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Dr. Idriss

Depuffer.

Dr. Idriss Depuffer
Serums

About this product

A topical arnica and centella serum from Dr. Idriss formulated to reduce the look of puffiness, swelling, redness, and inflammation in the skin.

Best for

Sensitive skin
Serums

The Guru Index verdict

94%

Approved

Approved · 94%
2Reviewers
2Approved
0Mixed
0Skip

What the gurus are saying

Gurus consistently praise this serum for rapidly calming redness and reducing puffiness, especially for flushing and morning eye puffiness. The roller ball and cooling effect (enhanced by refrigeration) are noted perks. The formula's concentration of arnica combined with centella asiatica and azelaic acid is highlighted as effective for rosacea and sensitive skin, with results visible within minutes. It's positioned as both a daily soother and quick fix for inflammation.
Synthesized from 2 expert reviews

Key actives & flags

NiacinamideSqualaneFragrance-freeAlcohol-free

Full ingredients

Water/​Aqua/​Eau, Niacinamide, Glycerin, Dimethicone, Pentylene Glycol, Butylene Glycol, Propanediol, Hydroxyethyl Acrylate/​Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Arnica Montana Flower Extract, Centella Asiatica Leaf Extract, Fraxinus Excelsior Bark Extract, Agastache Mexicana Flower/​Leaf/​Stem Extract, Avena Sativa (Oat) Kernel Extract, Camellia Sativa Leaf Extract, Hydroxyphenyl Propamidobenzoic Acid, Maltodextrin, Dimethicone Crosspolymer, Silanetriol, Sorbitan Isostearate, Polysorbate 60, Caprylyl Glycol, Hexylene Glycol, Ethylhexylglycerin, Phenoxyethanol

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored
Approved
"The depuffer by Dr. Idriss is my top pick. It has a roller. You can keep it in the fridge for a cooling effect, but if you have redness, hot flashes, this is amazing for reducing redness quickly. It usually takes my skin about 5 minutes to kind of calm down."
Top Pick: depuffer serum
All 2 takes from Beyond50Skin
BEST of 2025 Skincare & Makeup for Mature Skin (50+ Beauty Picks)
"The depuffer by Dr. Idriss is my top pick. It has a roller. You can keep it in the fridge for a cooling effect, but if you have redness, hot flashes, this is amazing for reducing redness quickly. It usually takes my skin about 5 minutes to kind of calm down."
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"The deeppuffer is great for redness, those flushes of redness you might get or if your eyes are kind of puffy in the morning when you wake up. It has this really cool roller. Super calming and soothing ingredients. You can kind of get some lymphatic drainage. Some people keep this in the refrigerator for that kind of cool sensation. I use it usually on my cheeks in the evening if I'm having kind of a hot flash, red flush and it takes down the heat in my skin really quickly."
Approved
"The Dr. Idriss Depuffer, which helps with holiday puffiness or one too many martinis. It's a hangover cure in a bottle."
Top Pick: best of beauty serumFounder Conflict
All 3 takes from Dr. Shereene Idriss
Slow Aging? Skin Longevity Tips for 20s, 30s, 40s & 50s+ from a Dermatologist!
"The Dr. Idriss Depuffer, which helps with holiday puffiness or one too many martinis. It's a hangover cure in a bottle."
Discoloration 101: Tips, Tricks, & Best Ingredients for Your Skin Type! | Dr. Shereene Idriss
"The Dr. Idriss Depuffer, this one won all Best of Beauty. It is an arnica serum with Centella Asiatica. So it's going to reduce the look of swelling and inflammation while helping to reduce the look of redness. And it comes with a roller ball, so you can help get a lymphatic drainage as you apply the serum."
Top 8 Ingredients to Treat Redness & Rosacea from a Dermatologist! | Dr. Shereene Idriss
"It has centella asiatica, arnica, and azelaic acid in it which all have anti-inflammatory effects and it reduces the look of inflammation. It has been shown to promote collagen production and it also has certain antioxidants that can protect the skin from damage caused by free radicals. I love this product if you have rosacea because it is loaded in centella asiatica but it also has arnica, and arnica is not one that is traditionally thought of for rosacea but it works like a charm because it helps reduce the redness and calms the inflammation in a synergistic way so your skin looks less flushed within a couple of minutes when done correctly. Arnica is tricky though because when you look for arnica products more often than not they're diluted in a homeopathic fashion. This one is purely arnica because it is pure arnica. The golden hue you see here is due to the high concentration of arnica in this formulation."
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