Index / Biossance / 100% Squalane Oil
Biossance

100% Squalane Oil.

Biossance 100% Squalane Oil
Serums

About this product

A 100% pure squalane oil designed to provide lightweight hydration without clogging pores.

Guru Score

73%

Mixed

7 experts · Strong agreement
7Gurus
6Yay
0Mixed
1Nay

What they liked

  • Lightweight, non-comedogenic texture
  • Safe for sensitive skin and perioral dermatitis
  • Versatile for skin and hair

What they flagged

    Nothing. None of the experts who reviewed it raised a problem.

    What the gurus are saying

    The bioengineered squalane (sourced from sugarcane or corn via biotech yeast) gets praise for being lightweight and penetrating well. Reviewers note it's skin-identical, non-comedogenic (won't clog pores), and non-occlusive (won't trap oil), making it safe even during flares like perioral dermatitis. At $65, gurus call it an affordable, sustainably made moisturizer.
    Synthesized from 7 expert reviews · most recent take July 2026

    What the gurus are saying.

    Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

    All takes Yay takes Nay takes Mixed takes Hide sponsored
    ~Yay
    "Squalane is skin identical, lightweight, non-occlusive, non-comedogenic. It's one of the safest moisturizing options during a perioral dermatitis flare. Biossance makes excellent squalane products at different price points."
    All 2 takes from Dr. Mamina
    2025 Skincare Predictions | Trends to Watch + What’s Worth the Hype
    "Biossance, I've been so fascinated they use sugarcane to make squalane so like they use sugarcane and then they bioengineer yeast to convert the sugar cane into squalane. It's really cool."
    How to Get Rid of Perioral Dermatitis (Everything Your Derm Wants You to Know)
    "Squalane is skin identical, lightweight, non-occlusive, non-comedogenic. It's one of the safest moisturizing options during a perioral dermatitis flare. Biossance makes excellent squalane products at different price points."
    ~Nay
    "Biossance had a 100% squalane face oil, whenever I use that, my skin was not happy the next day. My pores were clogged, all that stuff. So, for some reason, for me, even though I don't have very acne-prone skin, that squalane is very high up for me specifically. But, if I have use a product something like this where it's got a little bit of squalane in it, but not 100% squalane, it's fine."
    ~Yay
    "I also like Biossance Squalane Oil."
    ~Yay
    "If you have really dry skin or live in a dry climate, the Biossance squalane oil feels great on the skin. Squalane is a natural lipid that's incorporated into your moisture barrier."
    All 2 takes from 208SkinDoc
    Morning Shed: Dermatologist Explains Why This Viral TikTok Skincare Trend Could Damage Your Skin
    "If you have really dry skin or live in a dry climate, the Biossance squalane oil feels great on the skin. Squalane is a natural lipid that's incorporated into your moisture barrier."
    Beard Basics — Grooming, Skin Care, and Shaving Secrets
    "As my beard gets a little bit longer I like to use squalane oil. Squalane is something our skin produces as part of the moisture barrier, and it's a similar molecule that's good for our moisture barrier. You can get one hundred percent pure squalane oil, and I love the company Biossance, no affiliation with them, but they get theirs from sugar cane whereas other companies used to get it from sharks. It just takes a couple of drops, I rub it into the beard and comb it out, and that works really well for me. It's kind of my go-to, though it's a little more pricey than jojoba oil."
    ~Yay
    "I use the 100% squalane to shave my legs with, shave under my arms with. I'm happy for the kids to use it. Biossance created hempsqualane, which is a squalane molecule which they derive from corn and then they basically feed the corn to the bacteria, the bacteria produce the squalane and then it's half the size so it goes into the skin more, hydrating, amazing."
    ~Yay
    "I love the jojoba and the squalane, but you know what, if you want to be bougie, Biossance has it in a way that doesn't destroy the planet for literally $65."
    ~Yay
    "If you like skin oils, I love that little golden skin oil thing. Even though I'm not the biggest fan of skin oils, that product is incredible. I think it's the most elegant, unique, beautiful packaging and aesthetics skin oil out there altogether."
    Sponsored
    All 2 takes from Doctorly
    2025 BEST BLACK FRIDAY CYBER MONDAY SKINCARE AND DEVICE DEALS | DOCTORLY DEALS
    "If you like skin oils, I love that little golden skin oil thing. Even though I'm not the biggest fan of skin oils, that product is incredible. I think it's the most elegant, unique, beautiful packaging and aesthetics skin oil out there altogether."
    IS SQUALANE WORTH THE HYPE? | Doctorly Review
    "I do this at night. Sometimes I use my moisturizer and then I follow it with the 100% Squalane Oil. It stays on all night. Not only that, but this is one of those excellent oils for your skin and your hair. You can actually use this in the hair and it would be totally fine. I much prefer using this 100% Squalane Oil in your hair. I think this is a great and well-tolerated oil that I personally use and really like a lot."

    Frequently asked.

    What is Biossance 100% Squalane Oil?

    A 100% pure squalane oil designed to provide lightweight hydration without clogging pores.

    Is Biossance 100% Squalane Oil worth it?

    The gurus mostly approve it, but with enough reservations to keep it in the middle at a Guru Score of 73%.

    What is Biossance 100% Squalane Oil's Guru Score?

    Biossance 100% Squalane Oil holds a Guru Score of 73%. That is our read on how warmly the experts talk about it, based on the verdicts of 7 expert reviewers we have collected.

    Cheaper alternatives the gurus rate.

    Lower-priced serums the gurus still rate highly, versus this mid-range pick.

    See how they stack up →

    Similar products worth a look.

    Other products the same gurus have weighed in on, plus more from this brand and category.

    Compare side by side →

    Share this score

    Add this badge to your blog or website. It links back to this page and updates itself when the experts change their minds. Free, no sign-up.

    Then paste it into your site's HTML or embed block.

    This week's top beauty news, in your inbox.

    A weekly read of the takes worth catching up on: the raves, the splits, the ones the gurus won't shut up about. Free, no spam, unsubscribe whenever.

    Subscribe to the digest