couple more months once I'm in the thick of the hair loss time."

THE BEST HAIR, SKIN, NAILS & MORE OF 2025!

"Especially postpartum, I've been loving the OneSkin Hair Peptide Scalp Serum, using it every day for over a month. I'm starting to lose hair postpartum but so far it's not as bad [...] and I feel like it's really working. [...] It's not heavy, has no minty tingle, doesn't leave residue and doesn't weigh my hair down. It's a fabulous formula."

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"I'm really loving the Hair Peptide Scalp Serum from One Skin. It's a bit of a level up from my usual scalp treatments, but it was worth it, and I've been dousing my hair with it to try to get ahead of postpartum hair loss. There are other good scalp serums that aren't as expensive though."

Mixed Makeup

1.46M subs

✓Yay

"I've been using this for the last like 2 and a half, 3 months and I have seen such a huge difference when it comes to hair thinning. I have really thick hair, but up here in the front, ever since I had babies, my hair started getting a little bit more sparse. I started getting a lot of these baby hairs. They just are really growing out and growing into my hair. And it's all because I've been using this. I've been doing a lot of supplements, too. That probably plays a little part in it. But this is what I've been the most consistent with. And I'm so pumped about it because it's really easy to use. It's a really light texture, so it doesn't even mess up my hair. I don't have to wash it more often or anything like that. It doesn't mess up the style or make it frizzy, but it's really easy to add in. What I like about it is it contains a senescence blocking peptide in it. Senescent cells are basically these cells that start to build up as we age and that can lead to age related hair loss. It's not the main cause, but it's one of the main causes of hair loss as we age. So this is a really great serum to help with that because it also contains other ingredients I like for my scalp. Your scalp is also skin, right? So this should be a part of your morning and nighttime skincare routine, especially if you are dealing with these types of hair issues."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Frequently asked.

What is OneSkin OS-01 Hair Peptide Scalp Serum?

A topical hair serum designed to support scalp health and promote hair growth, formulated to be used alongside other haircare treatments.

Is OneSkin OS-01 Hair Peptide Scalp Serum worth it?

Yes. All 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 84%.

What is OneSkin OS-01 Hair Peptide Scalp Serum's Guru Score?

OneSkin OS-01 Hair Peptide Scalp Serum holds a Guru Score of 84%. That is our read on how warmly the experts talk about it, based on the verdicts of 5 expert reviewers we have collected.