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Agency

Custom Tretinoin Formula.

Agency
Custom Tretinoin Formula
Retinoids

About this product

A prescription tretinoin formula customized for mature skin concerns, available through an online service without requiring an in-person doctor visit.

Guru Score

Not verified

Score withheld

!
Not independently verified

4 of the 5 takes here are sponsored by the brand. That leaves a single independent take, which is not enough to verify a score, so we are holding it back rather than publishing a number built on paid reviews. The takes are below, each labeled.

5Gurus
4Yay
0Mixed
1Nay

What they liked

  • Custom formulas tailored to mature skin concerns

What they flagged

  • One expert discontinued their subscription

What the gurus are saying

Tretinoin with supporting actives like tranexamic acid and niacinamide, formulated specifically for age-related skin concerns rather than acne, is what draws reviewers. The main appeal is straightforward convenience: custom prescriptions delivered online without office visits. Most gurus report sustained long-term use, with at least one reporting steady results at the 0.1% strength, though one subscriber has stepped away.
Synthesized from 5 expert reviews · most recent take February 2026

What the gurus are saying.

Every take we've logged from this product's reviews across YouTube. Click any row to watch the moment they said it.

All takes Yay takes Nay takes Mixed takes Hide sponsored
Nay
"I just don't feel the need to spend that extra on the consultation plus the compounded formula. And I will be stopping my agency subscription."
Yay
"I've been with Agency for about two and a half, maybe three years now and I'm at 0.1%. And that's the beauty of Agency because as you progress and your skin changes, your skin's not going to stay stagnant. As your skin changes, your licensed dermatology provider at Agency can adjust your custom skincare to allow for those changes. When you first get on a retinoid, you got to take it easy. You want to go low and slow. There's no race because if you go too fast when it comes to starting a retinoid, it's going to slow you down. And it won't be pretty because it can come in the form of your skin peeling, irritation, burning, that sort of thing. But you do want to be consistent."
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"I've been with Agency for about two and a half, maybe three years now and I'm at 0.1%. And that's the beauty of Agency because as you progress and your skin changes, your skin's not going to stay stagnant. As your skin changes, your licensed dermatology provider at Agency can adjust your custom skincare to allow for those changes. When you first get on a retinoid, you got to take it easy. You want to go low and slow. There's no race because if you go too fast when it comes to starting a retinoid, it's going to slow you down. And it won't be pretty because it can come in the form of your skin peeling, irritation, burning, that sort of thing. But you do want to be consistent."
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"They send you all this information in the portal, all of the information on how to use your custom prescription, when to use it, what to use it with, what not to use it with. So it's like you're never alone. All you got to do is open up the portal, read the directions. If you have any questions, you can message the Agency licensed dermatology provider and they'll get back to you. I've been using their formula for a little over 2 years now. It might be going on year three pretty soon. I started at 0.035% tretinoin when I first started out almost maybe 2 or 3 years ago and right now they recently bumped me up to 0.1%. So over time we slightly increased the percentages and if there was a time where my skin was like yo I ain't going to be able to do it they either stayed at the same percentage or if need be maybe they'll take it down a notch. Tretinoin is that girl when it comes to dealing with rough texture, fine lines and wrinkles, and discoloration."
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"At night I use a custom prescription tretinoin from Agency Skincare and tretinoin is an amazing gold standard."
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"I currently get it from Agency which allows me to either inch up or inch down in the percentage that I'm using without ever having to leave my house because you get a licensed dermatology provider. Tretinoin absolutely, I love it. It's an amazing ingredient with a long history of efficacy for the skin and it does amazing things for the skin. It can help with skin texture, it can help to even the skin tone, it can help with discoloration and it can also help to prevent some of the premature signs of aging like it helps with fine lines and wrinkles as well, which is how I personally like to use it. I've been using tretinoin for years, my skin is used to it. I use it pretty much every night except maybe if I'm using a chemical exfoliant that night. But as it gets a little cold out, if my skin is a little dry or a little weather worn or a little sensitive, I might dial back how often I use the tretinoin because I don't want to cause any further irritation."
Yay
"What I'm really grateful for is it thickens the skin and has made mine so much more resilient. Even after an allergic reaction like I had, it was able to bounce back better. I have been using formulas from Agency for years now and prior to that from Curology. I like Agency because their formulas are more focused on age-related concerns as opposed to acne. You go through a skin quiz, submit photos, and then a dermatology provider will customize a formula that will target your main needs and concerns. For those who don't know, I only started using tretinoin properly in my 40s, so it's never too late. That's because my skin was so sensitive and the only prescription strengths available were 0.02, 0.025, and 0.05%, both of which were just way too strong. My dermatology provider would increase the strength when the time was right to a point where I got to 0.025%, but without any uncomfortable retinization along the way. I mean nothing beyond just slight peeling. Right after cleansing, I actually apply the eye balm first. I am using 0.004% tretinoin now. I started at 0.002%, but after I finish this I will be jumping to 0.01%. This has been really well tolerated. I can use it every single day."
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Yay
"If you have a lifetime of accumulated sun damage and you want to go for the big guns, the heavy hitters, I definitely recommend that you go for a prescription tretinoin. The way I get my tretinoin is from a service called Agency. I love this service. It is an online service that you can get your prescription tretinoin without having to go see a doctor in person and then have it filled at a pharmacy. The way this works is that you upload a few pictures to their website, then you're set up one-on-one with a consultation with a skincare provider who recommends the mix of ingredients that go into your custom formula. They actually offer two different formulas with the service. You can get the custom formula which would contain your tretinoin plus three other active ingredients. They also offer a dark spot formula which, if you're noticing increased dark spots after the summertime, is a great product to add on because this will contain four more active ingredients that are specifically targeting dark spots in your skin. My custom formula contains tretinoin at 0.14%, azelaic acid at 5%, tranexamic acid at 5%, and niacinamide at 4%."
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Yay
"This happens to be a wonderful one that is specifically made for more mature skin and was created by dermatology providers. This is specifically from Agency, and yes it has tretinoin, but it also has a blend of other ingredients. It has tranexamic acid which is great for pigmentation, niacinamide aka vitamin B3, and dexpanthenol which has been shown to help with eczema and is bioavailable, meaning it's available for our skin to take in and absorb."
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