Mary&May

Mary&May Spicule Collagen PDRN Cream.

Moisturizers

About this product

A moisturizing cream formulated with PDRN, collagen, and spicules to hydrate, plump, and promote product absorption into the skin.

Full ingredients

Aqua(Water), Methylpropanediol, Glycerin, 1,2-Hexanediol, Panthenol, Niacinamide, Caprylic/Capric Triglyceride, Polypropylsilsesquioxane, C14-22 Alcohols, Ammonium Acryloyldimethyltaurate/VP Copolymer, Glyceryl Stearate, Hydrolyzed Collagen, Cetyl Ethylhexanoate, Vinyl Dimethicone, Macadamia Ternifolia Seed Oil, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-20 Alkyl Glucoside, Arginine, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Brassica Campestris (Rapeseed) Sterols, Polyglyceryl-10 Laurate, Polyisobutene, Dextrin, Tocopherol, Allantoin, Ethylhexylglycerin, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Cholesterol, Hydrolyzed Sponge, Gardenia Florida Fruit Extract, Xanthan Gum, Butyrospermum Parkii (Shea) Butter, Adenosine, Lauryl Glucoside, Hydrogenated Lecithin, Sodium Hyaluronate, Polyglyceryl- 6 Laurate, Disodium EDTA

Guru Score

76%

Yay

3 experts · Moderate agreement

What the gurus are saying

The spicules work as tiny needles that push PDRN deeper into skin, and the brand strikes a balance: enough to help delivery without being overwhelming. This cream earns praise for the clever pairing, with hydrating collagen, soothing panthenol, and vegan PDRN all hitting the trending-ingredient marks. However, the formula leans into trends rather than innovation, gathering viral ingredients you might see from other brands.

Synthesized from 3 expert reviews · most recent take September 2026

What they liked

Gentle spicule concentration, not overwhelming
PDRN paired with spicules for deeper penetration
Vegan PDRN option

What they flagged

Feels like trend-chasing rather than innovation

Best for

Dry skin

Type

MoisturizersCream

Key actives

Niacinamide Hyaluronic acidVitamin E

Formula notes

Fragrance-freeNo drying alcohol

Where to buy

Amazon → Google → iHerb →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Mad About Skin

731k subs

✓Yay

"I love the fact that they've used the PDRN, which can struggle to get into the skin, so the spicules are going to help with that. Collagen is a great hydrating agent - this is going to plump and hydrate. I love [...] that you've got panthenol to calm and soothe. The PDRN is actually vegan, so if you're looking for PDRN without the salmon, it's a great option. [...] I think this is like PDRN leveled up. [...] Mary and May [...] knocked it out of the park. I'm impressed."

No BS Beauty

89k subs

✓Yay

"Has no scent. Feels really nice and silky. Actually, I'm kind of impressed. Feels really silky on your skin, which is really nice. [...] We've got slip ingredients, macadamia nut oil, which is great for your skin, vitamin E, allantoin, great soothing ingredient, some fatty acids, squalane, which is a great soothing ingredient, arginine, great skin-identical ingredient. Collagen, which is great for hydrating your skin. You can't apply collagen to make collagen, but it's great for hydrating."

AliceintheRabbitHole

59k subs

✓Mixed

"This has that hydrating spicule sponge ingredient along with sodium DNA PDRN, so it's two of the biggest viral trends of 2025 in one product. I tried it last night and washed it out this morning and it's fine, but my biggest critique with this product is that this is just so SEO coded, chasing whatever's trending. I love Mary and May as a brand, but for me I just can't help wanting to see something new instead of the same trending ingredients repeated across different brands."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Niacinamide

Niacinamide has evidence behind it for redness, uneven tone and supporting the skin barrier, and it is usually well tolerated even by skin that reacts to most things.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Vitamin E

Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.

Source: NIH, National Library of Medicine

Frequently asked.

What is Mary&May Spicule Collagen PDRN Cream?

A moisturizing cream formulated with PDRN, collagen, and spicules to hydrate, plump, and promote product absorption into the skin.

Is Mary&May Spicule Collagen PDRN Cream worth it?

Mostly yes. 2 of the 3 gurus who reviewed it give it their stamp of approval, for a Guru Score of 76%.

What is Mary&May Spicule Collagen PDRN Cream's Guru Score?

Mary&May Spicule Collagen PDRN Cream holds a Guru Score of 76%. That is our read on how warmly the experts talk about it, based on the verdicts of 3 expert reviewers we have collected.