Altreno

Tretinoin Lotion.

Retinoids

About this product

A prescription-strength tretinoin lotion formulated with a hydrating base containing hyaluronic acid and collagen, designed to deliver the anti-aging effects of tretinoin with reduced irritation and dryness.

Best for

Dry skin Sensitive skin Mature skin

Type

RetinoidsLotion

Key actives

Hyaluronic acid

Formula notes

Fragrance-freeNo drying alcohol

Full ingredients

Tretinoin (0.05%), Benzyl Alcohol, Butylated Hydroxytoluene, Carbomer Copolymer Type B (Pemulen Tr-1),Carbomer Homopolymer Type A (Carbopol 981), Glycerin, Methylparaben, Mineral Oil, Octoxynol-9, Purified Water, Sodium Hyaluronate, Soluble Collagen, Trolamine

Guru Score

80%

Approved

5 experts · Moderate agreement

5Gurus

5Approved

0Mixed

0Skip

What the gurus are saying

The hydrating base noticeably cuts down on peeling and irritation compared to standard tretinoin, though some people still find it irritating regardless. Gurus praise how the gel-like texture spreads smoothly across the face, especially when applied over a hydrating toner underneath, and it does require only a pea-size amount to cover the whole face. The main trade-off is cost: it's considerably more expensive than generic tretinoin lotion, so whether the gentler formula is worth the price depends on how your skin tolerates standard versions.

Synthesized from 5 expert reviews · most recent take July 2026

Where to buy

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How it works Independent by design. Every take comes from a creator we have no relationship with. We do not ask anyone to review, and affiliate links never move a score.

Every take, in full

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Approved takes Critical takes Mixed takes Hide sponsored

Mixed Makeup

1.47M subs

✓Approved

"I love Altreno. All my derm friends tell me to do it and then I never get on it because I'm scared. It's a brand name tretinoin, it's a lotion instead of a cream, and it's a 0.05% but it's formulated with collagen, glycerin, hyaluronic acid, some really great ingredients. So it's just a little bit more gentle, elegant."

Dr Dray

2.67M subs

✓Approved

"Altreno lotion, a topical retinoid, is formulated with hyaluronic acid and collagen to be more hydrating, more moisturizing, and it is allegedly a lot less drying and irritating."

All 2 takes from Dr Dray

Tretinoin Causes Death & Is Banned?

"We now have a newer form of tretinoin called Altreno Lotion. It is in a much more moisturizing, hydrating base. It has hyaluronic acid, it has collagen. People seem to do better with that, but I also have had patients say this is very irritating, I don't like it. So I don't know if a lot of that is just the drug companies hyping up the base. Altreno Lotion is also significantly more expensive."

5 Skincare Myths That Are Ruining Your Skin

"Altreno lotion, a topical retinoid, is formulated with hyaluronic acid and collagen to be more hydrating, more moisturizing, and it is allegedly a lot less drying and irritating."

Dr. Aleksandra Brown

131k subs

✓Approved

"Some of the common prescription brands for generic tretinoin are things like Altreno Lotion. This is the 0.05%. It's a little bit newer hydrating formula, really well tolerated. I do have this prescription. I like it. It spreads really nice."

All 3 takes from Dr. Aleksandra Brown

How a Dermatologist Transitions Her Skincare for Spring & Summer | Dr. Aleksandra Brown

"Altreno is a brand name. It lasts a very long time. If you want that gel texture but you don't want to be too irritated with the generic, which is Tretinoin Lotion, it feels like gel. I know it says lotion, but it feels just like gel. It's a very nice option, a very good alternative. I apply this directly on top of my serum at bedtime, and then I do moisturizer on top."

Dermatologist's Winter Skincare Routine: AM & PM Steps for Healthy Skin | Dr. Aleksandra Brown

"I also have the Altreno lotion, which is the brand name of the tretinoin. It does help with some of the irritation, but you can still experience peeling whenever you use your tretinoin regardless of whether you're using like a retinol over the counter or the actual tretinoin. You only want to use like a pea-size amount and cover your entire face. I like having the toner underneath because it really spreads the cream nice. Sometimes the cream is a little bit harder to spread, and having that hydration underneath helps the spread much much easier."

Retinol, Retinal, Tretinoin: What’s the Difference?

No BS Beauty

89k subs

✓Approved

"I love the Altreno Tretinoin Lotion. This is prescription, so I can't link to it below, but I just had my regular doctor write out a prescription for it and had it filled at the pharmacy. Walgreens was really expensive, but Costco is actually ridiculously cheap. If you have dry skin, this is a nice prescription retinoid that doesn't dry your skin out like a lot of them otherwise can. Some of them contain a lot of denatured alcohol, which can really dry your skin out in combination with the retinoids, making it even drier, but this one's really nice at preventing that."

Lab Muffin Beauty Science

858k subs

✓Approved

"There are some fancier versions like Altreno which has that nicer lotion base. It's less irritating."

Common questions

Frequently asked.

What is Altreno Tretinoin Lotion?

Is Altreno Tretinoin Lotion worth it?

Yes. All 5 gurus who reviewed it give it their stamp of approval, for a Guru Score of 80%.

What is Altreno Tretinoin Lotion's Guru Score?

Altreno Tretinoin Lotion holds a Guru Score of 80%. That is our read on how warmly the experts talk about it, based on the verdicts of 5 independent expert reviewers we have collected.