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Grande Cosmetics

GrandeLASH-MD.

Grande Cosmetics GrandeLASH-MD

About this product

An eyelash and eyebrow growth serum containing prostaglandin analog actives designed to lengthen and thicken lashes and brows with nightly application.

Full ingredients

Guru Score

47%

Nay

11 experts · Strong agreement
11Gurus
2Yay
1Mixed
8Nay

What they flagged

  • Unregulated prostaglandin analogs
  • Dry eyes and redness
  • Permanent eyelid and iris discoloration

What the gurus are saying

This serum works remarkably well at growing lashes and brows, but the prostaglandin analog it contains carries real risks that catch many people off guard. Gurus split sharply: some see the results as worth it if you stay watchful, while others warn the side effects (irritation, redness, hyperpigmentation around the eyes, unwanted hair growth, and in rare cases sunken eyes from fat loss) can sneak up over weeks or months and sometimes turn permanent. The irritation and discoloration reports have prompted FDA warning letters and lawsuits. If you try it, dermatologists suggest using it short-term before a specific event rather than continuously, keeping application precise with a spoolie to avoid migration, and watching closely for any redness or dark patches around the eyes as an early signal to stop.
Synthesized from 11 expert reviews · most recent take July 2026

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
Mixed
"There are also some over-the-counter prostaglandin analogs, like the ones in Grandelash and many others, and people also notice inflammatory effects and hyperpigmentation effects with them, and they can change your eye color. But they're extremely effective, and people are generally quite happy with them. Keep it directed with a spoolie on the eyebrows and you should see some growth with it."
Nay
"I want to talk about a beauty product that I feel like has done a lot of people dirty over the last 5 to 10 years, and those are lash growth serums that contain a class of ingredients called prostaglandin analogues. I actually made a whole YouTube video dedicated to this about 5 years ago. You will find prostaglandin analogues in a lot of very popular lash growth serums like Latisse, Grande Lash."
Nay
"Grande Cosmetics GrandeLASH-MD contains a prostaglandin analog. These compounds can be found in some of the popular brands like Grande Cosmetics GrandeLASH-MD, Babe Lash, and Revia Lash. If those are the risks that you are aware of and you want to avoid them, maybe get that lash serum out and check it against the list to make sure it doesn't contain a prostaglandin analog."
Nay
"I used Grande lash didn't really help much"
Nay
"Grande lash contains a prostaglandin analog, a common one is called isopropyl cloprostenate. There are many other ones, but this is a common one and it can be a problem because consumers don't know that, and when they're using it they may not be expecting this irritation and hyperpigmentation that may occur. The irritation and hyperpigmentation have been reported so much that the FDA has actually issued warning letters to the brand basically informing them they need to be fully transparent. There have also been class action lawsuits against brands like Grande lash. There are over-the-counter non-prescription analogs that do exist that work very similar to Latisse, maybe not as strong, but the common irritations, hyperpigmentation and other side effects exist."
Nay
"I do have my own experiences with these, and I won't use them anymore, I got irritation."
All 2 takes from AliceintheRabbitHole
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"I do have my own experiences with these, and I won't use them anymore, I got irritation."
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"This is the lash serum that changed the game for me, I used it every single night in a thin layer for three years, and it worked, within about two months I was getting so many compliments from strangers on my lashes. But at some point I started noticing red irritation around my eyelashes, a classic sign of inflammation, and I didn't stop using it. Near the end of my three years my lashes started falling out even though I was still applying it every night. I also experienced unwanted hair growth on my tear duct from the product migrating, which I'd have to pluck with tweezers, and that is extremely painful. It is because of these cons that I have an entire unopened box of this that I just let expire, I'm not going to use it anymore. My advice, if I could go back, would be to only use it short term for a couple of months before a specific event and then stop, not use it continuously the way I did."
Nay
"Grande Lash contains prostaglandin analogs which are not FDA regulated over-the-counter versions that are actually 10 times stronger than the prescription Latisse. These unregulated versions cause the same dangerous side effects as Latisse including dry eyes, redness, permanent eyelid discoloration, iris discoloration, eye color changes, fat atrophy causing sunken eyes, and deepening of the eyelid crease. The problem is that women don't realize what they're putting on their lashes and don't know to watch for these side effects, so they may not stop using it even when complications begin. These side effects start appearing as early as eight weeks of use and can be permanent."
All 2 takes from The Budget Dermatologist
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"Grande Lash contains prostaglandin analogs which are not FDA regulated over-the-counter versions that are actually 10 times stronger than the prescription Latisse. These unregulated versions cause the same dangerous side effects as Latisse including dry eyes, redness, permanent eyelid discoloration, iris discoloration, eye color changes, fat atrophy causing sunken eyes, and deepening of the eyelid crease. The problem is that women don't realize what they're putting on their lashes and don't know to watch for these side effects, so they may not stop using it even when complications begin. These side effects start appearing as early as eight weeks of use and can be permanent."
Nay
"My concern with these is always that they can have prostaglandin analog like compounds in them that definitely can cause dry eyes, and there are cases of people getting hyperpigmentation around the eyes related to these non-prescription lash enhancing serums, and they also can cause eye redness. There's one concerning rare side effect, more common in people actually using prostaglandin analogues to treat glaucoma, which is atrophy of the fat around the eye and a sunken eye appearance. It's reversible, it's not really something that we see with using the prostaglandin analogues like Latisse, but it's theoretically possible."
All 2 takes from Dr Dray
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"Other more popular brands like Grande lash Grande brow do"
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"My concern with these is always that they can have prostaglandin analog like compounds in them that definitely can cause dry eyes, and there are cases of people getting hyperpigmentation around the eyes related to these non-prescription lash enhancing serums, and they also can cause eye redness. There's one concerning rare side effect, more common in people actually using prostaglandin analogues to treat glaucoma, which is atrophy of the fat around the eye and a sunken eye appearance. It's reversible, it's not really something that we see with using the prostaglandin analogues like Latisse, but it's theoretically possible."
Yay
"The lash serum is really good. If you want to grow your lashes, if you want to try it, DermAngelo has spoken a lot about it. He really likes it. I was not into it and he was the one that was like convincing me. It worked. It was good."
All 2 takes from Cassandra Bankson
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"Even though this is a slightly different active ingredient, this still has the prostaglandin analog in it. Even if scientists and doctors and researchers don't know exactly how they work, we know that they can cause changes in pigmentation, we know that they can cause changes in the growth of lashes, and yeah, we know that in some people they can cause some of the fat in the skin to kind of deteriorate. Based on the research, there have been some medical studies that actually looked at people who were using lash serums and they looked at the before and afters not just of the lashes but also of how hollow the under eye area is, and they found that those who are using a topical prostaglandin analog saw a little bit more of the hollowing in that area, which for some of those people was not desired."
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"The lash serum is really good. If you want to grow your lashes, if you want to try it, DermAngelo has spoken a lot about it. He really likes it. I was not into it and he was the one that was like convincing me. It worked. It was good."
Nay
"I finished up a tube of Grande Lash. This was sent in PR from Amazon, so I thought I'd give it a try. This does have a prostaglandin analog in it, but I gotta say this didn't work for me as well as my RevitaLash does. I've probably been using this for about six months, that's how long it takes to go through one of these. I use it on my brows and my lashes. It did really well on my brows. My brows seem to be holding in more, but they didn't lose any ground. But I feel like using this for the last six months, my lashes are so stumpy now and I'm kind of bummed about it, so I'm back to using my RevitaLash."
Yay
"Grande Lash has panthenol in it to help make your hair fuller more elastic more supple especially on your eyebrows because you want to tame them and your eyelashes."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Vitamin C

Topical vitamin C is an antioxidant with reasonable evidence for dullness and uneven tone. It breaks down in light and air, so how a product is formulated and packaged matters as much as the percentage on the front.

Source: DermNet

Humectants and emollients

Ingredients like these draw water into the surface layers and slow how fast it leaves. The evidence is for comfort, softness and hydration rather than for changing the structure of the skin.

Source: DermNet

Vitamin E

Vitamin E is an antioxidant, and it is often in a formula to keep the other ingredients stable rather than as the active itself. It pairs well with vitamin C, though on its own the evidence for visible change is limited.

Source: NIH, National Library of Medicine

Frequently asked.

What is Grande Cosmetics GrandeLASH-MD?

An eyelash and eyebrow growth serum containing prostaglandin analog actives designed to lengthen and thicken lashes and brows with nightly application.

Is Grande Cosmetics GrandeLASH-MD worth it?

Mostly no. Only 2 of the 11 gurus who reviewed it approve, which leaves it a Guru Score of 47%.

What is Grande Cosmetics GrandeLASH-MD's Guru Score?

Grande Cosmetics GrandeLASH-MD holds a Guru Score of 47%. That is our read on how warmly the experts talk about it, based on the verdicts of 11 expert reviewers we have collected.

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