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Epiduo

Epiduo Gel.

Epiduo Epiduo Gel
Moisturizers

About this product

A prescription and over-the-counter acne treatment combining 0.1% adapalene (a retinoid) and 2.5% benzoyl peroxide in a single formula.

Guru Score

78%

Yay

7 experts · Strong agreement
7Gurus
7Yay
0Mixed
0Nay

What they liked

  • Two proven acne actives in one product
  • Now available over the counter
  • Safe for long-term daily use

What they flagged

    Nothing. None of the experts who reviewed it raised a problem.

    What the gurus are saying

    Epiduo's combination of adapalene and benzoyl peroxide works well for acne, and the two actives are stable enough to stay effective when paired together, which means you get both ingredients in one product instead of layering them separately. The gurus emphasize there is no established issue with using it long-term, even during sunny months, because adapalene does not increase sunburn risk and may actually help protect skin from sun damage. It's approved for children as young as nine, and if home treatments have not worked, this prescription option is worth asking your doctor about.
    Synthesized from 7 expert reviews · most recent take August 2026

    What the gurus are saying.

    Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

    All takes Yay takes Nay takes Mixed takes Hide sponsored
    Yay
    "We now have adapalene 0.1% plus benzoyl peroxide 2.5% in one combined gel marketed as Epiduo, and that's a great addition to the over-the-counter available armamentarium for patients with acne. Before this, you would have to go pursuing the Epiduo dupe, where you'd buy an over-the-counter adapalene gel and then go find a benzoyl peroxide leave-on product and wonder how to layer them. Now it's great, you have it in one thing you have to buy, one thing you have to apply, and you don't have to sit there wondering whether you can put it on."
    All 4 takes from Dr Dray
    Dermatologist Answers Skincare Questions | Sun Spots, Tretinoin, KP & More
    "Epiduo, if you're not familiar, is adapalene plus benzoyl peroxide. Yeah, you can use that indefinitely long term for the treatment of acne, which is what it's indicated for. There's no issue that has been established with long-term consistent use of either ingredient, adapalene or benzoyl peroxide. You don't need to take breaks in the summer or spring months. You don't need to take breaks for seasonal reasons from topicals. You really don't. You need to protect your skin from the sun year round. Summer and spring when you're spending a lot more time outdoors, obviously, you need to be more mindful of your sun exposure. But the topical retinoid, specifically adapalene too, in this case, it doesn't increase your chance of a sunburn. It's actually good for you to be using a topical retinoid in the sunnier months because it helps to protect collagen in your skin to a certain extent by limiting activation of matrix metalloproteinase enzymes that get upregulated with ultraviolet radiation that then destroy your collagen and facilitate wrinkles and premature skin aging. Adapalene also has this anti-inflammatory effect that can be beneficial as well."
    Can Sunscreen Stop Tanning? Dermatologist Q&A
    "The FDA has approved over-the-counter Epiduo, which combines adapalene and benzoyl peroxide. This is exciting because previously people who used both adapalene and benzoyl peroxide for acne treatment had to buy them separately and layer them together, but now they can get both ingredients in one product."
    Are Copper Peptides Better Than Vitamin C? Dermatologist Explain
    "Epiduo is adapalene plus benzoyl peroxide combined into one cream instead of two separate products, and that's great for patients with acne because it's a lot easier to stick with one cream than to layer two different creams, so patients are more compliant with it. The combination of adapalene and benzoyl peroxide together can be particularly powerful for acne and can get better results than either alone in some cases, though not everyone needs the combination. If you're already using over-the-counter adapalene for anti-aging, I don't see any reason to switch to Epiduo, because the benzoyl peroxide won't offer any anti-aging benefit and is just more likely to be drying and irritating, plus you have to deal with it bleaching fabrics. But if you're dealing with post-inflammatory hyperpigmentation, the combination can help by getting better control of the acne driving it. Epiduo is also a very good option for ingrown hairs, which are common in the beard area, especially for men with curlier or coiled hair, since those ingrown hairs often turn into inflamed, acne-like bumps that heal with hyperpigmentation. I'm really elated that it's now available over-the-counter, because it simplifies things a lot compared to telling patients to go find their own benzoyl peroxide separately, where they're statistically more likely to accidentally grab the more drying and irritating 10 percent instead of the 2.5 percent."
    Anua Azelaic Acid REFORMULATED? Controversy Explained | Derm Q&A
    "We now have adapalene 0.1% plus benzoyl peroxide 2.5% in one combined gel marketed as Epiduo, and that's a great addition to the over-the-counter available armamentarium for patients with acne. Before this, you would have to go pursuing the Epiduo dupe, where you'd buy an over-the-counter adapalene gel and then go find a benzoyl peroxide leave-on product and wonder how to layer them. Now it's great, you have it in one thing you have to buy, one thing you have to apply, and you don't have to sit there wondering whether you can put it on."
    Yay
    "The new Epiduo that's available over the counter would be great for this kind of skin. It used to be prescription, and it's got adapalene and benzoyl peroxide in it. Now it's OTC without a prescription."
    All 2 takes from 208SkinDoc
    I Watched A Cyst Removal And Regretted It
    "Epiduo was just approved by the FDA for over-the-counter use. This has been prescription only for a long time. It is adapalene, which was also prescription, and then went over the counter. Adapalene or Differin is the brand name. They also make one called Epiduo, and it has benzoyl peroxide with the adapalene. So, a really good acne treatment just went over the counter."
    Stop Popping Pimples With Your Nails
    "The new Epiduo that's available over the counter would be great for this kind of skin. It used to be prescription, and it's got adapalene and benzoyl peroxide in it. Now it's OTC without a prescription."
    Yay
    "FDA did approve the use of Epiduo in kids as young as the age of nine. Epiduo is a combination of 0.1 adapalene and 2.5% benzoyl peroxide so I'm comfortable with a 2.5% benzoyl peroxide. 0.1 adapalene, which is a prescription, is also safe for kids 9 and up."
    Yay
    "I have this, it's prescribed to me and I've had it for a really long time, but it's the Epiduo Gel, fantastic. It's proven for acne and breakout, changed the game for me."
    Yay
    "The stability from these rings makes it really good for acne because it means you can layer it with benzoyl peroxide and you can also get it in a relatively simple combo formula which is called Epiduo."
    Yay
    "If home remedies and acne treatments aren't working it's time for the doctor and he prescribed me Epiduo and it actually works"
    Yay
    "There is a medication called Epiduo. Epiduo is literally adapalene, which is a form of retinoid, plus benzoyl peroxide, and it works really great for acne. It's a prescription. A doctor or provider might say, hey, we're going to blend a retinoid in with benzoyl peroxide to help you get the most out of your skin care. If prescribed by your doctor, go for it."
    All 2 takes from Cassandra Bankson
    The Ultimate Guide to Benzoyl Peroxide by a Medical Esthetician
    "There is a medication called Epiduo. Epiduo is literally adapalene, which is a form of retinoid, plus benzoyl peroxide, and it works really great for acne. It's a prescription. A doctor or provider might say, hey, we're going to blend a retinoid in with benzoyl peroxide to help you get the most out of your skin care. If prescribed by your doctor, go for it."
    Adapalene vs Tretinoin - Which Is The Best ANTI-ACNE and ANTI-AGING Ingredient?
    "There's also Epiduo, which combines adapalene with benzoyl peroxide. Adapalene plays much better with benzoyl peroxide than tretinoin does, because tretinoin and benzoyl peroxide have a lot of irritation and can even cancel each other out, but adapalene is more stable and works well with benzoyl peroxide."

    Frequently asked.

    What is Epiduo Epiduo Gel?

    A prescription and over-the-counter acne treatment combining 0.1% adapalene (a retinoid) and 2.5% benzoyl peroxide in a single formula.

    Is Epiduo Epiduo Gel worth it?

    Yes. All 7 gurus who reviewed it give it their stamp of approval, for a Guru Score of 78%.

    What is Epiduo Epiduo Gel's Guru Score?

    Epiduo Epiduo Gel holds a Guru Score of 78%. That is our read on how warmly the experts talk about it, based on the verdicts of 7 expert reviewers we have collected.

    Who is Epiduo Epiduo Gel best for?

    Epiduo Epiduo Gel is generally suited to acne-prone skin and younger skin.

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