A peptide serum formulated with a bio-engineered growth factor complex designed to support skin firmness, texture, and overall quality without human-derived growth factors.
Full ingredients
Guru Score
77%
Yay
10 experts · Strong agreement
!
10Gurus
7Yay
2Mixed
1Nay
What they liked
Lightweight texture, absorbs without heaviness
Pump packaging, no product waste
Non-irritating and fragrance-free
What they flagged
Not hydrating enough for some people
Overperforms during sales promotions
What the gurus are saying
The serum's peptide and growth factor blend earns broad praise for stimulating collagen and elastin production, which gurus say can speed up skin cell turnover and improve texture. Most reviewers call it lightweight and hydrating with a pleasant feel, and dermatologists note it's a strong choice for those already familiar with retinoids and entry-level peptides who want to try a more advanced option at a fraction of the price of competitors. One reviewer found it insufficiently hydrating and didn't see results, though most suggest it works best paired with a moisturizer.
Synthesized from 10 expert reviews · most recent take August 2026
"Another one of my absolute favorites in this mid price point category is the DRMTLGY Needleless Growth Factor Serum. That needleless serum went viral around two years ago and everyone was singing its praises, genuinely an amazing peptide serum. They created an advanced version with growth factors added in, and if you look at the price point of their standard needleless serum versus the needleless with growth factors, there's very little price differential, so you're getting a whole lot more without actually paying much more. [...] That for me is why I tried it and I fell in love. Again, bio-engineered growth factors in this one, meaning you're really going to get a quick win when it comes to the results you see, and I think you're going to get some of the best results of any growth factor serum on the market. I love the technology that they use, the price point is phenomenal, and if you like your serums in a pump as opposed to a dropper, this is a quick win that you will absolutely love the packaging of. Just a nice all round product that [...] shows you can absolutely do quality growth factors without having to have a sky high price point."
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"Another one of my absolute favorites in this mid price point category is the DRMTLGY Needleless Growth Factor Serum. That needleless serum went viral around two years ago and everyone was singing its praises, genuinely an amazing peptide serum. They created an advanced version with growth factors added in, and if you look at the price point of their standard needleless serum versus the needleless with growth factors, there's very little price differential, so you're getting a whole lot more without actually paying much more. [...] That for me is why I tried it and I fell in love. Again, bio-engineered growth factors in this one, meaning you're really going to get a quick win when it comes to the results you see, and I think you're going to get some of the best results of any growth factor serum on the market. I love the technology that they use, the price point is phenomenal, and if you like your serums in a pump as opposed to a dropper, this is a quick win that you will absolutely love the packaging of. Just a nice all round product that [...] shows you can absolutely do quality growth factors without having to have a sky high price point."
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"This is like the new generation of their now viral and famous needleless serum, the original. This one has growth factors in and these again are lab engineered growth factors and they pack a punch. This is a phenomenal product that actually comes in at $67. That's around $60. This is one of the most affordable of those bio-engineer options and it's amazing. It's got five different forms of growth factor. So, it covers every base. They've done a lot of research into this product, put it through its testing, and the results really, I think, speak for themselves. People have been raving about this online. So, I bought it, I tried it, and I've been really, really impressed. I think this is the most affordable of the bioengineered growth factors. Works super quick. It doesn't need to break the bank and it's a really nice plumping and hydrating serum alongside packing that anti-aging punch with the growth factors. This is a relative newcomer to the skincare space, but I would recommend it to everybody that is looking for an advanced next level growth factors option without necessarily having to pay too high a price for it."
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"This isn't actually my favorite of the growth factor serums out there. It is a good product, it's a really good product, but there are a couple of growth factor serums I personally just prefer over this, it comes down to personal preference. When it was 50% off I bought a couple because it's really good, and at that price point who can argue. But I think the sales are slightly inflated because it had such a good saving attached to it, and I don't think it would have made this list were it not for that sale. However, if you love this serum, keep on using it because it's a really good formula. There's just one that I prefer a little bit more."
"This one is a bio-engineered, [...] vegan, biotech powered growth factor serum that's designed to support firmness, texture, and overall skin quality without using any human derived growth factors. It's also clinically proven to outperform the leading human growth factor serum that retails for $295. By far, this is the cheapest option on the list. The key ingredients here are the five times biogrowth factor complex, this versa chirata extract and the palmatyl trapeptide. I am currently using this one and I like it a lot."
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"This one is a bio-engineered, [...] vegan, biotech powered growth factor serum that's designed to support firmness, texture, and overall skin quality without using any human derived growth factors. It's also clinically proven to outperform the leading human growth factor serum that retails for $295. By far, this is the cheapest option on the list. The key ingredients here are the five times biogrowth factor complex, this versa chirata extract and the palmatyl trapeptide. I am currently using this one and I like it a lot."
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"My other recommendation from dermatology, and I'm using this currently, I'm wearing it right now, is their DRMTLGY Needleless Growth Factor Serum. I've used it morning, evening, and honestly, it works great morning and evening. I used it last night and this morning. I put it in the morning on top of my vitamin C. It's vegan. It's biotech powered growth factor serum designed to support firmness, texture, and overall skin quality without using any human derived growth factors. Some people are really particular on that, so this is completely vegan. It also has a really cool study where it's clinically proven to outperform the leading human growth factor serum. The key ingredients here are the 5x biogrowth factor complex, the swaia chiata extract, and the pelatil tripeptide."
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"This dermatology serum is relatively new to me. I really like the way it feels. I love it goes how it goes on. I have used it sometimes just in the evenings. I have also used it a couple times a day."
"This is the dermatology Needleless Growth Factor Serum. It's a really nice serum from dermatology and it has multiple different peptides that act as growth factors in the skin. And that is able to stimulate your skin cells, fibroblast growth factor, platelet derived growth factors that can stimulate your collagen and elastin to build. It can speed up your skin cell turnover. [...] If you're looking for growth factors, which I think are a little bit more advanced, meaning you've already mastered your retinoids and you've already mastered some of the more entry-level peptides like metatricxel or copper peptides and you haven't seen great results with them, I think growth factors are really the next step. I think the one from dermatology is a great option for somebody who is looking to introduce because it's not so expensive like the one from Allies of Skin."
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"This is the dermatology Needleless Growth Factor Serum. It's a really nice serum from dermatology and it has multiple different peptides that act as growth factors in the skin. And that is able to stimulate your skin cells, fibroblast growth factor, platelet derived growth factors that can stimulate your collagen and elastin to build. It can speed up your skin cell turnover. [...] If you're looking for growth factors, which I think are a little bit more advanced, meaning you've already mastered your retinoids and you've already mastered some of the more entry-level peptides like metatricxel or copper peptides and you haven't seen great results with them, I think growth factors are really the next step. I think the one from dermatology is a great option for somebody who is looking to introduce because it's not so expensive like the one from Allies of Skin."
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"The Dermatology Needleless Growth Factor Serum also has additional benefits. I love that, been using that a long time on and off. It's outstanding."
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"Look for peptides, something like the DRMTLGY Needleless Growth Factor Serum that has a combination of different peptides, can be phenomenal."
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"This serum is actually a really nice serum to just apply to the skin, and it would definitely replace your hydration serum. It also has other well-known peptides in it, that combination that forms Matrixyl, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. [...] It also has multiple types of ceramides. So overall it's just a really nice serum, but it has these really proven types of peptides. There's a pretty insane clinical study on this product to prove that it's effective, especially at this price point, which makes me a lot more confident in it. [...] They replicated something we see in the pharmaceutical space a lot: they took the leader in the space, [...] probably considered the best growth factor serum out there, the one with the most evidence, a $295 growth serum, and compared theirs head to head against it. [...] It was put in front of an institutional review board that made sure the study was well thought out and ethical, and it was a 12 week study with 20 individuals. By all the clinical endpoints, not only was this product non-inferior [...] to the expensive leader in the space, it actually outperformed it. That's notable for two reasons. One, [...] you don't necessarily have to pay an exorbitant amount of money for something that works. Two, it's a nice comparison because the DRMTLGY product is vegan, it does not use human-based growth factors, and it was compared to a human-based growth factor product. So it shows that while they are different in structure and shape, they hold up."
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"Look for peptides, something like the DRMTLGY Needleless Growth Factor Serum that has a combination of different peptides, can be phenomenal."
"This contains hyaluronic acid, ceramides, and niacinamide, but this also takes it a couple of steps further. This contains a couple of peptides and it also has a copper peptide in it. This is more spendy than most of the other things, at about $70. This is a really lightweight serum. I really love how it feels going on the skin, I love the finish on it, and it's just a great serum that is packed with really great anti-aging ingredients."
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"The last product of DRMTLGY that I really, really love is their needleless serum. This is a great serum that is so packed with so many great ingredients. This contains niacinamide, hyaluronic acid, a copper peptide material, it contains ceramides. It's normally $69 for an ounce, it's now $48.30 with your 30% off, and it also comes in a 2 ounce size."
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"Another product I talked about in my skincare video was the DRMTLGY Needleless Growth Factor Serum. This is a really great multitasking serum that I usually use in the summer when it's hot and humid and I don't feel like putting on a lot of heavy layers of moisturizer, and this has everything that is usually in two or three of my moisturizers all combined into one bottle, which is awesome. So it's got ceramides, it's got niacinamide, it's got a couple of peptides in it. This also contains a copper peptide, and a lot of people had written in and said you can't use copper peptides with vitamin C because I do put this on in my morning routine near my vitamin C. I don't think there's any problem with it, I don't think they're going to interact in a way that is problematic. I actually did a whole video on if you could use copper peptides with your vitamin C serum and I did a lot of research into it, and I don't think the conditions exist on our face for there to be a hugely bad reaction. This is not the kind of copper peptide that would interact with your vitamin C anyway, because this is not the blue kind of copper peptide, that's really the only one you need to worry about. This one is perfectly clear, as you can see, so no worries with this and your vitamin C serum."
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"This is the one copper peptide that I have ever used. It's not blue, it's a clear serum. Even though DRMTLGY says that their Needleless Serum can be used with anything, anywhere in your skincare routine, if you look at their product FAQs there's one about vitamin C and the Needleless Serum, and they say the one vitamin C serum that should be used at a separate time than the Needleless Serum is ascorbic acid, which is found in their Vitamin C E and F. So they don't recommend using it with ascorbic acid. I used it, it didn't seem to interact with anything in my skincare routine. I think I kept pushing it around, I used it sometimes in the morning, sometimes in the evening."
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"The needle is serum is more of a serum texture and it has all the same ingredients as the CeraVe it has ceramides and niacinamide and you know hyaluronic acid and glycerin and all that good stuff it also contains a copper peptide."
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"This is an ingredient-packed serum that I've been using in the morning in place of my CeraVe PM lotion. It's a really lightweight, watery serum, so it's not even like putting on a moisturizer, but it has moisturizing properties because it has hyaluronic acid and glycerin. It also contains niacinamide and ceramides, which are the same ingredients in the CeraVe lotion, so it makes a good substitute. It also contains a number of peptides so you could use this at night too. It's kind of like a combination of my CeraVe PM lotion and my Olay Night Recovery cream all packed into one little serum. I've looked into the research on vitamin C reacting with copper, and the kind of copper used in this is copper peptide, which is stabilized and bound together as an amino acid, so I don't think you need to worry about it. I've really been enjoying using this and I do use it in the morning."
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"I picked this up a couple of months ago and I just started using it because it just started getting warmer here but my gosh do I love this serum. This is a beautiful serum and the ingredients are so great. This is like a little powerhouse of a serum. It's super clear, it's a super lightweight liquid. It rubs in so beautifully, it doesn't leave any heaviness or any tack on the skin. It's got ceramides, it's got niacinamide, glycerin, it's got three different peptides in it, and it's got hyaluronic acid and it's all packed in this one nice little bottle."
"That is one product that just doesn't work for me. [...] I personally just didn't see that much of a difference in my skin when I used it. And also, it just wasn't quite hydrating enough for me."
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"That is one product that just doesn't work for me. [...] I personally just didn't see that much of a difference in my skin when I used it. And also, it just wasn't quite hydrating enough for me."
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"It's in the DRMTLGY Needleless Growth Factor Serum."
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"I've tried the Needleless Growth Factor Serum and I just didn't find the wild factor that so many of you love. [...] It has niacinamide, it has copper peptides, it has ceramides, and it has hyaluronic acid. For a one-and-one serum, for many of you this could be the answer, but I have very very dry skin and this isn't quite hydrating enough. I also treat different skincare concerns in my treatment step in the morning than just hydration. This is a slightly firming and hydrating type serum, but I need something geared toward anti-pigmentation, soothing, and anti-redness. If you have normal to oily skin type and you are just looking for a bit of hydration, this could be the perfect serum for you, but for me personally I need something a little bit more hydrating."
"This is from DRMTLGY, this is their Needleless Growth Factor Serum. I've been into growth factors and I'm always curious to know if something's worth telling you about. I don't have an opinion about this, so I'm not telling you to go out and buy it just yet, but I did start using it. It was sent to me in PR and so far the thing I can tell you the most is that it feels nice. [...] I got an instant glow, that in itself is a nice benefit."
"It has this anti-redness property, plus it's good for skin yellowing. So if you tolerate it, it's really quite a good ingredient. [...] If you were gifted it or you bought the DRMTLGY one, I'd say thumbs up, use it. It's good if you tolerate it. I had no problem with it."
"Their needleless serum, needleless serum, not needless serum, is also great and full of peptides. [...] It's worth looking at."
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"Their needleless serum, needleless serum, not needless serum, is also great and full of peptides. [...] It's worth looking at."
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"So in here we got ceramides, peptides, panthenol, vitamin E."
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"This one's really nice, it's just a water-based serum. It's got P extract which is really good for your skin, it's got the matrixyl 3000 peptide anti-aging duo, it's got ceramides, it's also got panthenol. So this one's really nice, it's a really nice water-based serum you can pretty much easily fit it into most routines without any issue. Some really nice anti-aging ingredients in there."
"I do think this is a good peptide serum. I like that it's nonirritating and fragrance free, it has some ceramides and panthenol in it, and it's got a nice lightweight texture, I think everybody will like this one. I received it in PR, but in all truth I don't think I'll buy it again because I like the Ordinary's multi-peptide serum just a little more, and if the Ordinary is working well for you, why change things."
"I also really like the Dermatology Needle-less Growth Factor Serum."
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"I find this serum to be a little bit thicker and it's also very hydrating on the skin. There's peptides in here, but this one has five bioengineered growth factors. So similar idea, it's still going to repair the skin, hydrate, stimulate collagen, and firm, but it just has different ingredients in it. And if you love dermatology, I would definitely recommend this product here. This is way better than the original needleless serum in my opinion because I love the growth factors in here. And this really does firm the skin and I find this gives a glow to the skin as well. And I do have a 20% off discount code with dermatology also. So if I'm not using the Allies of Skin, sometimes I will switch it up and use this one instead. And sometimes I will use this in my morning routine as well, as this can also be used twice a day."
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"This is another one that you can use every day twice a day. There's a lot of other great ingredients in here to nourish, to hydrate. It does plump up the skin and it's also very hydrating. [...] This is way better in my opinion than the original needleless serum. This has a milkiness to it, whereas the original needleless serum is more like water, but the original one does not have growth factors in it. So if you love growth factors and peptides, this formulation really is worth looking into. But this on its own is 10 out of 10. If you didn't want to pair this up with anything, then just pair this up with a moisturizer and a sunscreen if it's in your morning routine and away you go."
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"This is really nice and it's also very lightweight on the skin. There's no fragrance. Great for all skin types and this is 10 out of 10."
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"I do like to use this in the morning sometimes and sometimes I do like to use it at night time paired up with tronor or with a retinol. I do like to use this with other things of course you don't have to, you can just use this on its own paired up with a moisturizer, but it really is a lovely anti-aging serum for every day. I'm going to give this a 9 out of 10."
"This has to be Dermatologist's best seller. You see this everywhere. There are so many success stories with this, and this is a serum that I've been using for several years. I just always need to have it in my collection because I feel like it has a wonderful formula that actually performs. You can use this long term, and use this at least once a day, and this really does help to firm the skin and soften fine lines and wrinkles. You can use this twice a day if you want to. This is one that you can use with tretinoin and retinol if you really wanted to in your nighttime routine, and this is great just on its own in your morning routine. The great thing with these everything serums is that you might actually be using a separate serum right now that this contains, that you can eliminate once you're finished. So if you're using a separate niacinamide serum, once you're finished with that and you plan on using this, you can just eliminate that now and start incorporating this, because this has that niacinamide in it. There's really no need to use a separate niacinamide with this if you don't want to. This also contains hyaluronic acid, so you don't necessarily have to use a separate hyaluronic acid serum. There's just so many great ingredients all in one that you don't have to use all of these separate ingredients and products anymore. It just keeps everything so simple."
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"I am very impressed with this formulation. [...] This contains five bioengineered growth factors. Growth factors help to stimulate collagen and it helps with fine lines and wrinkles. It firms the skin, but it also has the ability to heal your skin. So if you have sensitive skin, you have a compromised skin barrier, then this can be a great product to use to keep your skin healthy and repaired. But it's also very hydrating and I find this serum to be quite plumping as well. This really is so good."
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"The DRMTLGY Needleless Growth Factor Serum is probably one of Dermatology's most popular products. It's a great anti-aging serum to soften fine lines and wrinkles, to help firm the skin, to give fullness, and it's an amazing hydrating serum as well. This serum contains several types of ceramides which can help to repair and strengthen your skin barrier, there are peptides in here, there's niacinamide, hyaluronic acid, provitamin B5, and there is a copper ingredient in here as well. I've always seen great results with this. You can bring this down your neck and your chest as well. You can use this every day, twice a day if you wish to, and this is also a great serum to pair up with retinol or tretinoin."
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"This is the DRMTLGY Needleless Growth Factor Serum. I haven't been using this for too long because this is a new launch, but I have been using it every day, twice a day, since I received it. [...] I am so impressed with this formulation. I had a feeling I was going to like it because I love the original needleless serum, but this is a little different, more advanced. The texture is very milky and has a thickness to it, way more hydrating and plumping than the original needleless serum. It truly gives the most incredible healthy glow to your skin, but without your skin looking greasy and shiny. It's also very lightweight, it sits great underneath other skin care products, including makeup and sunscreen. No peeling whatsoever, no irritation, no breakouts. I am very acne prone [...] and I have combination skin, and this has been exceptional. I think this is going to be a really nice one for the colder months because of how hydrating and plumping it is. Your skin feels and looks incredible, it just looks so healthy and rejuvenated after one use. So with consistency, with long-term use, I can see this being gamechanging for a lot of people. You don't have to have accelerated signs of aging to use this, you can use it as a preventative, you can use it just for hydration and skin repair. But if you are looking to improve elasticity and firmness, helping..."
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"Although I really love this, I'm going to pass for right now because I like the results that I see from a traditional copper peptide serum. But I would consider using this again. It really is a lovely serum, super hydrating, it's great to tackle signs of aging and of course to firm the skin as well."
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"This is a new product that just recently launched from DRMTLGY, the Needleless Growth Factor Serum. It's very similar to their Needleless Serum, their number one seller, but they've added growth factors in here, I believe five bioengineered growth factors. This is very hydrating, it just feels incredible on the skin, and it gives this youthful plump to the skin. I haven't been using this for too long, but I've been using it every day, twice a day, since I received it, and I am really impressed with the texture, the formulation, how it layers with my other skincare products. It also sits great underneath makeup. [...] I was using this all summer long, both morning and evening, and I can't say anything negative about it. This is absolutely, hands down, one of the nicest growth factor peptide serums I've ever used."
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"If you love your peptide serums and you want that [niacinamide] in there, those ceramides, then this would be a great serum to look into. I do have a backup in my linen closet. I actually have the large size, I believe it's 60 mils. This is a 30 mil size, so depending on what size you want to go with, you've got two options here, but if you're someone that is going to use it a lot, I would say go with the larger size because it's just going to last a lot longer, especially if you're using this twice a day."
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"This really is a lovely serum for signs of aging to firm the skin and also to hydrate the skin. This is a product that you can use every day twice a day and this is basically your peptide serum. It has a few different peptides but there's also a copper peptide complex in here which is another reason why I love this one so much because I am the biggest fan of copper peptides. I truly believe that this ingredient is really effective it does help to stimulate new collagen just like peptides do but with copper peptides I just feel like I see a bigger difference with my skin in terms of how it looks more firm. [...] Besides the peptides here there is niacinamide and I am one of the biggest fans of this ingredient as it really does help to even out your skin tone and it's a great antioxidant that really helps to prevent transepidermal water loss so it does help to hydrate the skin. It's great for acne prone skin and for those that have oily skin but even if you have dry skin niacinamide can be wonderful to incorporate as it really does help to hydrate and prevent water loss."
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"This is the new Needleless Growth Factor Serum, and I love this so much. It's a little similar to the original needleless serum, but this one has growth factors. I also really like the texture of this. It's more of a thicker, milky, creamy type of texture over the original needleless that's more thin and watery. This one gives more hydration to the skin. It gives a little plump to the skin as well. Growth factors are great to have in skin care because it can help with anti-aging, stimulates collagen. It can help to soften, prevent fine lines and wrinkles. It can help to heal your skin. So if you have sensitive skin, a compromised skin barrier, growth factors can really help to repair that skin barrier. Peptides help to stimulate collagen as well and it also helps to firm the skin. So having those two in this product is truly gamechanging, and I love peptides and growth factors together. This new one from DRMTLGY is really nice, and to be honest with you, this is way better than the original needleless serum in my opinion. Of course we all have different preferences, but I really like this a lot. This is actually the second bottle that I am working on, and I can't get enough. This actually sold out at the beginning of the sale. It is back in stock."
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"I actually like to alternate between this and the Allies of Skin serum, they're both fabulous and very similar. This one has five bio-engineered growth factors whereas the other has three, and this one has a thicker consistency, while the Allies of Skin is more thin and watery. It just depends on what you like in terms of thickness and whether you want more growth factors. [...] They both perform very similarly and will both firm the skin, though the texture and ingredients differ slightly. [...] This one is a little more moisturizing in my opinion, so if you're on the drier side or have tight skin, you might like this one more. [...] It doesn't interfere with skincare, I've never experienced peeling with it, and I pair it with retinol and copper peptides too. This is just as effective as Allies of Skin. I [...] have a 20% off discount code, and I have a backup so I don't need to purchase one right now."
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"If I'm not using the Allies of Skin one, then I really like the dermatology one, the Needleless Growth Factor Serum. This one contains five growth factors. The texture of this is a little bit thicker, it's still milky like the Allies of Skin one but a little bit on the thicker side. So if you are somebody that likes that heavier serum, something that's a little bit more moisturizing on the skin, then you might like this one a little bit more. This one also has other ingredients that the other doesn't. At the end of the day they are very similar and I really like to alternate between the two."
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"I also really like the Dermatology Needle-less Growth Factor Serum."
What the evidence says.
Independent of what the gurus think, this is what
the published research supports about the main active ingredients here.
Frequently asked.
What is DRMTLGY Needleless Growth Factor Serum?
A peptide serum formulated with a bio-engineered growth factor complex designed to support skin firmness, texture, and overall quality without human-derived growth factors.
Is DRMTLGY Needleless Growth Factor Serum worth it?
Mostly yes. 7 of the 10 gurus who reviewed it give it their stamp of approval, for a Guru Score of 77%.
What is DRMTLGY Needleless Growth Factor Serum's Guru Score?
DRMTLGY Needleless Growth Factor Serum holds a Guru Score of 77%. That is our read on how warmly the experts talk about it, based on the verdicts of 10 expert reviewers we have collected. At least one expert has named it a Top Pick in its category.
Who is DRMTLGY Needleless Growth Factor Serum best for?
DRMTLGY Needleless Growth Factor Serum is generally suited to mature skin.
Cheaper alternatives the gurus rate.
Lower-priced serums the gurus still rate highly, versus this mid-range pick.