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OneSkin

OS-01 Body Topical Supplement.

OneSkin OS-01 Body Topical Supplement
Body & Tan

About this product

OneSkin OS-01 Body Topical Supplement is a peptide-based body treatment designed to address crepiness, support skin renewal, and improve the appearance of aging skin on the body.

Guru Score

87%

Yay

6 experts · Moderate agreement
Guru Certified
Broad expert consensus
6Gurus
6Yay
0Mixed
0Nay

What they liked

  • Noticeably softens crepey skin on body
  • Lightweight lotion texture, spreads easily
  • Non-sticky finish, hydrates all day

What they flagged

  • Pricey, though a little goes a long way

What the gurus are saying

The OS-01 peptide in this formula visibly softens crepey skin within the first few uses, with gurus reporting noticeably smoother texture on arms, knees, and décolletage after just days of use. The treatment works by targeting senescent cells while encouraging collagen-building in younger cells, and reviewers praise it as rare actively repairing body care rather than just hydrating. It's pricey, but gurus who've tested it long-term call it a repurchase worth the investment; one expert suggests applying it strategically to problem areas rather than the whole body to extend its life.
Synthesized from 6 expert reviews · most recent take August 2026

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Yay
"The OneSkin body product for crepey skin is pretty expensive, but I used it for three months and the before and afters were crazy. I did not expect this at 60, but it actually helped get rid of the crepey skin, especially over my knees. To make it last longer because it's so pricey, I put a layer of Hydro Boost on first so my skin is already moisturized, which helps it glide on better and lets my skin accept all the peptides in it. It has a proprietary peptide that helps with senescent cells. Pretty cool product, pretty expensive product, but awesome."
Top Pick: crepey skin treatment
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"This is necessary the body retinol. Absolutely gorgeous. It's 0.1% retinol, [...] which is a pretty decent percentage. [...] This is one of my holy grails. I keep this in my bathroom all the time. And I layer it up with my OneSkin for the body with the OS-01 peptides for that help with senescent cells. [...] I can't give it up. And [...] honestly I haven't found anything that works better. You can combine this peptide formula with retinol, though you don't want to combine your body exfoliation night with your retinol, but you can combine it with the OS-01 for body. These are both already repurchased. They are sitting downstairs in my bathroom."
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"The peptides in this and the skin rejuvenating benefits that I've seen from this are just like no other body lotion I've ever used. I honestly can't skip this in my body care routine."
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"I just purchased another bottle of the body lotion, which I absolutely love. Is it expensive? Yes, it's expensive. But does it work on cranky skin? Yes, it does. It's kind of more of a serum like texture as opposed to a lotion. I guess if you don't have very dry skin, you might consider it like a light lotion, but it definitely isn't the only moisturizer I need for the body. I love this. I am going to have this on repeat as much as I can afford it. I love it over my crepey knees. I love it for my crepey underarms. You can use it in kind of targeted spots. You don't have to use it head to toe."
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"I've been using the OneSkin OS-01 Body Topical Supplement. I gave you a full detailed report in my fall skincare check-in and I love this. It had some amazing differences on the crepy skin on my upper legs."
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"I've been using their body formula and I was pretty surprised especially about the creepy skin over my legs. I only used the OneSkin OS-01 Body Topical Supplement over my knees the last eight weeks no other body products. I just went around that area and I also used it on my hands. I really tried to stay away from every other body product and exclusively use the OneSkin Body."
2025 Body Care for Crepey Skin Over 50 | Holy Grails, New Finds & OneSkin Results!
"This is the revolutionary body treatment that Mary and I have both used, and we are considering it a holy grail. It's the OneSkin OS-01 Body Topical Supplement. [...] I used this exclusively for 3 months, morning and night, none of my other body skincare, just to see what the results would be. [...] This is full of peptides. Whether you just jumped out of the shower or you're just waking up and getting dressed, the OneSkin body goes first in your body skincare routine. It acts to increase and firm the skin barrier. It has a proprietary peptide. [...] This is a step that we don't skip."
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"This is their body formula that I'm in the middle of. I think they're going to have a deal on this. I just have a feeling this has become so popular."
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"One of the body care products that I've been talking a lot about lately is the OneSkin OS-01 Body Topical Supplement. It's definitely bougie, not inexpensive, but it has transformed the crepey skin of my body. [...] Yes, it's expensive and yes, it's worth it, but you can just use it in targeted areas. [...] I started out just using it over my knees last fall because that was kind of my area of concern, and then this spring I did a trial and used it on my crepey upper arms and my lower legs, but I skipped the torso. So it can be used just in trouble spots."
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"Two new body products I've been trying late this fall are the OneSkin OS-01 body lotion and the Fenty Skin whipped body butter, these in combination are just amazing. The OS-01 peptide in this body lotion penetrates the skin and helps renew it from the inside out. OneSkin is having an amazing bundle deal for only $99."
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"OneSkin has been the creepy skin savior. If you haven't seen that video I'll link it up above, check it out. If you don't want creepy skin on the body, you have to check this out. Is it frightfully expensive? Yes. Do I wish I probably had never found it? Yes, but it is the number one for creepy skin."
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"The OneSkin body product for crepey skin is pretty expensive, but I used it for three months and the before and afters were crazy. I did not expect this at 60, but it actually helped get rid of the crepey skin, especially over my knees. To make it last longer because it's so pricey, I put a layer of Hydro Boost on first so my skin is already moisturized, which helps it glide on better and lets my skin accept all the peptides in it. It has a proprietary peptide that helps with senescent cells. Pretty cool product, pretty expensive product, but awesome."
Yay
"I love the OneSkin OS-01 Body Topical Supplement, which is essentially a body moisturizer. The one I'm using has no scent at all, no fragrance, nothing gross. I like it because it has the OS1 senescence blocking peptide, which is why I use it, and it's great for reversing cellular damage and improving crepiness above the knees, on the elbows, chest, hands and arms. It's so moisturizing, it has a few different oils in it but it's not oily, your clothes don't stick to your skin, and it has a beautiful silky satin texture. It really is one of the best body moisturizers I've ever used, especially one geared towards anti-aging and improving skin tone and softness. I know it's not exactly the cheapest body moisturizer out there, but the ingredients are very advanced and I'm very impressed with it."
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"I've just started using the OneSkin Topical Body Supplement [...] maybe two months ago and I am really impressed with how this product performs on my skin. [...] It really improves skin creepiness, so if you have creepiness above your knee or anywhere on your legs or the backs of your arms, this really does work. [...] It provides your skin with so much hydration, it nourishes the skin, it creates a softer, smoother look, and your skin is always glowing, not a greasy shiny glow, it just looks [...] healthy and repaired. [...] There's a lot of oils in here, different types of butters, ceramides, centella asiatica, and it's fragrance free. It's powered by OS-01, which is the peptide that's proven to reverse biological age. [...] It has that lotion texture, not too runny and not too thick, and a little amount goes a long way so you don't need to use much because it spreads really nicely. [...] Your skin feels nice and moist all day and it isn't sticky or tacky. [...] It's going to improve early signs of aging, prevent fine lines, and improve texture and tone. [...] This is like that one luxury body care product I like to resort to because it makes your skin feel so good, and I honestly haven't found anything like it before, so I really do recommend it."
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"I love the OneSkin OS-01 Body Topical Supplement, which is essentially a body moisturizer. The one I'm using has no scent at all, no fragrance, nothing gross. I like it because it has the OS1 senescence blocking peptide, which is why I use it, and it's great for reversing cellular damage and improving crepiness above the knees, on the elbows, chest, hands and arms. It's so moisturizing, it has a few different oils in it but it's not oily, your clothes don't stick to your skin, and it has a beautiful silky satin texture. It really is one of the best body moisturizers I've ever used, especially one geared towards anti-aging and improving skin tone and softness. I know it's not exactly the cheapest body moisturizer out there, but the ingredients are very advanced and I'm very impressed with it."
Yay
"This is the OneSkin OS-01 peptide, a body cream, and it plays really nicely with all the other peptides, so this is great to put on at night. I like to put this on first, morning and night, because it clears the way for the senescent cells so the other skincare I put on after has more chance to reach the healthy cells."
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"I don't know who else is making it with this particular peptide in it, the OSO1 peptide. [...] This has literally changed my skin. And not just the face one, but the body. [...] This has been a game changer. And in terms of the body one as well, a complete game changer when it comes to treating my body. [...] My OneSkin OS-01 is always like my last thing in terms of the body. For the face, it's always my first thing."
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"I don't know who else is making it with this particular peptide in it, the OSO1 peptide. [...] This has literally changed my skin. And not just the face one, but the body. [...] This has been a game changer. And in terms of the body one as well, a complete game changer when it comes to treating my body. [...] My OneSkin OS-01 is always like my last thing in terms of the body. For the face, it's always my first thing."
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"For the body, I cover my whole body with this."
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"I'm obsessed with the body. I'm obsessed with it because I have noticed my skin is a lot less dry. It's a lot more supple. It feels better. It's the best, one of the best moisturizers I think I've ever used. Not because it just slathers an inactive ingredient on top like moisture. Moisture is an inactive ingredient. If you only moisturized your entire life you're missing the opportunity to increase the function of your skin."
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"I'm using a moisturizer which is also kind of an active but not the way that you would think. It's like a new age active because it's telling those skin cells to purify. I'm loosening up those bonds between the skin cells. When you're using a retinoid, it's kind of the same thing. You're exfoliating by loosening the bond and really kind of taking off those dead skin cells. Now, I'm using something that's telling my skin cells, hey, those ones that are dying, get rid of them. So, it's kind of a double double whammy. I loved a combination of a retinoid with a peptide."
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"This is the OneSkin OS-01 peptide, a body cream, and it plays really nicely with all the other peptides, so this is great to put on at night. I like to put this on first, morning and night, because it clears the way for the senescent cells so the other skincare I put on after has more chance to reach the healthy cells."
Yay
"They've made moisturizers, the OS1 peptide face, the body moisturizers, they have good sunscreens."
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"If you want to use the OS1 peptide containing creams by OneSkin, they have a body moisturizer. You can consider that."
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"They've made moisturizers, the OS1 peptide face, the body moisturizers, they have good sunscreens."
Yay
"My body was sort of this slow realization. Because for years, I trusted my face like a science experiment, and my body like an afterthought. And at some point, it just stopped working. The skin in my arms was getting crepey, everything was getting drier, and I honestly didn't think that a body product could do that much. And then I tried OneSkin, the body supplement, and I genuinely regret not taking before photos. Because over time, the difference became so obvious. I just started using this here on my upper arms, and I went through multiple bottles, and then I started to see the results. And now, I use it everywhere. This was one of the first products that made me realize body care can actually be functional skin care. It's not just moisturizing, it's not just nice. I mean, actual visible change. OneSkin's whole thing is about targeting senescent cells. These are sometimes called zombie cells. So, these are basically damaged cells that contribute to aging by destroying the healthy cells around it. Whether it's the science, the formulation, or some kind of skin care witchcraft, my skin really responds to it. So, there's another one open in the bathroom. I even have these little minis just for travel. So, this will always survive the low buy."
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"My body was sort of this slow realization. Because for years, I trusted my face like a science experiment, and my body like an afterthought. And at some point, it just stopped working. The skin in my arms was getting crepey, everything was getting drier, and I honestly didn't think that a body product could do that much. And then I tried OneSkin, the body supplement, and I genuinely regret not taking before photos. Because over time, the difference became so obvious. I just started using this here on my upper arms, and I went through multiple bottles, and then I started to see the results. And now, I use it everywhere. This was one of the first products that made me realize body care can actually be functional skin care. It's not just moisturizing, it's not just nice. I mean, actual visible change. OneSkin's whole thing is about targeting senescent cells. These are sometimes called zombie cells. So, these are basically damaged cells that contribute to aging by destroying the healthy cells around it. Whether it's the science, the formulation, or some kind of skin care witchcraft, my skin really responds to it. So, there's another one open in the bathroom. I even have these little minis just for travel. So, this will always survive the low buy."
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"The OneSkin OS-01 Body Topical Supplement only takes minutes every other day, so it's super easy to fit into my routine. It's become a non-negotiable at this point and it's become a part of my daily routine. I'm even bringing a travel size with me because I'm making sure that I'm really looking after my body properly."
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"I always start with my One Skin Body Supplement right out of the shower because this is one of the products that has absolutely proven its place in my routine. I've tested it and it works. It's almost eradicated the crepiness of my skin."
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"One Skin, it's the OS1 body topical supplement. I did a whole video about this product and my only regret is that I didn't take before photos because I genuinely never expected the results I got. I used to have this really crepey, wrinkly, middle-aged arm skin right here. And it really bummed me out. I started using this product and I only started using it on my arms. I isolated it and I didn't use anything else because there was no way to find out if I used anything else. And honestly it blew my mind. I didn't change my diet. I didn't change my exercise, which was really quite minimal at the time. And I started to see a real change in the skin, and I've been hooked ever since. I've refused to stop using it. Yes, it's expensive for a body lotion, but I will continue to throw money at something if it works, and I can afford it."
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"This is OneSkin's body supplement. And this changed everything for my skin. Their OS1 peptide neutralizes senescent cells. Those are the zombie cells which destroy the healthy skin cells around it. It's like that one bad raspberry in the basket. But here is the thing. This product eliminated my middle-aged, crepey arm skin. Like, I couldn't believe it. So, I did a whole video about this, which I'll list below in the description bar if you want to check it out. I will never stop using this, and it's probably in my top pick of the year."
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"One Skin OS1 body supplement. This is the holy grail body lotion that completely eliminated my crepey skin. I will not be without it. And in fact, I have two empties here. It is pricey, but I keep"
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"Now, I use all of their products, but if I have to choose two, I would start with number one is the body supplement because it literally got rid of my crepey arm skin. No lie."
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"It's the OneSkin body supplement. I've talked about it a lot. It contains their OS1 peptide that helps reduce senescent cells, zombie cells, one of the root causes of aging. This product completely eradicated the crepey, wrinkly skin on my arms. It's really incredible and it has a permanent spot in my routine for hands."
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"This has become my holy grail body product. It contains that same OS1 peptide and I can honestly tell you my crepey skin is now gone because of it. I did an isolated test for about 6 months and I was shocked by the results. So yes, I have repurchased."
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"I love my OneSkin OS-01 Body Topical Supplement. When I stop using it, I totally know the difference. I'm on their subscription and get the body every about three months is how long this lasts me. This gets rid of senescent cells, and senescent cells are those aging cells, dead cells that linger around. We do have a process that gets rid of those, but as we age everything is not working efficiently, so this helps with that. I totally see a difference, and just overall good skin health and plumpness. I would use that too if I could."
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"I use each of these products every single day. I mean, this makes me so happy to get this in PR."
⭐️ Title
"This peptide helps to reduce those senescent cells but it also helps younger cells to multiply and that's what helps to build collagen to strengthen our barrier and just improve overall skin health. [...] I got their bundle which has the face supplement which I use as a serum, the eye cream as well as the body lotion. I haven't really been using these long enough to truly give my feedback but anecdotally I believe I'm actually seeing a difference particularly on the creepy skin of my arms."
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"I had a sagging, crepey old lady arm and I'm only 53 and I'm like this isn't right. So I isolated that and I have to say it took about three months. The result was incredible. Like, it was incredible. If I hadn't seen it with my own eyes, I wouldn't believe it. I have not stopped since because I'm afraid of what's going to happen if I stop to that skin. I have now used it repeatedly for over a year."
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"I've been using OneSkin's body supplement religiously for years. This is the product that completely changed my middle-aged skin, especially the crepey grossness I had, it is the only thing that has worked. But with the new import charges the real cost comes to about $300 for both supplements, so I'm going to try to go without it for a while."
Yay
"I'm floored by the OneSkin OS-01 body supplement. It's an investment and packed with peptides, meant to tackle crepiness and repair the skin. Postpartum my stomach skin felt crepey, and even though they say wait six weeks, in the first few uses my skin already felt more bouncy and the crepiness was disappearing. [...] I keep seeing results so I'm not going to stop."
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All 3 takes from Allie Glines
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"This is their body topical supplement and this is like a very intensely active packed body treatment which is so hard to find. [...] I wanted something that would actually be effective and not just be hydrating. I wanted something to actually repair my skin, but nothing was formulated for the body. [...] I started using this pretty consistently. It's been a couple of weeks now, few three weeks maybe. And after like the first couple of days, the crepiness was noticeably different and noticeably better. And [...] I've consistently used it every single day since. And I am so happy with like the visible results I'm already seeing."
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"I'm floored by the OneSkin OS-01 body supplement. It's an investment and packed with peptides, meant to tackle crepiness and repair the skin. Postpartum my stomach skin felt crepey, and even though they say wait six weeks, in the first few uses my skin already felt more bouncy and the crepiness was disappearing. [...] I keep seeing results so I'm not going to stop."
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"I've loved One Skin for a while for their face cream and eye cream, and [...] more recently [...] their body cream, which is so phenomenal. It's a peptide-packed body lotion, and postpartum [...] my skin felt dry and crepey, but within two days the crepiness was gone. I've been using it consistently and my skin has been really happy."

Frequently asked.

What is OneSkin OS-01 Body Topical Supplement?

OneSkin OS-01 Body Topical Supplement is a peptide-based body treatment designed to address crepiness, support skin renewal, and improve the appearance of aging skin on the body.

Is OneSkin OS-01 Body Topical Supplement worth it?

Yes. All 6 gurus who reviewed it give it their stamp of approval, for a Guru Score of 87%.

What is OneSkin OS-01 Body Topical Supplement's Guru Score?

OneSkin OS-01 Body Topical Supplement holds a Guru Score of 87%. That is our read on how warmly the experts talk about it, based on the verdicts of 6 expert reviewers we have collected. It is also Guru Certified, our mark for products that hold broad approval across many expert reviewers.

Who is OneSkin OS-01 Body Topical Supplement best for?

OneSkin OS-01 Body Topical Supplement is generally suited to mature skin.

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