DRMTLGY

Needleless Peptide Serum.

Serums

About this product

A lightweight serum formulated with peptides and growth factors designed to support skin firmness and address signs of aging.

Guru Score

78%

Yay

3 experts · Moderate agreement

3Gurus

2Yay

1Mixed

0Nay

What they liked

Growth factors and peptides combination

What they flagged

Less firming than copper peptide serums

What the gurus are saying

Peptides and growth factors in this serum earn consistent praise for delivering visible firming results at a competitive price point. One expert noted it's particularly solid if you're not drawn to copper peptides specifically, though a few gurus found other peptide serums more effective for anti-aging. The value proposition stands out: dermatologists say it matches or beats products that cost significantly more, making it a strong top pick for anyone adding a peptide serum to their routine.

Synthesized from 3 expert reviews · most recent take December 2025

Best for

Mature skin

Type

SerumsDrops & dropper

Where to buy

Amazon → Google →

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What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored

Mad About Skin

727k subs

✓Yay

"Dermatology do a wonderful um growth factors and peptides combo."

Doctorly

3.58M subs

✓Yay

"I love their Needleless Peptide Serum. They were really early to peptides too, and their peptide serum is a really good one."

All 2 takes from Doctorly

2025 BEST BLACK FRIDAY CYBER MONDAY SKINCARE AND DEVICE DEALS | DOCTORLY DEALS

"I love their Needleless Peptide Serum. They were really early to peptides too, and their peptide serum is a really good one."

BEST and WORST DRMTLGY Products | Doctorly Reviews

"This is your peptide product. They were doing peptides before peptides were cool. It has glycerin, palmitoyl tripeptide one, tetrapeptide seven, palmitoyl tripeptide five, ceramides, niacinamide, different copper ions. There are products that are much more expensive than this that don't deliver the same impact. If you're looking for a peptide serum in your routine, I wouldn't say this is like a necessary step necessarily, but it's definitely a top product for them. It's fragrance free, so of course I love that. It's a good complementing product, good mutual benefit profile. If you're looking for most things like skin barrier, photo aging, it's going to complement your retinol as well. Very straightforward, simplistic, fragrance free, which is always a plus."

Sincerely Miss Ash

195k subs

✓Mixed

"I have an empty Needleless Peptide Serum by DRMTLGY. This is their peptide serum that actually contains a copper ingredient as well. I do feel like this is very different from The Ordinary and meets copper peptides, and if I'm going to resort to a copper peptide serum I'm going to pick either The Ordinary or the NeoD one as I do feel like they are more effective for signs of aging and to firm the skin compared to this. But if you're not really too interested in copper peptides, then I would say go with this one. So again, this one has that copper ingredient, but there's also ceramides in here as well to keep that skin barrier nice and strong. There's niacinamide in here which is great for discoloration, it's a lovely antioxidant for so many things, and also this serum is very hydrating at the same time. So you can use this every day, twice a day. I do like the DRMTLGY brand and this is one formulation that I do enjoy. I would definitely purchase this again in the future."

What the evidence says.

Independent of what the gurus think, this is what the published research supports about the main active ingredients here.

Frequently asked.

What is DRMTLGY Needleless Peptide Serum?

A lightweight serum formulated with peptides and growth factors designed to support skin firmness and address signs of aging.

Is DRMTLGY Needleless Peptide Serum worth it?

Mostly yes. 2 of the 3 gurus who reviewed it give it their stamp of approval, for a Guru Score of 78%.

What is DRMTLGY Needleless Peptide Serum's Guru Score?

DRMTLGY Needleless Peptide Serum holds a Guru Score of 78%. That is our read on how warmly the experts talk about it, based on the verdicts of 3 expert reviewers we have collected.