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ISDIN

Eryfotona Actinica SPF 50.

ISDIN Eryfotona Actinica SPF 50
Sunscreen

About this product

A mineral sunscreen with SPF 50 and DNA repair enzymes designed to protect skin from UV damage while helping to reverse existing sun damage.

Full ingredients

Guru Score

81%

Yay

11 experts · Strong agreement
11Gurus
11Yay
0Mixed
0Nay
#16 in SunscreenSee the ranking →

What they liked

  • Lightweight mineral formula with no white cast
  • Layers seamlessly under makeup without pilling
  • Matte finish suits oily skin well

What they flagged

  • Contains fragrance and alcohol denaturant
  • Steep price at sixty dollars for 3.4 ounces
  • Requires shaking to disperse UV filters evenly

What the gurus are saying

This mineral sunscreen earns consistent praise for its lightweight, fluid texture that layers seamlessly under makeup without leaving a white cast once rubbed in, making it especially suited to those with dry or sensitive skin. What sets it apart is the inclusion of photolysase, DNA repair enzymes that gurus note can help reverse existing UV damage; dermatologists report that patients wearing it regularly show a measurable reduction in sun damage spots. The formula contains zinc oxide for broad-spectrum protection and vitamin E for antioxidant support, and does not irritate or sting.
Synthesized from 11 expert reviews · most recent take July 2026

Best for

Type

SunscreenLotion

Key actives

Vitamin CVitamin ESPF

Formula notes

Contains fragranceContains drying alcohol

Where to buy

Opens a search for this product. We do not sell anything ourselves.

More from ISDIN 6 products · Guru Score 93% How it works Independent by design. Every take comes from a creator we have no relationship with. We do not ask anyone to review, and affiliate links never move a score.

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
Yay
"For those a little older, after age 40, dealing with pre-skin cancers or skin cancers, I like Isdin's Eryfotona, which has a DNA repair ingredient. [...] It's a European sunscreen that comes in non-tinted and tinted versions, and it's very lightweight, though you have to shake it up well to disperse the UV filters evenly. [...] It blends in very well, only one tint though. I really like that it has the DNA repair mechanism, since as we get UV radiation damage and get older we aren't as good at picking up DNA repair mistakes. It's also packed with antioxidants, so you're paying more for it, but it's a great reliable brand. I recommend it to patients a little older, after age 40 or 45, dealing with pre-skin cancers to full-on skin cancer tumors."
All 4 takes from Dr. Daniel Sugai
Dermatologist Reviews: The Best Sunscreens of 2024
"Consider this if you have mature skin and you're going to your dermatologist and they're spraying you with liquid nitrogen quite a bit, consider the ISDIN Eryfotona Actinica sunscreen"
3 BIGGEST Skincare Regrets I See in Clinic | Dermatologist Explains
"The plankton extract has the DNA repair enzymes in the sunscreen to help decrease the risk of developing skin cancers and help repair those DNA mutations. We want to snip those out as much as possible, but as we get older we have a less efficient system in taking out those mutations and the system gets overwhelmed and that leads to tumors. So I recommend the ISDIN Eryfotona Actinica tinted or non-tinted, those emulsion sunscreens are very good. Just shake them up well to distribute the UV filters evenly throughout before applying."
Dermatologist Reviews: Holiday Skincare Picks for All Ages 2023
"If you're say 40s 50s 60s and you're dealing with pre-skin cancers or skin cancers I recommend isin aona tinted Sun screen that's been good because that helps with DNA repair the aerona in it"
The Best Tinted Sunscreens of 2026
"For those a little older, after age 40, dealing with pre-skin cancers or skin cancers, I like Isdin's Eryfotona, which has a DNA repair ingredient. [...] It's a European sunscreen that comes in non-tinted and tinted versions, and it's very lightweight, though you have to shake it up well to disperse the UV filters evenly. [...] It blends in very well, only one tint though. I really like that it has the DNA repair mechanism, since as we get UV radiation damage and get older we aren't as good at picking up DNA repair mistakes. It's also packed with antioxidants, so you're paying more for it, but it's a great reliable brand. I recommend it to patients a little older, after age 40 or 45, dealing with pre-skin cancers to full-on skin cancer tumors."
Yay
"The ISDIN Eryfotona, beautiful sunscreen."
All 2 takes from HotandFlashy
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"This next sunscreen is an SPF 50, but it's much more expensive. I love everything about it except that it has so much fragrance in it. I can't wear it because of all the fragrance, but I know people love it."
BEST DEALS In BEAUTY, FASHION, SUPPLEMENTS, HOME | Prime Day 2026
"The ISDIN Eryfotona, beautiful sunscreen."
Yay
"This sunscreen literally has been shown in clinical studies to reduce keratosis, so pre-cancerous changes. When they use this sunscreen regularly, some of that pre-cancerous change, the AKs actually go away. So not only is it sun protection, but may actually work synergistically and reduce the amount of sun damage one has, which is quite incredible. It's a pure mineral sunscreen along with the DNA repair enzyme. It also has vitamin E that's an antioxidant. It's a liquid kind of texture, absorbs really quickly and leaves minimal white cast. It's great for those with more immature skin, wanting to not only protect their skin, but also reduce some of the pre-existing sun damage that you have."
All 3 takes from Dr. Jenny Liu
Sephora Sale Must-Haves | Dermatologist-Approved Skincare & Haircare | Dr. Jenny Liu
"This sunscreen literally has been shown in clinical studies to reduce keratosis, so pre-cancerous changes. When they use this sunscreen regularly, some of that pre-cancerous change, the AKs actually go away. So not only is it sun protection, but may actually work synergistically and reduce the amount of sun damage one has, which is quite incredible. It's a pure mineral sunscreen along with the DNA repair enzyme. It also has vitamin E that's an antioxidant. It's a liquid kind of texture, absorbs really quickly and leaves minimal white cast. It's great for those with more immature skin, wanting to not only protect their skin, but also reduce some of the pre-existing sun damage that you have."
Dermatologists Answer Sunscreen Questions
"One of my two favorites at the moment is the ISDIN Eryfotona Actinica, which is a mineral based sunscreen. It's made in Spain and it contains these really unique DNA repair enzymes that help to reverse DNA damage from the sun, so that's pretty cool. It rubs in really well, ultra lightweight. Mineral sunscreens get a bad reputation because they can leave a white cast, so I'm really picky, and this one is very elegant, it does not leave a white cast at all."
Your Skin After 40: A Derm’s Guide to Menopause & Perimenopause Skincare | Dr. Jenny Liu
"The first one is ISDIN Eryfotona Actinica SPF 50 Plus. It's a Spanish brand, they make elegant sunscreens, and this one is really popular among dermatologists because not only is it a pure mineral filter, great for anyone with dry and sensitive skin, it's lightweight and elegant, fluid like, but does not leave a white cast. I believe it's also water resistant, but it's got high SPF protection, SPF 50, but also has this unique DNA repair zone that [...] helps to repair DNA damage that has basically happened or accumulated in your skin. So not only is it protecting your skin, it can actually reverse some of that damage that's happening to your skin. And I have some dermatology colleagues that swear that when their patients are wearing this regularly, the amount of sun damage, aka actinic keratosis, which we [...] sometimes even call precancerous spots, actually goes down. So it's a great way to not only protect your skin, but also reverse some of the actual sun damage happening to your skin. But overall, it's just a really nice, elegant mineral sunscreen. It doesn't cause irritation, doesn't burn or sting. So just a really nice elegant sunscreen for anyone, especially if you are more sensitive."
Yay
"The brand that I know of that does this and the products that I personally use myself are from ISDIN. They're sunscreens. They have a tinted sunscreen and a non-tinted sunscreen here in the US with DNA repair enzymes. So definitely something of interest, but they're kind of expensive. I don't think it is a must-have. It's not like something that is in the guidelines for treating patients who have a history of non-melanoma skin cancer moving forward. It's not standard of care, but it is a compelling angle."
All 2 takes from Dr Dray
Beyond Sunscreen: The Ultimate Guide to Photoprotection for Your Skin
"The brand that I know of that does this and the products that I personally use myself are from ISDIN. They're sunscreens. They have a tinted sunscreen and a non-tinted sunscreen here in the US with DNA repair enzymes. So definitely something of interest, but they're kind of expensive. I don't think it is a must-have. It's not like something that is in the guidelines for treating patients who have a history of non-melanoma skin cancer moving forward. It's not standard of care, but it is a compelling angle."
ANTI-AGING DNA REPAIR ENZYMES 🤔 ISDIN Eryfotona SUNSCREEN REVIEW @DrDrayzday
"This is a zinc oxide mineral sunscreen that protects against UVA and UVB rays and has photolyase, the DNA repair enzyme, in it. It leaves a pretty sheer white cast, it's not chalky at all. It's really nice in terms of application consistency, it leaves the skin moisturized but not greasy, so it's a great base for cosmetics, and it's also a great matte option if you have oily skin. It's lightweight and fast absorbing. It does have alcohol denaturant in it, which some people are fearful of or find drying, but it allows for a quicker dry formula and lets sweat evaporate so it helps you feel less overheated. It's water resistant up to 40 minutes, which is great if you live somewhere humid, though you still need to reapply every two hours if you're outdoors for a while. I don't get any pilling with it, which I cannot stand. It does have fragrance, a powdery fresh scent that fades quickly and isn't overpowering, though fragrance isn't my preference, especially in sunscreens. It comes in a generous 3.4 ounce bottle, but at sixty dollars it's a pretty steep price point. They're worth it in my mind if you really like the way they look and feel and it motivates you to wear them consistently, but I don't know that they're necessarily any better at protecting you from UV exposure and skin cancer than a more affordable option."
Yay
"Next is the ISDIN Eryfotona Actinica SPF 50. I've also talked about this before because this is a true staple in my routine and my mother-in-law's routine. This contains photolyase, which are DNA repair enzymes that help reverse existing UV induced damage. [...] It has this really fast absorbing, lightweight texture that doesn't peel under makeup. Initially when you put it on, you might [...] notice a little bit of a white cast, but the more you rub it in, it really does go away. This is mineral-based broad spectrum UVA UVB coverage, contains zinc oxide, and it really layers very well under makeup, BB creams, anything else you want to put on top of it. It also contains vitamin E for that antioxidant protection against free radicals. It does come in a tinted form as well, which doesn't have this orange label. That tint is a little bit darker on my skin, and so I prefer the non-tinted version."
All 2 takes from Tea with MD
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"Next is the ISDIN Eryfotona Actinica SPF 50. I've also talked about this before because this is a true staple in my routine and my mother-in-law's routine. This contains photolyase, which are DNA repair enzymes that help reverse existing UV induced damage. [...] It has this really fast absorbing, lightweight texture that doesn't peel under makeup. Initially when you put it on, you might [...] notice a little bit of a white cast, but the more you rub it in, it really does go away. This is mineral-based broad spectrum UVA UVB coverage, contains zinc oxide, and it really layers very well under makeup, BB creams, anything else you want to put on top of it. It also contains vitamin E for that antioxidant protection against free radicals. It does come in a tinted form as well, which doesn't have this orange label. That tint is a little bit darker on my skin, and so I prefer the non-tinted version."
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"The non-tinted version is the ISDIN Eryfotona Actinica SPF 50, and this one I actually worked with them a couple months ago in New York but they're obviously not sponsoring this video, I'm not being paid to say this, but it just contains this really amazing technology. All of their sunscreens contain these unique DNA repair enzymes called photolyase, which actually helps to repair DNA damage from the sun. And actually, back in the day, photolyase actually won a Nobel Prize when that enzyme was first discovered. So I think it's really cool. I'm a huge nerd, so I think the science behind it is really fascinating. And if you have a product that can protect your skin from the sun while also helping fix DNA damage from the sun, I mean that's like that's such a win."
Yay
"This is the ISDIN Eryfotona Actinica SPF 50 and this is so good, it is phenomenal, especially if you have actinic keratosis. ISDIN specifically designs these products for actinic damage and this is a mineral formula. You got to shake, shake, shake it because of how lightweight and liquidy this is. What's fantastic about this formula is not only is it a sunscreen that protects you and your skin from actinic keratoses and skin damage and precancerous growths, but it also has a little bit of dimethicone in there, a couple of silicone products that just feels so nice on the skin. This is beautiful and this is lightweight and it feels luxurious, which is why a lot of doctors and derms recommend it."
Yay
"The ISDIN Eryfotona Actinica sunscreen has DNA repair enzymes and sunscreens are such an easy way to incorporate them into your routine"
Yay
"I'm using this one myself, the Isdin Eryfotona Actinica. It's super popular, and it's not an inexpensive sunscreen, but it's one hundred percent mineral."
Yay
"Another untinted mineral sunscreen that I really like is the ISDIN Eryfotona Actinica SPF 50. It's a [...] really good mineral option, both because it goes on really seamlessly and because it plays well under makeup. I will say this does leave a little bit of a white cast on my skin, but I'm typically wearing it under a little bit of foundation or tinted moisturizer, and that cancels that out. This uses 11% zinc oxide as the mineral filter, and it's water resistant for 40 minutes. This is actually probably the most common mineral sunscreen that I use on my son when we're going into the water or going to the pool or the beach. One thing that's important to note about this sunscreen [...] is that it's not a particularly moisturizing sunscreen, so I think it's actually really nice if you have oily skin, but if you have dry skin I would put a good layer of moisturizer on first before layering this on top."
Yay
"Isdin has their Eryfotona Actinica, a zinc oxide sunscreen loaded with DNA repair, so it not only protects from future sun damage but also helps reverse the sun damage you already have."
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All 3 takes from Dr. Shereene Idriss
Anti-Aging Skincare for 50s+, Mature Skin, & Menopause | Dr. Shereene Idriss
"But there are two sunscreens on the market that have an ingredient known as photoliase that helps to reverse the damage of your skin that's been already done by the sun it helps to reverse it these two are is den"
How to Prevent Skin Thinning & Boost Your Collagen! From a Dermatologist | Dr. Shereene Idriss
"I love these two ISDIN products and I've spoken about them in the past. There is the Eryfotona Actinica as well as the Agist, they are both SPF 50 and they also help repair existing sun damage with DNA repair enzymes. They're mineral with zinc, vitamin E, and they are lightweight, they are super super light. You have to shake it and it's like light, okay, very very lightweight to get the coverage that you need so you don't feel like your skin is suffocating. That is the number one way that you are going to protect your skin over time, especially if you start at a young age."
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"Isdin has their Eryfotona Actinica, a zinc oxide sunscreen loaded with DNA repair, so it not only protects from future sun damage but also helps reverse the sun damage you already have."
Yay
"This non-tinted mineral sunscreen blends phenomenally well. It's as about as good as it gets when it comes to a mineral sunscreen blending with any skin tone. Like, you cannot get better than this. It feels so lightweight when you put it on. If you're looking for that more elegant sunscreen, this is certainly one of the products that you want to try out. Just be aware that this product does have fragrance in it."
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What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Vitamin C

Topical vitamin C is an antioxidant with reasonable evidence for dullness and uneven tone. It breaks down in light and air, so how a product is formulated and packaged matters as much as the percentage on the front.

Source: DermNet

Sunscreen filters

Sun protection is the best evidenced way to slow visible ageing, and the filters are what does the work. Mineral and chemical filters both protect when a product is applied thickly enough and often enough, which is where most people fall short rather than on the choice of filter.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Frequently asked.

What is ISDIN Eryfotona Actinica SPF 50?

A mineral sunscreen with SPF 50 and DNA repair enzymes designed to protect skin from UV damage while helping to reverse existing sun damage.

Is ISDIN Eryfotona Actinica SPF 50 worth it?

Yes. All 11 gurus who reviewed it give it their stamp of approval, for a Guru Score of 81%.

What is ISDIN Eryfotona Actinica SPF 50's Guru Score?

ISDIN Eryfotona Actinica SPF 50 holds a Guru Score of 81%. That is our read on how warmly the experts talk about it, based on the verdicts of 11 expert reviewers we have collected.

Who is ISDIN Eryfotona Actinica SPF 50 best for?

ISDIN Eryfotona Actinica SPF 50 is generally suited to acne-prone skin.

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