Index / Dermatology / Needleless Growth Factor Serum
Dermatology

Needleless Growth Factor Serum.

Dermatology Needleless Growth Factor Serum
Serums

About this product

A serum formulated with bio-engineered growth factors and peptides designed to support skin hydration, firmness, and collagen production, available in a pump bottle.

Best for

Mature skin
Serums

The Guru Index verdict

75%

Approved

✓Approved · 75%
7Reviewers
6Approved
1Mixed
0Skip

What the gurus are saying

The gurus who reviewed it found this delivers visible results at a fair price point, with several praising its peptide blend and clinical backing that showed it matched or outperformed a much pricier competitor. The texture feels lightweight and hydrating, layers well under makeup, and those with sensitive skin or acne-prone skin reported no irritation. One reviewer noted that while it's a genuinely solid formula, personal preference sometimes tips toward other growth factor serums instead, and it pairs safely with vitamin C except for pure ascorbic acid formulas.
Synthesized from 7 expert reviews

Where to buy

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved only Skip only Mixed only Hide sponsored
Mad About Skin
Mad About Skin
720k subs · 10k devotees
✓Approved
"Another one of my absolute favorites in this midprice point category is the Dermatology Needleless Growth Factor Serum. That needleless serum went viral around two years ago and everyone was singing its praises. Genuinely an amazing peptide serum. They created like an advanced version with growth factors added in. And if you look at the price point of their standard needleless serum versus the needleless with growth factors, very very little price differential. So you're kind of getting a whole lot more without actually paying much more in terms of this product. That for me is why I tried it and I fell in love. Bio-engineered growth factors in this one, meaning you're really going to get a quick win when it comes to the results you see. And I think you're going to get some of the best results of any growth factor serum on the market. I love this. I love the technology that they use. The price point is phenomenal. And if you like your serums in a pump as opposed to a dropper, this is a quick win that you will absolutely love the packaging of. Just a nice all round product that again I think shows you can absolutely do quality growth factors without having to have a sky-high price point."
All 2 takes from Mad About Skin
BEST GROWTH FACTOR SERUMS 2026 (For Every Budget)
"Another one of my absolute favorites in this midprice point category is the Dermatology Needleless Growth Factor Serum. That needleless serum went viral around two years ago and everyone was singing its praises. Genuinely an amazing peptide serum. They created like an advanced version with growth factors added in. And if you look at the price point of their standard needleless serum versus the needleless with growth factors, very very little price differential. So you're kind of getting a whole lot more without actually paying much more in terms of this product. That for me is why I tried it and I fell in love. Bio-engineered growth factors in this one, meaning you're really going to get a quick win when it comes to the results you see. And I think you're going to get some of the best results of any growth factor serum on the market. I love this. I love the technology that they use. The price point is phenomenal. And if you like your serums in a pump as opposed to a dropper, this is a quick win that you will absolutely love the packaging of. Just a nice all round product that again I think shows you can absolutely do quality growth factors without having to have a sky-high price point."
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"It is a good product. It's a really good product, but there are a couple of growth factor serums I personally just prefer over this. It comes down to personal preference. And honestly, when it was 50% off, I bought a couple because it's really good. And at that price point, who can argue? But I think the sales are slightly inflated because it had such a good saving attached to it. However, if you love this serum, keep on using it because it's a really good formula. There's just one that I prefer a little bit more."
Mixed Makeup
Mixed Makeup
1.47M subs · 10k devotees
~Mixed
"This is from Dermatology. This is their Needleless Growth Factor Serum. I've been into growth factors and I'm always curious to know if something's worth telling you about. I don't have an opinion about this, so I'm not telling you to go out and buy it just yet, but I did start using it. It was sent to me in PR and so far the thing I can tell you the most is that it feels nice. I got like an instant glow. That in itself is a nice benefit."
Dr Dray
Dr Dray
2.66M subs · 30k devotees
✓Approved
"If you were gifted or you bought the Dermatology Needleless Growth Factor Serum, I'd say thumbs up. Yeah, use it. It's good if you tolerate it. I really I had no problem with it."
No BS Beauty
No BS Beauty
89k subs · 2k devotees
✓Approved
"Their needleless serum is also great and full of peptides. It's worth looking at."
Doctorly
Doctorly
3.56M subs · 90k devotees
✓Approved
"This serum it's actually a really nice serum to just apply to the skin and it would definitely replace your hydration serum. It also has other peptides that are well-known in it, so that combination that forms matrixyl palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 is also in this. It also has multiple types of ceramides. And overall, it's just a really nice serum with these really proven types of peptides. There's a pretty insane clinical study on this product to prove that it's effective, especially at this price point. They replicated something we see in the pharmaceutical space a lot. They took the leader in the space in terms of what was probably considered the best growth factor serum out there, then they compared theirs head-to-head to it. So it was like a $295 growth serum versus theirs. It was put in front of an institutional review board, and those individuals reviewed it, made sure the study was well thought out and ethical. And then it was a 12-week study with 20 individuals. By all the clinical endpoints, not only was this product non-inferior, it actually outperformed it. It's notable because you don't necessarily have to pay an exorbitant amount of money for something that works. But also, this one is vegan. It does not use human-based growth factors, and it was compared to a human-based growth factor product. It shows that while they are different in structure and shape, the results speak for themselves."
All 3 takes from Doctorly
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"Look for peptides, something like the Dermatology Needleless Growth Factor Serum that has a combination of different peptides can be phenomenal."
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"This serum it's actually a really nice serum to just apply to the skin and it would definitely replace your hydration serum. It also has other peptides that are well-known in it, so that combination that forms matrixyl palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 is also in this. It also has multiple types of ceramides. And overall, it's just a really nice serum with these really proven types of peptides. There's a pretty insane clinical study on this product to prove that it's effective, especially at this price point. They replicated something we see in the pharmaceutical space a lot. They took the leader in the space in terms of what was probably considered the best growth factor serum out there, then they compared theirs head-to-head to it. So it was like a $295 growth serum versus theirs. It was put in front of an institutional review board, and those individuals reviewed it, made sure the study was well thought out and ethical. And then it was a 12-week study with 20 individuals. By all the clinical endpoints, not only was this product non-inferior, it actually outperformed it. It's notable because you don't necessarily have to pay an exorbitant amount of money for something that works. But also, this one is vegan. It does not use human-based growth factors, and it was compared to a human-based growth factor product. It shows that while they are different in structure and shape, the results speak for themselves."
Building a Morning Skincare Routine For Every Skin Conccern!
"Look for peptides, something like the Dermatology Needleless Growth Factor Serum that has a combination of different peptides can be phenomenal."
HotandFlashy
HotandFlashy
1.23M subs · 70k devotees
✓Approved
"This is a great serum that is so packed with so many great ingredients. This contains niacinamide, hyaluronic acid, a copper peptide, ceramides. It's normally $69 for an ounce, it's now $48.30 with your 30% off."
All 4 takes from HotandFlashy
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"This contains a couple of peptides and it also has a copper peptide in it. This is more spendy than most of the other things at about $70. This is a really lightweight serum. I really love how it feels going on the skin. I love the finish on it and it's just a great serum that is just packed with really great anti-aging ingredients."
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"This is a great serum that is so packed with so many great ingredients. This contains niacinamide, hyaluronic acid, a copper peptide, ceramides. It's normally $69 for an ounce, it's now $48.30 with your 30% off."
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"This is a really great multitasking serum that I usually use in the summer when it's hot and humid and I don't feel like putting on a lot of heavy layers of moisturizer, and this has everything that is usually in two or three of my moisturizers all combined into one bottle, which is awesome. It's got ceramides, niacinamide, a couple of peptides in it, and a copper peptide. I do put this on in my morning routine near my vitamin C and I don't think there's any problem with it. This is not the kind of copper peptide that would interact with your vitamin C because this is not the blue kind of copper peptide. This one is perfectly clear, so no worries with this and your vitamin C serum."
What You CAN Use With COPPER PEPTIDES!
"The copper lysinate prolinate is the copper peptide that is used in the Dermatology Needleless Growth Factor Serum. It's a clear serum. Even though Dermatology says that their Needleless Serum can be used with anything anywhere in your skincare routine, if you look at their product frequently asked questions there is one about vitamin C and Needleless Serum and they say that the one vitamin C serum that should be used at a separate time than Needleless Serum is ascorbic acid, which is found in their vitamin C E and F. I used it and it didn't seem to interact with anything in my skincare routine, though I kept pushing it around and used it sometimes in the morning sometimes in the evening."
Sincerely Miss Ash
Sincerely Miss Ash
194k subs · 4k devotees
✓Approved
"I find this serum to be a little bit thicker and it's also very hydrating on the skin. There's peptides in here, but this one has five bioengineered growth factors. It's still going to repair the skin, hydrate, stimulate collagen, and firm, but it just has different ingredients in it. This is way better than the original needleless serum in my opinion because I love the growth factors in here. And this really does firm the skin and I find this gives a glow to the skin as well. This can also be used twice a day."
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All 6 takes from Sincerely Miss Ash
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"I find this serum to be a little bit thicker and it's also very hydrating on the skin. There's peptides in here, but this one has five bioengineered growth factors. It's still going to repair the skin, hydrate, stimulate collagen, and firm, but it just has different ingredients in it. This is way better than the original needleless serum in my opinion because I love the growth factors in here. And this really does firm the skin and I find this gives a glow to the skin as well. This can also be used twice a day."
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"You can use this long term and use this at least once a day, and this really does help to firm the skin and soften fine lines and wrinkles. You can use this twice a day if you want to. Yes, this is one that you can use with tretinoin and retinol if you really wanted to in your nighttime routine. And this is great just on its own in your morning routine. And I love this. This has to be Dermatology's best seller. You see this everywhere. There are so many success stories with this. And this is a serum that I've been using for several years. And I just always need to have it in my collection because I feel like it has a wonderful formula that actually performs. This contains niacinamide, so you don't necessarily have to use a separate niacinamide serum. This also contains hyaluronic acid. So you don't necessarily have to use a separate hyaluronic acid serum. There's just so many great ingredients all in one that you don't have to use all of these separate ingredients and products anymore. It just keeps everything so simple."
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"This is the new Dermatology Needleless Growth Factor Serum. I have been using this everyday twice a day since I received it. I am so impressed with this formulation. I love the original needleless serum, but this is a little different, more advanced. The texture is very milky and it has a thickness to it. Way more hydrating and plumping than the original needleless serum. And this truly gives the most incredible healthy glow to your skin, but without your skin looking greasy and shiny. It's also very lightweight. It sits great underneath other skin care products, including makeup and sunscreen. No peeling whatsoever. No irritation, no breakouts. I am very acne prone and I have combination skin. This has been exceptional, and I think this is going to be a really nice one for the colder months because of how hydrating and plumping it is. Your skin feels and looks incredible. It just looks so healthy and rejuvenated after one use. So with consistency, with long-term use, I can see this being gamechanging for a lot of people. You don't have to have accelerated signs of aging to use this. You can use this as a preventative. You can use this just for hydration and skin repair. But if you are looking to improve elasticity and firmness, helping"
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"This is a new product that just recently launched from Dermatology. This is the Needleless Growth Factor Serum. This is very similar to their Needleless Serum, their number one seller, but they have added growth factors in here. I do believe five bioengineered growth factors. This is very hydrating. Also, it just feels incredible on the skin. It gives this youthful plump to the skin. I haven't been using this for too long, but I have been using this everyday twice a day since I received it and I am really impressed with the texture, the formulation, how it layers with my other skincare products. And it also sits great underneath makeup. This is absolutely wonderful and I was using this all summer long both morning and evening and I can't say anything negative about this. It is absolutely hands down one of the nicest growth factor peptide serums I've ever used."
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"If you love your peptide serums and you want that nice niacinamide in there, those ceramides, then this would be a great serum to look into. I do have a backup in my linen closet. I actually have the large size. I believe it's 60 ml. This is a 30 ml size. So depending on what size you want to go with, you got two options here, but if you're someone that is going to use it a lot, I would say go with the larger size because it's just going to last a lot longer, especially if you're using this twice a day."
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"This is the new Dermatology Needleless Growth Factor Serum, and I love this so much. It's a little similar to the original needleless serum, but this one has growth factors. I also really like the texture of this. It's more of a thicker, milky, creamy type of texture over the original needleless that's more thin and watery. This one gives more hydration to the skin. It gives a little plump to the skin as well. Growth factors are great to have in skin care because it can help with anti-aging, stimulates collagen. It can help to soften, prevent fine lines and wrinkles. It can help to heal your skin. If you have sensitive skin, a compromised skin barrier, growth factors can really help to repair that skin barrier. Peptides help to stimulate collagen as well and it also helps to firm the skin. Having those two in this product is truly gamechanging. This is way better than the original needleless serum in my opinion. This is actually the second bottle that I am working on, and I can't get enough."
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