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NIOD

Copper Amino Isolate Serum.

NIOD Copper Amino Isolate Serum
Serums

About this product

A water-based serum containing 1% copper peptides, vitamin E, and additional peptides designed to support collagen production and address fine lines, wrinkles, and skin firmness.

Best for

Mature skin
Serums

The Guru Index verdict

81%

Approved

Approved · 81%
6Reviewers
5Approved
1Mixed
0Skip

What the gurus are saying

Gurus found this serum effective for anti-aging, with the copper peptides and supporting peptide blend delivering results that some felt came faster than comparable options. The texture is notably thin and watery, which spreads easily and layers well, though that lightweight feel is a personal preference, some prefer a serum with more substance. The main thing to keep in mind: it doesn't pair well with exfoliating acids, L-ascorbic acid, resveratrol, retinol, or tretinoin, so those with sensitive skin or already using those actives may want to use it on separate days or skip it altogether. Price sits on the higher end, though a few gurus felt the advanced formula justified the cost.
Synthesized from 6 expert reviews

Key actives & flags

Hyaluronic acidPeptidesFragrance-freeAlcohol-free

Full ingredients

Glycerin*, Copper Tripeptide-1*, Aqua (Water)*, Methylglucoside Phosphate*, Copper Lysinate/​Prolinate*, Ppg-26-Buteth-26*, Peg-40 Hydrogenated Castor Oil*, Chlorphenesin*, Phenoxyethanol*, Aqua (Water)**, Sodium Hyaluronate Crosspolymer**, Glycerin**, Dimethyl Isosorbide**, Ethoxydiglycol**, Decapeptide-22**, Ogliopeptide-78**, Palmitoyl Decapeptide-21**, Zinc Palmitoyl Nonapeptide-14**, Myristoyl Nonapeptide-3**, Hydrolyzed Wheat Protein**, Pentylene Glycol**, Ppg-26-Buteth-26**, Peg-40 Hydrogenated Castor Oil**, Xanthan Gum**, Caprylyl Glycol**, Glyceryl Caprylate**, Phenylpropanol**, Ethylhexylglycerin**, Chlorphenesin**, Phenoxyethanol**

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored
Approved
"One of the most respected products in this space is NIOD's Copper Amino Isolate Serum. It's around $65 and is formulated with a 1% copper peptide complex that can help improve skin elasticity and structural anti-aging. It's a great product."
Approved
"This has been a staple in my routine for years. I think this was one of the first peptide serums I ever used and I've absolutely loved it. It's not the cheapest product out there, but it's definitely an advanced formula that makes sure those peptides get to where they need to be in the skin in order to deliver maximum benefit. Such a great product, such a great formula, and definitely for people that have used peptides for some time and want to kick it up a notch. This is a product that will definitely help you to achieve that. This is an advanced product that definitely takes your peptide game to the next level."
All 8 takes from Mad About Skin
Top 5 ULTIMATE SKIN FIRMING SERUMS - Best Anti Aging Routine Yet
"If you want to go for the most advanced copper peptide option, then you could reach for the NIOD Copper Amino Isolate Serum. This is a fantastic product that has multiple layers of technology to make sure those copper peptides are getting to where they need to be to give you quick and effective results. It's also got a great blend of peptides in here which are really going to double down on that collagen production. Full price, it is actually a little bit out of the reach of a lot of people, but with the sale on, it will make it slightly more accessible."
Next Generation Botox In A Bottle - BEST PEPTIDE SERUMS 2026
"This has been a staple in my routine for years. I think this was one of the first peptide serums I ever used and I've absolutely loved it. It's not the cheapest product out there, but it's definitely an advanced formula that makes sure those peptides get to where they need to be in the skin in order to deliver maximum benefit. Such a great product, such a great formula, and definitely for people that have used peptides for some time and want to kick it up a notch. This is a product that will definitely help you to achieve that. This is an advanced product that definitely takes your peptide game to the next level."
Peptides Are Not Over! BEST PEPTIDE SERUMS 2024
"When it comes to what I call the best advanced peptide product, if you want a product that does it all super quick and gives you the maximum results, then I would recommend going for the NIOD Copper Amino Isolate Serum. The reason this is so advanced is not only does it have a great blend of peptides and copper peptides within it, but it also uses a bespoke and patented delivery technology which means that it directs those peptides to where they need to be to get maximum results. You're getting the key ingredients but you're also harnessing technology to make sure that it works as quickly and effectively as possible. If you use this serum you will definitely start to notice results in terms of increase in elasticity in the skin, hydration and plumpness within like a couple of days to a week. In the long term you definitely see that payoff for minimizing fine lines and wrinkles. This is honestly one of the best peptide serums on the market."
2024 ULTIMATE SKINCARE ROUTINE - How To Use Copper Peptides For Anti-Aging
"The standout performer of today is the Copper Amino Isolate Serum by NIOD. This is the copper peptide that I'm using today. There are others on the market, but the technology far outstrips anything else on the market. I do love this, but I will only buy it when it's on sale. I'm too cheap to be buying it full price."
NIOD SALE ANNOUNCED - Up To 50% Off 😱 (My NIOD Favourites)
"If you prefer something that isn't in a lipid base but is more traditional serum then the Copper Amino Isolate Serum is a great option very similar in terms of outcomes but this is a little bit more lightweight and has slightly lower price point. If you're on a slightly lower budget don't feel you have to compromise this is a really great anti-aging option."
2 X FIRMER SKIN - The Best Copper Peptides #skincare
"You only need to use a tiny tiny amount and it spreads beautifully on the skin so that makes the application super easy. This is probably going to give you the best and the quickest results in terms of copper peptides. It's in a more watery serum base. If you want something that sinks in super quick then the serum might be more for you. Why this is so special is not only you have that high dose of copper peptides but you also have the delivery mechanism built in to make sure every single one of those peptides gets to exactly where it needs to be which is why you get such quick results."
TOP 10 SKINCARE 2023 - Skincare Awards Part 2
"The best of the best in copper peptides is the NIOD Copper Amino Isolate Serum. It's got technology in here that makes sure those copper peptides get to where they need to be in order to deliver maximum results. It's also beautifully hydrating. However, it comes with a higher price point, so whilst this is absolutely worth every penny, for those of you that are on a budget, maybe don't want to stretch this price point."
Next Level SKIN FIRMING SERUMS - Reduce Sagging Jowls and Tighten Skin
"The Neostrata product uses some trademarked technology they actually spent so much money on, going through the trademark process, which is a sign that it's good at getting those peptides to where they need to be in the skin to give you maximum results. With the Neostrata product you're getting a good dose of peptides but that technology really helps them work extra hard for you. It's a nice middle ground, not the cheapest product out there but also not super expensive, so it's a good mid price point. The copper peptides in here are the ones that stand out, and whilst it doesn't have quite the same advanced blend of different firming peptides as some others, it uses that technology to really get maximum results for the skin. It's a really nice option."
Approved
"This is more advanced because of the ingredients. Neod is more advanced which is why this brand is more money than the ordinary. The ingredients that you see in some of the Neod products you won't see in the ordinary brand. I do feel like this provides quicker results, at least from my experience with this product. If I were to compare the two together, this one does give better results. It has a different texture. This is very thin like water and it's also dark blue. Once you open this up, you have about six months to finish it. This one has a really nice texture that spreads across the skin. It's hydrating. It's not sticky or tacky either. I've never experienced peeling. You can also use this everyday twice a day. If you want to take your skin to the next level and you love your peptides, try copper peptides. You can't go wrong with this one."
Top Pick: copper peptide serum
All 8 takes from Sincerely Miss Ash
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"This is more advanced because of the ingredients. Neod is more advanced which is why this brand is more money than the ordinary. The ingredients that you see in some of the Neod products you won't see in the ordinary brand. I do feel like this provides quicker results, at least from my experience with this product. If I were to compare the two together, this one does give better results. It has a different texture. This is very thin like water and it's also dark blue. Once you open this up, you have about six months to finish it. This one has a really nice texture that spreads across the skin. It's hydrating. It's not sticky or tacky either. I've never experienced peeling. You can also use this everyday twice a day. If you want to take your skin to the next level and you love your peptides, try copper peptides. You can't go wrong with this one."
LUXURY SKINCARE THAT'S ACTUALLY WORTH THE MONEY - MY MOST USED HIGH-END PRODUCTS WITH REAL RESULTS
"I've been using this serum for so many years that I just felt like I had to mention it in this video because it really is a luxe product that is worth every penny. This is truly a holy grail. Copper peptides is one of my favorite ingredients to incorporate on an everyday basis or several times through the week. I love copper peptides because peptides are great, but copper peptides truly take your skin to the next level. It firms the skin a little bit quicker. It also helps to stimulate collagen. It has wound healing properties to it. So it helps to speed up that healing process of the skin, just keeping your skin really healthy and radiant looking. And I just love the glow that copper peptides gives my skin as well, especially this product. The texture of this is very thin like water. It spreads so nicely. A little bit goes a long way. And it never peels. It's never sticky or tacky. It always sits great with other skincare products. And this can be used every day twice a day as well."
6 BEST COPPER PEPTIDE SERUMS || STIMULATE COLLAGEN & ACHIEVE FIRMER SKIN - SINCERELY MISS ASH
"I really do like this option especially if I'm looking for something that is a little bit more moisturizing that has that balmy effect and I really like the way that this applies to the skin."
DECIEM SALE 2024 | MUST HAVE PRODUCTS YOU NEED FROM THE ORDINARY, NIOD & LOOPHA - SINCERELY MISS ASH
"This is a product that I talk a lot about here on my channel and this is a product that I really believe in. You would not believe the results that I have seen with this serum alone and I have been very consistent with this for over 2 years now, and I am just absolutely in love and obsessed with this. Copper peptides have wound healing properties, it can help to stimulate new collagen, address fine lines and wrinkles, and it can help to firm the skin. I have noticed that with this serum in particular it does help to firm the skin and it does give a glow to the skin as well. Copper peptides has anti-inflammatory properties as well, so if you have facial redness this can help to reduce on that rosiness. This is a product that can be used every day twice a day. You do need to be cautious on what you pair this up with, exfoliating acids, certain types of antioxidants like L-ascorbic acid and Resveratrol. They also don't recommend using this with retinol or tretinoin. I have used it a few times but I much prefer to keep them separate."
AGING BACKWARDS OVER 30 | BEST ANTI-AGING SKINCARE PRODUCTS OF 2023 | THESE ACTUALLY WORK!
"This is the Copper Amino Isolate Serum. This is very very similar to the ordinary one but this one is a little bit more advanced in terms of the ingredients and also the texture of this is more like water. This one spreads even better across the skin and your skin also absorbs this really nicely as well. The texture is thicker on the ordinary one which is a little bit more moisturizing on the skin, but this one is still quite nice and it really helps to hydrate the skin at the same time."
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"I use this one almost every day. If I'm not using The Ordinary copper peptides, I am using this one. I do feel like this one is a little bit more effective. I do feel like this one works a little quicker. This one has more of that watery texture whereas the one from The Ordinary is more like that jelly, more like a hyaluronic acid type of texture. It's great for fine lines, great for signs of aging. The serum is thin, it's lightweight, it layers up nicely with skincare."
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"I love that copper ingredient. If you're looking for something that is a little bit more advanced, something that possibly could work a little bit faster because for my experience this one works a little bit faster than The Ordinary one, this is the NIOD Copper Amino Isolate Serum. The ingredients in here are more advanced. I do find that this works a lot quicker but it's very comparable and similar to The Ordinary. You honestly can't go wrong with either one. This one unfortunately is more expensive. This one has more of that thin watery consistency whereas this one is a little bit more of that gel type of serum. It kind of mimics hyaluronic acid in the way of texture so it just depends on maybe what consistency you like better, what your budget is, but these two are exceptional, especially if you're looking for a copper peptide."
THE ORDINARY & NIOD SALE 2023 | I SPLURGED ONCE AGAIN AND THIS IS WHAT I PURCHASED!
"I'm really curious to see how this is going to work because it's been a while since I've used this and I can't remember how I liked it. I can't remember if it pilled or how it layered out with my skin care."
~Mixed
"I find that the NIOD serum is fine, it works well, but I don't know, I don't enjoy using it as much. I find it a bit more unwieldy texturally speaking. The Ordinary serum has a little bit more substance to it and feels like you're putting more on than just a very thin liquid that slips through your fingers. That's really just a personal preference; it doesn't necessarily speak to efficacy per se. Having really given the NIOD one a rigorous test, I found it to be effective and beneficial, but I honestly don't really have a strong reason to encourage you to buy the NIOD one if you're interested in copper peptides."
Approved
"The copper amino isolate serum is a copper peptide serum great for nighttime use to help with anti-aging. We've got 1% copper peptides, we've got vitamin E, we've got that retinol peptide 189, and then we've got prolene peptide. It's a water-based peptide serum. We also have an ingredient called tholin 4 which is a peptide that's claimed to work with the youth hormone, works by compensating the loss of thymic factors that come with age and it's thought to stimulate the skin immune defenses and help the skin to regenerate and produce more collagen. So buy this for the copper peptides and the other peptides in here and keep using it for the other beneficial goodies in here. It's a really nice serum."
Approved
"It's a collagen stimulating peptide that signals to our body to create collagen, but it also is a carrier peptide for copper and it helps deliver the copper deeper into the skin where it can create more meaningful results. So I really like the combination here, there's some other peptides in the mix. This is a very expensive serum that is up in the like the $90 range, but it works. This is one of the very few expensive products where I would say if it fits your budget go for it. I don't think that you will regret it. It will show you results. It made my skin feel so firm so fast, amazing."
All 2 takes from Kelly Driscoll
Hyped Skincare Ingredients, Are They Worth It?
"It's a collagen stimulating peptide that signals to our body to create collagen, but it also is a carrier peptide for copper and it helps deliver the copper deeper into the skin where it can create more meaningful results. So I really like the combination here, there's some other peptides in the mix. This is a very expensive serum that is up in the like the $90 range, but it works. This is one of the very few expensive products where I would say if it fits your budget go for it. I don't think that you will regret it. It will show you results. It made my skin feel so firm so fast, amazing."
Skincare That Actually Firms Skin!
"It's an expensive product, about $62 for 15ml of product or $93 for a 30ml bottle, but the reason I bring it up is because it works. I would never recommend something at that price point if I didn't have personal results with it. This firms the skin, makes it feel thicker but in a good way, thicker and firmer and more lifted. After a couple of weeks of consistent use it absolutely firms the skin. It has this really interesting refining quality to the skin. If you have enlarged pores it really helps to smooth those and make them look more refined and slightly tighter. It makes your skin look really smooth, really lifted, feels thick, feels firm, and that really comes down to those peptides that are helping with the structural integrity of the skin. The peptides help keep the pore from sagging, which is why we're seeing those results with the pores. It's also overall helping the skin to feel more firm and lifted."
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