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Dermatology

Peptide Night Cream.

Dermatology Peptide Night Cream
Serums

About this product

A fragrance-free night cream enriched with peptides, ceramides, and moisturizing ingredients like shea butter and vitamin E, designed to support skin barrier repair and anti-aging.

Best for

Dry skinSensitive skinMature skin
Serums

The Guru Index verdict

81%

Approved

Approved · 81%
3Reviewers
3Approved
0Mixed
0Skip

What the gurus are saying

Gurus consistently praise this cream for its strong peptide complex, ceramide content, and nourishing formula at an accessible price point. A recurring theme is that despite being marketed as a night cream, it works well for daytime use too, though some find it slightly heavy for summer or with certain makeup and sunscreen combinations. The only noted concern is packaging durability, with one reviewer mentioning the label smears easily.
Synthesized from 3 expert reviews
Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

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Approved
"The dermatology peptide night cream has main components of glycerin and shea butter. It's also got ceramides, the Matrixyl 3000 peptide duo, and the SynKen peptide which can help skin produce sodium hyaluronate according to research, and then squalane. It's fragrance-free, alcohol-free, cruelty-free, and vegan."
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"Dermatology peptide night cream very nice product love it. I already have a backup above this one as well."
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"The Dermatology Peptide Night Cream is really full of good ingredients. We've got shea butter, we've got peptides, we've got ceramides, we've got vitamin E, we've got alantin, we've got cholesterol. It's really nice. It's a pretty thick product and wonderful."
Which Peptides Do You Need in Your Skincare for Anti-Aging? Top Peptides for Wrinkles
"The Dermatology Peptide Night Cream is about 46 bucks. It's a peptide-enriched cream. It's fragrance-free, great for sensitive skin. It's great for barrier repair as well. It's really nice."
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"The Dermatology Peptide Night Cream is 34 bucks. This one also contains ceramides, shea butter, vitamin E and A, and lanolin. It's got a nice variety of peptides, so if you're looking for one that's got them all, this is going to be one of my favorites and easy to fit in your routine."
My Favorite Peptides - Peptides You Want in Your Skincare Routine & Product Favorites
"The Dermatology Peptide Night Cream, which is 34 bucks, contains glycine, shea butter, vitamin E and A, and lanolin. It's one of the products with good peptides and a nice variety of peptides, so if you're looking for one that's got them all, it's going to be one of my favorites and easy to fit in your routine."
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"The dermatology peptide night cream has main components of glycerin and shea butter. It's also got ceramides, the Matrixyl 3000 peptide duo, and the SynKen peptide which can help skin produce sodium hyaluronate according to research, and then squalane. It's fragrance-free, alcohol-free, cruelty-free, and vegan."
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"The Dermatology Peptide Night Cream is 2 oz for 32 bucks and it contains the M trixel 3000 peptide, contains the sinol peptide, and then it contains the syntax peptide. It also contains shea butter, ceramides, and vitamin E. It's really nice and you don't have to just use it during your evening routine, you can use it morning or whenever."
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"The Dermatology Peptide Night Cream is really nice, nice moisturizing cream, not terribly expensive. It's got the good peptides in there."
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"This one is 2.1 ounces, forty-four dollars. It contains five peptides and it also contains several ceramides which make it really nice for skin. It's fragrance free, cruelty free, and vegan. I don't know why they named it a night cream because it really works well daytime or evening."
Best Thick Moisturizers for Dry Skin & Winter Weather - My Favorite Ultra Hydrating Face Creams!
"The Dermatology Peptide Night Cream is really nice. It's got peptides in it, some silicones, ceramid, urea, allantoin, and vitamin E. It's thicker than some others. It's great for anti-aging. They do say it's a night cream, but honestly I use this one in my daytime if I'm not using a salicylic acid serum. I will use this under or over my topical serum or something like that. But if I'm using salicylic acid, then I don't like the peptides mixing around with the salicylic acid because I feel like salicylic acid can break it down, so I don't go crazy with it. But if I'm using something else, it's great with that."
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"The Dermatology Peptide Night Cream is 46 bucks. In here we've got shea butter, we've got several different ceramides, we've got five different peptides and we've got vitamin E. I geek out on peptides because I think they're amazing and what the peptides can do is amazing."
Approved
"This is one of my favorites for fall and even transitioning into the winter months. I don't necessarily use this during the summer because I just feel like it's a little bit too much for my combination skin. It is very moisturizing but at the same time it's very lightweight and it doesn't feel heavy on the skin and it has that nice spreadability. It's not super thick, which is why I feel like this is a great cream to transition from summer to fall. You can use this in the morning even though this is marketed as a night cream, it just depends if this is going to work well with the types of makeup and sunscreen that you are pairing with it. I have used this a handful of times in my morning routine and it's nice, it does give a glow to your skin. I mainly keep this for my nighttime routine paired with trojan copper peptides and chemical exfoliants. It just has that nice richness without feeling heavy."
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All 2 takes from Sincerely Miss Ash
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"This is one of my favorites for fall and even transitioning into the winter months. I don't necessarily use this during the summer because I just feel like it's a little bit too much for my combination skin. It is very moisturizing but at the same time it's very lightweight and it doesn't feel heavy on the skin and it has that nice spreadability. It's not super thick, which is why I feel like this is a great cream to transition from summer to fall. You can use this in the morning even though this is marketed as a night cream, it just depends if this is going to work well with the types of makeup and sunscreen that you are pairing with it. I have used this a handful of times in my morning routine and it's nice, it does give a glow to your skin. I mainly keep this for my nighttime routine paired with trojan copper peptides and chemical exfoliants. It just has that nice richness without feeling heavy."
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"If you wish to use a cream based product that contains peptides then I really love the Dermatology Peptide Night Cream. I really like this one specifically for the fall winter months because it's very rich and very moisturizing but you're also getting the benefits of those peptide ingredients. I feel like if I pair this up with let's say the Polish Choice peptide serum or some other type of peptide serum I just feel like the two work really well together. Of course it's not necessary to use a peptide serum with a peptide cream one or the other is sufficient enough. This is a night cream this is thicker and richer so you could use this in your morning routine you may or may not feel like this is suited based on the types of sunscreens you use or the makeup it is a little bit heavier for day time but now that we're coming into fall this actually might be a great option for you. I like to keep this strictly for my nighttime routine."
Approved
"My Holy Grail peptide night cream now comes in a huge tub and I certainly hope they do something with the lettering because mine always smears off. You guys asked and apparently they decided to deliver on a jumbo tub of the peptide night cream so it will save you a little bit and you won't have to keep repurchasing and wasting plastic, so I think that is an awesome move on their part."
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All 4 takes from Beyond50Skin
Should You Change Your FALL & WINTER ANTI-AGING SKINCARE ROUTINE?
"My budget pick for moisturizer is the Dermatology Peptide Night Cream. Great budget pick, gets the job done, super nourishing. You can use it as a day moisturizer or a night moisturizer."
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"My Holy Grail peptide night cream now comes in a huge tub and I certainly hope they do something with the lettering because mine always smears off. You guys asked and apparently they decided to deliver on a jumbo tub of the peptide night cream so it will save you a little bit and you won't have to keep repurchasing and wasting plastic, so I think that is an awesome move on their part."
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"I like it just as well as I like the peptide night cream from Dermatology."
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"The Dermatology peptide night cream is a midweight moisturizer that can be used for morning and night. Honestly, I wouldn't skip the moisturizer if you are looking for an anti-aging skin care routine. Just plumping the skin up with humectants and a little bit of emollients can really make a big difference in the skin."
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