Radiant Tone Dual Serum with Thiamidol.

"There's a newer ingredient called Thiamidol, one of the most potent tyrosinase inhibitors available over the counter, and it's tolerated really well even by deeper skin tones. A 24 week randomized controlled trial showed it was significantly superior to placebo for moderate to severe melasma, and I believe it's also been compared to 4% hydroquinone and found to be superior. Thiamidol is available through Eucerin in their radiant tone collection, which has a moisturizer, a sunscreen, a serum, a cleanser, and I believe an eye cream also. If you want a full routine that really focuses on pigmentation, I do highly recommend the Eucerin radiant tone collection."

"I'm liking the data behind this. Thiamidol by Eucerin. Eucerin came out with the Radiant Tone line last year and they have Thiamidol in it. I have a few patients who have tried it and they actually do see success with it, especially on their breaks from hydroquinone. We avoid the rebound from hydroquinone by being on the Radiant Tone line. The downside to it is one, you have to use it frequently. The studies show you get max benefit by using it four times a day, which is a lot. You got to use it in the serums twice a day, sunscreen, and also in the night cream. There's ways to apply it four times a day but it is a lot. And also it's heavily fragrance, and I worry about my patients who are sensitive to fragrance. I am not sensitive to it, so I've used the Radiant Tone line without any issues, but it is quite strong. Hydroquinone can cause a halo effect around your dark spots, and the nice thing about Thiamidol is that it's blocking tyrosinase powerfully without causing any halo effect around your dark spots."

"The dual serum is a lightweight creamy serum that basically contains the active ingredient Thiamidol along with hyaluronic acid as well as a derivative of licorice root that is really meant to help soothe and calm any sort of redness or irritation. But licorice itself does have some brightening properties. I've used it with my retinol at night as well as my vitamin C in the morning and I have not gotten any irritation. When I struggle with hyperpigmentation, I probably just use the serum because it's got the most concentrated active. I have recommended it to many of my patients in clinic that are wanting a skin brightening product without a prescription. The one thing I would have to say is I do wish this line was fragrance-free or at least had a fragrance-free version, but I haven't had any issues being irritated by this product."

"One of the most recent ones that launched is called Thiamidol. It's an ingredient that's in a product called Eucerin Radiant Tone and it's actually been available around the world for the last seven years. It's been a big component of what people around the world have been using to treat pigment, but we just got it here in the US. It works by inhibiting tyrosinase. Tyrosinase is the enzyme that is the most critical enzyme in the manufacturing of melanin. So if you inhibit tyrosinase, you reduce melanin in the skin because it can't create it. What made it unique is that it inhibits human tyrosinase. All of the active ingredients that we know of that inhibit tyrosinase have been tested on mushroom tyrosinase because mushrooms have tyrosinase, that's why they turn brown. The scientists who were working on this ingredient found an assay to look at what inhibits human tyrosinase which is actually quite different than mushroom tyrosinase. And they found it to be a really potent inhibitor of mushroom tyrosinase. They developed this product around this active ingredient and it works great. I've been using it in my practice."

"I had a great opportunity learning about Eucerin, and the best thing about it is they've done a lot of research, especially on human skin, which is very promising for us as clinical practitioners to understand its safety profile and its comparative study with hydroquinone and how superior it is. I have a lot of faith in molecules which have more research compared to no research. What I like about Thiamidol is that it's very safe, very gentle on the skin, and shows good results, and the best thing is the way it makes your skin feel, it improves your overall skin texture too. The way this dual serum has been formulated, it not only targets the pigment but improves the overall skin, so I get patients who tell me it's looking a little glowy, a little more plump, and I think that's also what makes them want to use it for longer. The beauty about Thiamidol is you can go on and on for the patient to use it, unlike other molecules which irritate, even on a vacation it's absolutely safe to use. That's my go-to molecule. As somebody who struggles with melasma, I personally use anti-melasma products, and I've noticed it really improves the quality of the skin. The reduction in dark spots is slow, like anything else, two to three weeks or four weeks you have to give it to see results, but the quality of skin improvement is quite instant, in three to four days you can notice your skin looks much better."